Jiang He
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View article: Risk factors for mortality in patients with kidney failure on hemodialysis identified by proteomic analysis of CRIC and PACE studies
Risk factors for mortality in patients with kidney failure on hemodialysis identified by proteomic analysis of CRIC and PACE studies Open
More than 50% of patients with kidney failure undergoing maintenance hemodialysis die within 5 years, a fate unexplained by traditional risk factors. To identify biological risk factors, we analyze 6287 circulating proteins and mortality i…
View article: Sex Differences in Social, Behavioral, and Metabolic Risk Factors for Cardiovascular Disease Mortality among US Adults
Sex Differences in Social, Behavioral, and Metabolic Risk Factors for Cardiovascular Disease Mortality among US Adults Open
Background Prevalence and associations of risk factors for cardiovascular disease (CVD) may differ between women and men, but previous findings are inconclusive. We investigated the simultaneous contributions of social determinants of heal…
View article: Machine learning glucose forecasting models for septic patients
Machine learning glucose forecasting models for septic patients Open
Sepsis-induced glucose fluctuations present major challenges in critical care, underscoring the importance of accurate glucose monitoring and forecasting to improve patient outcomes. This study introduces a suite of forecasting models trai…
View article: Diurnal variation of wearable device-based heart rate variability in the Chronic Renal Insufficiency Cohort study
Diurnal variation of wearable device-based heart rate variability in the Chronic Renal Insufficiency Cohort study Open
View article: 655 Theranostic PET defines a ‘goldilocks zone’ for focused ultrasound ablation: balancing tumor disruption and immunotherapeutic antibody delivery
655 Theranostic PET defines a ‘goldilocks zone’ for focused ultrasound ablation: balancing tumor disruption and immunotherapeutic antibody delivery Open
View article: 102 New developments in spatial transcriptomics using MERFISH 2.0 unlock insights into the tumor microenvironment
102 New developments in spatial transcriptomics using MERFISH 2.0 unlock insights into the tumor microenvironment Open
View article: 101 Combining Vizgen’s MERSCOPE gene expression profiling and InSituPlex multiplex immunofluorescence (mIF) to unravel the complexity of the tumor microenvironment (TME)
101 Combining Vizgen’s MERSCOPE gene expression profiling and InSituPlex multiplex immunofluorescence (mIF) to unravel the complexity of the tumor microenvironment (TME) Open
View article: Predictive Value of Serum N‐Terminal pro‐B‐Type Natriuretic Peptide and Troponin T for Incident Heart Failure: A Meta‐Analysis of 9 International Cohorts
Predictive Value of Serum N‐Terminal pro‐B‐Type Natriuretic Peptide and Troponin T for Incident Heart Failure: A Meta‐Analysis of 9 International Cohorts Open
Background Prior prediction equations for heart failure (HF) omitted cardiac biomarkers and used select populations. We assessed the added value of NT‐proBNP (NT‐terminal pro‐brain natriuretic peptide) and hsTnT (high‐sensitivity troponin …
View article: Evaluating dexmedetomidine in mitigating emergence agitation and perioperative complications in pediatric tonsillectomy and/or adenoidectomy: a systematic review and meta-analysis
Evaluating dexmedetomidine in mitigating emergence agitation and perioperative complications in pediatric tonsillectomy and/or adenoidectomy: a systematic review and meta-analysis Open
Background Perioperative complications and emergence agitation (EA) are common after pediatric tonsillectomy and/or adenoidectomy (T&A), and may be influenced by the use of preoperative sedatives. The effectiveness of dexmedetomidine (…
View article: Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis
Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis Open
View article: Frailty is Independently Associated with Stress Urinary Incontinence in Women: A SHAP-Enhanced Machine Learning Analysis
Frailty is Independently Associated with Stress Urinary Incontinence in Women: A SHAP-Enhanced Machine Learning Analysis Open
This study demonstrates that elevated FI levels are independently associated with an increased risk of SUI in women and identifies FI as a key nonlinear predictor, underscoring its potential utility in early screening and risk assessment.
View article: Design and Scientific Prospects of the POLAR-2 Mission
Design and Scientific Prospects of the POLAR-2 Mission Open
The POLAR-2 mission consists of 3 instruments designed with the combined aim of producing a deeper understanding of Gamma-Ray Bursts. To achieve this, POLAR-2 relies on polarisation measurements and, for the first time will provide these u…
View article: MON-574 Healthy sleep patterns, plasma metabolome, and type 2 diabetes: the Bogalusa Heart Study
MON-574 Healthy sleep patterns, plasma metabolome, and type 2 diabetes: the Bogalusa Heart Study Open
Disclosure: X. Li: None. L. Du: None. Y. Pan: None. X. Sun: None. Z. Huang: None. R. Zhang: None. S. Reutrakul: None. M.L. Daviglus: None. C. Li: None. L. Qi: None. J. He: None. L.A. Bazzano: None. B.T. Layden: None. T.N. Kelly: None. Back…
View article: Whole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals
Whole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals Open
This study provides a meta-analysis framework for large-scale whole genome sequence association analyses from diverse population groups, yielding novel rare non-coding variant associations.
View article: Health Systems and Self-Reported Medication Adherence in Patients with Hypertension: A cross-sectional comparison of Jamaica and Colombia
Health Systems and Self-Reported Medication Adherence in Patients with Hypertension: A cross-sectional comparison of Jamaica and Colombia Open
Robust health care systems can support medication adherence as a strategy to improve blood pressure control in Latin America and the Caribbean. The Caribbean and South American Team Based Strategies to Control Hypertension (CATCH) study, c…
View article: Soluble Triggering Receptor Expressed on Myeloid Cells 2 as a Promising Biomarker for Poststroke Depression After Acute Ischemic Stroke
Soluble Triggering Receptor Expressed on Myeloid Cells 2 as a Promising Biomarker for Poststroke Depression After Acute Ischemic Stroke Open
Background Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) was reported to induce inflammatory responses, enhance microglial survival, and contribute to the development of neurodegenerative disorders. We aimed to prospect…
View article: Cerebral Microbleeds and the Effect of Early Antihypertensive Treatment in Patients with Acute Ischemic Stroke: A Secondary Analysis of the CATIS-2 Trial
Cerebral Microbleeds and the Effect of Early Antihypertensive Treatment in Patients with Acute Ischemic Stroke: A Secondary Analysis of the CATIS-2 Trial Open
Background and Objectives To explore whether the presence, burden or distribution of cerebral microbleeds (CMBs) modifies the effect of early versus delayed antihypertensive treatment on clinical outcomes in acute ischemic stroke (AIS) pat…
View article: Pesticide exposure and cardiovascular health in non-CVD mortality population: novel evidence from NHANES 2007–2018 using Life's Essential 8
Pesticide exposure and cardiovascular health in non-CVD mortality population: novel evidence from NHANES 2007–2018 using Life's Essential 8 Open
Background While pesticide exposure has become a global public health concern, its impact on cardiovascular health among non-cardiovascular mortality populations remains understudied. Methods Based on NHANES 2007–2018 data ( n = 12,432), w…
View article: Identification and validation of serum amino acids as diagnostic biomarkers for diabetic peripheral neuropathy
Identification and validation of serum amino acids as diagnostic biomarkers for diabetic peripheral neuropathy Open
BACKGROUND Diabetic peripheral neuropathy (DPN) is the most prevalent complication of type 2 diabetes mellitus (T2DM). Due to a lack of specific biomarkers, the early diagnosis of this disorder is limited. AIM To identify and validate seru…
View article: A genetic variant of the glutamate-cysteine ligase catalytic subunit is associated with susceptibility to ischemic stroke in the Chinese population
A genetic variant of the glutamate-cysteine ligase catalytic subunit is associated with susceptibility to ischemic stroke in the Chinese population Open
These results indicated that rs12524494 GG may be linked to decreasing IS susceptibility. The identified rs12524494 GG may serve as a potential biomarker for predicting IS susceptibility in the Chinese population, which could inform person…
View article: Recent status and trends regarding oxidative stress in gliomas (2013 - 2025): a systematic review and bibliometric analysis
Recent status and trends regarding oxidative stress in gliomas (2013 - 2025): a systematic review and bibliometric analysis Open
Background Glioma, a prevalent brain tumor originating from glial cells, exhibits rapid growth, high recurrence, and significant invasiveness. Standard treatments include surgery, radiotherapy, and chemotherapy, yet their effectiveness rem…
View article: Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes
Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes Open
View article: Inherited causes of clonal haematopoiesis in 97,691 whole genomes
Inherited causes of clonal haematopoiesis in 97,691 whole genomes Open
View article: A multi-center study to discern the diurnal variation of wearable device-based heart rate variability (HRV) in the Chronic Renal Insufficiency Cohort (CRIC) Study
A multi-center study to discern the diurnal variation of wearable device-based heart rate variability (HRV) in the Chronic Renal Insufficiency Cohort (CRIC) Study Open
Little is known about the prognostic value of out-of-clinic biometric monitoring of cardiovascular function in chronic kidney disease (CKD). Using real-world sampling strategies, a mean (±SD) of 50.3±9.3 hours of ECG recordings from wearab…
View article: Deoxycholic Acid and Cognitive Impairment and Decline in the Chronic Renal Insufficiency Cohort (CRIC)
Deoxycholic Acid and Cognitive Impairment and Decline in the Chronic Renal Insufficiency Cohort (CRIC) Open
View article: Efficacy of immediate anti-hypertensive treatment in patients with acute ischaemic stroke stratified by mean arterial pressure and pulse pressure: a secondary analysis of the China Antihypertensive Trial in Acute Ischemic Stroke trial
Efficacy of immediate anti-hypertensive treatment in patients with acute ischaemic stroke stratified by mean arterial pressure and pulse pressure: a secondary analysis of the China Antihypertensive Trial in Acute Ischemic Stroke trial Open
Background Whether mean arterial pressure (MAP) and pulse pressure (PP), two indicators of cerebral perfusion, could guide the selection of anti-hypertensive strategies after acute ischaemic stroke remains uncertain. Our study was to explo…
View article: Estimating Glucose Disposal Rate and Its Association with All-Cause and Etiologically Specific Mortality in Cardiovascular-Kidney-Metabolic Syndrome among US Adults: Insights from NHANES 1999–2018
Estimating Glucose Disposal Rate and Its Association with All-Cause and Etiologically Specific Mortality in Cardiovascular-Kidney-Metabolic Syndrome among US Adults: Insights from NHANES 1999–2018 Open
Background: The estimated glucose disposal rate (eGDR) is a useful indicator of insulinresistance. Thisstudy explores its asociation with cadiovascular-kidney-metabolic syndrome (CKM), a relationship that has rarely been investigated. The …
View article: Whole genome sequencing analysis of body mass index identifies novel African ancestry-specific risk allele
Whole genome sequencing analysis of body mass index identifies novel African ancestry-specific risk allele Open
Obesity is a major public health crisis associated with high mortality rates. Previous genome-wide association studies (GWAS) investigating body mass index (BMI) have largely relied on imputed data from European individuals. This study lev…
View article: A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies
A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies Open
View article: Numerical Simulation Study of the Optimization on Tubing-to-Sediment Surface Distance in Small-Spacing Dual-Well (SSDW) Salt Caverns
Numerical Simulation Study of the Optimization on Tubing-to-Sediment Surface Distance in Small-Spacing Dual-Well (SSDW) Salt Caverns Open
The small-spacing dual-well (SSDW) technique plays a crucial role in the establishment of underground salt cavern gas storage reservoirs. However, during the cavity dissolution and brine discharge processes, insoluble sediment is prone to …