Hejun Deng
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View article: Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in <i>BRCA</i> -mutated cancer
Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in <i>BRCA</i> -mutated cancer Open
Recent studies have pointed to PARP1 trapping as a key determinant of the anticancer effects of PARP1 inhibitors (PARPi). We identified RNF114, as a PARylation-dependent, E3 ubiquitin ligase involved in DNA damage response. Upon sensing ge…
View article: Modular synthesis of nimbolide and its analogues as PARP1 trapping inducers
Modular synthesis of nimbolide and its analogues as PARP1 trapping inducers Open
PARP1 inhibitors (PARPi) has reshaped the clinical treatment of cancer patients with germline BRCA1/2 mutations presumably due to their ability to induce PARP1 trapping. Since PARPi resistance is frequently observed, there is still an unme…
View article: Nimbolide Targets RNF114 to Induce the Trapping of PARP1 and Poly-ADP-Ribosylation-Dependent DNA Repair Factors
Nimbolide Targets RNF114 to Induce the Trapping of PARP1 and Poly-ADP-Ribosylation-Dependent DNA Repair Factors Open
PARP1 is an abundant nuclear enzyme that is critically involved in DNA damage response. Its main enzymatic function is to catalyze a protein post-translational modification known as poly-ADP-ribosylation (PARylation). Despite the tremendou…
View article: Hepatic splenosis: Rare yet important – A case report and literature review
Hepatic splenosis: Rare yet important – A case report and literature review Open
Hepatic splenosis is an uncommon condition that occurs following traumatic splenic rupture or splenectomy. The case of a 41-year-old male patient with multiple isolated liver masses indistinguishable from primary and metastatic liver tumou…