Chih‐Jung Chang
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View article: Targeting MDM2 homodimer and heterodimer disruption with DRx-098D in TP53 wild-type and mutant cancer cells
Targeting MDM2 homodimer and heterodimer disruption with DRx-098D in TP53 wild-type and mutant cancer cells Open
View article: Woman with beaver tail liver and splenic injury
Woman with beaver tail liver and splenic injury Open
Objective This study aims to highlight the diagnostic challenges posed by beaver tail liver—a rare anatomical variant—during point‐of‐care ultrasonography (POCUS) in the assessment of splenic injury. This case demonstrates how beaver tail …
View article: Hematological and biochemical markers and cytokine levels in hospitalized psychiatric patients with COVID-19
Hematological and biochemical markers and cytokine levels in hospitalized psychiatric patients with COVID-19 Open
Background Multiple lines of evidence indicate a connection between the pathogenesis of coronavirus disease 2019 (COVID-19) and psychiatric diseases (PDs). To improve the treatment and management of individuals with psychosis and COVID-19,…
View article: Woman with right abdominal pain
Woman with right abdominal pain Open
Objective The objective of this study was to assess the role of point‐of‐care ultrasonography (POCUS) in the diagnosis of epiploic appendagitis, a relatively rare but important cause of right lower quadrant (RLQ) abdominal pain, in an emer…
View article: Identification of Progression‐Associated Biomarkers in Lung Cancer Based on the Integrated Analysis of RNA Sequencing Data From Platelets and Tumor Tissues
Identification of Progression‐Associated Biomarkers in Lung Cancer Based on the Integrated Analysis of RNA Sequencing Data From Platelets and Tumor Tissues Open
Objective: This study is aimed at exploring disease progression–associated genes from platelet‐derived genes and at investigating their underlying roles in prognostic outcomes in lung cancer. Methods: Platelet RNA sequencing (RNA‐seq) from…
View article: Immune checkpoint inhibitor-induced severe epidermal necrolysis mediated by macrophage-derived CXCL10 and abated by TNF blockade
Immune checkpoint inhibitor-induced severe epidermal necrolysis mediated by macrophage-derived CXCL10 and abated by TNF blockade Open
Immune checkpoint inhibitors (ICI) represent new anticancer agents and have been used worldwide. However, ICI can potentially induce life-threatening severe cutaneous adverse reaction (SCAR), such as Stevens-Johnson syndrome/toxic epiderma…
View article: Plant‐Derived Extracellular Vesicles as Potential Emerging Tools for Cancer Therapeutics
Plant‐Derived Extracellular Vesicles as Potential Emerging Tools for Cancer Therapeutics Open
Extracellular vesicles (EVs) are membranous structures secreted by cells that play important roles in intercellular communication and material transport. Due to its excellent biocompatibility, lipophilicity, and homing properties, EVs have…
View article: Correction: Metformin modifies plasma microbial-derived extracellular vesicles in polycystic ovary syndrome with insulin resistance
Correction: Metformin modifies plasma microbial-derived extracellular vesicles in polycystic ovary syndrome with insulin resistance Open
View article: Metformin modifies plasma microbial-derived extracellular vesicles in polycystic ovary syndrome with insulin resistance
Metformin modifies plasma microbial-derived extracellular vesicles in polycystic ovary syndrome with insulin resistance Open
View article: Altered microbiome of serum exosomes in patients with acute and chronic cholecystitis
Altered microbiome of serum exosomes in patients with acute and chronic cholecystitis Open
View article: Proteomic analysis of serum extracellular vesicles from biliary tract infection patients to identify novel biomarkers
Proteomic analysis of serum extracellular vesicles from biliary tract infection patients to identify novel biomarkers Open
Biliary tract infection (BTI), a commonly occurring abdominal disease, despite being extensively studied for its initiation and underlying mechanisms, continues to pose a challenge in the quest for identifying specific diagnostic biomarker…
View article: Proteomic analysis of exosomal proteins associated with bone healing speed in a rat tibial fracture model
Proteomic analysis of exosomal proteins associated with bone healing speed in a rat tibial fracture model Open
This study investigates the impact of exosomes on bone fracture healing in a rat tibial model, distinguishing between fast and slow healing processes. Bone healing and protein expression were assessed through X‐ray examinations, hematoxyli…
View article: Clinical characteristics and outcomes among critically ill patients with cancer and COVID-19-related acute respiratory failure
Clinical characteristics and outcomes among critically ill patients with cancer and COVID-19-related acute respiratory failure Open
View article: Man With Swollen Penis
Man With Swollen Penis Open
View article: A Closer Look at Geometric Temporal Dynamics for Face Anti-Spoofing
A Closer Look at Geometric Temporal Dynamics for Face Anti-Spoofing Open
Face anti-spoofing (FAS) is indispensable for a face recognition system. Many texture-driven countermeasures were developed against presentation attacks (PAs), but the performance against unseen domains or unseen spoofing types is still un…
View article: POS0925 AUTOMATIC SCORING OF ULTRASOUND SYNOVIAL HYPERTROPHY IN RHEUMATOID ARTHRITIS THROUGH INTEGRATING MULTIPLE CONVOLUTIONAL NEURAL NETWORK MODELS
POS0925 AUTOMATIC SCORING OF ULTRASOUND SYNOVIAL HYPERTROPHY IN RHEUMATOID ARTHRITIS THROUGH INTEGRATING MULTIPLE CONVOLUTIONAL NEURAL NETWORK MODELS Open
View article: A woman with hoarseness
A woman with hoarseness Open
View article: Associations of HLA-A and HLA-B with vancomycin-induced drug reaction with eosinophilia and systemic symptoms in the Han-Chinese population
Associations of HLA-A and HLA-B with vancomycin-induced drug reaction with eosinophilia and systemic symptoms in the Han-Chinese population Open
Vancomycin is a commonly used antibiotic; however, it can cause life-threatening severe cutaneous adverse reactions, such as drug reaction with eosinophilia and systemic symptoms (DRESS). A previous study has reported a strong association …
View article: Self-Supervised Pyramid Representation Learning for Multi-Label Visual Analysis and Beyond
Self-Supervised Pyramid Representation Learning for Multi-Label Visual Analysis and Beyond Open
While self-supervised learning has been shown to benefit a number of vision tasks, existing techniques mainly focus on image-level manipulation, which may not generalize well to downstream tasks at patch or pixel levels. Moreover, existing…
View article: Microbiome profiling of nasal extracellular vesicles in patients with allergic rhinitis
Microbiome profiling of nasal extracellular vesicles in patients with allergic rhinitis Open
View article: Implementation of <i>NUDT15</i> Genotyping to Prevent Azathioprine‐Induced Leukopenia for Patients With Autoimmune Disorders in Chinese Population
Implementation of <i>NUDT15</i> Genotyping to Prevent Azathioprine‐Induced Leukopenia for Patients With Autoimmune Disorders in Chinese Population Open
Azathioprine (AZA) is commonly used for many autoimmune disorders; however, the limitation of its clinical use is due to potential toxicities, including severe leukopenia. Recent studies have identified genetic NUDT15 variants strongly ass…
View article: Shikonin, Gallic Acid, and Hydroxysafflor Yellow A Decrease the Pathogenesis and Normalize the Microbiota of Cervical Erosion
Shikonin, Gallic Acid, and Hydroxysafflor Yellow A Decrease the Pathogenesis and Normalize the Microbiota of Cervical Erosion Open
Background and Objective: Cervical erosion is a common gynecological disease that increases the risk of human papillomavirus (HPV) infection and causes cervical lesions. Without prompt treatment, this disease may lead to the occurrence of …
View article: Man With New-Onset Seizure
Man With New-Onset Seizure Open
View article: Metagenomic Anaysis of Nasal Microbiota-Derived Extracellular Vesicle in Patients with Allergic Rhinitis.
Metagenomic Anaysis of Nasal Microbiota-Derived Extracellular Vesicle in Patients with Allergic Rhinitis. Open
Nasal Microbiota is crucial for the pathogenesis of allergic rhinitis (AR). However, never study investigates the microbiota in nasal extracellular vesicles (EVs). Objective: We aim to compare the microbiome composition and diversity in EV…
View article: Compositional Features of Distinct Microbiota Base on Serum Extracellular Vesicle Metagenomics Analysis in Moderate to Severe Psoriasis Patients
Compositional Features of Distinct Microbiota Base on Serum Extracellular Vesicle Metagenomics Analysis in Moderate to Severe Psoriasis Patients Open
The bacterial microbiota in the skin and intestine of patients with psoriasis were different compared with that of healthy individuals. However, the presence of a distinct blood microbiome in patients with psoriasis is yet to be investigat…
View article: Intestinal fatty <scp>acid‐binding</scp> protein is a biomarker for diagnosis of biliary tract infection
Intestinal fatty <span>acid‐binding</span> protein is a biomarker for diagnosis of biliary tract infection Open
Background and Aim Biliary tract infection (BTI) is an inflammatory disease and commonly associated with bacteremia. Delays in diagnosis or treatment of BTI cause high morbidity and mortality. However, an early diagnosis depends on appropr…
View article: Distinct Proteomic Profiling of Plasma Extracellular Vesicles from Moderate-to-Severe Atopic Dermatitis Patients
Distinct Proteomic Profiling of Plasma Extracellular Vesicles from Moderate-to-Severe Atopic Dermatitis Patients Open
SLP-76 tyrosine phosphoprotein (SLP76) involved in platelet activation may significantly contribute to the pathogenesis of AD. We will further verify the role of SLP67 in AD via animal and cell experiments to provide a promising therapeuti…
View article: Gut microbiota modulates COPD pathogenesis: role of anti-inflammatory <i>Parabacteroides goldsteinii</i> lipopolysaccharide
Gut microbiota modulates COPD pathogenesis: role of anti-inflammatory <i>Parabacteroides goldsteinii</i> lipopolysaccharide Open
Objective Chronic obstructive pulmonary disease (COPD) is a global disease characterised by chronic obstruction of lung airflow interfering with normal breathing. Although the microbiota of respiratory tract is established to be associated…
View article: Synergistic Antifungal Activity of Chitosan with Fluconazole against Candida albicans, Candida tropicalis, and Fluconazole-Resistant Strains
Synergistic Antifungal Activity of Chitosan with Fluconazole against Candida albicans, Candida tropicalis, and Fluconazole-Resistant Strains Open
(1) Background: Few antifungal drugs are currently available, and drug-resistant strains have rapidly emerged. Thus, the aim of this study is to evaluate the effectiveness of the antifungal activity from a combinational treatment of chitos…
View article: 151P Treatment patterns, healthcare resource use, economic and survival outcomes associated with unresectable advanced metastatic gastric cancers in Taiwan
151P Treatment patterns, healthcare resource use, economic and survival outcomes associated with unresectable advanced metastatic gastric cancers in Taiwan Open