Héctor Sánchez-Iranzo
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View article: Comparative insight into the regenerative mechanisms of the adult brain in zebrafish and mouse: highlighting the importance of the immune system and inflammation in successful regeneration
Comparative insight into the regenerative mechanisms of the adult brain in zebrafish and mouse: highlighting the importance of the immune system and inflammation in successful regeneration Open
Regeneration, the complex process of restoring damaged or absent cells, tissues, and organs, varies considerably between species. The zebrafish is a remarkable model organism for its impressive regenerative abilities, particularly in organ…
View article: Telomeres Fuse During Cardiomyocyte Maturation
Telomeres Fuse During Cardiomyocyte Maturation Open
Although polyploidization is a hallmark of adult mammalian cardiomyocytes and may constrain their proliferation, the mechanisms leading to ploidy increase in cardiomyocytes remain elusive.1 Our laboratory and others have reported the forma…
View article: Pluripotency factors regulate the onset of <i>Hox</i> cluster activation in the early embryo
Pluripotency factors regulate the onset of <i>Hox</i> cluster activation in the early embryo Open
Pluripotent cells are a transient population of the mammalian embryo dependent on transcription factors, such as OCT4 and NANOG, which maintain pluripotency while suppressing lineage specification. However, these factors are also expressed…
View article: Strength of interactions in the Notch gene regulatory network determines patterning and fate in the notochord
Strength of interactions in the Notch gene regulatory network determines patterning and fate in the notochord Open
Development of multicellular organisms requires the generation of gene expression patterns that determines cell fate and organ shape. Groups of genetic interactions known as Gene Regulatory Networks (GRNs) play a key role in the generation…
View article: Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma
Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma Open
View article: Author response: Strength of interactions in the Notch gene regulatory network determines patterning and fate in the notochord
Author response: Strength of interactions in the Notch gene regulatory network determines patterning and fate in the notochord Open
View article: Strength of interactions in the Notch gene regulatory network determines patterning and fate in the notochord
Strength of interactions in the Notch gene regulatory network determines patterning and fate in the notochord Open
Development of multicellular organisms requires the generation of gene expression patterns that determines cell fate and organ shape. Groups of genetic interactions known as Gene Regulatory Networks (GRNs) play a key role in the generation…
View article: Using migrating cells as probes to illuminate features in live embryonic tissues
Using migrating cells as probes to illuminate features in live embryonic tissues Open
Migrating cells can serve as probes for determining tissue properties in live embryos.
View article: Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma
Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma Open
The mesothelium forms epithelial membranes that line the bodies cavities and surround the internal organs. Mesothelia widely contribute to organ homeostasis and regeneration, and their dysregulation can result in congenital anomalies of th…
View article: Supplementary code: Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma
Supplementary code: Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma Open
This repository contains all code necessary to reproduce all analyses and figures from our above-mentioned manuscript. A browesable workflowr website of the analysis can be viewed HERE.
View article: A 3D Brillouin microscopy dataset of the in-vivo zebrafish eye
A 3D Brillouin microscopy dataset of the in-vivo zebrafish eye Open
View article: Fisetin protects against cardiac cell death through reduction of ROS production and caspases activity
Fisetin protects against cardiac cell death through reduction of ROS production and caspases activity Open
View article: <i>Nanog</i> regulates <i>Pou3f1</i> expression at the exit from pluripotency during gastrulation
<i>Nanog</i> regulates <i>Pou3f1</i> expression at the exit from pluripotency during gastrulation Open
Pluripotency is regulated by a network of transcription factors that maintain early embryonic cells in an undifferentiated state while allowing them to proliferate. NANOG is a critical factor for maintaining pluripotency and its role in pr…
View article: Adult sox10+ Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafish
Adult sox10+ Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafish Open
View article: <i>Nanog</i> regulates <i>Pou3f1</i> expression and represses anterior fate at the exit from pluripotency
<i>Nanog</i> regulates <i>Pou3f1</i> expression and represses anterior fate at the exit from pluripotency Open
Pluripotency is regulated by a network of transcription factors that maintains early embryonic cells in an undifferentiated state while allowing them to proliferate. NANOG is a critical factor for maintaining pluripotency and its role in p…
View article: Pluripotency factors regulate the onset of Hox cluster activation in the early embryo
Pluripotency factors regulate the onset of Hox cluster activation in the early embryo Open
Pluripotent cells are a transient population present in the early mammalian embryo dependent on transcription factors, such as OCT4 and NANOG, which maintain pluripotency while simultaneously suppressing lineage specification. Interestingl…
View article: Imaging mechanical properties of sub-micron ECM in live zebrafish using Brillouin microscopy
Imaging mechanical properties of sub-micron ECM in live zebrafish using Brillouin microscopy Open
In this work, we quantify the mechanical properties of the extra-cellular matrix (ECM) in live zebrafish using Brillouin microscopy. Optimization of the imaging conditions and parameters, combined with careful spectral analysis, allows us …
View article: Transient fibrosis resolves via fibroblast inactivation in the regenerating zebrafish heart
Transient fibrosis resolves via fibroblast inactivation in the regenerating zebrafish heart Open
Significance After myocardial infarction in the mammalian heart, millions of cardiomyocytes are lost and replaced by fibrotic scar tissue. While fibrosis is persistent in adult mammals, there are some vertebrates, including zebrafish, with…
View article: Transient fibrosis resolves via fibroblast inactivation in the regenerating zebrafish heart
Transient fibrosis resolves via fibroblast inactivation in the regenerating zebrafish heart Open
In the zebrafish ( Danio rerio ), regeneration and fibrosis after cardiac injury are not mutually exclusive responses. Upon cardiac cryoinjury, collagen and other extracellular matrix (ECM) proteins accumulate at the injury site. However, …
View article: Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration
Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration Open
View article: Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration (Supplementary Figures 5 to 17)
Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration (Supplementary Figures 5 to 17) Open
Sup 5. Open with ImageJ. Sup 6. Open with ImageJ. Sup 7. Open with ImageJ. Sup 8. Open with ImageJ. Sup 9. Open with ImageJ. Sup 10. Open with ImageJ. Sup 11. Open with ImageJ. Sup 12. Open with ImageJ (lif files) and Vevo (the rest of the…
View article: Characterisation of cardiomyocyte plasticity and the role of fibroblast during zebrafish heart regeneration
Characterisation of cardiomyocyte plasticity and the role of fibroblast during zebrafish heart regeneration Open
The zebrafish is an established model organism to study heart regeneration, in which pre-existing cardiomyocytes (CMs) proliferate to replace the lost myocardium.During development, mesodermal progenitors from the first heart field (FHF) f…
View article: 2C-Cas9: a versatile tool for clonal analysis of gene function
2C-Cas9: a versatile tool for clonal analysis of gene function Open
CRISPR/Cas9-mediated targeted mutagenesis allows efficient generation of loss-of-function alleles in zebrafish. To date, this technology has been primarily used to generate genetic knockout animals. Nevertheless, the study of the function …