Helen Chen
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View article: Deep Learning Models to Screen Electronic Health Records for Breast and Colorectal Cancer Progression: Performance Evaluation Study
Deep Learning Models to Screen Electronic Health Records for Breast and Colorectal Cancer Progression: Performance Evaluation Study Open
Background Cancer progression is an important outcome in cancer research. However, it is frequently documented only in electronic health records (EHRs) as unstructured text, which requires lengthy and costly chart reviews to extract for re…
View article: Feeding practices and concerns as mediators between maternal mental health and eating behaviours in early childhood
Feeding practices and concerns as mediators between maternal mental health and eating behaviours in early childhood Open
Depression and anxiety symptoms influence children's eating behaviours differently. Anxiety symptoms were linked with child eating behaviours only through maternal feeding concerns, whereas depression symptoms were linked with child eating…
View article: Consensus statements on perinatal depression and anxiety in the Asia-Pacific region
Consensus statements on perinatal depression and anxiety in the Asia-Pacific region Open
These guidelines, developed for maternal and child health practitioners in the Asia-Pacific, promote a holistic approach-combining lifestyle changes, early screening, and tailored interventions-to improve perinatal mental health and enhanc…
View article: Assessment of ecological fidelity of human microbiome-associated mice in observational studies and an interventional trial
Assessment of ecological fidelity of human microbiome-associated mice in observational studies and an interventional trial Open
Composition and function of the gut microbiome are associated with diverse health conditions and treatment responses. Human microbiota-associated (HMA) mouse models are used to establish causal links for these associations but have importa…
View article: Amygdala-hippocampus connectivity and childhood depressive symptoms: subnuclei insights and self-concept roles
Amygdala-hippocampus connectivity and childhood depressive symptoms: subnuclei insights and self-concept roles Open
View article: The Therapeutic Effects of Semaglutide in Congenital Linear Scleroderma.
The Therapeutic Effects of Semaglutide in Congenital Linear Scleroderma. Open
Congenital linear scleroderma (CLS) is a rare connective tissue disorder characterized by unilateral linear induration that can lead to restricted mobility and limb deformities. Various treatments have been proposed, including D-penicillam…
View article: Hearing From Mums-to-Be: A Qualitative Study Looking at the Experience of Mothers on the PRAM Project
Hearing From Mums-to-Be: A Qualitative Study Looking at the Experience of Mothers on the PRAM Project Open
Aims: Antenatal depression significantly impacts maternal and foetal health outcomes, yet it remains underdiagnosed and undertreated. The Psychological Resilience in Antenatal Management (PRAM) programme at KK Women’s and Children’s Hospit…
View article: How Useful Is Synthetic Data in Developing Predictive Models for Health?
How Useful Is Synthetic Data in Developing Predictive Models for Health? Open
Synthetic data, generated using generative AI techniques, closely mimics the characteristics of real data while enhancing privacy for sensitive health data. This study evaluates synthetic tabular data based on fidelity and utility for pred…
View article: A Review of the Clinical Progress of CT1812, a Novel Sigma-2 Receptor Antagonist for the Treatment of Alzheimer’s Disease
A Review of the Clinical Progress of CT1812, a Novel Sigma-2 Receptor Antagonist for the Treatment of Alzheimer’s Disease Open
Alzheimer’s disease (AD) is a neurodegenerative disease marked by the accumulation of toxic amyloid-beta (Aβ) oligomers. These oligomers are thought to cause synaptic dysfunction and contribute to neurodegeneration. CT1812 is a small-molec…
View article: Numerous Hyperkeratotic Papules On Palms
Numerous Hyperkeratotic Papules On Palms Open
View article: Assessment of ecological fidelity of human microbiome-associated mice in observational studies and an interventional trial
Assessment of ecological fidelity of human microbiome-associated mice in observational studies and an interventional trial Open
Composition and function of the gut microbiome is associated with diverse health conditions and treatment responses. Human microbiota-associated (HMA) mouse models are used to establish causal links for these associations but have importan…
View article: Incontinentia Pigmenti: A Rare Case of Survival of a Male Infant
Incontinentia Pigmenti: A Rare Case of Survival of a Male Infant Open
This case describes a seven-month-old male infant with incontinentia pigmenti (IP), a rare X-linked dominant disorder that is typically lethal in male fetuses. The infant presented with blaschkoid hyperpigmentation but showed no neurologic…
View article: Predictive models on patients’ eligibility for peritoneal dialysis
Predictive models on patients’ eligibility for peritoneal dialysis Open
Background Peritoneal dialysis (PD) is being promoted because it is cost-effective and has equivalent outcomes to facility-based hemodialysis (HD). Determining PD eligibility is critical but subjective, with high variability among renal pr…
View article: Maternal depressive symptoms in childhood and offspring brain cortical and subcortical volumetric change: A repeated imaging study from age 4–10 years
Maternal depressive symptoms in childhood and offspring brain cortical and subcortical volumetric change: A repeated imaging study from age 4–10 years Open
Maternal depressive symptoms have been associated with offspring's brain structural differences. However, previous studies were limited by cross-sectional designs, brain region-of-interest analyses, or clinical samples. Importantly, few st…
View article: Randomized phase 2 study to assess the role of single-agent nivolumab to maintain remission in acute myeloid leukemia
Randomized phase 2 study to assess the role of single-agent nivolumab to maintain remission in acute myeloid leukemia Open
We conducted a multicenter, open-label, randomized phase 2 study to assess the efficacy of nivolumab (Nivo) as maintenance therapy for patients with acute myeloid leukemia (AML) in first complete remission (CR) or CR with incomplete hemato…
View article: Real-world satisfaction and experience with injection and autoinjector device for ofatumumab indicated for multiple sclerosis
Real-world satisfaction and experience with injection and autoinjector device for ofatumumab indicated for multiple sclerosis Open
Regardless of prior DMT experience, patients with MS report high satisfaction levels and positive experiences with the use of the ofatumumab Sensoready device in real-world practice, mostly driven by reasonable administration time and ease…
View article: Feeding Practices and Concerns as Mediators between Maternal Mental Health and Eating Behaviours in Early Childhood
Feeding Practices and Concerns as Mediators between Maternal Mental Health and Eating Behaviours in Early Childhood Open
View article: A Welfare Test for Sharing Health Data
A Welfare Test for Sharing Health Data Open
Machine learning and artificial intelligence methods are being increasingly used in the analysis of patient level and other health data, resulting in new insights and significant societal benefits. However, researchers are often denied acc…
View article: Deep Learning Models to Screen Electronic Health Records for Breast and Colorectal Cancer Progression: Performance Evaluation Study (Preprint)
Deep Learning Models to Screen Electronic Health Records for Breast and Colorectal Cancer Progression: Performance Evaluation Study (Preprint) Open
BACKGROUND Cancer progression is an important outcome in cancer research. However, it is frequently documented only in electronic health records (EHRs) as unstructured text, which requires lengthy and costly chart reviews to extract for r…
View article: Modulation of Oxidative Stress and Neuroinflammation by Cannabidiol (CBD): Promising Targets for the Treatment of Alzheimer’s Disease
Modulation of Oxidative Stress and Neuroinflammation by Cannabidiol (CBD): Promising Targets for the Treatment of Alzheimer’s Disease Open
Alzheimer’s disease (AD) is a progressive neurodegenerative disease and the most common form of dementia globally. Although the direct cause of AD remains under debate, neuroinflammation and oxidative stress are critical components in its …
View article: Uncovering Shortcomings in Advertising Strategies for Over-the-Counter Minoxidil Products on Amazon
Uncovering Shortcomings in Advertising Strategies for Over-the-Counter Minoxidil Products on Amazon Open
View article: Take My Breath Away: Logistical and Social Dynamics of Terminal Weaning from High Flow Nasal Cannula, A Case Report
Take My Breath Away: Logistical and Social Dynamics of Terminal Weaning from High Flow Nasal Cannula, A Case Report Open
View article: Examining Social Support Buffering in a Serial Mediation Model relating Stress to Depressive Symptoms
Examining Social Support Buffering in a Serial Mediation Model relating Stress to Depressive Symptoms Open
A body of evidence supports the role of social support as a buffer against stress in the development of depressive symptoms. However, there are several conceptualisations and measures of stress and their relationships to depression and soc…
View article: Validating part of the social media infodemic listening conceptual framework using structural equation modelling
Validating part of the social media infodemic listening conceptual framework using structural equation modelling Open
This study was supported by the 2023-24 Ontario Graduate Scholarship.
View article: Vitamin C Deficiency Masquerading as Vasculitis in a Patient With Crohn’s Disease
Vitamin C Deficiency Masquerading as Vasculitis in a Patient With Crohn’s Disease Open
View article: Investigating Factors Associated with the Development of Postnatal Depression After Cesarean Delivery: A Validation Cohort Study
Investigating Factors Associated with the Development of Postnatal Depression After Cesarean Delivery: A Validation Cohort Study Open
The proposed model performed well in a local population. Further refinement is necessary to test the proposed model in populations with social and cultural differences.
View article: Patient derived model of<i>UBA5-</i>associated encephalopathy identifies defects in neurodevelopment and highlights potential therapies
Patient derived model of<i>UBA5-</i>associated encephalopathy identifies defects in neurodevelopment and highlights potential therapies Open
UBA5 encodes for the E1 enzyme of the UFMylation cascade, which plays an essential role in ER homeostasis. The clinical phenotypes of UBA5-associated encephalopathy include developmental delays, epilepsy and intellectual disability. To dat…
View article: Factors That Influence Patient Satisfaction With the Service Quality of Home-Based Teleconsultation During the COVID-19 Pandemic: Cross-Sectional Survey Study
Factors That Influence Patient Satisfaction With the Service Quality of Home-Based Teleconsultation During the COVID-19 Pandemic: Cross-Sectional Survey Study Open
Background Ontario stroke prevention clinics primarily held in-person visits before the COVID-19 pandemic and then had to shift to a home-based teleconsultation delivery model using telephone or video to provide services during the pandemi…
View article: Understanding the help-seeking behaviours of women at risk of postnatal depression
Understanding the help-seeking behaviours of women at risk of postnatal depression Open
Background: Postnatal depression, which affects between 10 and 25% of women worldwide, is a major public health problem. However, studies have shown that patients with postnatal depression engage poorly with treatment. Objectives: This qua…
View article: Hofbauer cell function in the term placenta associates with adult cardiovascular and depressive outcomes
Hofbauer cell function in the term placenta associates with adult cardiovascular and depressive outcomes Open
Pathological placental inflammation increases the risk for several adult disorders, but these mediators are also expressed under homeostatic conditions, where their contribution to adult health outcomes is unknown. Here we define an inflam…