Marja Hedman
YOU?
Author Swipe
View article: Prevalence and risk factors of thoracic aortic dilatation detected incidentally in adjuvant radiotherapy planning CT scans in patients with breast cancer
Prevalence and risk factors of thoracic aortic dilatation detected incidentally in adjuvant radiotherapy planning CT scans in patients with breast cancer Open
Thoracic aortic dilatations (TADs) are commonly detected incidentally. A TAD may develop into aortic aneurysm and subsequently lead to aortic dissection, a highly lethal condition. Earlier detection of TADs could improve the surveillance a…
View article: Cardiometabolic disorders affect myocardial [18F]fluorodeoxyglucose uptake– impact on diagnostic PET/CT imaging
Cardiometabolic disorders affect myocardial [18F]fluorodeoxyglucose uptake– impact on diagnostic PET/CT imaging Open
Background Corresponding to impaired insulin response in skeletal muscle, insulin resistance may occur in the myocardium, suggesting a link between cardiometabolic disorders and cardiac glucose metabolism. We aimed to investigate whether c…
View article: Impact of the carina width in atrial fibrillation re-ablation after primary cryo-ablation
Impact of the carina width in atrial fibrillation re-ablation after primary cryo-ablation Open
Background Reconnection of the pulmonary veins (PVs) is the primary cause of atrial fibrillation (AF) episodes after pulmonary vein isolation (PVI). Cryoballoon ablation does not always include the isolation of the carina due to anatomic v…
View article: Burden of Modifiable Risk Factors in Young-Onset Cryptogenic Ischemic Stroke by High-Risk Patent Foramen Ovale
Burden of Modifiable Risk Factors in Young-Onset Cryptogenic Ischemic Stroke by High-Risk Patent Foramen Ovale Open
BACKGROUND: The incidence of young-onset ischemic stroke is rising, driven by cryptogenic ischemic stroke (CIS) and patients without vascular risk factors. This study examines the burden and associations of modifiable traditional, nontradi…
View article: Association of the ascending aortic length with acute type A aortic dissection: A retrospective cohort study
Association of the ascending aortic length with acute type A aortic dissection: A retrospective cohort study Open
Background and Aims: To investigate whether, alongside aortic dilatation, ascending aortic (AA) elongation is associated with the increased risk for aortic dissection. Methods: This retrospective study included patients treated for Stanfor…
View article: Linear growth pattern can be used to predict ascending aortic aneurysm growth
Linear growth pattern can be used to predict ascending aortic aneurysm growth Open
Objectives. Current guidelines recommend that surveillance imaging should be performed at least every third year for patients with ascending thoracic aortic aneurysm (ATAA) even though such aneurysms' growth rate is mostly minimal. …
View article: Association of Hypertension With Early‐Onset Cryptogenic Ischemic Stroke by the Presence of Patent Foramen Ovale: A Case–Control Study
Association of Hypertension With Early‐Onset Cryptogenic Ischemic Stroke by the Presence of Patent Foramen Ovale: A Case–Control Study Open
View article: Heparin does not improve myocardial glucose metabolism suppression in [18 F]FDG PET/CT in patients with low β-hydroxybutyrate level
Heparin does not improve myocardial glucose metabolism suppression in [18 F]FDG PET/CT in patients with low β-hydroxybutyrate level Open
View article: Association between heavy alcohol consumption and cryptogenic ischaemic stroke in young adults: a case–control study
Association between heavy alcohol consumption and cryptogenic ischaemic stroke in young adults: a case–control study Open
Background The underlying risk factors for young-onset cryptogenic ischaemic stroke (CIS) remain unclear. This multicentre study aimed to explore the association between heavy alcohol consumption and CIS with subgroup analyses stratified b…
View article: Central Obesity is Associated with Increased Left Ventricular Maximal Wall Thickness and Intrathoracic Adipose Tissue Measured with Cardiac Magnetic Resonance
Central Obesity is Associated with Increased Left Ventricular Maximal Wall Thickness and Intrathoracic Adipose Tissue Measured with Cardiac Magnetic Resonance Open
View article: Repaired coarctation of the aorta does not affect four-dimensional flow metrics in bicuspid aortic valve disease
Repaired coarctation of the aorta does not affect four-dimensional flow metrics in bicuspid aortic valve disease Open
OBJECTIVES The objective of this study was primarily to compare four-dimensional flow magnetic resonance imaging metrics in the ascending aorta (AA) of patients with right–left fusion type bicuspid aortic valve (RL-BAV) and repaired coarct…
View article: Association of Left Atrial Stiffness With Risk of Cryptogenic Ischemic Stroke in Young Adults
Association of Left Atrial Stiffness With Risk of Cryptogenic Ischemic Stroke in Young Adults Open
LA myopathy with increased LA stiffness and impaired LA mechanics more than doubles the risk of CIS in patients under the age of 50 years. This provides new insights into the link between LA dysfunction and CIS at young ages. (Searching fo…
View article: Twenty years’ experience of type B aortic dissections: a population-based national registry study from Finland
Twenty years’ experience of type B aortic dissections: a population-based national registry study from Finland Open
OBJECTIVES The objective of this study was to investigate the incidence, treatment and survival of Stanford type B aortic dissection (BTAD) during 20 years in the Finnish population. METHODS Data collection was made from the Nationwide Car…
View article: Ascending aortic length associates to acute aortic dissection
Ascending aortic length associates to acute aortic dissection Open
Background Acute Stanford type A aortic dissection is a life-threatening condition that is challenging to predict and prevent. The risk for aortic dissection is known to increase with ascending aortic (AA) dilatation, which sets indication…
View article: Measuring Cardiac Dyssynchrony with DENSE (Displacement Encoding with Stimulated Echoes)—A Systematic Review
Measuring Cardiac Dyssynchrony with DENSE (Displacement Encoding with Stimulated Echoes)—A Systematic Review Open
Background: In this review, we introduce the displacement encoding with stimulated echoes (DENSE) method for measuring myocardial dyssynchrony using cardiovascular magnetic resonance (CMR) imaging. We provide an overview of research findin…
View article: 24-hour ambulatory blood pressure and cryptogenic ischemic stroke in young adults
24-hour ambulatory blood pressure and cryptogenic ischemic stroke in young adults Open
Non-dipping patterns of BP were associated with CIS in the absence of a PFO but not in the absence of hypertension. This may reflect differing pathophysiology underlying CIS in patients with versus without a PFO. Due to limitations of the …
View article: Nondestructive Evaluation of Mechanical and Histological Properties of the Human Aorta With Near-Infrared Spectroscopy
Nondestructive Evaluation of Mechanical and Histological Properties of the Human Aorta With Near-Infrared Spectroscopy Open
NIRS could be a potential technique for in situ evaluation of biomechanical and histological properties of human aorta and therefore useful in patient-specific treatment planning.
View article: Late-onset and classic phenotypes of Fabry disease in males with the <i>GLA</i>-Thr410Ala mutation
Late-onset and classic phenotypes of Fabry disease in males with the <i>GLA</i>-Thr410Ala mutation Open
Objective To present phenotypic characteristics and biomarkers of a family with the rare mutation Thr410Ala of the α-galactosidase A gene (T410A/ GLA ) causing Fabry disease (FD). Methods and results In a woman in her 60s with hypertrophic…
View article: 4D Flow<i>Versus</i>2D Phase Contrast MRI in Populations With Bi- and Tricuspid Aortic Valves
4D Flow<i>Versus</i>2D Phase Contrast MRI in Populations With Bi- and Tricuspid Aortic Valves Open
4D flow MRI seems to be accurate in comparison to 2D PC MRI in normal aortic valves and in BAV with mild to moderate stenosis. However, the varying interobserver reproducibility and impaired accuracy at higher flow velocities should be tak…
View article: Direct intramyocardial injection of VEGF mRNA in patients undergoing coronary artery bypass grafting
Direct intramyocardial injection of VEGF mRNA in patients undergoing coronary artery bypass grafting Open
View article: Cardiac remodelling in association with left ventricular dyssynchrony and systolic dysfunction in patients with coronary artery disease
Cardiac remodelling in association with left ventricular dyssynchrony and systolic dysfunction in patients with coronary artery disease Open
Background In patients with coronary artery disease (CAD), ischaemic cardiomyopathy may result in progressive cardiac remodelling and left ventricular (LV) dysfunction. Myocardial perfusion imaging (MPI) can be used to quantify LV size and…
View article: Safety and efficacy of the 5-lipoxygenase-activating protein inhibitor AZD5718 in patients with recent myocardial infarction: The phase 2a FLAVOUR study
Safety and efficacy of the 5-lipoxygenase-activating protein inhibitor AZD5718 in patients with recent myocardial infarction: The phase 2a FLAVOUR study Open
View article: Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic Aorta
Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic Aorta Open
Objectives: In thoracic aortic aneurysm (TAA) of the ascending aorta (AA), AA is progressively dilating due to the weakening of the aortic wall. Predicting and preventing aortic dissections and ruptures in TAA continues to be challenging, …
View article: Large Vessel Cell Heterogeneity and Plasticity: Focus in Aortic Aneurysms
Large Vessel Cell Heterogeneity and Plasticity: Focus in Aortic Aneurysms Open
Smooth muscle cells and endothelial cells have a remarkable level of plasticity in vascular pathologies. In thoracic and abdominal aortic aneurysms, smooth muscle cells have been suggested to undergo phenotypic switching and to contribute …
View article: Reversible myocardial ischaemia caused by ectopic left circumflex coronary artery: a case report
Reversible myocardial ischaemia caused by ectopic left circumflex coronary artery: a case report Open
Background Coronary artery anomalies (CAAs) are congenital disorders associated with variable manifestations and pathophysiological mechanisms. Anomalies can be asymptomatic or cause chest pain, myocardial infarction, or even sudden cardia…
View article: Dilatation of the ascending aorta – Growth rate, risk factors and clinical outcomes in the long-term follow-up
Dilatation of the ascending aorta – Growth rate, risk factors and clinical outcomes in the long-term follow-up Open
Less than half of the patients followed due to AA dilatation displayed significant AA growth during the long-term follow-up. In addition, the growth rate per year was small. None of the patients experienced any aortic catastrophes indicati…
View article: Obesity and the Risk of Cryptogenic Ischemic Stroke in Young Adults
Obesity and the Risk of Cryptogenic Ischemic Stroke in Young Adults Open
Abdominal obesity measured with WHR was an independent risk factor for CIS in young adults after rigorous adjustment for concomitant risk factors.
View article: Flow displacement and decreased wall shear stress might be associated with the growth rate of an ascending aortic dilatation
Flow displacement and decreased wall shear stress might be associated with the growth rate of an ascending aortic dilatation Open
OBJECTIVES Our goal was to evaluate whether four-dimensional (4D) flow magnetic resonance imaging (MRI) can predict the growth rate of dilatation of the ascending aorta (AA) in patients with a tricuspid, normally functioning aortic valve. …
View article: Artificial Intelligence for Hospital Health Care: Application Cases and Answers to Challenges in European Hospitals
Artificial Intelligence for Hospital Health Care: Application Cases and Answers to Challenges in European Hospitals Open
The development and implementation of artificial intelligence (AI) applications in health care contexts is a concurrent research and management question. Especially for hospitals, the expectations regarding improved efficiency and effectiv…
View article: The Ablation of VEGFR-1 Signaling Promotes Pressure Overload-Induced Cardiac Dysfunction and Sudden Death
The Ablation of VEGFR-1 Signaling Promotes Pressure Overload-Induced Cardiac Dysfunction and Sudden Death Open
Molecular mechanisms involved in cardiac remodelling are not fully understood. To study the role of vascular endothelial growth factor receptor 1 (VEGFR-1) signaling in left ventricular hypertrophy (LVH) and heart failure, we used a mouse …