Heike Petzold
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View article: Permeability-driven pressure and cell proliferation control lumen morphogenesis in pancreatic organoids
Permeability-driven pressure and cell proliferation control lumen morphogenesis in pancreatic organoids Open
Lumen formation in organ epithelia involves processes such as polarization, secretion, exocytosis and contractility, but what controls lumen shape remains unclear. Here we study how lumina develop spherical or complex structures using panc…
View article: Control of lumen geometry and topology by the interplay between pressure and cell proliferation rate in pancreatic organoids
Control of lumen geometry and topology by the interplay between pressure and cell proliferation rate in pancreatic organoids Open
Many internal organs in multicellular organisms comprise epithelia which enclose fluid-filled cavities. These are referred to as lumens and their formation is regulated by a wide range of processes, including epithelial polarization, secre…
View article: Generic comparison of lumen nucleation and fusion in epithelial organoids with and without hydrostatic pressure
Generic comparison of lumen nucleation and fusion in epithelial organoids with and without hydrostatic pressure Open
Many internal organs in the body harbor a fluid-filled lumen. The mechanisms of lumens initiation and fusion have been reported as dependent on organ-type during organogenesis. In contrast, the physics of lumen suggests that force balance …
View article: Inside Cover
Inside Cover Open
Biological cells are highly light scattering, largely precluding the optical access of light microscopes into living tissues. Using a scheme of mutation and high throughput optical selection, the authors present the directed evolution of m…
View article: Optical plasticity of mammalian cells
Optical plasticity of mammalian cells Open
Transparency is widespread in nature, ranging from transparent insect wings to ocular tissues that enable you to read this text, and transparent marine vertebrates. And yet, cells and tissue models in biology are usually strongly light sca…
View article: Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice
Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice Open
Rod photoreceptors of nocturnal mammals display a striking inversion of nuclear architecture, which has been proposed as an evolutionary adaptation to dark environments. However, the nature of visual benefits and the underlying mechanisms …
View article: Author response: Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice
Author response: Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Rod photoreceptors of nocturnal mammals di…
View article: Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice
Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice Open
Rod photoreceptors of nocturnal mammals display a striking inversion of nuclear architecture, which has been proposed as an evolutionary adaptation to dark environments. However, the nature of visual benefits and underlying mechanisms rema…
View article: Active gelation breaks time-reversal-symmetry of mitotic chromosome mechanics
Active gelation breaks time-reversal-symmetry of mitotic chromosome mechanics Open
In cell division, mitosis is the phase in which duplicated sets of chromosomes are mechanically aligned to form the metaphase plate before being segregated in two daughter cells. Irreversibility is a hallmark of this process, despite the f…