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View article: Personalized Fluid Management in Patients With Sepsis and Acute Kidney Injury: A Causal Machine Learning Approach
Personalized Fluid Management in Patients With Sepsis and Acute Kidney Injury: A Causal Machine Learning Approach Open
IMPORTANCE: IV fluids are the cornerstone for management of acute kidney injury (AKI) after sepsis but can cause fluid overload. A restrictive fluid strategy may benefit some patients; however, identifying them is challenging. Novel causal…
View article: Jugular bulb venous to arterial carbon dioxide gradient is associated with treatment-responsive phenotypes of hypoxic-ischemic brain injury
Jugular bulb venous to arterial carbon dioxide gradient is associated with treatment-responsive phenotypes of hypoxic-ischemic brain injury Open
When interpreted with SjvO2, the cerebral pCO2 gap may uncover covert cerebral dysfunction, and can identify treatment-responsive causes of elevated SjvO2. Thus, the pCO2 gap may be a useful adjunct for phenotyping HIBI.
View article: Implementing Artificial Intelligence in Critical Care Medicine: a consensus of 22
Implementing Artificial Intelligence in Critical Care Medicine: a consensus of 22 Open
Artificial Intelligence (AI) is rapidly transforming the landscape of critical care, offering opportunities for enhanced diagnostic precision and personalized patient management. However, its integration into ICU clinical practice presents…
Preventing acute kidney injury and its longer-term impact in the critically ill Open
Acute kidney injury (AKI) is a heterogeneous syndrome that not only affects short-term morbidity and mortality but also influences long-term outcomes. AKI is part of acute kidney disease (AKD) that encompasses a range of different conditio…
View article: Automatic Cannulation of Femoral Vessels in a Porcine Shock Model
Automatic Cannulation of Femoral Vessels in a Porcine Shock Model Open
Rapid and reliable vascular access is critical in trauma and critical care. Central vascular catheterization enables high-volume resuscitation, hemodynamic monitoring, and advanced interventions like ECMO and REBOA. While peripheral access…
View article: ORAKLE: Optimal Risk prediction for mAke30 in patients with acute Kidney injury using deep Learning
ORAKLE: Optimal Risk prediction for mAke30 in patients with acute Kidney injury using deep Learning Open
Background Major Adverse Kidney Events within 30 days (MAKE30) is an important patient-centered outcome for assessing the impact of acute kidney injury (AKI). The existing prediction models for MAKE30 are static and overlook dynamic change…
View article: Personalized Fluid Management in Patients with Sepsis and AKI: A Casual Machine Learning Approach
Personalized Fluid Management in Patients with Sepsis and AKI: A Casual Machine Learning Approach Open
Importance Intravenous (IV) fluids are cornerstone for management of acute kidney injury (AKI) after sepsis but can cause fluid overload. Restrictive fluid strategy may benefit some patients, however, identifying them is challenging. Novel…
View article: Hemoadsorption: consensus report of the 30th Acute Disease Quality Initiative workgroup
Hemoadsorption: consensus report of the 30th Acute Disease Quality Initiative workgroup Open
Adsorption-based extracorporeal therapies have been subject to technical developments and clinical application for close to five decades. More recently, new technological developments in membrane and sorbent manipulation have made it possi…
View article: Metformin for sepsis-associated AKI: a protocol for the Randomized Clinical Trial of the Safety and FeasibiLity of Metformin as a Treatment for sepsis-associated AKI (LiMiT AKI)
Metformin for sepsis-associated AKI: a protocol for the Randomized Clinical Trial of the Safety and FeasibiLity of Metformin as a Treatment for sepsis-associated AKI (LiMiT AKI) Open
Introduction Acute kidney injury (AKI) is a common complication of sepsis associated with increased risk of death. Preclinical data and observational human studies suggest that activation of AMP-activated protein kinase, an ubiquitous mast…
Adapting Animal Models to Assess Sufficiency of Fluid Resuscitation in Humans (Student Abstract) Open
Fluid resuscitation is an initial treatment frequently employed to treat shock, restore lost blood, protect tissues from injury, and prevent organ dysfunction in critically ill patients. However, it is not without risk (e.g., overly aggres…
View article: Feasibility Assessment of a Biomarker-Guided Kidney-Sparing Sepsis Bundle: The Limiting Acute Kidney Injury Progression In Sepsis Trial
Feasibility Assessment of a Biomarker-Guided Kidney-Sparing Sepsis Bundle: The Limiting Acute Kidney Injury Progression In Sepsis Trial Open
OBJECTIVES: To determine the feasibility, safety, and efficacy of a biomarker-guided implementation of a kidney-sparing sepsis bundle (KSSB) of care in comparison with standard of care (SOC) on clinical outcomes in patients with sepsis. DE…
View article: Sepsis-associated acute kidney injury—treatment standard
Sepsis-associated acute kidney injury—treatment standard Open
Sepsis is a host's deleterious response to infection, which could lead to life-threatening organ dysfunction. Sepsis-associated acute kidney injury (SA-AKI) is the most frequent organ dysfunction and is associated with increased morbidity …
Reprogramming Metabolism to Enhance Kidney Tolerance during Sepsis: The Role of Fatty Acid Oxidation, Aerobic Glycolysis, and Epithelial De-Differentiation Open
Background: The recognition that sepsis induces acute kidney injury (AKI) in the absence of overt necrosis or apoptosis and even in the presence of increased renal blood flow has led to the consideration that kidney tubular epithelial cell…
SEVERE CORONAVIRUS DISEASE 2019: FROM PATHOGENESIS TO THERAPY Open
The COVID-19 pandemic has been a challenge to propose efficient therapies. Because severe SARS-CoV2 infection is a viral sepsis eventually followed by an immunological autoinflammatory phenomenon, many approaches have been inspired by the …
Identification of Clinical Phenotypes in Septic Patients Presenting With Hypotension or Elevated Lactate Open
Introduction Targeted therapies for sepsis have failed to show benefit due to high variability among subjects. We sought to demonstrate different phenotypes of septic shock based solely on clinical features and show that these relate to ou…
ECMO and Impella Support Strategies as a Bridge to Surgical Repair of Post-Infarction Ventricular Septal Rupture Open
Background and Objectives: Post-infarct ventricular septal rupture (PIVSR) continues to have significant morbidity and mortality, despite decreased prevalence. Impella and venoarterial extracorporeal membranous oxygenation (VA-ECMO) have b…
The Pathogenesis of Ischemia-Reperfusion Induced Acute Kidney Injury Depends on Renal Neutrophil Recruitment Whereas Sepsis-Induced AKI Does Not Open
Acute kidney injury (AKI) may be induced by different causes, including renal ischemia-reperfusion injury and sepsis, which represent the most common reasons for AKI in hospitalized patients. AKI is defined by reduced urine production and/…
Sepsis with liver dysfunction and coagulopathy predicts an inflammatory pattern of macrophage activation Open
Background Interleukin-1 receptor antagonists can reduce mortality in septic shock patients with hepatobiliary dysfunction and disseminated intravascular coagulation (HBD + DIC), an organ failure pattern with inflammatory features consiste…
Toward Robotically Automated Femoral Vascular Access Open
Advanced resuscitative technologies, such as Extra Corporeal Membrane Oxygenation (ECMO) cannulation or Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA), are technically difficult even for skilled medical personnel. This p…
Metabolic Reprogramming and Host Tolerance: A Novel Concept to Understand Sepsis-Associated AKI Open
Acute kidney injury (AKI) is a frequent complication of sepsis that increases mortality and the risk of progression to chronic kidney disease. However, the mechanisms leading to sepsis-associated AKI are still poorly understood. The recogn…