Heleen Marynissen
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View article: Glucocorticoids Do Not Affect the Vascular Component of TRP-Mediated Neurogenic Skin Inflammation
Glucocorticoids Do Not Affect the Vascular Component of TRP-Mediated Neurogenic Skin Inflammation Open
View article: Functional Analysis of TRPA1, TRPM3, and TRPV1 Channels in Human Dermal Arteries and Their Role in Vascular Modulation
Functional Analysis of TRPA1, TRPM3, and TRPV1 Channels in Human Dermal Arteries and Their Role in Vascular Modulation Open
Transient receptor potential (TRP) channels are pivotal in modulating vascular functions. In fact, topical application of cinnamaldehyde or capsaicin (TRPA1 and TRPV1 channel agonists, respectively) induces “local” changes in blood flow by…
View article: TRPA1 Antagonist LY3526318 Inhibits the Cinnamaldehyde‐Evoked Dermal Blood Flow Increase: Translational Proof of Pharmacology
TRPA1 Antagonist LY3526318 Inhibits the Cinnamaldehyde‐Evoked Dermal Blood Flow Increase: Translational Proof of Pharmacology Open
Transient receptor potential Ankyrin 1 (TRPA1) is an ion channel expressed by sensory neurons, where it mediates pain signaling. Consequently, it has emerged as a promising target for novel analgesics, yet, to date, no TRPA1 antagonists ha…
View article: <scp>First‐in‐human</scp> development of a pharmacodynamic biomarker for <scp>PAC<sub>1</sub></scp> receptor antagonists using intradermal injections of maxadilan
<span>First‐in‐human</span> development of a pharmacodynamic biomarker for <span>PAC<sub>1</sub></span> receptor antagonists using intradermal injections of maxadilan Open
Maxadilan, a potent vasodilator peptide, selectively activates the PAC 1 receptor, a promising target for migraine therapy. Therefore, maxadilan has been suggested as a tool to study the pharmacodynamics (PDs) of PAC 1 receptor antagonists…
View article: Co-creation with research participants to inform the design of electronic informed consent
Co-creation with research participants to inform the design of electronic informed consent Open
Objective This study aimed to provide recommendations for a personalized electronic informed consent interface that is adapted to research participants’ needs and could enable a longitudinal interaction between the participants and the res…
View article: Doppler ultrasound to assess the pharmacodynamic effects of splanchnic vasoactive compounds
Doppler ultrasound to assess the pharmacodynamic effects of splanchnic vasoactive compounds Open
Aims In search of noninvasive biomarkers to assess the pharmacodynamic effects of portal pressure‐lowering drugs, the reproducibility of flow measurements in the superior mesenteric artery was evaluated using Doppler ultrasound. Methods A …
View article: Pharmacokinetics during therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy: a literature review
Pharmacokinetics during therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy: a literature review Open
Background Neonatal hypoxic ischaemic encephalopathy due to perinatal asphyxia, can result in severe neurodevelopmental disability or mortality. Hypothermia is at present the only proven neuroprotective intervention. During hypothermia, th…