Heike E. Daldrup‐Link
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View article: Apparent diffusion coefficient can assist in differentiating between benign and malignant primary bone tumors in pediatric patients
Apparent diffusion coefficient can assist in differentiating between benign and malignant primary bone tumors in pediatric patients Open
Objective To evaluate differences in apparent diffusion coefficient (ADC) values between benign and malignant primary pediatric bone tumors and to assess their diagnostic accuracy in differentiating these tumors. Materials and methods We r…
View article: MRI detection of senescent cells in porcine knee joints with a β-galactosidase responsive Gd-chelate
MRI detection of senescent cells in porcine knee joints with a β-galactosidase responsive Gd-chelate Open
Senescent cells promote osteoarthritis progression through the secretion of inflammatory mediators. Preclinical studies have identified senescence-associated beta-galactosidase (β-gal) as a biomarker of senescence, but in vivo detection re…
View article: Dual-enzyme activated theranostic nanoparticles for image-guided glioblastoma therapy
Dual-enzyme activated theranostic nanoparticles for image-guided glioblastoma therapy Open
Matrix metalloproteinase-14 (MMP-14) and Cathepsin-B (Cat-B) are overexpressed in glioblastoma (GBM) and not normal brain, making them promising targets for prodrug activation. We investigated a novel combination therapy using two tumor-en…
View article: Multimodal imaging approach to track theranostic nanoparticle accumulation in glioblastoma with magnetic resonance imaging and intravital microscopy
Multimodal imaging approach to track theranostic nanoparticle accumulation in glioblastoma with magnetic resonance imaging and intravital microscopy Open
Magnetic resonance imaging and two-photon intravital microscopy metrics were correlated to track Ferumoxytol-based theranostic nanoparticles targeting glioblastoma multiforme in vivo at both macroscopic and microscopic levels.
View article: <i>In vivo</i>imaging of T-cell coregulator B7-H4 reveals protumor macrophage status in prostate cancer
<i>In vivo</i>imaging of T-cell coregulator B7-H4 reveals protumor macrophage status in prostate cancer Open
Background B7-H4 is a cell surface ligand overexpressed by tumors to inhibit T cell functions and evade the immune system. B7-H4 is minimally expressed in normal tissues but is highly expressed by various cancer cells and tumor-associated …
View article: Applications of Artificial Intelligence for Pediatric Cancer Imaging
Applications of Artificial Intelligence for Pediatric Cancer Imaging Open
Artificial intelligence (AI) is transforming the medical imaging of adult patients. However, its utilization in pediatric oncology imaging remains constrained, in part due to the inherent scarcity of data associated with childhood cancers.…
View article: Detecting High-Dose Methotrexate–Induced Brain Changes in Pediatric and Young Adult Cancer Survivors Using [<sup>18</sup>F]FDG PET/MRI: A Pilot Study
Detecting High-Dose Methotrexate–Induced Brain Changes in Pediatric and Young Adult Cancer Survivors Using [<sup>18</sup>F]FDG PET/MRI: A Pilot Study Open
Significant improvements in treatments for children with cancer have resulted in a growing population of childhood cancer survivors who may face long-term adverse outcomes. Here, we aimed to diagnose high-dose methotrexate–induced brain in…
View article: Two-Photon Intravital Microscopy of Glioblastoma in a Murine Model
Two-Photon Intravital Microscopy of Glioblastoma in a Murine Model Open
The delivery of intravenously administered cancer therapeutics to brain tumors is limited by the blood-brain barrier. A method to directly image the accumulation and distribution of macromolecules in brain tumors in vivo would greatly enha…
View article: Increased Metabolic Activity of the Thymus and Lymph Nodes in Pediatric Oncology Patients After Coronavirus Disease 2019 Vaccination
Increased Metabolic Activity of the Thymus and Lymph Nodes in Pediatric Oncology Patients After Coronavirus Disease 2019 Vaccination Open
We hypothesized that 18F-FDG PET/MRI would reveal thymus activation in children after coronavirus disease 2019 (COVID-19) vaccination. Methods: We retrospectively analyzed the 18F-FDG PET/MRI scans of 6 children with extrathoracic cancer b…
View article: Novel Clinically Translatable Iron Oxide Nanoparticle for Monitoring Anti-CD47 Cancer Immunotherapy
Novel Clinically Translatable Iron Oxide Nanoparticle for Monitoring Anti-CD47 Cancer Immunotherapy Open
Objectives A novel clinically translatable iron oxide nanoparticle (IOP) is currently being tested in phase 2 clinical trials as a magnetic resonance imaging (MRI) contrast agent for hepatocellular carcinoma diagnosis. The purpose of our s…
View article: Tyrosine kinase inhibitor therapy in pediatric sarcoma: Prognostic implications of pulmonary metastatic cavitation
Tyrosine kinase inhibitor therapy in pediatric sarcoma: Prognostic implications of pulmonary metastatic cavitation Open
Purposes This study aims to ascertain the prevalence of cavitations in pulmonary metastases among pediatric and young adult patients with sarcoma undergoing tyrosine kinase inhibitor (TKI) therapy, and assess whether cavitation can predict…
View article: Assessment of the Interval to Diagnosis in Pediatric Bone Sarcoma
Assessment of the Interval to Diagnosis in Pediatric Bone Sarcoma Open
Objectives The timely diagnosis of primary bone malignancies in pediatric patients is critical to clinical outcomes. The purpose of this study is to investigate the initial presentation of pediatric bone sarcoma patients to an academic hea…
View article: Measurement of Tumor T2* Relaxation Times after Iron Oxide Nanoparticle Administration
Measurement of Tumor T2* Relaxation Times after Iron Oxide Nanoparticle Administration Open
T2* relaxometry is one of the established methods to measure the effect of superparamagnetic iron oxide nanoparticles on tumor tissues with magnetic resonance imaging (MRI). Iron oxide nanoparticles shorten the T1, T2, and T2* relaxation t…
View article: Co-Clinical Imaging Metadata Information (CIMI) for Cancer Research to Promote Open Science, Standardization, and Reproducibility in Preclinical Imaging
Co-Clinical Imaging Metadata Information (CIMI) for Cancer Research to Promote Open Science, Standardization, and Reproducibility in Preclinical Imaging Open
Preclinical imaging is a critical component in translational research with significant complexities in workflow and site differences in deployment. Importantly, the National Cancer Institute’s (NCI) precision medicine initiative emphasizes…
View article: AI Transformers for Radiation Dose Reduction in Serial Whole-Body PET Scans
AI Transformers for Radiation Dose Reduction in Serial Whole-Body PET Scans Open
Masked-LMCTrans achieved high image quality reconstruction of 1% low-dose whole-body PET images.Keywords: Pediatrics, PET, Convolutional Neural Network (CNN), Dose Reduction Supplemental material is available for this article. © RSNA, 2023.
View article: PET/MRI Applications in Pediatric Epilepsy
PET/MRI Applications in Pediatric Epilepsy Open
Epilepsy neuroimaging assessment requires exceptional anatomic detail, physiologic and metabolic information. Magnetic resonance (MR) protocols are often time-consuming necessitating sedation and positron emission tomography (PET)/computed…
View article: Figure S6 from A Novel Theranostic Strategy for <i>MMP-14</i>–Expressing Glioblastomas Impacts Survival
Figure S6 from A Novel Theranostic Strategy for <i>MMP-14</i>–Expressing Glioblastomas Impacts Survival Open
Biodistribution and toxicity data from CLIO-ICT-treated mice
View article: Data from A Novel Theranostic Strategy for <i>MMP-14</i>–Expressing Glioblastomas Impacts Survival
Data from A Novel Theranostic Strategy for <i>MMP-14</i>–Expressing Glioblastomas Impacts Survival Open
Glioblastoma (GBM) has a dismal prognosis. Evidence from preclinical tumor models and human trials indicates the role of GBM-initiating cells (GIC) in GBM drug resistance. Here, we propose a new treatment option with tumor enzyme-activatab…
View article: Figure S4 from A Novel Theranostic Strategy for <i>MMP-14</i>–Expressing Glioblastomas Impacts Survival
Figure S4 from A Novel Theranostic Strategy for <i>MMP-14</i>–Expressing Glioblastomas Impacts Survival Open
Immunofluorescent confocal images for MMP-14 expression in pcGBM39 tumors
View article: Figure S1 from A Novel Theranostic Strategy for <i>MMP-14</i>–Expressing Glioblastomas Impacts Survival
Figure S1 from A Novel Theranostic Strategy for <i>MMP-14</i>–Expressing Glioblastomas Impacts Survival Open
CLIO-ICTs induce apoptosis in GBM
View article: Data from A Novel Theranostic Strategy for <i>MMP-14</i>–Expressing Glioblastomas Impacts Survival
Data from A Novel Theranostic Strategy for <i>MMP-14</i>–Expressing Glioblastomas Impacts Survival Open
Glioblastoma (GBM) has a dismal prognosis. Evidence from preclinical tumor models and human trials indicates the role of GBM-initiating cells (GIC) in GBM drug resistance. Here, we propose a new treatment option with tumor enzyme-activatab…
View article: Figure S6 from A Novel Theranostic Strategy for <i>MMP-14</i>–Expressing Glioblastomas Impacts Survival
Figure S6 from A Novel Theranostic Strategy for <i>MMP-14</i>–Expressing Glioblastomas Impacts Survival Open
Biodistribution and toxicity data from CLIO-ICT-treated mice
View article: Figure S2 from A Novel Theranostic Strategy for <i>MMP-14</i>–Expressing Glioblastomas Impacts Survival
Figure S2 from A Novel Theranostic Strategy for <i>MMP-14</i>–Expressing Glioblastomas Impacts Survival Open
Flowcytometric characterization of GICs in pcGBM39 and pcGBM2
View article: Figure S3 from A Novel Theranostic Strategy for <i>MMP-14</i>–Expressing Glioblastomas Impacts Survival
Figure S3 from A Novel Theranostic Strategy for <i>MMP-14</i>–Expressing Glioblastomas Impacts Survival Open
In vivo tumorigenic assay for GIC derived from pcGBM39
View article: Figure S2 from A Novel Theranostic Strategy for <i>MMP-14</i>–Expressing Glioblastomas Impacts Survival
Figure S2 from A Novel Theranostic Strategy for <i>MMP-14</i>–Expressing Glioblastomas Impacts Survival Open
Flowcytometric characterization of GICs in pcGBM39 and pcGBM2