Heidi Gerke
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View article: Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance
Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance Open
The pituitary gland is the central endocrine regulatory organ producing and releasing hormones that coordinate major body functions. The physical location of the pituitary gland at the base of the brain, though outside the protective blood…
View article: Body‐wide genetic deficiency of poly( <scp>ADP</scp> ‐ribose) polymerase 14 sensitizes mice to colitis
Body‐wide genetic deficiency of poly( <span>ADP</span> ‐ribose) polymerase 14 sensitizes mice to colitis Open
Inflammatory bowel disease (IBD) is a chronic disease of the gastrointestinal tract affecting millions of people. Here, we investigated the expression and functions of poly(ADP‐ribose) polymerase 14 (Parp14), an important regulatory protei…
View article: Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance
Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance Open
The pituitary gland is the central endocrine regulatory organ underneath the brain, producing and releasing a variety of hormones that coordinate major body functions. The physical location of the pituitary gland underneath the brain, thou…
View article: Body-wide genetic deficiency of poly(ADP-ribose) polymerase 14 sensitizes mice to colitis
Body-wide genetic deficiency of poly(ADP-ribose) polymerase 14 sensitizes mice to colitis Open
Inflammatory bowel disease (IBD) is a debilitating and relapsing chronic disease of the gastrointestinal tract affecting millions of people. Here, we investigated the expression and functions of poly (ADP-ribose) polymerase 14 (Parp14), an…
View article: Supplementary Figure S6 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis
Supplementary Figure S6 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis Open
Supplementary Figure S6. Anti-Clever-1 treatment does not modify the severity of arthritis.
View article: Supplementary Materials and Methods, Supplementary Figure 1-6 Legends from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis
Supplementary Materials and Methods, Supplementary Figure 1-6 Legends from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis Open
Supplementary Materials and Methods, Supplementary Figure 1-6 Legends. Materials and Methods, References, Figure 1-6 Legends
View article: Supplementary Figure S4 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis
Supplementary Figure S4 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis Open
Supplementary Figure S4. B16 melanoma and EL-4 cells are Clever-1 negative.
View article: Supplementary Figure S6 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis
Supplementary Figure S6 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis Open
Supplementary Figure S6. Anti-Clever-1 treatment does not modify the severity of arthritis.
View article: Supplementary Figure S3 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis
Supplementary Figure S3 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis Open
Supplementary Figure S3. Clever-1 is present in rabbit lymphatics but the lymphoma cell line KCA used in the homing experiments lacks its expression.
View article: Supplementary Table S1 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis
Supplementary Table S1 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis Open
Supplementary Table S1. Relative intensity of SPARC staining
View article: Data from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis
Data from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis Open
Purpose: Immunosuppressive leukocytes and vasculature are important host cell components regulating tumor progression. Clever-1/Stabilin-1, a multifunctional scavenger and adhesion receptor, is constitutively present on a subset of type II…
View article: Supplementary Figure S5 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis
Supplementary Figure S5 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis Open
Supplementary Figure S5. Density of MRC positive macrophages is not dependent on tumor size and tumor cells are able to induce Clever-1 expression.
View article: Supplementary Figure S4 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis
Supplementary Figure S4 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis Open
Supplementary Figure S4. B16 melanoma and EL-4 cells are Clever-1 negative.
View article: Supplementary Figure S5 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis
Supplementary Figure S5 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis Open
Supplementary Figure S5. Density of MRC positive macrophages is not dependent on tumor size and tumor cells are able to induce Clever-1 expression.
View article: Supplementary Figure S1 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis
Supplementary Figure S1 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis Open
Supplementary Figure S1. Clever-1 positive macrophages are not present in lymph nodes undergoing immune response
View article: Supplementary Figure S1 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis
Supplementary Figure S1 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis Open
Supplementary Figure S1. Clever-1 positive macrophages are not present in lymph nodes undergoing immune response
View article: Supplementary Figure S3 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis
Supplementary Figure S3 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis Open
Supplementary Figure S3. Clever-1 is present in rabbit lymphatics but the lymphoma cell line KCA used in the homing experiments lacks its expression.
View article: Data from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis
Data from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis Open
Purpose: Immunosuppressive leukocytes and vasculature are important host cell components regulating tumor progression. Clever-1/Stabilin-1, a multifunctional scavenger and adhesion receptor, is constitutively present on a subset of type II…
View article: Supplementary Materials and Methods, Supplementary Figure 1-6 Legends from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis
Supplementary Materials and Methods, Supplementary Figure 1-6 Legends from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis Open
Supplementary Materials and Methods, Supplementary Figure 1-6 Legends. Materials and Methods, References, Figure 1-6 Legends
View article: Supplementary Table S1 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis
Supplementary Table S1 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis Open
Supplementary Table S1. Relative intensity of SPARC staining
View article: Supplementary Figure S2 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis
Supplementary Figure S2 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis Open
Supplementary Figure S2. Genotyping of different Clever-1 targeted mice
View article: Supplementary Figure S2 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis
Supplementary Figure S2 from Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis Open
Supplementary Figure S2. Genotyping of different Clever-1 targeted mice
View article: Exploring the Ion Channel TRPV2 and Testicular Macrophages in Mouse Testis
Exploring the Ion Channel TRPV2 and Testicular Macrophages in Mouse Testis Open
The cation channel TRPV2 is known to be expressed by murine macrophages and is crucially involved in their functionality. Macrophages are frequent cells of the mouse testis, an immune-privileged and steroid-producing organ. TRPV2 expressio…
View article: Fetal‐derived macrophages persist and sequentially maturate in ovaries after birth in mice
Fetal‐derived macrophages persist and sequentially maturate in ovaries after birth in mice Open
Macrophages, which are highly diverse in different tissues, play a complex and vital role in tissue development, homeostasis, and inflammation. The origin and heterogeneity of tissue‐resident monocytes and macrophages in ovaries remains un…
View article: Preperitoneal Fat Grafting Inhibits the Formation of Intra-abdominal Adhesions in Mice
Preperitoneal Fat Grafting Inhibits the Formation of Intra-abdominal Adhesions in Mice Open
Fat grafting can inhibit the formation of peritoneal adhesions in mice. Our results suggest that fat grafting promotes the peritoneal healing process in a paracrine manner thereby enabling rapid regeneration of the peritoneal mesothelial c…
View article: Stabilin-1 expression defines a subset of macrophages that mediate tissue homeostasis and prevent fibrosis in chronic liver injury
Stabilin-1 expression defines a subset of macrophages that mediate tissue homeostasis and prevent fibrosis in chronic liver injury Open
Significance Organ fibrosis is a major cause of global morbidity and mortality. It is driven by chronic inflammation and associated oxidative stress with depletion of cellular antioxidant defenses. We demonstrate a pathway in which the evo…