Huixing Zhou
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View article: Renal response of selinexor, bortezomib, pomalidomide, and dexamethasone in newly diagnosed multiple myeloma patients with renal impairment: A phase 2, prospective, multicenter study
Renal response of selinexor, bortezomib, pomalidomide, and dexamethasone in newly diagnosed multiple myeloma patients with renal impairment: A phase 2, prospective, multicenter study Open
Renal impairment (RI) is a common complication of multiple myeloma (MM), accounting for ~40% of newly diagnosed MM (NDMM), which associated with higher mortality, increased hospitalization, and poorer prognosis. Rapid and effective interve…
View article: A Novel Strategy for Accurate Posterior Fragment Reduction in Posterior Pilon Fracture
A Novel Strategy for Accurate Posterior Fragment Reduction in Posterior Pilon Fracture Open
Background: Reducing the posterior fragment in posterior pilon fractures presents a significant surgical challenge due to its complex anatomy and limited exposure. In recent years, the transfibular approach has gained attention for enhanci…
View article: High GOLT1A expression induces poor prognosis in papillary thyroid carcinoma
High GOLT1A expression induces poor prognosis in papillary thyroid carcinoma Open
This study aims to investigate the clinical relevance of GOLT1A in papillary thyroid carcinoma (PTC) and evaluate its significance in prognosis of PTC. In this study, 527 data downloaded from the TCGA database and 280 data downloaded from …
View article: Postoperative functions and complications in minimally invasive percutaneous plate osteosynthesis compared with intramedullary nail for distal tibial fractures: a meta-analysis and systematic review
Postoperative functions and complications in minimally invasive percutaneous plate osteosynthesis compared with intramedullary nail for distal tibial fractures: a meta-analysis and systematic review Open
Objective: This meta-analysis aims to compare the minimally invasive percutaneous plate osteosynthesis (MIPPO) versus intramedullary nail (IMN) for distal tibial fractures. The comparison focuses on postoperative functional outcomes, compl…
View article: The efficacy of new drug regimens in treating newly diagnosed high-risk cytogenetic multiple myeloma patients: a systematic literature review and meta-analysis
The efficacy of new drug regimens in treating newly diagnosed high-risk cytogenetic multiple myeloma patients: a systematic literature review and meta-analysis Open
Introduction Multiple myeloma (MM) is a plasma cell malignancy comprising 10% of hematologic cancers, associated with bone marrow dysfunction and organ damage. High-risk cytogenetic MM patients, identified by specific genetic abnormalities…
View article: Clinical Characteristics and Prognostic Value of Circulating Plasma Cells in Newly Diagnosed Multiple Myeloma Patients in China
Clinical Characteristics and Prognostic Value of Circulating Plasma Cells in Newly Diagnosed Multiple Myeloma Patients in China Open
Our study suggested that newly diagnosed MM patients with CPC had poor outcome, but CPC was not an independent poor prognostic factor for patients with newly diagnosed MM.
View article: High Efficacy of Adding G-CSF to Venetoclax Plus Azacitidine As Front-Line Treatment in Previously Untreated Acute Myeloid Leukaemia:a Pilot Study
High Efficacy of Adding G-CSF to Venetoclax Plus Azacitidine As Front-Line Treatment in Previously Untreated Acute Myeloid Leukaemia:a Pilot Study Open
Background: Venetoclax plus azacitidine (VA regimen) is recommended for treatment-naive patients with acute myeloid leukaemia (AML) who are unfit for intensive chemotherapy. However, the composite complete remission rate after one cycle of…
View article: A new prognostic scoring system for newly diagnosed multiple myeloma in the era of new drugs
A new prognostic scoring system for newly diagnosed multiple myeloma in the era of new drugs Open
Background We developed a new predictive staging system to explore the heterogeneity of survival in newly diagnosed multiple myeloma (NDMM) patients in the real world. Methods In this retrospective study, we evaluated the predictive value …
View article: Chromosome 1q21 Aberrations Are Poor Prognostic Factors for Newly Diagnosed Multiple Myeloma Patients
Chromosome 1q21 Aberrations Are Poor Prognostic Factors for Newly Diagnosed Multiple Myeloma Patients Open
Background Chromosome 1q21 aberrations are one of the most common cytogenetic abnormalities in patients with multiple myeloma (MM). However, the prognostic value remains controversial. This study aimed to determine the prognostic value of …
View article: Esophageal ulcer and multisystem inflammatory syndrome after COVID-19: A case report
Esophageal ulcer and multisystem inflammatory syndrome after COVID-19: A case report Open
BACKGROUND Multisystem inflammatory syndrome in adults (MIS-A) is a rare but severe disease occurring several weeks after severe acute respiratory syndrome coronavirus 2 infection. It develops in adults with inflammation of different organ…
View article: [Minimal residual disease assessment and progress in multiple myeloma].
[Minimal residual disease assessment and progress in multiple myeloma]. Open
With the rapid iteration of multiple myeloma therapeutics over the last two decades, as well as increasing remission rates and depth of remission in patients, traditional methods for monitoring disease response are insufficient to meet the…
View article: Deficiency of Transcription Factor Sp1 Contributes to Hypertrophic Cardiomyopathy
Deficiency of Transcription Factor Sp1 Contributes to Hypertrophic Cardiomyopathy Open
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is the most prevalent monogenic heart disorder. However, the pathogenesis of HCM, especially its nongenetic mechanisms, remains largely unclear. Transcription factors are known to be involved i…
View article: Efficacy and safety of generic pomalidomide plus low-dose dexamethasone in relapsed or refractory multiple myeloma: a multicenter, open-label, single-arm trial
Efficacy and safety of generic pomalidomide plus low-dose dexamethasone in relapsed or refractory multiple myeloma: a multicenter, open-label, single-arm trial Open
This multicenter, open-label, single-arm trial (ClinicalTrials.gov, NCT05236621) was conducted to confirm the efficacy and safety of generic pomalidomide plus dexamethasone in Chinese patients with relapsed or refractory multiple myeloma (…
View article: P925: PHASE 1 TRIAL OF ANTI-CD38 MONOCLONAL ANTIBODY CM313 IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA OR LYMPHOMA
P925: PHASE 1 TRIAL OF ANTI-CD38 MONOCLONAL ANTIBODY CM313 IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA OR LYMPHOMA Open
Topic: 14. Myeloma and other monoclonal gammopathies - Clinical Background: Relapsed/refractory multiple myeloma (RRMM) and relapsed/refractory lymphoma are malignancies that pose significant therapeutic challenges. CM313, an anti-CD38 mon…
View article: Identification of aberrantly expressed lncRNAs and ceRNA networks in multiple myeloma: a combined high-throughput sequencing and microarray analysis
Identification of aberrantly expressed lncRNAs and ceRNA networks in multiple myeloma: a combined high-throughput sequencing and microarray analysis Open
Background This study aimed to explore the potential effects of long non-coding RNAs (lncRNAs) in multiple myeloma (MM) patients using two detection methods: high-throughput sequencing and microarray. Methods In this study, lncRNAs were de…
View article: Characteristics and Risk Factors of Ultra-High-Risk Patients with Newly Diagnosed Multiple Myeloma
Characteristics and Risk Factors of Ultra-High-Risk Patients with Newly Diagnosed Multiple Myeloma Open
Objective: To investigate the clinical characteristics and risk factors of ultra-high-risk (UHR) patients with newly diagnosed multiple myeloma (MM). Methods: We screened UHR patients with a survival of less than 24 months and we selected …
View article: Prognostic nomogram for multiple myeloma early relapse after autologous stem cell transplant in the novel agent era
Prognostic nomogram for multiple myeloma early relapse after autologous stem cell transplant in the novel agent era Open
Background The present study intended to establish a predictive nomogram for early relapse (ER) ( UNL, and response less than very good partial response (VGPR) after ASCT. The calibration curve showed good fitness between the nomogram pred…
View article: Endothelial deletion of PTBP1 disrupts ventricular chamber development
Endothelial deletion of PTBP1 disrupts ventricular chamber development Open
The growth and maturation of the ventricular chamber require spatiotemporally precise synergy between diverse cell types. Alternative splicing deeply affects the processes. However, the functional properties of alternative splicing in card…
View article: Prognostic value of t(4;14) translocation in newly diagnosed multiple myeloma patients in novel agent era
Prognostic value of t(4;14) translocation in newly diagnosed multiple myeloma patients in novel agent era Open
These results demonstrated that t(4; 14) alone may be not a poor prognostic factor patients with newly diagnosed MM in the novel agent era.
View article: Impact of dialysis dependence on survival for multiple myeloma with renal impairment: a multicenter study in China.
Impact of dialysis dependence on survival for multiple myeloma with renal impairment: a multicenter study in China. Open
Renal impairment (RI) is a very common complication of multiple myeloma (MM) with a negative impact on survival. Herein we retrospectively analyzed 334 MM patients with renal impairment at diagnosis from three hospitals in China. All 334 p…
View article: CD20 expression: A risk stratification factor for newly diagnosed multiple myeloma with t(11;14)
CD20 expression: A risk stratification factor for newly diagnosed multiple myeloma with t(11;14) Open
Objective Translocation (11;14) is one of the most frequent recurrent cytogenetic abnormalities in multiple myeloma (MM), while its clinical prognostic value remains controversial. CD20 expression is uncommon in MM while strongly associate…
View article: Low Barthel index score is a poor prognostic factor for newly diagnosed multiple myeloma patients
Low Barthel index score is a poor prognostic factor for newly diagnosed multiple myeloma patients Open
Background: The basic activities of daily life may affect the prognosis of multiple myeloma (MM) patients and the Barthel index (BI) is currently the most widely used tool to evaluate basic activities of daily life, but few studies have ev…
View article: Newly diagnosed multiple myeloma patients with CD56 expression benefit more from autologous stem cell transplantation
Newly diagnosed multiple myeloma patients with CD56 expression benefit more from autologous stem cell transplantation Open
Background Several studies showed that lack of CD56 expression was a poor prognostic factor for patients with newly diagnosed multiple myeloma (NDMM). However, other studies were not able to confirm the prognostic value of CD56 in NDMM. Th…
View article: Mechanisms underlying synergism between circularized tumor necrosis factor‐related apoptosis inducing ligand and bortezomib in bortezomib‐sensitive or ‐resistant myeloma cells
Mechanisms underlying synergism between circularized tumor necrosis factor‐related apoptosis inducing ligand and bortezomib in bortezomib‐sensitive or ‐resistant myeloma cells Open
Mechanisms underlying interactions between a novel, clinically relevant circularized tumor necrosis factor‐related apoptosis inducing ligand (TRAIL) agonist, circularly permuted TRAIL (CPT) have been examined in multiple myeloma (MM) cells…
View article: Echocardiography‐defined pulmonary hypertension is an adverse prognostic factor for newly diagnosed multiple myeloma patients
Echocardiography‐defined pulmonary hypertension is an adverse prognostic factor for newly diagnosed multiple myeloma patients Open
Background Pulmonary hypertension (PH) is a common but rarely recognized comorbidity of multiple myeloma (MM) patients, while its prognostic significance for MM has been rarely reported. Methods We retrospectively analyzed the clinical cha…
View article: LRP5 regulates cardiomyocyte proliferation and neonatal heart regeneration by the AKT/P21 pathway
LRP5 regulates cardiomyocyte proliferation and neonatal heart regeneration by the AKT/P21 pathway Open
The neonatal heart can efficiently regenerate within a short period after birth, whereas the adult mammalian heart has extremely limited capacity to regenerate. The molecular mechanisms underlying neonatal heart regeneration remain elusive…