Héctor Serrano
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View article: Regulatory T cells in cancer: from immunosuppression to therapeutic targeting
Regulatory T cells in cancer: from immunosuppression to therapeutic targeting Open
Regulatory T cells (Tregs) play a pivotal role in maintaining immune homeostasis; however, their presence in the tumor microenvironment contributes to immune evasion and cancer progression. The modulation of Tregs has emerged as a key stra…
View article: Seed Viability and Morphology Evaluation of Three Mexican Orchid Species
Seed Viability and Morphology Evaluation of Three Mexican Orchid Species Open
Here we studied some aspects of morphology and seed viability of three Mexican orchid species with different life forms, two epiphytes Cuitlauzina pendula and Laelia anceps and one terrestrial Epidendrum radicans, evaluating its viability …
View article: Uso de fitoestrogenios no controle reprodutivo da cães não domiciliados
Uso de fitoestrogenios no controle reprodutivo da cães não domiciliados Open
Stray dogs represent a public health problem in large cities, both due to the zoonotic diseases they transmit and the injuries they cause. The high economic investment in treatment and eradication does not provide stable results, so low-co…
View article: Altered PLCβ/IP3/Ca2+ Signaling Pathway Activated by GPRCs in Olfactory Neuronal Precursor Cells Derived from Patients Diagnosed with Schizophrenia
Altered PLCβ/IP3/Ca2+ Signaling Pathway Activated by GPRCs in Olfactory Neuronal Precursor Cells Derived from Patients Diagnosed with Schizophrenia Open
Background: Schizophrenia (SZ) is a multifactorial chronic psychiatric disorder with a worldwide prevalence of 1%. Altered expression of PLCβ occurs in SZ patients, suggesting alterations in the PLCβ/IP3/Ca2+ signaling pathway. This cascad…
View article: Nucleoredoxin Redox Interactions Are Sensitized by Aging and Potentiated by Chronic Alcohol Consumption in the Mouse Liver
Nucleoredoxin Redox Interactions Are Sensitized by Aging and Potentiated by Chronic Alcohol Consumption in the Mouse Liver Open
Aging is characterized by increased reactive species, leading to redox imbalance, oxidative damage, and senescence. The adverse effects of alcohol consumption potentiate aging-associated alterations, promoting several diseases, including l…
View article: Potential of olfactory neuroepithelial cells as a model to study schizophrenia: A focus on GPCRs (Review)
Potential of olfactory neuroepithelial cells as a model to study schizophrenia: A focus on GPCRs (Review) Open
Schizophrenia (SZ) is a multifactorial disorder characterized by volume reduction in gray and white matter, oxidative stress, neuroinflammation, altered neurotransmission, as well as molecular deficiencies such as punctual mutation in Disr…
View article: Neuro-Endocrinology of Amphibians and Reptiles: An Overview
Neuro-Endocrinology of Amphibians and Reptiles: An Overview Open
This review describes the anatomy and histology of the organs that make up the nervous and endocrine systems in amphibians and reptiles.It also includes the effects of the various substances produced by these organs during the ontogeny of …
View article: Is Nucleoredoxin a Master Regulator of Cellular Redox Homeostasis? Its Implication in Different Pathologies
Is Nucleoredoxin a Master Regulator of Cellular Redox Homeostasis? Its Implication in Different Pathologies Open
Nucleoredoxin (NXN), an oxidoreductase enzyme, contributes to cellular redox homeostasis by regulating different signaling pathways in a redox-dependent manner. By interacting with seven proteins so far, namely disheveled (DVL), protein ph…
View article: Fallo renal e infarto de miocardio: ¿un marcador pronóstico?
Fallo renal e infarto de miocardio: ¿un marcador pronóstico? Open
Renal insufficiency is a poor prognostic factor in ST elevation Myocardial Infarction (STEMI). Objective: To evaluate the prevalence of renal dysfunction (RD) and determine its prognostic role in STEMI. Material and methods: Analysis of a …
View article: Mass spectrometric analysis of digesta does not improve the allergenicity assessment of GM crops
Mass spectrometric analysis of digesta does not improve the allergenicity assessment of GM crops Open
An investigation of the potential allergenicity of newly expressed proteins in genetically modified (GM) crops comprises part of the assessment of GM crop safety. However, allergenicity is not completely predictable from a definitive assay…
View article: Can Mass Spectrometry Analysis of In Vitro Digestion Products Improve the Assessment of Allergenic Potential of a Newly Expressed Protein?
Can Mass Spectrometry Analysis of In Vitro Digestion Products Improve the Assessment of Allergenic Potential of a Newly Expressed Protein? Open
The rigorous safety assessment conducted on genetically modified crops includes an evaluation of allergenic potential for an associated newly expressed protein (NEP). Since no single method is recognized as a predictor for protein allergen…
View article: SARS-CoV-2 in a Tropical Area of Colombia, a Remarkable Conversion of Presymptomatic to Symptomatic People Impacts Public Health
SARS-CoV-2 in a Tropical Area of Colombia, a Remarkable Conversion of Presymptomatic to Symptomatic People Impacts Public Health Open
The ability of SARS-CoV-2 to remain in asymptomatic individuals facilitates its dissemination and makes its control difficult. Objective. To establish a cohort of asymptomatic individuals, change to the symptomatic state, and determine the…
View article: Ecophysiological Relationships of Environment and Reproduction in Males of Rock Mouse (Peromyscus difficilis felipensis) at a Temperate Forest
Ecophysiological Relationships of Environment and Reproduction in Males of Rock Mouse (Peromyscus difficilis felipensis) at a Temperate Forest Open
Background and Objective: The ecophysiological relationship between reproductive parameters and environmental variables is mostly unknown in wild temperate species of small rodents, inhabiting mid-latitude, temperate forests.Here the goal …
View article: Effect of a single application of coumestrol and/or dimethyl sulfoxide, on sex hormone levels and vaginal cytology of anestrus bitches
Effect of a single application of coumestrol and/or dimethyl sulfoxide, on sex hormone levels and vaginal cytology of anestrus bitches Open
Canine overpopulation continues to be a problem with serious public health implications, despite a diversity of programs and strategies that have been implemented for its control. Coumestrol (COU) is an organic compound with estrogenic act…
View article: Protease resistance of food proteins: a mixed picture for predicting allergenicity but a useful tool for assessing exposure
Protease resistance of food proteins: a mixed picture for predicting allergenicity but a useful tool for assessing exposure Open
Sub-optimal pH, low pepsin-to protein ratio, and sequential pepsin and pancreatin digestion protocols do not improve the predictive value in distinguish allergens from non-allergens. Digestion conditions facilitating such distinction diffe…