Heewon Seo
YOU?
Author Swipe
View article: PSV-7 The reproductive tract microbiota of cyclic and pregnant gilts.
PSV-7 The reproductive tract microbiota of cyclic and pregnant gilts. Open
The composition of bacterial communities within the female reproductive tract has been associated with fertility status in mammals; however, limited research has explored reproductive tract microbiota in swine. The objective of this study …
View article: Conceptus Elongation, Implantation, and Early Placental Development in Species with Central Implantation: Pigs, Sheep, and Cows
Conceptus Elongation, Implantation, and Early Placental Development in Species with Central Implantation: Pigs, Sheep, and Cows Open
Species have different strategies for implantation and placentation. Much can be learned about general molecular and cellular biology through the examination and comparison of these differences. To varying degrees, implantation in all spec…
View article: 95 The microbiomes of reproductive tissues in cyclic and early gestation gilts
95 The microbiomes of reproductive tissues in cyclic and early gestation gilts Open
During early gestation, the conceptus is undergoing elongation and begins to signal maternal recognition of pregnancy (day 12) with implantation occurring at approximately day 15. Additionally, luteolysis occurs in cyclic gilts at approxim…
View article: Characterization of the expression of XPR1 in ovine utero-placental tissues
Characterization of the expression of XPR1 in ovine utero-placental tissues Open
In brief Phosphate plays a critical role in conceptus development, yet the mechanisms regulating utero-placental availability remain underinvestigated. This research characterized the spatiotemporal expression and endocrine regulation of X…
View article: Characterization of TNSALP expression and activity in porcine utero-placental tissues
Characterization of TNSALP expression and activity in porcine utero-placental tissues Open
Tissue non-specific alkaline phosphatase (TNSALP) regulates postnatal phosphate homeostasis, but its role in utero-placental phosphate availability remains poorly understood. Gilts were bred and hysterectomized on Day 60 or Day 90 of gesta…
View article: Effects of dietary supplementation of creatine on fetal development in gilts at d 60 and d 90 of gestation
Effects of dietary supplementation of creatine on fetal development in gilts at d 60 and d 90 of gestation Open
Background The creatine-creatine kinase-phosphocreatine (Cr-CK-PCr) system maintains intracellular ratios of ATP/ADP for support of cellular functions and has been characterized at the placental-uterine interface of rodents, primates, swin…
View article: Spatiotemporal modeling reveals high-resolution invasion states in glioblastoma
Spatiotemporal modeling reveals high-resolution invasion states in glioblastoma Open
The compendium of programs presented here provides a basis for rational targeting of tumor and/or TME components. We anticipate that our approach will facilitate an ecosystem-level understanding of the immediate and long-term consequences …
View article: Progesterone regulates tissue non-specific alkaline phosphatase (TNSALP) expression and activity in ovine utero-placental tissues
Progesterone regulates tissue non-specific alkaline phosphatase (TNSALP) expression and activity in ovine utero-placental tissues Open
Background Tissue non-specific alkaline phosphatase (TNSALP; encoded by the ALPL gene) has a critical role in the postnatal regulation of phosphate homeostasis, yet how TNSALP activity and expression are regulated during pregnancy remain l…
View article: PSIII-8 Expression of Toll-Like Receptors in endometrium of gilts during early gestation
PSIII-8 Expression of Toll-Like Receptors in endometrium of gilts during early gestation Open
Interactions between the innate immune system and reproductive tissues via Toll-like receptors (TLRs) have a pivotal role in maintaining the health and fertility status of mammalian species. TLRs are pattern recognition receptors used by t…
View article: Abstract 1518 Development of a diverse activity-based probe library for studying serine proteases
Abstract 1518 Development of a diverse activity-based probe library for studying serine proteases Open
View article: Immunohistochemical examination of the uteroplacental interface of cows on days 21, 31, 40, and 67 of gestation
Immunohistochemical examination of the uteroplacental interface of cows on days 21, 31, 40, and 67 of gestation Open
In brief Cattle are classified as having synepitheliochorial placentation in which the majority of the uterine luminal epithelial cells remain intact with some luminal epithelial cells fusing with binucleate trophoblast cells to form syncy…
View article: PSIII-9 Bacterial Community Diversity in Reproductive Tissues and Fetal Fluids of Pregnant Gilts
PSIII-9 Bacterial Community Diversity in Reproductive Tissues and Fetal Fluids of Pregnant Gilts Open
The fertility status of women has previously been linked to shifts in bacterial diversity within the reproductive tract. The objective of this study was to analyze the diversity of bacterial populations within reproductive tissues (i.e., v…
View article: Integrins and their potential roles in mammalian pregnancy
Integrins and their potential roles in mammalian pregnancy Open
Integrins are a highly complex family of receptors that, when expressed on the surface of cells, can mediate reciprocal cell-to-cell and cell-to-extracellular matrix (ECM) interactions leading to assembly of integrin adhesion complexes (IA…
View article: Impaired parvalbumin interneurons in the retrosplenial cortex as the cause of sex-dependent vulnerability in Alzheimer’s disease
Impaired parvalbumin interneurons in the retrosplenial cortex as the cause of sex-dependent vulnerability in Alzheimer’s disease Open
Alzheimer’s disease is a debilitating neurodegenerative disorder with no cure and few treatment options. In early stages of Alzheimer’s disease, impaired metabolism, and functional connectivity of the retrosplenial cortex strongly predict …
View article: Review: Implantation and placentation in ruminants
Review: Implantation and placentation in ruminants Open
Ruminants have a unique placenta in comparison to other mammalian species. Initially, they possess a non-invasive epitheliochorial type of placenta during conceptus elongation. As the conceptus trophectoderm begins to attach to the luminal…
View article: 9 Relationship Between Progesterone and Reproductive Tract Microbiota in Pregnant Gilts
9 Relationship Between Progesterone and Reproductive Tract Microbiota in Pregnant Gilts Open
Female reproductive performance is essential for economic profitability of swine operations, and sex steroid hormones, such as progesterone (P4), are necessary for proper reproductive function. Recent research targeting the reproductive mi…
View article: 20 The Microbiome of Reproductive Tissues, and Amniotic and Allantoic Fluid of Pregnant Gilts During Mid- and Late Gestation
20 The Microbiome of Reproductive Tissues, and Amniotic and Allantoic Fluid of Pregnant Gilts During Mid- and Late Gestation Open
The differences between the microbial communities in reproductive tissues, and amniotic and allantoic fluids of cattle have previously been investigated. Our objective was to provide insight into microbial differences across reproductive t…
View article: Dietary supplementation with 0.4% L-arginine between days 14 and 30 of gestation enhances NO and polyamine syntheses and water transport in porcine placentae
Dietary supplementation with 0.4% L-arginine between days 14 and 30 of gestation enhances NO and polyamine syntheses and water transport in porcine placentae Open
Background Most embryonic loss in pigs occurs before d 30 of gestation. Dietary supplementation with L -arginine (Arg) during early gestation can enhance the survival and development of conceptuses (embryo/fetus and its extra-embryonic mem…
View article: 278 Awardee Talk: Progesterone Regulates the Abundance of Mrnas and Proteins Involved in Polyamine Metabolism in the Sheep Endometrium
278 Awardee Talk: Progesterone Regulates the Abundance of Mrnas and Proteins Involved in Polyamine Metabolism in the Sheep Endometrium Open
Agmatine and polyamines (putrescine, spermidine, and spermine), metabolites of L-arginine, are important for development of mammalian conceptuses. The objective of this study was to determine if exogenous progesterone administered during t…
View article: Osteopontin (OPN)/Secreted Phosphoprotein 1 (SPP1) Binds Integrins to Activate Transport of Ions Across the Porcine Placenta
Osteopontin (OPN)/Secreted Phosphoprotein 1 (SPP1) Binds Integrins to Activate Transport of Ions Across the Porcine Placenta Open
Background: Fetal-placental development depends on a continuous and efficient supply of nutrients from maternal blood that are acquired by exchange through the placenta. However, the placenta is a low permeability barrier, and effective tr…
View article: Effects of exogenous progesterone on the expression of mineral regulatory molecules by ovine endometrium and placentomes
Effects of exogenous progesterone on the expression of mineral regulatory molecules by ovine endometrium and placentomes Open
This study aimed to determine whether the acceleration of conceptus development induced by the administration of exogenous progesterone (P4) during the preimplantation period of pregnancy alters calcium, phosphate, and vitamin D signaling …
View article: Effects of progesterone and interferon tau on ovine endometrial phosphate, calcium, and vitamin D signaling
Effects of progesterone and interferon tau on ovine endometrial phosphate, calcium, and vitamin D signaling Open
Given recent reports of expression of postnatal mineral transport regulators at the maternal–conceptus interface during the peri-implantation period, this study tested the hypothesis that progesterone (P4) and interferon tau (IFNT) regulat…
View article: Disrupting porcine glutaminase does not block preimplantation development and elongation nor decrease mTORC1 activation in conceptuses
Disrupting porcine glutaminase does not block preimplantation development and elongation nor decrease mTORC1 activation in conceptuses Open
Elongation of pig conceptuses is a dynamic process, requiring adequate nutrient provisions. Glutamine is used as an energy substrate and is involved in the activation of mechanistic target of rapamycin complex 1 (mTORC1) during porcine pre…
View article: Expression of an immunocomplex consisting of Fc fragment fused with a consensus dengue envelope domain III in Saccharomyces cerevisiae
Expression of an immunocomplex consisting of Fc fragment fused with a consensus dengue envelope domain III in Saccharomyces cerevisiae Open
Objectives To explore Saccharomyces cerevisiae as an expression platform for dengue oral immune complex vaccine development. Results Molecular engineering was applied to create a fusion gene construct (scEDIII-PIGS) consisting of a yeast c…
View article: Integrin Adhesion Complex Organization in Sheep Myometrium Reflects Changing Mechanical Forces during Pregnancy and Postpartum
Integrin Adhesion Complex Organization in Sheep Myometrium Reflects Changing Mechanical Forces during Pregnancy and Postpartum Open
Cells respond to extracellular mechanical forces through the assembly of integrin adhesion complexes (IACs) that provide a scaffold through which cells sense and transduce responses to those forces. IACs are composed of transmembrane integ…
View article: Pre-implantation exogenous progesterone and pregnancy in sheep. II. Effects on fetal-placental development and nutrient transporters in late pregnancy
Pre-implantation exogenous progesterone and pregnancy in sheep. II. Effects on fetal-placental development and nutrient transporters in late pregnancy Open
Background Administration of progesterone (P4) to ewes during the first 9 to 12 days of pregnancy accelerates blastocyst development by day 12 of pregnancy, likely due to P4-induced up-regulation of key genes in uterine epithelia responsib…
View article: Pre-implantation exogenous progesterone and pregnancy in sheep: I. polyamines, nutrient transport, and progestamedins
Pre-implantation exogenous progesterone and pregnancy in sheep: I. polyamines, nutrient transport, and progestamedins Open
View article: PCOSP: Pancreatic cancer overall survival predictor
PCOSP: Pancreatic cancer overall survival predictor Open
View article: 410 Steroids Regulate SLC2A1 and SLC2A3 to Deliver Glucose into Trophectoderm for Metabolism via Glycolysis
410 Steroids Regulate SLC2A1 and SLC2A3 to Deliver Glucose into Trophectoderm for Metabolism via Glycolysis Open
The conceptuses (embryo/fetus and placental membranes) of pigs require energy to support elongation and implantation, and amounts of glucose and fructose increase in the uterine lumen during the peri-implantation period. Conceptuses from D…
View article: Integrins and OPN localize to adhesion complexes during placentation in sheep
Integrins and OPN localize to adhesion complexes during placentation in sheep Open
Integrins and OPN are potential mediators of blastocyst attachment to the endometrium to initiate implantation. The goals were to examine the temporal/spatial pattern of expression of integrins at the endometrial–placental interface of she…