Héctor Castro-Abril
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View article: Improving Cell-to-Cell and Cell-to-Matrix Contact inside Microphysiological Systems
Improving Cell-to-Cell and Cell-to-Matrix Contact inside Microphysiological Systems Open
Innovative microfluidic technology aims to create more realistic in vitro simulations of human tissues. Organ-on-a-chip (OoC) devices within microfluidic chips mimic in vivo environments but face limitations due to inert material between c…
View article: Reducing Inert Materials for Optimal Cell–Cell and Cell–Matrix Interactions within Microphysiological Systems
Reducing Inert Materials for Optimal Cell–Cell and Cell–Matrix Interactions within Microphysiological Systems Open
In the pursuit of achieving a more realistic in vitro simulation of human biological tissues, microfluidics has emerged as a promising technology. Organ-on-a-chip (OoC) devices, a product of this technology, contain miniature tissues withi…
View article: Nanoparticles Stokes radius assessment through permeability coefficient determination within a new stratified epithelium on-chip model
Nanoparticles Stokes radius assessment through permeability coefficient determination within a new stratified epithelium on-chip model Open
Tissue barrier permeability plays a crucial role in determining the selective transport of substances across epithelial tissues, including drugs, cosmetic substances, and chemicals. The ability of these substances to cross through tissue b…
View article: A Mechanical Approach to the Growth Plate Behaviour and Chondrocytes Columns Organization
A Mechanical Approach to the Growth Plate Behaviour and Chondrocytes Columns Organization Open
This study aims to explore the behaviour of mechanical stimuli and their effect on growth plate shape under different physiological scenarios and loading conditions. A linear elastic, isotropic, and homogeneous model was implemented to mod…
View article: 3D Biomimetic in Vitro Model of Self-induced Cardiac Ischemia Based on the Co-culture of Cardiomyocytes Derived from hiPSC and Primary Human Cardiac Fibroblast
3D Biomimetic in Vitro Model of Self-induced Cardiac Ischemia Based on the Co-culture of Cardiomyocytes Derived from hiPSC and Primary Human Cardiac Fibroblast Open
Large cardiac spheroids (i.e., > 500 µm diameter) that self-induce an ischemic core were generated by co-culture of cardiomyocytes derived from induced pluripotent cells (hiPSC-CMs) and primary cardiac fibroblast (hCF). Without modificatio…
View article: The Role of Mechanical Properties and Structure of Type I Collagen Hydrogels on Colorectal Cancer Cell Migration
The Role of Mechanical Properties and Structure of Type I Collagen Hydrogels on Colorectal Cancer Cell Migration Open
Mechanical interactions between cells and their microenvironment play an important role in determining cell fate, which is particularly relevant in metastasis, a process where cells invade tissue matrices with different mechanical properti…
View article: A mechanobiological model for tumor spheroid evolution with application to glioblastoma: A continuum multiphysics approach
A mechanobiological model for tumor spheroid evolution with application to glioblastoma: A continuum multiphysics approach Open
Glioblastoma tumor spheroid evolution is driven by mechanical interactions of the cell aggregate and the dynamical evolution of the cell population. All this information can be used to further investigate mechanistic effects in the evoluti…
View article: Nanoparticles Stokes radius assessment through permeability coefficient determination within a new stratified epithelium on-chip model
Nanoparticles Stokes radius assessment through permeability coefficient determination within a new stratified epithelium on-chip model Open
Tissue barrier permeability plays a crucial role in determining the selective transport of substances across epithelial tissues, including drugs, cosmetic substances, and chemicals. The ability of these substances to cross through tissue b…
View article: A mechanobiological model for tumor spheroids evolution: application to glioblastoma
A mechanobiological model for tumor spheroids evolution: application to glioblastoma Open
Spheroids are in vitro spherical structures of cell aggregates, eventually cultured within a hydrogel matrix, that are used, among other applications, as a technological platform to investigate tumor formation and evolution. Several intere…
View article: Growth Plate Pathology in the Mucopolysaccharidosis Type VI Rat Model—An Experimental and Computational Approach
Growth Plate Pathology in the Mucopolysaccharidosis Type VI Rat Model—An Experimental and Computational Approach Open
Background: Mucopolysaccharidoses (MPS) are a group of inherited metabolic diseases caused by impaired function or absence of lysosomal enzymes involved in degradation of glycosaminoglycans. Clinically, MPS are skeletal dysplasias, charact…
View article: Biophysical Stimuli: A Review of Electrical and Mechanical Stimulation in Hyaline Cartilage
Biophysical Stimuli: A Review of Electrical and Mechanical Stimulation in Hyaline Cartilage Open
Objective Hyaline cartilage degenerative pathologies induce morphologic and biomechanical changes resulting in cartilage tissue damage. In pursuit of therapeutic options, electrical and mechanical stimulation have been proposed for improvi…