Hefu Zhen
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View article: A comprehensive reference catalog of human skin DNA virome reveals novel viral diversity and microenvironmental influences
A comprehensive reference catalog of human skin DNA virome reveals novel viral diversity and microenvironmental influences Open
Human skin serves as a dynamic habitat for a diverse microbiome, including a complex array of viruses whose diversity and roles are not fully understood. A total of 2,760 skin metagenomes from 6 published skin studies were collected. A ski…
View article: SEMA-YOLO: Lightweight Small Object Detection in Remote Sensing Image via Shallow-layer Enhancement and Multi-scale Adaptation
SEMA-YOLO: Lightweight Small Object Detection in Remote Sensing Image via Shallow-layer Enhancement and Multi-scale Adaptation Open
Small object detection remains a challenge in remote sensing field due to feature loss during downsampling and interference from complex backgrounds. A novel network, termed SEMA-YOLO, is proposed in this paper as an enhanced YOLOv11-based…
View article: A Comprehensive Reference Catalog of Human Skin DNA Virome Reveals Novel Viral Diversity and Microenvironmental Influences
A Comprehensive Reference Catalog of Human Skin DNA Virome Reveals Novel Viral Diversity and Microenvironmental Influences Open
Introduction Human skin serves as a dynamic habitat for a diverse microbiome, including a complex array of viruses whose diversity and roles are not fully understood. Objectives This study aims to enhance our understanding of this skin vir…
View article: A human skin microbiome reference catalog and the skin microbial landscape of plateau adults
A human skin microbiome reference catalog and the skin microbial landscape of plateau adults Open
Comprehensive reference genomes are needed for the classification and functional characterization of the human skin microbiota. Here, we established human skin microbiome genome (HSMG) and protein (HSMP) catalogs by integrating 739 newly s…
View article: Integrative multi-omics analysis reveals chrono-modulation by time-restricted eating ameliorates non-alcoholic fatty liver disease
Integrative multi-omics analysis reveals chrono-modulation by time-restricted eating ameliorates non-alcoholic fatty liver disease Open
ObjectiveTo assess the impact of early and late time-restricted eating (eTRE and lTRE) on non-alcoholic fatty liver disease (NAFLD) and its underlying mechanisms involving gut microbiota and serum metabolome changes. DesignThis 8-week rand…
View article: Astrocytic Neuroligin-3 influences gene expression and social behavior, but is dispensable for synapse number
Astrocytic Neuroligin-3 influences gene expression and social behavior, but is dispensable for synapse number Open
View article: Age‐dependent changes in the gut microbiota and serum metabolome correlate with renal function and human aging
Age‐dependent changes in the gut microbiota and serum metabolome correlate with renal function and human aging Open
Human aging is invariably accompanied by a decline in renal function, a process potentially exacerbated by uremic toxins originating from gut microbes. Based on a registered household Chinese Guangxi longevity cohort ( n = 151), we conduct…
View article: Integrated Human Skin Bacteria Genome Catalog Reveals Extensive Unexplored Habitat‐Specific Microbiome Diversity and Function
Integrated Human Skin Bacteria Genome Catalog Reveals Extensive Unexplored Habitat‐Specific Microbiome Diversity and Function Open
The skin is the largest organ in the human body. Various skin environments on its surface constitutes a complex ecosystem. One of the characteristics of the skin micro‐ecosystem is low biomass, which greatly limits a comprehensive identifi…
View article: Supplementation with Berry Juice and Vitamin E Ameliorates Blood Cholesterol Level and Alters Gut Microbiota Composition
Supplementation with Berry Juice and Vitamin E Ameliorates Blood Cholesterol Level and Alters Gut Microbiota Composition Open
Scope Antioxidants, including vitamin E (VE) and grape seed extract, as anti-aging supplementation have been widely used to improve human health. However, the role of gut microbiota in dietary antioxidant supplementation is debatable. This…
View article: Plasma Extracellular Vesicle MicroRNA Analysis of Alzheimer’s Disease Reveals Dysfunction of a Neural Correlation Network
Plasma Extracellular Vesicle MicroRNA Analysis of Alzheimer’s Disease Reveals Dysfunction of a Neural Correlation Network Open
Small extracellular vesicle (sEV) is an emerging source of potential biomarkers of Alzheimer's disease (AD), but the role of microRNAs (miRNAs) in sEV is not well understood. In this study, we conducted a comprehensive analysis of sEV-deri…
View article: A population-based study of precision health assessments using multi-omics network-derived biological functional modules
A population-based study of precision health assessments using multi-omics network-derived biological functional modules Open
View article: Plasma Exo-miRNAs Correlated with AD-Related Factors of Chinese Individuals Involved in Aβ Accumulation and Cognition Decline
Plasma Exo-miRNAs Correlated with AD-Related Factors of Chinese Individuals Involved in Aβ Accumulation and Cognition Decline Open
Numerous studies have investigated the risk factors of Alzheimer’s disease (AD); however, AD-risk factors related miRNAs were rarely reported. In this study, AD-risk factor related miRNAs of 105 Chinese individuals (45 AD patients and 60 c…
View article: Network Pharmacology Integrated with Transcriptomics Deciphered the Potential Mechanism of Codonopsis pilosula against Hepatocellular Carcinoma
Network Pharmacology Integrated with Transcriptomics Deciphered the Potential Mechanism of Codonopsis pilosula against Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC) is the fourth main reason of cancer-related death. Codonopsis pilosula is a commonly used traditional Chinese medicine (TCM) for patients with HCC. However, its potential mechanism for treatment of HCC remain…
View article: Distinct biological ages of organs and systems identified from a multi-omics study
Distinct biological ages of organs and systems identified from a multi-omics study Open
Biological age (BA) has been proposed to evaluate the aging status instead of chronological age (CA). Our study shows evidence that there might be multiple "clocks" within the whole-body system: systemic aging drivers/clocks overlaid with …
View article: Species-Level Analysis of the Human Gut Microbiome Shows Antibiotic Resistance Genes Associated With Colorectal Cancer
Species-Level Analysis of the Human Gut Microbiome Shows Antibiotic Resistance Genes Associated With Colorectal Cancer Open
Colorectal cancer (CRC) is the second leading cause of cancer deaths and continuously increases new cancer cases globally. Accumulating evidence links risks of CRC to antibiotic use. Long-term use and abuse of antibiotics increase the resi…
View article: Identification and replication of novel genetic variants of ABO gene to reduce the incidence of diseases and promote longevity by modulating lipid homeostasis
Identification and replication of novel genetic variants of ABO gene to reduce the incidence of diseases and promote longevity by modulating lipid homeostasis Open
Genes related to human longevity have not been studied so far, and need to be investigated thoroughly. This study aims to explore the relationship among ABO gene variants, lipid levels, and longevity phenotype in individuals (≥90yrs old) w…
View article: Plasma Exo-miRNAs Correlated with AD-Related Factors of Chinese Individuals Involved in Aβ Accumulation and Cognition Decline
Plasma Exo-miRNAs Correlated with AD-Related Factors of Chinese Individuals Involved in Aβ Accumulation and Cognition Decline Open
Numerous studies have investigated the risk factors of Alzheimer’s disease (AD), however, AD- risk factors related miRNAs were rarely reported. In this study, AD- risk factor related miRNAs of 119 Chinese individuals (47 AD patients and 62…
View article: RNA-sequencing of peripheral blood circular RNAs in Parkinson disease
RNA-sequencing of peripheral blood circular RNAs in Parkinson disease Open
Background: Circular RNAs (circRNAs) play an important role in many neurological diseases and can serve as biomarkers for these diseases. However, the information about circRNAs in Parkinson disease (PD) remained limited. In this study, we…
View article: Plasma exosomal miRNA analysis of Alzheimer’s disease reveals the dysfunction of a neural network
Plasma exosomal miRNA analysis of Alzheimer’s disease reveals the dysfunction of a neural network Open
Exosomal microRNA (miRNA) is an emerging source for biomarkers of Alzheimer’s disease (AD). Here, we profiled miRNA expression in AD, mild cognitive impairment (MCI), and controls. The assessment and validation of differentially expressed …
View article: Characterization of the human skin resistome and identification of two microbiota cutotypes
Characterization of the human skin resistome and identification of two microbiota cutotypes Open
View article: Additional file 2 of Characterization of the human skin resistome and identification of two microbiota cutotypes
Additional file 2 of Characterization of the human skin resistome and identification of two microbiota cutotypes Open
Additional file 1: Table S1. Statistics for sequencing data of the 822 samples from Shanghai-China and the 538 HMP samples. Table S2. Description of the genus-level bacteria associated with the skin. Table S3. Detailed information on the g…
View article: IDDF2020-ABS-0141 The gut microbiome and serum metabolome orchestrate healthy aging and longevity with novel implications for renal function
IDDF2020-ABS-0141 The gut microbiome and serum metabolome orchestrate healthy aging and longevity with novel implications for renal function Open
Background Aging is closely associated with the occurrence and development of many complex diseases such as cardiovascular conditions, type 2 diabetes, gastrointestinal (GI) and renal diseases. Detecting changes as early as possible in the…
View article: Differential Expression of Plasma Exo-miRNA in Neurodegenerative Diseases by Next-Generation Sequencing
Differential Expression of Plasma Exo-miRNA in Neurodegenerative Diseases by Next-Generation Sequencing Open
Neurodegenerative diseases encompass a wide variety of pathological conditions caused by a loss of neurons in the central nervous system (CNS) and are severely debilitating. Exosome contains bio-signatures of great diagnostic and therapeut…
View article: Evaluation of Commercially Available Exosomal Isolation Kits from Human Plasma
Evaluation of Commercially Available Exosomal Isolation Kits from Human Plasma Open
Exosomes are cell-derived lipid bilayer particles which are abundant in biological fluids. Exosome is an emerging source of biomarkers to diagnose various human diseases. Sequencing based exosomal studies could provide a comprehensive view…
View article: Comparison of single cell sequencing data between two whole genome amplification methods on two sequencing platforms
Comparison of single cell sequencing data between two whole genome amplification methods on two sequencing platforms Open
View article: Identifying Human Genome-Wide CNV, LOH and UPD by Targeted Sequencing of Selected Regions
Identifying Human Genome-Wide CNV, LOH and UPD by Targeted Sequencing of Selected Regions Open
Copy-number variations (CNV), loss of heterozygosity (LOH), and uniparental disomy (UPD) are large genomic aberrations leading to many common inherited diseases, cancers, and other complex diseases. An integrated tool to identify these abe…