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A rare ORAI1 missense variant associates with risk of vascular diseases in White British adults Open

Heba Shawer, Chew W. Cheng, Karen E. Hemmings, Abeer M. Aldawsari, Gonzalo Revilla-González , et al. · 2024

Medicine Biology

Background Pathological remodelling of native vascular smooth muscle cells (VSMC) within the arterial wall is a key contributor to vascular disease. A driver of this remodelling is platelet-derived growth factor BB (PDGF-BB) and its signal…

Side-by-side comparison of published small molecule inhibitors against thapsigargin-induced store-operated Ca2+ entry in HEK293 cells Open

Katherine Norman, Karen E. Hemmings, Heba Shawer, Hollie L. Appleby, Alan J. Burnett , et al. · 2024

Chemistry Biology

Calcium (Ca 2+ ) is a key second messenger in eukaryotes, with store-operated Ca 2+ entry (SOCE) being the main source of Ca 2+ influx into non-excitable cells. ORAI1 is a highly Ca 2+ -selective plasma membrane channel that encodes SOCE. …

Whole-body insulin resistance leads to accelerated atherosclerosis: role for Nox2 NADPH oxidase Open

Azhar Maqbool, Hema Viswambharan, Anna Skromna, Natalia Makava, Heba Shawer , et al. · 2024

Medicine

Insulin resistance underpins the progression of type 2 diabetes mellitus and leads to a collection of risk factors for the development of atherosclerosis. Whether or not insulin resistance at a whole-body level per se leads to accelerated …

Figure S6 from miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway Open

Mohamed E. Salem, Jacob A. O’Brien, Stefanie Bernaudo, Heba Shawer, Gang Ye , et al. · 2023

Medicine Chemistry Biology

Relationship between FOXA2 or VCAN mRNA levels and patient survival.

Figure S4 from miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway Open

Mohamed E. Salem, Jacob A. O’Brien, Stefanie Bernaudo, Heba Shawer, Gang Ye , et al. · 2023

Medicine

Grouping of tumour samples in TCGA ovarian cancer database for the analysis of FOXA2 and VCAN expression

Supplementary Tables from miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway Open

Mohamed E. Salem, Jacob A. O’Brien, Stefanie Bernaudo, Heba Shawer, Gang Ye , et al. · 2023

Biology Medicine

Table S1 to S3. Description of clinical samples; sequences of primers, siRNAs, and microRNA mimics and inhibitors; and analysis of top regulated genes by mir-590.

Figure S3 from miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway Open

Mohamed E. Salem, Jacob A. O’Brien, Stefanie Bernaudo, Heba Shawer, Gang Ye , et al. · 2023

Medicine Chemistry Biology

Regulation of FOXA2 by miR-590-3p and effects of FOXA2 on cell invasion and VCAN expression.

Figure S4 from miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway Open

Mohamed E. Salem, Jacob A. O’Brien, Stefanie Bernaudo, Heba Shawer, Gang Ye , et al. · 2023

Medicine Chemistry

Grouping of tumour samples in TCGA ovarian cancer database for the analysis of FOXA2 and VCAN expression

Figure S5 from miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway Open

Mohamed E. Salem, Jacob A. O’Brien, Stefanie Bernaudo, Heba Shawer, Gang Ye , et al. · 2023

Medicine Biology

Relationship between FOXA2 and VCAN methylation status and their mRNA levels in the TCGA ovarian tumour samples

Figure S2 from miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway Open

Mohamed E. Salem, Jacob A. O’Brien, Stefanie Bernaudo, Heba Shawer, Gang Ye , et al. · 2023

Chemistry Biology Medicine

Generation of EOC cell lines stably over expressing mir-590 and the effect of mir-590 over expression on colony formation

Figure S2 from miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway Open

Mohamed E. Salem, Jacob A. O’Brien, Stefanie Bernaudo, Heba Shawer, Gang Ye , et al. · 2023

Medicine Biology

Generation of EOC cell lines stably over expressing mir-590 and the effect of mir-590 over expression on colony formation

Figure S5 from miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway Open

Mohamed E. Salem, Jacob A. O’Brien, Stefanie Bernaudo, Heba Shawer, Gang Ye , et al. · 2023

Medicine Biology

Relationship between FOXA2 and VCAN methylation status and their mRNA levels in the TCGA ovarian tumour samples

Data from miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway Open

Mohamed E. Salem, Jacob A. O’Brien, Stefanie Bernaudo, Heba Shawer, Gang Ye , et al. · 2023

Biology Medicine

miRNAs play important roles in gene regulation, and their dysregulation is associated with many diseases, including epithelial ovarian cancer (EOC). In this study, we determined the expression and function of miR-590-3p in EOC. miR-590-3p …

Data from miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway Open

Mohamed E. Salem, Jacob A. O’Brien, Stefanie Bernaudo, Heba Shawer, Gang Ye , et al. · 2023

Medicine Biology

miRNAs play important roles in gene regulation, and their dysregulation is associated with many diseases, including epithelial ovarian cancer (EOC). In this study, we determined the expression and function of miR-590-3p in EOC. miR-590-3p …

Figure S1 from miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway Open

Mohamed E. Salem, Jacob A. O’Brien, Stefanie Bernaudo, Heba Shawer, Gang Ye , et al. · 2023

Chemistry Biology Medicine

miR-590-3p promotes cell proliferation, migration, and invasion in multiple EOC cell lines.

Figure S1 from miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway Open

Mohamed E. Salem, Jacob A. O’Brien, Stefanie Bernaudo, Heba Shawer, Gang Ye , et al. · 2023

Chemistry Biology Medicine

miR-590-3p promotes cell proliferation, migration, and invasion in multiple EOC cell lines.

Figure S6 from miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway Open

Mohamed E. Salem, Jacob A. O’Brien, Stefanie Bernaudo, Heba Shawer, Gang Ye , et al. · 2023

Medicine Biology

Relationship between FOXA2 or VCAN mRNA levels and patient survival.

Supplementary Tables from miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway Open

Mohamed E. Salem, Jacob A. O’Brien, Stefanie Bernaudo, Heba Shawer, Gang Ye , et al. · 2023

Biology Medicine

Table S1 to S3. Description of clinical samples; sequences of primers, siRNAs, and microRNA mimics and inhibitors; and analysis of top regulated genes by mir-590.

Figure S3 from miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway Open

Mohamed E. Salem, Jacob A. O’Brien, Stefanie Bernaudo, Heba Shawer, Gang Ye , et al. · 2023

Medicine Biology

Regulation of FOXA2 by miR-590-3p and effects of FOXA2 on cell invasion and VCAN expression.

Absence of association between host genetic mutations in the ORAI1 gene and COVID-19 fatality Open

Heba Shawer, Chew W. Cheng, Marc Bailey · 2022

Medicine Biology

The calcium ion channel ORAI1 has emerged as a promising therapeutic target for the Coronavirus Disease 19 (COVID-19)-associated pneumonia, and a pharmacological inhibitor of ORAI1 has now reached clinical trials for severe COVID-19 pneumo…

ORAI1 Ca2+ Channel as a Therapeutic Target in Pathological Vascular Remodelling Open

Heba Shawer, Katherine Norman, Chew W. Cheng, Richard Foster, David J. Beech , et al. · 2021

Biology

In the adult, vascular smooth muscle cells (VSMC) are normally physiologically quiescent, arranged circumferentially in one or more layers within blood vessel walls. Remodelling of native VSMC to a proliferative state for vascular developm…

Imaging Biological Pathways in Abdominal Aortic Aneurysms Using Positron Emission Tomography Open

Michael Bell, Richa Gandhi, Heba Shawer, Charalampos Tsoumpas, Marc A. Bailey · 2021

Medicine Biology

Abdominal aortic aneurysm (AAA) is a focal dilation of the aorta associated with high mortality through rupture. Most of our understanding of the biology that drives AAA progression originates from surgical samples acquired in cases of ele…

A missense mutation of ErbB2 produces a novel mouse model of stillbirth associated with a cardiac abnormality but lacking abnormalities of placental structure Open

Heba Shawer, Esther Aiyelaagbe, Christopher Clowes, Samantha C. Lean, Yinhui Lu , et al. · 2020

Biology Medicine

Embryonic lethality in the ErbB2 homozygous mutant mouse cannot be attributed to placental pathology. As such, we conclude the ErbB2M802R mutant is a model of stillbirth with a non-placental cause of death. The mechanism of the atrial bloc…

Divergent effects of genetic and pharmacological inhibition of Nox2 NADPH oxidase on insulin resistance-related vascular damage Open

Azhar Maqbool, Nicole T. Watt, Natalie J Haywood, Hema Viswambharan, Anna Skromna , et al. · 2020

Biology Medicine

Insulin resistance leads to excessive endothelial cell (EC) superoxide generation and accelerated atherosclerosis. The principal source of superoxide from the insulin-resistant endothelium is the Nox2 isoform of NADPH oxidase. Here we exam…

Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca <sup>2+</sup> Handling After Pressure Overload Open

Fiona Bartoli, Marc A. Bailey, Baptiste Rode, Philippe Matéo, Fabrice Antigny , et al. · 2020

Medicine

Background: Orai1 is a critical ion channel subunit, best recognized as a mediator of store-operated Ca 2+ entry (SOCE) in nonexcitable cells. SOCE has recently emerged as a key contributor of cardiac hypertrophy and heart failure but the …

miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway Open

Mohamed A. Salem, Jacob A. O’Brien, Stefanie Bernaudo, Heba Shawer, Gang Ye , et al. · 2018

Medicine

miRNAs play important roles in gene regulation, and their dysregulation is associated with many diseases, including epithelial ovarian cancer (EOC). In this study, we determined the expression and function of miR-590-3p in EOC. miR-590-3p …

Disruption of Claudin-1 Expression by miRNA-182 Alters the Susceptibility to Viral Infectivity in HCV Cell Models Open

Sarah E. Riad, Dalia S. Elhelw, Heba Shawer, Nada El‐Ekiaby, Ayman Salah , et al. · 2018

Biology Chemistry

HCV entry involves a complex interplay between viral and host molecules. During post-binding interactions, the viral E2 complexes with CD81 receptor for delivery to the tight junction proteins CLDN1 and OCLN, which aid in viral internaliza…

The potential involvement of the cofactor of BRCA1 in hepatocellular carcinoma pathogenesis Open

Aya Youssef, Heba Shawer, Alaa Afify, Asma Amleh · 2016

Biology

The cofactor of BRCA1 (COBRA1), which also refers to negative elongation factor polypeptide B (NELF-B), is a negative elongation factor (NELF) subunit that has been implicated in the development and progression of several cancers. While re…

New genetic variants of LATS1 detected in urinary bladder and colon cancer Open

Mona Kamal Saadeldin, Heba Shawer, Ahmed Mostafa, Neemat Kassem, Asma Amleh , et al. · 2015

Biology

LATS1, the large tumor suppressor 1 gene, encodes for a serine/threonine kinase protein and is implicated in cell cycle progression. LATS1 is down-regulated in various human cancers, such as breast cancer, and astrocytoma. Point mutations …

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