Philip Lee
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View article: Differential encoding of noxious heat and self-reported pain along corticospinal networks: a simultaneous spinal cord-brain fMRI study
Differential encoding of noxious heat and self-reported pain along corticospinal networks: a simultaneous spinal cord-brain fMRI study Open
Chronic pain poses a substantial public health burden. Elucidating how the healthy central nervous system (CNS) differentially encodes objective stimulus intensity and subjective experiences of pain perception may offer key insights into t…
View article: Selective reporting of antibiotic susceptibility testing results: a retrospective evaluation of a nudging strategy to improve antibiotic prescribing for ampC-producing <i>Enterobacterales</i> infections in hospitalized adults
Selective reporting of antibiotic susceptibility testing results: a retrospective evaluation of a nudging strategy to improve antibiotic prescribing for ampC-producing <i>Enterobacterales</i> infections in hospitalized adults Open
Background: Moderate-risk ampC beta-lactamase-producing Enterobacterales (HECK-Yes organisms) render many beta-lactams ineffective. Objective: This study evaluates selective reporting (SR) of antimicrobial susceptibility testing (AST) resu…
View article: Position as Probability: Self-Supervised Transformers that Think Past Their Training for Length Extrapolation
Position as Probability: Self-Supervised Transformers that Think Past Their Training for Length Extrapolation Open
Deep sequence models typically degrade in accuracy when test sequences significantly exceed their training lengths, yet many critical tasks--such as algorithmic reasoning, multi-step arithmetic, and compositional generalization--require ro…
View article: 430 Smart sensor promoters drive state-specific gene circuits to convert immunosuppressive macrophages into an anti-tumor phenotype
430 Smart sensor promoters drive state-specific gene circuits to convert immunosuppressive macrophages into an anti-tumor phenotype Open
Background Immunosuppressive signaling from myeloid cells and macrophages in tumor microenvironments hampers the clinical efficacy of immunotherapies. Macrophages, however, are a highly plastic cell type that can be polarized to either a p…
View article: 228 Multi-arming and regulator dial gene circuits tackle key challenges in solid tumors
228 Multi-arming and regulator dial gene circuits tackle key challenges in solid tumors Open
Background Chimeric antigen receptor (CAR) cell therapy for solid tumors is hampered by the immunosuppressive tumor microenvironment (TME), which can inhibit the function of endogenous and therapeutic immune cells, as well as a paucity of …
View article: Multiple lineages of monkeypox virus detected in the United States, 2021–2022
Multiple lineages of monkeypox virus detected in the United States, 2021–2022 Open
Monkeypox is a viral zoonotic disease endemic in Central and West Africa. In May 2022, dozens of non-endemic countries reported hundreds of monkeypox cases, most with no epidemiological link to Africa. We identified two lineages of monkeyp…
View article: A feasibility study of objective outcome measures used in clinical trials of freezing of gait
A feasibility study of objective outcome measures used in clinical trials of freezing of gait Open
Background Freezing of gait (FOG) is notoriously difficult to quantify, which has led to the use of multiple markers as outcomes for clinical trials. The instrumented timed up and go (TUG) and the many parameters that can be derived from i…
View article: Multiple lineages of <i>Monkeypox virus</i> detected in the United States, 2021- 2022
Multiple lineages of <i>Monkeypox virus</i> detected in the United States, 2021- 2022 Open
Monkeypox is a viral zoonotic disease endemic in Central and West Africa. In May 2022, dozens of non-endemic countries reported hundreds of monkeypox cases, most with no epidemiological link to Africa. We identified two lineages of Monkeyp…
View article: Consumer representative experiences of partnership with health workers in Australia
Consumer representative experiences of partnership with health workers in Australia Open
We examine the experiences of Consumer Representatives participating in consumer engagement activities across a public health service in NSW, Australia. A team of Consumer Representatives and staff members use a participatory, constructivi…
View article: Consumer representative experiences of partnership with health workers in Australia
Consumer representative experiences of partnership with health workers in Australia Open
We examine the experiences of Consumer Representatives participating in consumer engagement activities across a public health service in NSW, Australia. A team of Consumer Representatives and staff members use a participatory, constructivi…
View article: Under-utilization of Narrow-Spectrum Antibiotics in the Ambulatory Management of Pediatric UTI: A Single-Center Experience
Under-utilization of Narrow-Spectrum Antibiotics in the Ambulatory Management of Pediatric UTI: A Single-Center Experience Open
Objective: There are urinary tract infection (UTI) guidelines for treatment of patients <2 years old, but there is a paucity of data for other pediatric age groups including the potential role for stewardship to reduce prescription of b…
View article: SENTI-101, a Preparation of Mesenchymal Stromal Cells Engineered to Express IL12 and IL21, Induces Localized and Durable Antitumor Immunity in Preclinical Models of Peritoneal Solid Tumors
SENTI-101, a Preparation of Mesenchymal Stromal Cells Engineered to Express IL12 and IL21, Induces Localized and Durable Antitumor Immunity in Preclinical Models of Peritoneal Solid Tumors Open
Advanced peritoneal carcinomatosis including high-grade ovarian cancer has poor prognoses and a poor response rate to current checkpoint inhibitor immunotherapies; thus, there is an unmet need for effective therapeutics that would provide …
View article: A Comparative Study of Objective Outcome Measures Used in Clinical Trials of Freezing of Gait&nbsp;
A Comparative Study of Objective Outcome Measures Used in Clinical Trials of Freezing of Gait Open
Background: Freezing of gait (FOG) is notoriously difficult to quantify, leading to multiple metrics utilized as outcomes for clinical trials. The instrumented timed up a go and the many parameters that can be derived from it are commonly …
View article: Rejecting Honorary Whiteness: Asian Americans and the Attack on Race-Conscious Admissions
Rejecting Honorary Whiteness: Asian Americans and the Attack on Race-Conscious Admissions Open
Since the 1960s, Asian Americans have been labeled by the dominant society as the “model minority.” This status is commonly juxtaposed against so-called “problem” minorities such as African Americans and Latinx Americans. In theory, the mo…
View article: The Underlying Mechanism of Paeonia lactiflora Pall. in Parkinson’s Disease Based on a Network Pharmacology Approach
The Underlying Mechanism of Paeonia lactiflora Pall. in Parkinson’s Disease Based on a Network Pharmacology Approach Open
Background: Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide, yet as of currently, there is no disease-modifying therapy that could delay its progression. Paeonia lactiflora Pall. is the most frequentl…
View article: Bladder Care in Palliative Care Inpatients: A Prospective Dual Site Cohort Study
Bladder Care in Palliative Care Inpatients: A Prospective Dual Site Cohort Study Open
Background: Urinary catheterization is often undertaken to relieve distressing bladder symptoms in palliative care. Objective: The primary aim of this study was to determine the incidence of, and clinical indications that predispose patien…
View article: HIV and COVID-19 Co-Infection in an Urban Setting
HIV and COVID-19 Co-Infection in an Urban Setting Open
Objective:The purpose of this study is to investigate potential factors associated with patient survival (primary outcome) and need for mechanical ventilation (secondary outcome) for people living with HIV (PLWH) who have COVID-19.Design: …
View article: 1446. The Impact of Enterobacteriaceae Isolate Breakpoints on Prescriber Treatment Choices for Discordant Pattern Urinary Tract Infections
1446. The Impact of Enterobacteriaceae Isolate Breakpoints on Prescriber Treatment Choices for Discordant Pattern Urinary Tract Infections Open
Background Our institution revealed Enterobacteriaceae with discordant cefazolin (CEF)-resistant / ampicillin-sulbactam (SAM) susceptible patterns (CRASS-P). This discordance could be from the multiple MIC cephalosporin breakpoint adjustme…
View article: A Wall of Hate: Eminent Domain and Interest-Convergence
A Wall of Hate: Eminent Domain and Interest-Convergence Open
Through the power of eminent domain, President Donald Trump is seeking to take properties owned by private landowners and Native American tribes, including people’s homes and businesses, to build a continuous physical wall along the two th…
View article: 1518. Assessment of Antibiotic Prescribing in the Outpatient Setting for Uncomplicated Urinary Tract Infection in Pediatrics (UTIP Trial) with a Review of Local <i>E. coli</i> Susceptibilities
1518. Assessment of Antibiotic Prescribing in the Outpatient Setting for Uncomplicated Urinary Tract Infection in Pediatrics (UTIP Trial) with a Review of Local <i>E. coli</i> Susceptibilities Open
BACKGROUND: The IDSA recommends the use of sulfamethoxazole-trimethoprim (SXT) as empiric therapy (E/T) for uncomplicated urinary tract infections (UTI) in areas where the resistance rate is <20%. We sought to describe the susceptibility p…
View article: 532. Recurrent <i>C. difficile</i> in Children: Not Easy to Cure
532. Recurrent <i>C. difficile</i> in Children: Not Easy to Cure Open
BACKGROUND: Little is known about the clinical characteristics and appropriate treatment of children with repeated C. difficile infections (rCDI). Current IDSA treatment recommendations for rCDI include oral vancomycin (VAN) or metronidazo…
View article: Twenty years’ experience with myelomeningocele management at a single institution: lessons learned
Twenty years’ experience with myelomeningocele management at a single institution: lessons learned Open
OBJECTIVE The authors reviewed 20 years’ experience with the surgical management of open myelomeningocele in a well-defined retrospective cohort from a single large academic medical center. Their goal was to define the characteristics of a…
View article: Isolated Left Trochlear Nerve Palsy Caused by Sphenoid Sinus Mucocele
Isolated Left Trochlear Nerve Palsy Caused by Sphenoid Sinus Mucocele Open
Paranasal sinus mucoceles are an uncommon cause of isolated palsies of cranial nerves III, IV, and VI. The trochlear nerve has been reported to be less frequently affected than the abducens and oculomotor nerves. Isolated sphenoid sinus di…
View article: Student Protests and Academic Freedom in an Age of #Blacklivesmatter
Student Protests and Academic Freedom in an Age of #Blacklivesmatter Open
Student activism for racial equity and inclusion is on a historic rise on college and university campuses across the country. Students are reminding us that Black lives matter. They are bringing attention to the ways in which the normal op…
View article: Economic evaluation of aerobic exercise training in older adults with vascular cognitive impairment: PROMoTE trial
Economic evaluation of aerobic exercise training in older adults with vascular cognitive impairment: PROMoTE trial Open
Background/objectives Evidence suggests that aerobic exercise may slow the progression of subcortical ischaemic vascular cognitive impairment (SIVCI) by modifying cardiovascular risk factors. Yet the economic consequences relating to aerob…
View article: Political Order in the Anthropocene
Political Order in the Anthropocene Open
The advent of the epoch known as the Anthropocene has been treated as a paradigm shift throughout the natural as well as parts of the social sciences. This shift entails mankind’s becoming of a geological force alongside others. Political …
View article: Expanding the Schoolhouse Gate: Public Schools (K-12) and the Regulation of Cyberbullying
Expanding the Schoolhouse Gate: Public Schools (K-12) and the Regulation of Cyberbullying Open
Cyberbullying has received increasing societal attention in the aftermath of the tragic suicides of some of its youngest and most vulnerable victims — 15-year-old Phoebe Prince from Massachusetts, 13-year-old Ryan Halligan from Vermont, 12…