Helen Dimaras
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View article: Retinoblastoma Research in Africa: A Scoping Review
Retinoblastoma Research in Africa: A Scoping Review Open
Achieving equity in childhood cancer represents a global challenge. In Africa, where retinoblastoma has high mortality and morbidity, strengthening research capacity is crucial in developing clinical guidelines from local evidence. This re…
View article: Retinoma: An overview
Retinoma: An overview Open
Retinoma, also referred to as retinocytoma, is a benign manifestation of biallelic retinoblastoma gene ( RB1 ) inactivation. Genetic or epigenetic loss of retinoblastoma protein in maturing cone precursors induces genomic instability which…
View article: Development and preliminary evaluation of a genetics education booklet for retinoblastoma
Development and preliminary evaluation of a genetics education booklet for retinoblastoma Open
Background Parents and survivors of retinoblastoma often hold misconceptions about the disease and desire more extensive and detailed information about its genetic nature. The aim of this study was to co‐develop and evaluate a genetic educ…
View article: Development of a Patient-Centered Pathway of Care for Retinoblastoma Patients: A Mixed-Methods Pilot Study
Development of a Patient-Centered Pathway of Care for Retinoblastoma Patients: A Mixed-Methods Pilot Study Open
Introduction: Retinoblastoma treatment and follow-up is complex and varies between patients. Pathways of care can enhance the quality of care, patient outcomes, safety, satisfaction, and resource optimization. Developing a pathway of care …
View article: Navigating familial retinoblastoma in Kenya: A mother's journey
Navigating familial retinoblastoma in Kenya: A mother's journey Open
*This story is based on a true story; names and other personal details have been changed to protect privacy. As a child, Mama Zawadi was diagnosed with unilateral retinoblastoma, an aggressive eye cancer. Too young to remember, she relies …
View article: Health-Related Quality of Life Questionnaire for Corneal Anesthesia Patients: A Content Validity Assessment
Health-Related Quality of Life Questionnaire for Corneal Anesthesia Patients: A Content Validity Assessment Open
Background/Objectives: FACE-Q Craniofacial Module (FACE-Q) is a validated patient-reported outcome measure (PROM) for appearance. This study aimed to assess the content validity of FACE-Q for use in patients treated for corneal anesthesia.…
View article: Use of the CONSIDER statement by eye health researchers when conducting and reporting research involving Indigenous peoples: an online survey
Use of the CONSIDER statement by eye health researchers when conducting and reporting research involving Indigenous peoples: an online survey Open
View article: The Potential of Aqueous Humor Sampling in Diagnosis, Prognosis, and Treatment of Retinoblastoma
The Potential of Aqueous Humor Sampling in Diagnosis, Prognosis, and Treatment of Retinoblastoma Open
Retinoblastoma (RB) is a rare malignant tumor that arises in the developing retina in one or both eyes of children. Pathogenic variants of the RB1 tumor suppressor gene drive the majority of germline and sporadic RB tumors. Considering the…
View article: Social Determinants of Health in Pediatric Ophthalmology Patients: Availability of Data in the Electronic Health Record and Association With Clinic Attendance
Social Determinants of Health in Pediatric Ophthalmology Patients: Availability of Data in the Electronic Health Record and Association With Clinic Attendance Open
This study highlights a need for improved documentation of social determinants of health variables in electronic health records.
View article: Exploring the knowledge, attitudes, and practice towards child eye health: A qualitative analysis of parent experience focus groups
Exploring the knowledge, attitudes, and practice towards child eye health: A qualitative analysis of parent experience focus groups Open
Background The majority of childhood blindness causes in low-income countries are treatable or avoidable. Parents or guardians are responsible for making decisions regarding a child’s eye care. Understanding parents’ awareness and percepti…
View article: Child eye health in Ethiopia: a mixed methods analysis of policy and commitment to action
Child eye health in Ethiopia: a mixed methods analysis of policy and commitment to action Open
Background Child eye health is a serious public health issue in Ethiopia, where children under the age of 15 account for over half of the population. Our aim was to review Ethiopian health policy and practice to reveal approaches and commi…
View article: Health Services Needs Assessment for Retinoblastoma in Ethiopia
Health Services Needs Assessment for Retinoblastoma in Ethiopia Open
PURPOSE The aim of this study was to document the available resources and needs for the detection, diagnosis, and treatment of retinoblastoma (RB) in Ethiopia. METHODS A health services needs assessment focused on RB care in Ethiopia was c…
View article: Incidence and geographic distribution of retinoblastoma in Ethiopia
Incidence and geographic distribution of retinoblastoma in Ethiopia Open
View article: Referral patterns for retinoblastoma patients in Ethiopia
Referral patterns for retinoblastoma patients in Ethiopia Open
Background Increased lag time between the onset of symptoms and treatment of retinoblastoma (RB) is one of the factors contributing to delay in diagnosis. The aim of this study was to understand the referral patterns and lag times for RB p…
View article: Caring for a child with retinoblastoma: Experience of Ethiopian parents
Caring for a child with retinoblastoma: Experience of Ethiopian parents Open
Objective This study explored the lived experience of parents of children with retinoblastoma. Design and method A phenomenological qualitative study design was used, and a purposive sampling technique to recruit parents of children with r…
View article: DNA hypermethylation/boundary control loss identified in retinoblastomas associated with genetic and epigenetic inactivation of the <i>RB1</i> gene promoter
DNA hypermethylation/boundary control loss identified in retinoblastomas associated with genetic and epigenetic inactivation of the <i>RB1</i> gene promoter Open
DNA hypermethylation events occur frequently in human cancers, but less is known of the mechanisms leading to their initiation. Retinoblastoma, an intraocular cancer affecting young children, involves bi-allelic inactivation of the RB1<…
View article: Clinicopathological Presentation of Retinoblastoma in Ethiopia
Clinicopathological Presentation of Retinoblastoma in Ethiopia Open
Introduction: The presenting symptoms of retinoblastoma in Ethiopia, as well as their relationship to the stage of the disease, are poorly understood, but they could be important as background knowledge for creating early det…
View article: Characterization of international partnerships in global retinoblastoma care and research: A network analysis
Characterization of international partnerships in global retinoblastoma care and research: A network analysis Open
Global cooperation is an integral component of global health research and practice. One Retinoblastoma World (1RBW) is a cooperative network of global treatment centers that care for children affected by retinoblastoma. The study aimed to …
View article: Patient preferences in retinal drug delivery
Patient preferences in retinal drug delivery Open
View article: Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity
Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity Open
View article: Opportunities and barriers for genetic service delivery in Kenya from a health personnel perspective
Opportunities and barriers for genetic service delivery in Kenya from a health personnel perspective Open
View article: Development of a Pediatric Ophthalmology Biobank
Development of a Pediatric Ophthalmology Biobank Open
View article: Patient preferences in retinal drug delivery
Patient preferences in retinal drug delivery Open
View article: Defining Clinical Public Health
Defining Clinical Public Health Open
Purpose To solve complex health issues, an innovative and multidisciplinary framework is necessary. The Clinical Public Health (CPH) Division was established at the University of Toronto (UofT), Canada to foster inte-gration of primary car…
View article: Asynchronous pineoblastoma is more likely after early diagnosis of retinoblastoma: a meta‐analysis
Asynchronous pineoblastoma is more likely after early diagnosis of retinoblastoma: a meta‐analysis Open
Purpose To determine the risk of patients with an early diagnosis of heritable retinoblastoma being diagnosed with TRb (or pineoblastoma) asynchronously in a later stage and its effect on screening. Methods We updated the search (PubMed an…
View article: DNA hypermethylation/boundary control loss identified in retinoblastomas associated with genetic and epigenetic inactivation of the <i>RB1</i> gene promoter
DNA hypermethylation/boundary control loss identified in retinoblastomas associated with genetic and epigenetic inactivation of the <i>RB1</i> gene promoter Open
DNA hypermethylation events occur frequently in human cancers, but less is known of the mechanisms leading to their initiation. Retinoblastoma, an intraocular cancer affecting young children, involves bi-allelic inactivation of the RB1<…
View article: DNA hypermethylation/boundary control loss identified in retinoblastomas associated with genetic and epigenetic inactivation of the <i>RB1</i> gene promoter
DNA hypermethylation/boundary control loss identified in retinoblastomas associated with genetic and epigenetic inactivation of the <i>RB1</i> gene promoter Open
DNA hypermethylation events occur frequently in human cancers, but less is known of the mechanisms leading to their initiation. Retinoblastoma, an intraocular cancer affecting young children, involves bi-allelic inactivation of the RB1<…
View article: Development of a pediatric ophthalmology academic partnership between Canada and Ethiopia: a situational analysis
Development of a pediatric ophthalmology academic partnership between Canada and Ethiopia: a situational analysis Open
View article: Patient-reported outcome measures for retinoblastoma: a scoping review
Patient-reported outcome measures for retinoblastoma: a scoping review Open
View article: Feasibility of a school-based vision screening program to detect undiagnosed visual problems in kindergarten children in Ontario
Feasibility of a school-based vision screening program to detect undiagnosed visual problems in kindergarten children in Ontario Open
Many children in Ontario with a visual problem were not being identified by the status quo in 2015-2017. We found that in-school vision screening with follow-up eye examinations is an effective strategy for identifying at-risk children and…