Helen E. Jolin
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View article: Recipient tissue microenvironment determines developmental path of intestinal innate lymphoid progenitors
Recipient tissue microenvironment determines developmental path of intestinal innate lymphoid progenitors Open
Innate lymphoid cells (ILCs) are critical in maintaining tissue homeostasis, and during infection and inflammation. Here we identify, by using combinatorial reporter mice, a rare ILC progenitor (ILCP) population, resident to the small inte…
View article: Mef2d potentiates type-2 immune responses and allergic lung inflammation
Mef2d potentiates type-2 immune responses and allergic lung inflammation Open
Innate lymphoid cells (ILCs) and adaptive T lymphocytes promote tissue homeostasis and protective immune responses. Their production depends on the transcription factor GATA3, which is further elevated specifically in ILC2s and T helper 2 …
View article: Identification of aceNKPs, a committed common progenitor population of the ILC1 and NK cell continuum
Identification of aceNKPs, a committed common progenitor population of the ILC1 and NK cell continuum Open
The development of innate lymphoid cell (ILC) transcription factor reporter mice has shown a previously unexpected complexity in ILC hematopoiesis. Using novel polychromic mice to achieve higher phenotypic resolution, we have characterized…
View article: An innate IL-25–ILC2–MDSC axis creates a cancer-permissive microenvironment for <i>Apc</i> mutation–driven intestinal tumorigenesis
An innate IL-25–ILC2–MDSC axis creates a cancer-permissive microenvironment for <i>Apc</i> mutation–driven intestinal tumorigenesis Open
Interleukin-25 (IL-25) and group 2 innate lymphoid cells (ILC2s) defend the host against intestinal helminth infection and are associated with inappropriate allergic reactions. IL-33–activated ILC2s were previously found to augment protect…
View article: Eosinophils are an essential element of a type 2 immune axis that controls thymus regeneration
Eosinophils are an essential element of a type 2 immune axis that controls thymus regeneration Open
Therapeutic interventions used for cancer treatment provoke thymus damage and limit the recovery of protective immunity. Here, we show that eosinophils are an essential part of an intrathymic type 2 immune network that enables thymus recov…
View article: SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation
SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation Open
Macrophages exhibit a spectrum of activation states ranging from classical to alternative activation1. Alternatively, activated macrophages are involved in diverse pathophysiological processes such as confining tissue parasites2, improving…
View article: Group 2 Innate Lymphoid Cells Exhibit Tissue-Specific Dynamic Behaviour During Type 2 Immune Responses
Group 2 Innate Lymphoid Cells Exhibit Tissue-Specific Dynamic Behaviour During Type 2 Immune Responses Open
Group 2 innate lymphoid cells (ILC2s) are early effectors of mucosal type 2 immunity, producing cytokines such as interleukin (IL)-13 to mediate responses to helminth infection and allergen-induced inflammation. ILC2s are also present in l…
View article: OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer
OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer Open
Methionine-1 (M1)-linked polyubiquitin chains conjugated by the linear ubiquitin chain assembly complex (LUBAC) control NF-κB activation, immune homoeostasis, and prevents tumour necrosis factor (TNF)-induced cell death. The deubiquitinase…
View article: OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer
OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer Open
Summary The deubiquitinase OTULIN removes methionine-1 (M1)-linked polyubiquitin chains to regulate TNF-mediated inflammation and cell death, but the physiological role of OTULIN outside the immune system is poorly understood. Here, we ide…
View article: A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue
A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue Open
Group-2 innate lymphoid cells (ILC2), type-2 cytokines, and eosinophils have all been implicated in sustaining adipose tissue homeostasis. However, the interplay between the stroma and adipose-resident immune cells is less well understood.…
View article: BET Bromodomain Inhibitor iBET151 Impedes Human ILC2 Activation and Prevents Experimental Allergic Lung Inflammation
BET Bromodomain Inhibitor iBET151 Impedes Human ILC2 Activation and Prevents Experimental Allergic Lung Inflammation Open
Group 2 innate lymphoid cells (ILC2) increase in frequency in eczema and allergic asthma patients, and thus represent a new therapeutic target cell for type-2 immune-mediated disease. The bromodomain and extra-terminal (BET) protein family…
View article: First-Breath-Induced Type 2 Pathways Shape the Lung Immune Environment
First-Breath-Induced Type 2 Pathways Shape the Lung Immune Environment Open
From birth onward, the lungs are exposed to the external environment and therefore harbor a complex immunological milieu to protect this organ from damage and infection. We investigated the homeostatic role of the epithelium-derived alarmi…
View article: Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite–derived phospholipase
Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite–derived phospholipase Open
Lack of the skin barrier protein filaggrin worsens atopic dermatitis by allergenic activation of CD1a-reactive T cells.