Helen Eachus
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View article: Optogenetic induction of chronic glucocorticoid exposure in early‐life leads to blunted stress‐response in larval zebrafish
Optogenetic induction of chronic glucocorticoid exposure in early‐life leads to blunted stress‐response in larval zebrafish Open
Early life stress (ELS) exposure alters stress susceptibility in later life and affects vulnerability to stress‐related disorders, but how ELS changes the long‐lasting responsiveness of the stress system is not well understood. Zebrafish p…
View article: Glucocorticoid effects on the brain: from adaptive developmental plasticity to allostatic overload
Glucocorticoid effects on the brain: from adaptive developmental plasticity to allostatic overload Open
Exposure to stress during early life may alter the developmental trajectory of an animal by a mechanism known as adaptive plasticity. For example, to enhance reproductive success in an adverse environment, it is known that animals accelera…
View article: Glucocorticoid receptor regulates protein chaperone, circadian clock and affective disorder genes in the zebrafish brain
Glucocorticoid receptor regulates protein chaperone, circadian clock and affective disorder genes in the zebrafish brain Open
Glucocorticoid resistance is commonly observed in depression, and has been linked to reduced expression and/or function of the glucocorticoid receptor (NR3C1 in human, hereafter referred to as GR). Previous studies have shown that GR-mutan…
View article: Lifelong molecular consequences of high Glucocorticoids exposure during development
Lifelong molecular consequences of high Glucocorticoids exposure during development Open
Early life stress (ELS) is one of the strongest risk factors for developing psychiatric disorders in humans. As conserved key stress hormones of vertebrates, glucocorticoids (GCs) are thought to play an important role in mediating the effe…
View article: Elevated glucocorticoid alters the developmental dynamics of hypothalamic neurogenesis
Elevated glucocorticoid alters the developmental dynamics of hypothalamic neurogenesis Open
Exposure to excess glucocorticoid (GC) during early development is implicated in adult dysfunctions. Reduced adult hippocampal neurogenesis is a well-known consequence of exposure to early life stress or elevated GC, however the effects on…
View article: Optogenetic induction of chronic glucocorticoid exposure in early-life impairs stress-response in larval zebrafish
Optogenetic induction of chronic glucocorticoid exposure in early-life impairs stress-response in larval zebrafish Open
Organisms respond to stressors through a coordinated set of physiological and behavioural responses. Zebrafish provides an opportunity to study conserved mechanisms underlying the stress-response that is regulated largely by the neuroendoc…
View article: The Effects of Early Life Stress on the Brain and Behaviour: Insights From Zebrafish Models
The Effects of Early Life Stress on the Brain and Behaviour: Insights From Zebrafish Models Open
The early life period represents a window of increased vulnerability to stress, during which exposure can lead to long-lasting effects on brain structure and function. This stress-induced developmental programming may contribute to the beh…
View article: Regulation of neuron-specific gene transcription by stress hormone signalling requires synaptic activity in zebrafish
Regulation of neuron-specific gene transcription by stress hormone signalling requires synaptic activity in zebrafish Open
The Glucocorticoid Receptor (GR) co-ordinates metabolic and behavioural responses to stressors. We hypothesised that GR influences behaviour by modulating specific epigenetic and transcriptional processes in the brain. Using the zebrafish …
View article: Genetic Disruption of 21-Hydroxylase in Zebrafish Causes Interrenal Hyperplasia
Genetic Disruption of 21-Hydroxylase in Zebrafish Causes Interrenal Hyperplasia Open
Congenital adrenal hyperplasia is a group of common inherited disorders leading to glucocorticoid deficiency. Most cases are caused by 21-hydroxylase deficiency (21OHD). The systemic consequences of imbalanced steroid hormone biosynthesis …
View article: Disrupted-in-Schizophrenia-1 is essential for normal hypothalamic-pituitary-interrenal (HPI) axis function
Disrupted-in-Schizophrenia-1 is essential for normal hypothalamic-pituitary-interrenal (HPI) axis function Open
Psychiatric disorders arise due to an interplay of genetic and environmental factors, including stress. Studies in rodents have shown that mutants for Disrupted-In-Schizophrenia-1 (DISC1), a well-accepted genetic risk factor for mental ill…
View article: Rx3 and Shh direct anisotropic growth and specification in the zebrafish tuberal/anterior hypothalamus
Rx3 and Shh direct anisotropic growth and specification in the zebrafish tuberal/anterior hypothalamus Open
In the developing brain, growth and differentiation are intimately linked. Here we show that in the zebrafish embryo, the homeodomain transcription factor rx3 co-ordinates these processes to build the tuberal/anterior hypothalamus. Analysi…