Hediyeh Baradaran
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View article: The insidious degeneration of white matter and cognitive decline in Fabry disease
The insidious degeneration of white matter and cognitive decline in Fabry disease Open
Fabry disease is a rare X-linked deficiency of lysosomal alpha-galactosidase that causes glycolipid accumulation in tissues, including the brain. The most common neurologic sequelae of Fabry are cognitive decline and white matter lesions (…
View article: Extracranial carotid artery atherosclerotic plaque and APOE polymorphisms: a systematic review and meta-analysis
Extracranial carotid artery atherosclerotic plaque and APOE polymorphisms: a systematic review and meta-analysis Open
Introduction Carotid atherosclerotic plaque is an important independent risk factor for stroke. Apolipoprotein E (APOE) influences cholesterol levels and certain isoforms are associated with increased carotid atherosclerosis, though the ex…
View article: Report from the society of magnetic resonance angiography: clinical applications of 7T neurovascular MR in the assessment of intracranial vascular disease
Report from the society of magnetic resonance angiography: clinical applications of 7T neurovascular MR in the assessment of intracranial vascular disease Open
In recent years, ultra-high-field magnetic resonance imaging (MRI) applications have been rapidly increasing in both clinical research and practice. Indeed, 7-Tesla (7T) MRI allows improved depiction of smaller structures with high signal-…
View article: Extracranial Carotid Plaque Calcification and Cerebrovascular Ischemia: A Systematic Review and Meta-Analysis
Extracranial Carotid Plaque Calcification and Cerebrovascular Ischemia: A Systematic Review and Meta-Analysis Open
BACKGROUND: Although coronary calcification quantification is an established approach for cardiovascular risk assessment, the value of quantifying carotid calcification is less clear. As a result, we performed a systematic review and meta-…
View article: Association Between Spotty Calcification in Nonstenosing Extracranial Carotid Artery Plaque and Ipsilateral Ischemic Stroke
Association Between Spotty Calcification in Nonstenosing Extracranial Carotid Artery Plaque and Ipsilateral Ischemic Stroke Open
Background Small spotty calcifications in the coronary arteries are associated with an increased risk of myocardial infarction. We examined the association between spotty calcifications near the carotid bifurcations and ipsilateral ischemi…
View article: CGRP, Migraine, and Brain MRI in CADASIL
CGRP, Migraine, and Brain MRI in CADASIL Open
Background: Migraine is associated with neuroimaging differences in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). However, it is unknown if migraine-related disability (MRD) or if cal…
View article: MRI Detection of Carotid Intraplaque Hemorrhage and Postintervention Cognition
MRI Detection of Carotid Intraplaque Hemorrhage and Postintervention Cognition Open
Cognitive improvement was observed after carotid intervention, and this was attributable to intraplaque hemorrhage (-) plaque. MR imaging detection of intraplaque hemorrhage status may be an important determinant of cognitive change after …
View article: Calcifying Pseudoneoplasm of the Neuraxis Presenting with Vasogenic Edema and a Perilesional Cyst
Calcifying Pseudoneoplasm of the Neuraxis Presenting with Vasogenic Edema and a Perilesional Cyst Open
Calcifying pseudoneoplasms of the neuraxis (CAPNONs) are uncommon benign lesions that are rarely diagnosed radiographically. We report an unusual case of a left middle cerebellar peduncle CAPNON with vasogenic edema and a perilesional cyst…
View article: The role of cross-sectional imaging of the extracranial and intracranial vasculature in embolic stroke of undetermined source
The role of cross-sectional imaging of the extracranial and intracranial vasculature in embolic stroke of undetermined source Open
Despite an extensive workup, nearly one third of ischemic strokes are defined as Embolic Stroke of Undetermined Source (ESUS), indicating that no clear etiologic cause has been identified. Since large vessel atherosclerotic disease is a ma…
View article: Association of Carotid Intima Media Thickening with Future Brain Region Specific Amyloid-β Burden
Association of Carotid Intima Media Thickening with Future Brain Region Specific Amyloid-β Burden Open
Background: Carotid atherosclerosis is associated with cognitive impairment and dementia, though there is limited evidence of a direct link between carotid disease and amyloid-β (Aβ) burden. Objective: We studied the association of baselin…
View article: Comparison of Recent Practice Guidelines for the Management of Patients With Asymptomatic Carotid Stenosis
Comparison of Recent Practice Guidelines for the Management of Patients With Asymptomatic Carotid Stenosis Open
Despite the publication of several national/international guidelines, the optimal management of patients with asymptomatic carotid stenosis (AsxCS) remains controversial. This article compares 3 recently released guidelines (the 2020 Germa…
View article: Carotid Artery Stiffness: Imaging Techniques and Impact on Cerebrovascular Disease
Carotid Artery Stiffness: Imaging Techniques and Impact on Cerebrovascular Disease Open
Arterial stiffness is an important measure of vascular aging and atherosclerosis. Though it is measured in many well-known epidemiologic cohort studies, arterial stiffness is often overlooked in routine clinical practice for a number of re…
View article: Optimal Management of Asymptomatic Carotid Stenosis: Counterbalancing the Benefits with the Potential Risks
Optimal Management of Asymptomatic Carotid Stenosis: Counterbalancing the Benefits with the Potential Risks Open
We thank Dr. Abbott for her interest in our work. 1r. Abbott supports that best medical treatment (BMT) has improved considerably over the last 3 to 4 decades since the landmark randomized controlled trials (RCTs) were performed.However, s…
View article: The burden of carotid-related strokes
The burden of carotid-related strokes Open
After 3 decades of endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAA), the infrarenal neck is considered the most important determining factor for an uncomplicated and sustainable outcome. As the envelope has been pus…
View article: Supplementary Material for: Association between Extracranial Carotid Artery Plaque and Cognitive Dysfunction: A Systematic Review and Meta-Analysis
Supplementary Material for: Association between Extracranial Carotid Artery Plaque and Cognitive Dysfunction: A Systematic Review and Meta-Analysis Open
Background: Extracranial carotid atherosclerosis has been variably associated with dementia. Prior studies have focused on the association of carotid intima media thickness or carotid stenosis; however, there is evidence that…
View article: Asymptomatic Carotid Disease and Cognitive Impairment: What Is the Evidence?
Asymptomatic Carotid Disease and Cognitive Impairment: What Is the Evidence? Open
The development of cognitive dysfunction and dementia is a complex, multifactorial process. One of the contributors to various types of cognitive dysfunction is carotid atherosclerosis which can frequently be seen in asymptomatic individua…
View article: Optimal Management of Asymptomatic Carotid Stenosis in 2021: The Jury is Still Out. An International, Multispecialty, Expert Review and Position Statement
Optimal Management of Asymptomatic Carotid Stenosis in 2021: The Jury is Still Out. An International, Multispecialty, Expert Review and Position Statement Open
View article: Carotid Compliance and Parahippocampal and Hippocampal Volume over a 20-Year Period
Carotid Compliance and Parahippocampal and Hippocampal Volume over a 20-Year Period Open
Introduction: We evaluated the association between carotid compliance, a measure of arterial stiffness, to parahippocampal volume (PHV) and hippocampal volume (HV) over 20 years later in the Atherosclerosis Risk in the Commun…
View article: MR Perfusion in the Evaluation of Mechanical Thrombectomy Candidacy
MR Perfusion in the Evaluation of Mechanical Thrombectomy Candidacy Open
Stroke is a leading cause of disability and mortality, and the incidence of ischemic stroke is projected to continue to rise in coming decades. These projections emphasize the need for improved imaging techniques for accurate diagnosis all…
View article: Management of Patients with Asymptomatic Carotid Stenosis May Need to Be Individualized: A Multidisciplinary Call for Action
Management of Patients with Asymptomatic Carotid Stenosis May Need to Be Individualized: A Multidisciplinary Call for Action Open
The optimal management of patients with asymptomatic carotid stenosis (ACS) is the subject of extensive debate. According to the 2017 European Society for Vascular Surgery guidelines, carotid endarterectomy should (Class IIa; Level of Evid…
View article: Extracranial Vascular Disease
Extracranial Vascular Disease Open
View article: Using Ultrasound and Inflammation to Improve Prediction of Ischemic Stroke: A Secondary Analysis of the Multi-Ethnic Study of Atherosclerosis
Using Ultrasound and Inflammation to Improve Prediction of Ischemic Stroke: A Secondary Analysis of the Multi-Ethnic Study of Atherosclerosis Open
Introduction: Current ischemic stroke risk prediction is primarily based on clinical factors, rather than imaging or laboratory markers. We examined the relationship between baseline ultrasound and inflammation measurements a…
View article: Optimal Carotid Plaque Features on Computed Tomography Angiography Associated With Ischemic Stroke
Optimal Carotid Plaque Features on Computed Tomography Angiography Associated With Ischemic Stroke Open
Background Stenosis has historically been the major factor used to determine carotid stroke sources. Recent evidence suggests that specific plaque features detected on imaging may be more highly associated with ischemic stroke than stenosi…
View article: Supplementary Material for: Using Ultrasound and Inflammation to Improve Prediction of Ischemic Stroke: A Secondary Analysis of the Multi-Ethnic Study of Atherosclerosis
Supplementary Material for: Using Ultrasound and Inflammation to Improve Prediction of Ischemic Stroke: A Secondary Analysis of the Multi-Ethnic Study of Atherosclerosis Open
Introduction: Current ischemic stroke risk prediction is primarily based on clinical factors, rather than imaging or laboratory markers. We examined the relationship between baseline ultrasound and inflammation measurements a…
View article: Rabbit models of intracranial atherosclerotic disease for pathological validation of vessel wall MRI
Rabbit models of intracranial atherosclerotic disease for pathological validation of vessel wall MRI Open
Introduction Vessel wall magnetic resonance imaging can improve the evaluation of intracranial atherosclerotic disease. However, pathological validation is needed to improve vessel wall magnetic resonance imaging techniques. Human patholog…
View article: Carotid artery plaque characteristics: current reporting practices on CT angiography
Carotid artery plaque characteristics: current reporting practices on CT angiography Open
View article: Brain imaging biomarkers of carotid artery disease
Brain imaging biomarkers of carotid artery disease Open
Extracranial carotid artery atherosclerotic disease is a major contributor to ischemic stroke. Carotid atherosclerotic disease can present with a spectrum of findings ranging from mild carotid intima-media thickness to high-risk vulnerable…
View article: Carotid Vessel Wall Imaging on CTA
Carotid Vessel Wall Imaging on CTA Open
Vessel wall imaging has been increasingly used to characterize plaque beyond luminal narrowing to identify patients who may be at the highest risk of cerebrovascular ischemia. Although detailed plaque information can be obtained from many …
View article: The progression of carotid atherosclerosis and imaging markers of dementia
The progression of carotid atherosclerosis and imaging markers of dementia Open
Introduction We studied the association of carotid intima‐media thickness (CIMT) with hippocampal volume (HV) in community dwelling individuals, testing the hypothesis that persons with carotid atherosclerosis progression would have lower …
View article: Reclassification of Ischemic Stroke Etiological Subtypes on the Basis of High-Risk Nonstenosing Carotid Plaque
Reclassification of Ischemic Stroke Etiological Subtypes on the Basis of High-Risk Nonstenosing Carotid Plaque Open
Background and Purpose— Carotid artery plaque with <50% luminal stenosis may be an underappreciated stroke mechanism. We assessed how many stroke causes might be reclassified after accounting for nonstenosing plaques with high-risk feature…