Heba Abdelmegeed
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View article: Protective effects of commercial artichoke (Cynara scolymus L.) leaf powder against aflatoxin B1-induced reproductive toxicity in male rats
Protective effects of commercial artichoke (Cynara scolymus L.) leaf powder against aflatoxin B1-induced reproductive toxicity in male rats Open
View article: Discovery of N′-(1-(coumarin-3-yl)ethylidene)benzenesulfonohydrazide as a novel wound healing enhancer: synthesis, biological assessment, and molecular modeling
Discovery of N′-(1-(coumarin-3-yl)ethylidene)benzenesulfonohydrazide as a novel wound healing enhancer: synthesis, biological assessment, and molecular modeling Open
Wound healing poses a considerable challenge in the domain of medical science. In modern clinical practice, there is a growing trend towards using herbal compounds to aid in the repair process. Among these, coumarin, a phytochemical recogn…
View article: Mitochondria in cancer: a comprehensive review, bibliometric analysis, and future perspectives
Mitochondria in cancer: a comprehensive review, bibliometric analysis, and future perspectives Open
Introduction Mitochondria are essential organelles for many aspects of cellular homeostasis. They play an indispensable role in the development and progression of diseases, particularly cancer which is a major cause of death worldwide. We …
View article: Coumarins: Quorum Sensing and Biofilm Formation Inhibition
Coumarins: Quorum Sensing and Biofilm Formation Inhibition Open
Quorum sensing (QS) is a bacterial cell-to-cell communication mechanism that plays an essential role in bacterial pathogenesis. QS governs bacterial behavior and controls biofilm formation, which in turn contributes to antibiotic resistanc…
View article: Exploring the antitumor potential of novel quinoline derivatives <i>via</i> tubulin polymerization inhibition in breast cancer; design, synthesis and molecular docking
Exploring the antitumor potential of novel quinoline derivatives <i>via</i> tubulin polymerization inhibition in breast cancer; design, synthesis and molecular docking Open
A series of quinoline derivatives was designed and synthesized as novel tubulin inhibitors targeting the colchicine binding site.
View article: Author response: Succinate mediates inflammation-induced adrenocortical dysfunction
Author response: Succinate mediates inflammation-induced adrenocortical dysfunction Open
View article: Synthetic Analogs of Marine Alkaloid Aplysinopsin Suppress Anti-Apoptotic Protein BCL2 in Prostate Cancer
Synthetic Analogs of Marine Alkaloid Aplysinopsin Suppress Anti-Apoptotic Protein BCL2 in Prostate Cancer Open
Aplysinopsins are a class of indole alkaloids that possess various pharmacological activities. Although their action has been studied in regard to many diseases, their effect on prostate cancer has not yet been examined. Therefore, we synt…
View article: Succinate mediates inflammation-induced adrenocortical dysfunction
Succinate mediates inflammation-induced adrenocortical dysfunction Open
The hypothalamus-pituitary-adrenal (HPA) axis is activated in response to inflammation leading to increased production of anti-inflammatory glucocorticoids by the adrenal cortex, thereby representing an endogenous feedback loop. However, s…
View article: Obesity-associated lipidomic remodeling of the adrenal gland indicates an important role of the FADS2-arachidonic acid axis in adrenocortical hormone production
Obesity-associated lipidomic remodeling of the adrenal gland indicates an important role of the FADS2-arachidonic acid axis in adrenocortical hormone production Open
Objective Adrenocortical hormone levels increase in obesity, potentially contributing to development of obesity-associated pathologies. Here we explored whether lipidomic remodeling of the adrenal gland could mediate altered adrenocortical…