Heidi Zakoul
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View article: Extracting Cognitive Impairment Assessment Information From Unstructured Notes in Electronic Health Records Using Natural Language Processing Tools: Validation with Clinical Assessment Data
Extracting Cognitive Impairment Assessment Information From Unstructured Notes in Electronic Health Records Using Natural Language Processing Tools: Validation with Clinical Assessment Data Open
We developed an NLP algorithm to accurately extract cognitive scores from unstructured EHR, and these extracted cognitive scores were well correlated with cognition function recorded in CMS-mandated clinical assessments. This could help re…
View article: Physician Experiences With and Perspectives on Clozapine Prescribing
Physician Experiences With and Perspectives on Clozapine Prescribing Open
Importance Clozapine is an effective medication for treatment-resistant schizophrenia but can cause agranulocytosis. Since its approval, patients taking clozapine have been required to undergo regular blood testing to screen for neutropeni…
View article: Comparative Safety of In Utero Exposure to Buprenorphine Combined With Naloxone vs Buprenorphine Alone
Comparative Safety of In Utero Exposure to Buprenorphine Combined With Naloxone vs Buprenorphine Alone Open
Importance Buprenorphine combined with naloxone is commonly used to treat opioid use disorders outside of pregnancy. In pregnancy, buprenorphine alone is generally recommended because of limited perinatal safety data on the combination pro…
View article: Sodium-Glucose Cotransporter 2 Inhibitors and Nephrolithiasis Risk in Patients With Type 2 Diabetes
Sodium-Glucose Cotransporter 2 Inhibitors and Nephrolithiasis Risk in Patients With Type 2 Diabetes Open
Importance Type 2 diabetes (T2D) is associated with an increased risk of kidney stones. Sodium-glucose cotransporter 2 inhibitors (SGLT2is) might lower the risk of nephrolithiasis by altering urine composition. However, no studies have inv…
View article: Identifying Functional Status Impairment in People Living With Dementia Through Natural Language Processing of Clinical Documents: Cross-Sectional Study
Identifying Functional Status Impairment in People Living With Dementia Through Natural Language Processing of Clinical Documents: Cross-Sectional Study Open
Background Assessment of activities of daily living (ADLs) and instrumental ADLs (iADLs) is key to determining the severity of dementia and care needs among older adults. However, such information is often only documented in free-text clin…
View article: Common <scp>non‐cardiovascular</scp> multimorbidity groupings and clinical outcomes in older adults with major cardiovascular disease
Common <span>non‐cardiovascular</span> multimorbidity groupings and clinical outcomes in older adults with major cardiovascular disease Open
Background Among older adults, non‐cardiovascular multimorbidity often coexists with cardiovascular disease (CVD) but their clinical significance is uncertain. We identified common non‐cardiovascular comorbidity patterns and their associat…
View article: Emulation of Randomized Clinical Trials With Nonrandomized Database Analyses
Emulation of Randomized Clinical Trials With Nonrandomized Database Analyses Open
Importance Nonrandomized studies using insurance claims databases can be analyzed to produce real-world evidence on the effectiveness of medical products. Given the lack of baseline randomization and measurement issues, concerns exist abou…
View article: Comparing the Benefits and Harms of Different Long-Term Treatments for Blood Clots – The DARE Warfarin Study
Comparing the Benefits and Harms of Different Long-Term Treatments for Blood Clots – The DARE Warfarin Study Open
View article: Identifying Functional Status Impairment in People Living With Dementia Through Natural Language Processing of Clinical Documents: Cross-Sectional Study (Preprint)
Identifying Functional Status Impairment in People Living With Dementia Through Natural Language Processing of Clinical Documents: Cross-Sectional Study (Preprint) Open
BACKGROUND Assessment of activities of daily living (ADLs) and instrumental ADLs (iADLs) is key to determining the severity of dementia and care needs among older adults. However, such information is often only documented in free-text cli…
View article: Trends in the Use of Oral Anticoagulants for Adults With Venous Thromboembolism in the US, 2010-2020
Trends in the Use of Oral Anticoagulants for Adults With Venous Thromboembolism in the US, 2010-2020 Open
Importance The introduction of direct oral anticoagulants (DOACs) has transformed the treatment of venous thromboembolism (VTE). Large health care databases offer valuable insight into how oral anticoagulants (OACs) are used in clinical pr…
View article: COMMON NONCARDIOVASCULAR MULTIMORBIDITY PATTERNS AND OUTCOMES IN OLDER ADULTS WITH MAJOR CARDIOVASCULAR DISEASE
COMMON NONCARDIOVASCULAR MULTIMORBIDITY PATTERNS AND OUTCOMES IN OLDER ADULTS WITH MAJOR CARDIOVASCULAR DISEASE Open
Non-cardiovascular multimorbidity often coexists in older adults with cardiovascular disease (CVD), but their clinical significance is uncertain. Using Medicare data, we examined common non-cardiovascular comorbidity patterns and their ass…
View article: Association of Antipsychotic Drug Exposure in Pregnancy With Risk of Neurodevelopmental Disorders
Association of Antipsychotic Drug Exposure in Pregnancy With Risk of Neurodevelopmental Disorders Open
The findings of this birth cohort study suggest that the increased risk of NDD seen in children born to women who took antipsychotic drugs late in pregnancy seems to be explained by maternal characteristics and is not causally related with…