Héctor Isaac Rocha‐González
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View article: Dietary interventions on nutritional management of population with urolithiasis: a systematic review of clinical evidence
Dietary interventions on nutritional management of population with urolithiasis: a systematic review of clinical evidence Open
Urolithiasis (UL) is a multifactorial condition whose global prevalence has been increasing in recent years, and it is closely associated with dietary factors. Diet is one of the key elements linked to the development of UL due to the inta…
View article: Circulating miRNAs are Down-regulated in Asthmatic Patients; Case-control Study
Circulating miRNAs are Down-regulated in Asthmatic Patients; Case-control Study Open
Purpose: Microribonucleic acids (miRNAs) play an important role as non-invasive biomarkers and predictors of inflammatory disease activity. This study aimed to determine differences in expression profiles of miRNAs in patients with …
View article: Evaluation of the Antinociceptive Effect of Sesamin: Role of 5HT1A Serotonergic Receptors
Evaluation of the Antinociceptive Effect of Sesamin: Role of 5HT1A Serotonergic Receptors Open
Background/Objectives: Sesame (Sesamum indicum L.) is used in folk medicine to treat painful disorders. Sesamin is the main lignan found in this plant; however, its antinociceptive potential has scarcely been studied. The aim was to invest…
View article: Sociodemographic Factors and Risk Indicators for Functional Impairment in Elderly Patients in Primary Care Settings: A Cross-sectional Study
Sociodemographic Factors and Risk Indicators for Functional Impairment in Elderly Patients in Primary Care Settings: A Cross-sectional Study Open
Aims: To identify and describe sociodemographic characteristics of elderly subjects with functional impairment and their associated factors. Study Design: it was designed a descriptive, and cross-sectional study with an analytical approach…
View article: Development of a Novel Co-Amorphous Curcumin and L-Arginine (1:2): Structural Characterization, Biological Activity and Pharmacokinetics
Development of a Novel Co-Amorphous Curcumin and L-Arginine (1:2): Structural Characterization, Biological Activity and Pharmacokinetics Open
Background: Curcumin appears to be well tolerated and effective for managing chronic inflammatory pain, but its poor oral bioavailability has been a hurdle in its use as a therapeutic agent. The current study was performed to characterize …
View article: Comprendiendo la obesidad y las medidas para su combate por el paciente
Comprendiendo la obesidad y las medidas para su combate por el paciente Open
La obesidad es una enfermedad crónica y persistente, en la que participan múltiples factores en su desarrollo. En México, cerca del 70% de los adultos tiene sobrepeso u obesidad. Más allá del impacto estético y social, la obesidad aumenta …
View article: [Risk of postoperative delirium in older adults under balanced general anesthesia].
[Risk of postoperative delirium in older adults under balanced general anesthesia]. Open
MAC ≥ 0.9 represents a risk factor for DPO, so individualized dosing of volatile anesthetics should be used.
View article: MUC5B rs35705950 Promoter Variant Is Associated with Usual Interstitial Pneumonia in Patients with Antisynthetase Syndrome
MUC5B rs35705950 Promoter Variant Is Associated with Usual Interstitial Pneumonia in Patients with Antisynthetase Syndrome Open
Background: The presence of the rs35705950 variant in the MUC5B gene promoter is a critical genetic risk factor in idiopathic pulmonary fibrosis (IPF). It has been associated with usual interstitial pneumonia (UIP) in several interstitial …
View article: Editorial: Precision treatments for patients with obesity
Editorial: Precision treatments for patients with obesity Open
EDITORIAL article Front. Med., 29 May 2024Sec. Precision Medicine Volume 11 - 2024 | https://doi.org/10.3389/fmed.2024.1423460
View article: Effect of the Melanocortin 4-Receptor Ile269Asn Mutation on Weight Loss Response to Dietary, Phentermine and Bariatric Surgery Interventions
Effect of the Melanocortin 4-Receptor Ile269Asn Mutation on Weight Loss Response to Dietary, Phentermine and Bariatric Surgery Interventions Open
The loss of function melanocortin 4-receptor (MC4R) Ile269Asn mutation has been proposed as one of the most important genetic contributors to obesity in the Mexican population. However, whether patients bearing this mutation respond differ…
View article: Cachexia measured by bioelectrical impedance vector analysis and risk of infection in women with rheumatoid arthritis
Cachexia measured by bioelectrical impedance vector analysis and risk of infection in women with rheumatoid arthritis Open
View article: Metformin improves the weight reduction effect of mazindol in prediabetic obese Mexican subjects
Metformin improves the weight reduction effect of mazindol in prediabetic obese Mexican subjects Open
Our results highlight the effectiveness of mazindol-metformin to achieve higher rates of 7% weight reduction and to improve the glycemic profile in prediabetic obese subjects, which could be useful to prevent or delay T2D in these subjects.
View article: Combined First Month Body Weight Loss and Development of Tolerance as Predictors of 6-Month Efficacy of Mazindol in Mild and Moderate Obese Subjects
Combined First Month Body Weight Loss and Development of Tolerance as Predictors of 6-Month Efficacy of Mazindol in Mild and Moderate Obese Subjects Open
The weight loss response to anti-obesity drugs is highly variable and poorly understood, which does not allow us to know, in advance, in which subjects the drug will be effective and in which it will not. The objective of this study was to…
View article: SOFA Score Plus Impedance Ratio Predicts Mortality in Critically Ill Patients Admitted to the Emergency Department: Retrospective Observational Study
SOFA Score Plus Impedance Ratio Predicts Mortality in Critically Ill Patients Admitted to the Emergency Department: Retrospective Observational Study Open
Background: The Sequential Organ Failure Assessment (SOFA) is a scoring system used for the evaluation of disease severity and prognosis of critically ill patients. The impedance ratio (Imp-R) is a novel mortality predictor. Aims: This stu…
View article: SOFA Score Plus Impedance Ratio Predict Mortality in Critically Ill Patients Admitted to the Emergency Department: Retrospective Observational Study
SOFA Score Plus Impedance Ratio Predict Mortality in Critically Ill Patients Admitted to the Emergency Department: Retrospective Observational Study Open
Background: The Sequential Organ Failure Assessment (SOFA) is a scoring system used for the evaluation of disease severity and prognosis of critically ill patients. The impedance ratio (Imp-R) is a novel mortality predictor. Aims: This stu…
View article: GPR55 and GPR119 Receptors Contribute to the Processing of Neuropathic Pain in Rats
GPR55 and GPR119 Receptors Contribute to the Processing of Neuropathic Pain in Rats Open
Orphan G-protein-coupled receptors (GPCR) comprise a large number of receptors which are widely distributed in the nervous system and represent an opportunity to identify new molecular targets in pain medicine. GPR55 and GPR119 are two orp…
View article: Weight Loss at First Month and Development of Tolerance as Possible Predictors of 30 mg Phentermine Efficacy at 6 Months
Weight Loss at First Month and Development of Tolerance as Possible Predictors of 30 mg Phentermine Efficacy at 6 Months Open
The efficacy of anti-obesity drugs usually does not consider the high degree of interindividual variability in responses to the drug which could affect the decision to withdraw the drug early due to ineffectiveness or to continue therapy a…
View article: Evaluation of the Antinociceptive, Antiallodynic, Antihyperalgesic and Anti-Inflammatory Effect of Polyalthic Acid
Evaluation of the Antinociceptive, Antiallodynic, Antihyperalgesic and Anti-Inflammatory Effect of Polyalthic Acid Open
Nonsteroidal anti-inflammatory drugs (NSAIDs) are very commonly used, but their adverse effects warrant investigating new therapeutic alternatives. Polyalthic acid, a labdane-type diterpenoid, is known to produce gastroprotection, tracheal…
View article: All-cause mortality among patients treated with repurposed antivirals and antibiotics for COVID-19 in Mexico City: A real-world observational study
All-cause mortality among patients treated with repurposed antivirals and antibiotics for COVID-19 in Mexico City: A real-world observational study Open
The aim of our study was to evaluate all-cause mortality risk in patients with laboratory-confirmed COVID-19 in Mexico City treated with repurposed antivirals and antibiotics. This real-world retrospective cohort study contemplated 395,343…
View article: Obesity is a strong risk factor for short-term mortality and adverse outcomes in Mexican patients with COVID-19: a national observational study
Obesity is a strong risk factor for short-term mortality and adverse outcomes in Mexican patients with COVID-19: a national observational study Open
Conflicting results have been obtained through meta-analyses for the role of obesity as a risk factor for adverse outcomes in patients with coronavirus disease-2019 (COVID-19), possibly due to the inclusion of predominantly multimorbid pat…
View article: Efficacy and safety of the metformin-mazindol anorectic combination in rat
Efficacy and safety of the metformin-mazindol anorectic combination in rat Open
The current study investigates the anorectic interaction and safety of the mazindol-metformin combination in rats. Isobologram and interaction index were used to determine anorectic interaction between mazindol and metformin in the sweeten…
View article: Antinociceptive Interaction and Pharmacokinetics of the Combination Treatments of Methyleugenol Plus Diclofenac or Ketorolac
Antinociceptive Interaction and Pharmacokinetics of the Combination Treatments of Methyleugenol Plus Diclofenac or Ketorolac Open
Although nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the main types of drugs used to treat pain, they have several adverse effects, and such effects can be reduced by combining two analgesic drugs. The aim of this study was to…
View article: All-cause mortality among patients treated with repurposed antivirals and antibiotics for COVID-19 in Mexico City: A Real-World Observational Study
All-cause mortality among patients treated with repurposed antivirals and antibiotics for COVID-19 in Mexico City: A Real-World Observational Study Open
Aim To evaluate all-cause mortality risk in patients with laboratory-confirmed COVID-19 in Mexico City treated with repurposed antivirals and antibiotics. Methods This real-world retrospective cohort study contemplated 395,343 patients eva…
View article: Antiallodynic effect of PhAR‐DBH‐Me involves cannabinoid and TRPV1 receptors
Antiallodynic effect of PhAR‐DBH‐Me involves cannabinoid and TRPV1 receptors Open
The antiallodynic effect of PhAR‐DBH‐Me was evaluated on two models of neuropathic pain, and the potential roles of CB1, CB2, and TRPV1 receptors as molecular targets of PhAR‐DBH‐Me were studied. Female Wistar rats were submitted to L5/L6 …
View article: Possible involvement of peripheral TRP channels in the hydrogen sulfide-induced hyperalgesia in diabetic rats
Possible involvement of peripheral TRP channels in the hydrogen sulfide-induced hyperalgesia in diabetic rats Open
View article: Adverse Events Reported with the Use of Mazindol in Adult Obese Mexican Patients
Adverse Events Reported with the Use of Mazindol in Adult Obese Mexican Patients Open
Background: Obesity is a pandemic disease. Lifestyle modifications as diet and exercise remain as the first-line intervention for obesity; however, many patients fail to attain adequate weight loss and require drug treatment. Mazindol is a…
View article: ATF2, but not ATF3, participates in the maintenance of nerve injury-induced tactile allodynia and thermal hyperalgesia
ATF2, but not ATF3, participates in the maintenance of nerve injury-induced tactile allodynia and thermal hyperalgesia Open
Transcription factors are proteins that modulate the transcriptional rate of target genes in the nucleus in response to extracellular or cytoplasmic signals. Activating transcription factors 2 (ATF2) and 3 (ATF3) respond to environmental s…
View article: Role of Anoctamin-1 and Bestrophin-1 in Spinal Nerve Ligation-Induced Neuropathic Pain in Rats
Role of Anoctamin-1 and Bestrophin-1 in Spinal Nerve Ligation-Induced Neuropathic Pain in Rats Open
Background Calcium-activated chloride channels (CaCCs) activation induces membrane depolarization by increasing chloride efflux in primary sensory neurons that can facilitate action potential generation. Previous studies suggest that CaCCs…