Heather Sweeney
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View article: Inpatient Buprenorphine Induction for Opioid Use Disorder in Pregnancy
Inpatient Buprenorphine Induction for Opioid Use Disorder in Pregnancy Open
Objective Buprenorphine is a commonly used medication to manage opioid use disorder, however there is limited data to guide induction protocols specifically during pregnancy. Similar to non-pregnant patients the Clinical Opiate Withdrawal …
View article: The shrinking city school: following trajectories of shrinkage across three decades of an urban school desert
The shrinking city school: following trajectories of shrinkage across three decades of an urban school desert Open
Late on the evening of January 12th, 2021, the Saint Louis Public Schools (SLPS) Board voted to close seven of its schools and transition one of its high schools to a middle school (Clancy, 2021). Sweeping closures are not a new phenomenon…
View article: Comprehensive Metabolic Profiling of MYC-Amplified Medulloblastoma Tumors Reveals Key Dependencies on Amino Acid, Tricarboxylic Acid and Hexosamine Pathways
Comprehensive Metabolic Profiling of MYC-Amplified Medulloblastoma Tumors Reveals Key Dependencies on Amino Acid, Tricarboxylic Acid and Hexosamine Pathways Open
Reprograming of cellular metabolism is a hallmark of cancer. Altering metabolism allows cancer cells to overcome unfavorable microenvironment conditions and to proliferate and invade. Medulloblastoma is the most common malignant brain tumo…
View article: OTME-9. Comprehensive Metabolic Profiling Of high MYC Medulloblastoma Reveals Key Differences Between In <i>Vitro</i> And In <i>Vivo</i> Glucose And Glutamine Usage
OTME-9. Comprehensive Metabolic Profiling Of high MYC Medulloblastoma Reveals Key Differences Between In <i>Vitro</i> And In <i>Vivo</i> Glucose And Glutamine Usage Open
Reprograming of cellular metabolism is a hallmark of cancer. The metabolic alterations in cancer cells is not only defined by series of genetic mutations, but also reflecting the crosstalk between cancer cells and other factors in the micr…
View article: Novel Glutamine Antagonist JHU395 Suppresses MYC-Driven Medulloblastoma Growth and Induces Apoptosis
Novel Glutamine Antagonist JHU395 Suppresses MYC-Driven Medulloblastoma Growth and Induces Apoptosis Open
Medulloblastoma is the most common malignant pediatric brain tumor. Amplification of c-MYC is a hallmark of a subset of poor-prognosis medulloblastoma. MYC upregulates glutamine metabolism across many types of cancer. We modified the natur…
View article: FSMP-18. COMPREHENSIVE METABOLIC PROFILING OF HIGH MYC MEDULLOBLASTOMA REVEALS KEY DIFFERENCES BETWEEN IN VITRO AND IN VIVO GLUCOSE AND GLUTAMINE USAGE
FSMP-18. COMPREHENSIVE METABOLIC PROFILING OF HIGH MYC MEDULLOBLASTOMA REVEALS KEY DIFFERENCES BETWEEN IN VITRO AND IN VIVO GLUCOSE AND GLUTAMINE USAGE Open
Reprograming of cellular metabolism is a hallmark of cancer. Altered metabolism can overcome unfavorable conditions, allowing cancer cells to proliferate and invade in different tumor microenvironments. Medulloblastoma is the most common m…
View article: Unbiased Proteomic and Phosphoproteomic Analysis Identifies Response Signatures and Novel Susceptibilities After Combined MEK and mTOR Inhibition in BRAFV600E Mutant Glioma
Unbiased Proteomic and Phosphoproteomic Analysis Identifies Response Signatures and Novel Susceptibilities After Combined MEK and mTOR Inhibition in BRAFV600E Mutant Glioma Open
The mitogen-activated protein kinase pathway is one of the most frequently altered pathways in cancer. It is involved in the control of cell proliferation, invasion, and metabolism, and can cause resistance to therapy. A number of aggressi…
View article: MEK Inhibition Suppresses Growth of Atypical Teratoid/Rhabdoid Tumors
MEK Inhibition Suppresses Growth of Atypical Teratoid/Rhabdoid Tumors Open
Atypical teratoid/rhabdoid (AT/RT) tumors are the most common malignant brain tumor of infancy and have a poor prognosis. We have previously identified very high expression of LIN28A and/or LIN28B in AT/RT tumors and showed that AT/RT have…
View article: Inhibition of hyaluronan synthesis attenuates pulmonary hypertension associated with lung fibrosis
Inhibition of hyaluronan synthesis attenuates pulmonary hypertension associated with lung fibrosis Open
Background and Purpose Group III pulmonary hypertension (PH) is a highly lethal and widespread lung disorder that is a common complication in idiopathic pulmonary fibrosis (IPF) where it is considered to be the single most significant pred…
View article: Model studies aimed toward constructing PI3K pathways in leukemia T-cells from shRNA knockdowns
Model studies aimed toward constructing PI3K pathways in leukemia T-cells from shRNA knockdowns Open
Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2017.