Heidi T. May
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View article: Schizophrenia, Bipolar, or Major Depressive Disorder and Postacute Sequelae of COVID-19
Schizophrenia, Bipolar, or Major Depressive Disorder and Postacute Sequelae of COVID-19 Open
Importance Given the increased vulnerability to COVID-19 among those with a serious mental illness (SMI), it remains unclear whether these individuals face a higher risk of developing postacute sequelae of SARS-CoV-2 (PASC). Understanding …
View article: Atrial Fibrillation as a Predictor of Age‐Related Macular Degeneration
Atrial Fibrillation as a Predictor of Age‐Related Macular Degeneration Open
Background Aging of the population has resulted in more patients living with atrial fibrillation (AF) and age‐related macular degeneration (AMD). AF is associated with macro‐ and micro‐thromboembolism, microvascular dysfunction, and system…
View article: Weight loss-independent changes in human growth hormone during water-only fasting: a secondary evaluation of a randomized controlled trial
Weight loss-independent changes in human growth hormone during water-only fasting: a secondary evaluation of a randomized controlled trial Open
Introduction Water-only fasting for one day or more may provide health benefits independent of weight loss. Human growth hormone (HGH) may play a key role in multiple fasting-triggered mechanisms. Whether HGH changes during fasting are ind…
View article: The impact of common and rare genetic variants on bradyarrhythmia development
The impact of common and rare genetic variants on bradyarrhythmia development Open
To broaden our understanding of bradyarrhythmias and conduction disease, we performed common variant genome-wide association analyses in up to 1.3 million individuals and rare variant burden testing in 460,000 individuals for sinus node dy…
View article: Periodic Fasting and Acute Cardiac Events in Patients Evaluated for COVID-19: An Observational Prospective Cohort Study
Periodic Fasting and Acute Cardiac Events in Patients Evaluated for COVID-19: An Observational Prospective Cohort Study Open
Background: Periodic fasting was previously associated with greater longevity and a lower incidence of heart failure (HF) in a pre-pandemic population. In patients with coronavirus disease 2019 (COVID-19), periodic fasting was associated w…
View article: Meta-Analysis of Genome-Wide Association Studies Reveals Genetic Mechanisms of Supraventricular Arrhythmias
Meta-Analysis of Genome-Wide Association Studies Reveals Genetic Mechanisms of Supraventricular Arrhythmias Open
BACKGROUND: Substantial data support a heritable basis for supraventricular tachycardias, but the genetic determinants and molecular mechanisms of these arrhythmias are poorly understood. We sought to identify genetic loci associated with …
View article: Weight Loss-Independent Changes in Human Growth Hormone During Water-Only Fasting: A Secondary Evaluation of a Randomized Controlled Trial
Weight Loss-Independent Changes in Human Growth Hormone During Water-Only Fasting: A Secondary Evaluation of a Randomized Controlled Trial Open
Introduction Water-only fasting for one day or more may provide health benefits independent of weight loss. Human growth hormone (HGH) may play a key role in multiple fasting-triggered mechanisms. Whether HGH changes during fasting are ind…
View article: Coronary Calcium Is Elevated in Patients with Myocardial Infarction without Standard Modifiable Risk Factors
Coronary Calcium Is Elevated in Patients with Myocardial Infarction without Standard Modifiable Risk Factors Open
Objectives: Recent reports have highlighted myocardial infarction (MI) patients without standard modifiable risk factors (SMRF), noting them to be surprisingly common and to have a substantial risk of adverse outcomes. The objective of thi…
View article: Residual or recurrent mitral regurgitation predicts mortality following transcatheter edge-to-edge mitral valve repair
Residual or recurrent mitral regurgitation predicts mortality following transcatheter edge-to-edge mitral valve repair Open
Patients undergoing SMVr and TEER are vastly different with respect to baseline patient characteristics and clinical outcomes, with patients who undergo TEER being much greater risk with poorer prognosis. Moderate or greater RRMR predicted…
View article: Common and Rare Variant Contributions to Bradyarrhythmias from Multi-Ancestry Meta-Analyses
Common and Rare Variant Contributions to Bradyarrhythmias from Multi-Ancestry Meta-Analyses Open
To broaden our understanding of bradyarrhythmias and diseases of the cardiac conduction system, we performed cross-sectional multi-ancestry genome-wide association study meta-analyses in up to 1.3 million individuals for sinus node dysfunc…
View article: LP(A) MEASUREMENT IN PRIMARY PREVENTION POPULATION MAY LEAD TO INCREASED UTILIZATION OF STATIN THERAPY, A REAL-WORLD EXPERIENCE
LP(A) MEASUREMENT IN PRIMARY PREVENTION POPULATION MAY LEAD TO INCREASED UTILIZATION OF STATIN THERAPY, A REAL-WORLD EXPERIENCE Open
Therapeutic Area: ASCVD/CVD Risk Reduction Background: Lp(a) is an important independent risk factor for ASCVD, and Lp(a) lowering therapies are in development. We evaluated Lp(a) trends to review impact of Lp(a) testing on utilization of …
View article: Higher docosahexaenoic acid levels lower the protective impact of eicosapentaenoic acid on long-term major cardiovascular events
Higher docosahexaenoic acid levels lower the protective impact of eicosapentaenoic acid on long-term major cardiovascular events Open
Introduction Long-chain omega-3 polyunsaturated fatty acids (OM3 PUFA) are commonly used for cardiovascular disease prevention. High-dose eicosapentaenoic acid (EPA) is reported to reduce major adverse cardiovascular events (MACE); however…
View article: Quantitative imaging biomarkers of coronary plaque morphology: insights from EVAPORATE
Quantitative imaging biomarkers of coronary plaque morphology: insights from EVAPORATE Open
Aims Residual cardiovascular risk persists despite statin therapy. In REDUCE-IT, icosapent ethyl (IPE) reduced total events, but the mechanisms of benefit are not fully understood. EVAPORATE evaluated the effects of IPE on plaque character…
View article: Frequency and Outcomes of Patients Presenting with Non-ST Elevation Myocardial Infarction (NSTEMI) without Standard Modifiable Risk Factors: A US Healthcare Experience
Frequency and Outcomes of Patients Presenting with Non-ST Elevation Myocardial Infarction (NSTEMI) without Standard Modifiable Risk Factors: A US Healthcare Experience Open
Patients with ST-elevation myocardial infarction (STEMI), but without standard modifiable risk factors (SMuRF-less), are surprisingly common and appear to have a worse, or at best similar, short-term prognosis. However, relatively little a…