Helen Gika
YOU?
Author Swipe
View article: Putrescine functions as a metabolic checkpoint in replication stress-induced senescence
Putrescine functions as a metabolic checkpoint in replication stress-induced senescence Open
View article: A Lipidomic Exploration of the Effects of High-Intensity Interval Exercise in Healthy Men after Metformin Intake
A Lipidomic Exploration of the Effects of High-Intensity Interval Exercise in Healthy Men after Metformin Intake Open
We have previously found that high-intensity interval exercise (HIIE) affected metformin pharmacokinetics compared with rest. In this scenario, changes in individual lipids could play an important role. The prolonged responses of the lipid…
View article: Serum and Liver Lipidome Following Empagliflozin Administration for Six Months in a Fast Food Diet Mouse Model
Serum and Liver Lipidome Following Empagliflozin Administration for Six Months in a Fast Food Diet Mouse Model Open
Empagliflozin is a sodium–glucose co-transporter inhibitor approved for the treatment of type 2 diabetes mellitus. The aim of this study was the 6-month effect of empagliflozin on serum and liver lipidome in C57BL/6J mice fed on a fast foo…
View article: Effect of high‐intensity interval exercise on metformin pharmacokinetics in healthy men, assessed through a population pharmacokinetic model
Effect of high‐intensity interval exercise on metformin pharmacokinetics in healthy men, assessed through a population pharmacokinetic model Open
Background and Purpose Metformin and exercise are first‐line therapies for prediabetes and type 2 diabetes. However, it is unclear whether the combination of metformin and exercise is synergistic or antagonistic. The aim of this study was …
View article: Connecting the Dots: Bridging Microsamples and Conventional Blood Matrices in Metabolic Biomarker Analysis
Connecting the Dots: Bridging Microsamples and Conventional Blood Matrices in Metabolic Biomarker Analysis Open
Bridging the gap between microsampling techniques and standard blood matrices presents a groundbreaking opportunity in metabolic biomarker analysis, offering minimally invasive, patient‐centric alternatives to traditional venipuncture. Thi…
View article: UHPLC-MS/MS analysis of PFAS in the serum of patients with Alzheimer's disease, mild cognitive impairment and controls: A preliminary study
UHPLC-MS/MS analysis of PFAS in the serum of patients with Alzheimer's disease, mild cognitive impairment and controls: A preliminary study Open
Complimentary UHPLC-MS methods for 6 ultra short chain (polar) and 30 long chain (and relatively non-polar) PFAS compounds have been developed and used to profile these compounds in human serum. The methods were developed to be rapid, with…
View article: Metabolomics Insights into the Benefits of SGLT2 Inhibitors in Type 2 Diabetes
Metabolomics Insights into the Benefits of SGLT2 Inhibitors in Type 2 Diabetes Open
SGLT2 inhibitors consistently induce a metabolic shift away from glucose utilization toward more energy-efficient substrates, including ketone bodies, fatty acids, and certain amino acids. These metabolomic adaptations may underlie their o…
View article: Oxygen attachment dissociation (OAD) MS/MS in the identification of positional isomers of dysregulated lipids detected in an ethanol exposure metabolomics study in mice
Oxygen attachment dissociation (OAD) MS/MS in the identification of positional isomers of dysregulated lipids detected in an ethanol exposure metabolomics study in mice Open
View article: A lipidomic exploration of the effects of high-intensity interval exercise in healthy men after metformin intake
A lipidomic exploration of the effects of high-intensity interval exercise in healthy men after metformin intake Open
We have previously found that high-intensity interval exercise (HIIE) affected metformin pharmacokinetics, causing higher maximal plasma concentration compared with rest. In this scenario, changes in individual lipids could play an importa…
View article: LC-MS-Based Global Metabolic Profiles of Alternative Blood Specimens Collected by Microsampling
LC-MS-Based Global Metabolic Profiles of Alternative Blood Specimens Collected by Microsampling Open
Blood microsampling (BμS) has recently emerged as an interesting approach in the analysis of endogenous metabolites but also in metabolomics applications. Their non-invasive way of use and the simplified logistics that they offer renders t…
View article: Poly(ethylene terepthalate) oligomers: assessing their migration in foods and food simulants using an UHPLC-qTOF-HRMS method
Poly(ethylene terepthalate) oligomers: assessing their migration in foods and food simulants using an UHPLC-qTOF-HRMS method Open
View article: Toward minimally invasive metabolomics: GC-MS metabolic fingerprints of dried blood microsamples in comparison to plasma
Toward minimally invasive metabolomics: GC-MS metabolic fingerprints of dried blood microsamples in comparison to plasma Open
The first comprehensive study comparing global metabolic profiles from three BµS devices against plasma and venous liquid blood using GC-MS.
View article: A Comprehensive Analysis of Liver Lipidomics Signature in Adults with Metabolic Dysfunction-Associated Steatohepatitis—A Pilot Study
A Comprehensive Analysis of Liver Lipidomics Signature in Adults with Metabolic Dysfunction-Associated Steatohepatitis—A Pilot Study Open
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is the most common chronic liver disorder in Western countries, encompassing a range of conditions from steatosis to Metabolic Dysfunction-Associated Steatohepatitis (MASH), …
View article: Multiplatform metabolomic interlaboratory study of a whole human stool candidate reference material from omnivore and vegan donors
Multiplatform metabolomic interlaboratory study of a whole human stool candidate reference material from omnivore and vegan donors Open
View article: Unraveling Cecal Alterations in <i>Clostridioides difficile</i> Colonized Mice through Comprehensive Metabolic Profiling
Unraveling Cecal Alterations in <i>Clostridioides difficile</i> Colonized Mice through Comprehensive Metabolic Profiling Open
The disruption of gut microbiota caused by antibiotics favors the intestinal colonization of Clostridioides difficile - a Gram-positive, spore-forming anaerobic bacterium that causes potentially fatal gastrointestinal infections. In…
View article: Unveiling Lipidomic Alterations in Metabolic Syndrome: A Study of Plasma, Liver, and Adipose Tissues in a Dietary-Induced Rat Model
Unveiling Lipidomic Alterations in Metabolic Syndrome: A Study of Plasma, Liver, and Adipose Tissues in a Dietary-Induced Rat Model Open
Metabolic syndrome (MetS) is a complex condition characterized by fat accumulation, dyslipidemia, impaired glucose control and hypertension. In this study, rats were fed a high-fat high-fructose (HFF) diet in order to develop MetS. After t…
View article: Recent Advances in Metabolomics and Lipidomics Studies in Human and Animal Models of Multiple Sclerosis
Recent Advances in Metabolomics and Lipidomics Studies in Human and Animal Models of Multiple Sclerosis Open
Multiple sclerosis (MS) is a neurodegenerative and inflammatory disease of the central nervous system (CNS) that leads to a loss of myelin. There are three main types of MS: relapsing-remitting MS (RRMS) and primary and secondary progressi…
View article: Untargeted Blood Lipidomics Analysis in Critically Ill Pediatric Patients with Ventilator-Associated Pneumonia: A Pilot Study
Untargeted Blood Lipidomics Analysis in Critically Ill Pediatric Patients with Ventilator-Associated Pneumonia: A Pilot Study Open
This study aims to explore the diagnostic potential of blood lipid profiles in suspected ventilator-associated pneumonia (VAP). Early detection of VAP remains challenging for clinicians due to subjective clinical criteria and the limited e…
View article: Lipidomic-Based Algorithms Can Enhance Prediction of Obstructive Coronary Artery Disease
Lipidomic-Based Algorithms Can Enhance Prediction of Obstructive Coronary Artery Disease Open
Lipidomics emerges as a promising research field with the potential to help in personalized risk stratification and improve our understanding on the functional role of individual lipid species in the metabolic perturbations occurring in co…
View article: Effects of Combined Low-Dose Spironolactone Plus Vitamin E versus Vitamin E Monotherapy on Lipidomic Profile in Non-Alcoholic Fatty Liver Disease: A Post Hoc Analysis of a Randomized Controlled Trial
Effects of Combined Low-Dose Spironolactone Plus Vitamin E versus Vitamin E Monotherapy on Lipidomic Profile in Non-Alcoholic Fatty Liver Disease: A Post Hoc Analysis of a Randomized Controlled Trial Open
Background/Objectives: Lipid dysmetabolism seems to contribute to the development and progression of nonalcoholic fatty liver disease (NAFLD). Our aim was to compare serum lipidomic profile between patients with NAFLD having received monot…
View article: Microplastics and nanoplastics: Exposure and toxicological effects require important analysis considerations
Microplastics and nanoplastics: Exposure and toxicological effects require important analysis considerations Open
View article: Predicting Non-Alcoholic Steatohepatitis: A Lipidomics-Driven Machine Learning Approach
Predicting Non-Alcoholic Steatohepatitis: A Lipidomics-Driven Machine Learning Approach Open
Nonalcoholic fatty liver disease (NAFLD), nowadays the most prevalent chronic liver disease in Western countries, is characterized by a variable phenotype ranging from steatosis to nonalcoholic steatohepatitis (NASH). Intracellular lipid a…
View article: Proteomics in Patients with Fibromyalgia Syndrome: A Systematic Review of Observational Studies
Proteomics in Patients with Fibromyalgia Syndrome: A Systematic Review of Observational Studies Open
Purpose of Review Fibromyalgia syndrome (FMS) is a disease of unknown pathophysiology, with the diagnosis being based on a set of clinical criteria. Proteomic analysis can provide significant biological information for the pathophysiology …
View article: Gastric Fluid Metabolomics Predicting the Need for Surfactant Replacement Therapy in Very Preterm Infants Results of a Case–Control Study
Gastric Fluid Metabolomics Predicting the Need for Surfactant Replacement Therapy in Very Preterm Infants Results of a Case–Control Study Open
Respiratory distress syndrome (RDS) is a major morbidity of prematurity. In this case–control study, we prospectively evaluated whether untargeted metabolomic analysis (gas chromatography–mass spectrometry) of the gastric fluid could predi…
View article: Lipidomic Analysis of Liver and Adipose Tissue in a High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease Mice Model Reveals Alterations in Lipid Metabolism by Weight Loss and Aerobic Exercise
Lipidomic Analysis of Liver and Adipose Tissue in a High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease Mice Model Reveals Alterations in Lipid Metabolism by Weight Loss and Aerobic Exercise Open
Detailed investigation of the lipidome remodeling upon normal weight conditions, obesity, or weight loss, as well as the influence of physical activity, can help to understand the mechanisms underlying dyslipidemia in metabolic conditions …
View article: Detection of 26 Drugs of Abuse and Metabolites in Quantitative Dried Blood Spots by Liquid Chromatography–Mass Spectrometry
Detection of 26 Drugs of Abuse and Metabolites in Quantitative Dried Blood Spots by Liquid Chromatography–Mass Spectrometry Open
A method was developed for the determination of 26 drugs of abuse from different classes, including illicit drugs in quantitative dried blood spots (qDBSs), with the aim to provide a convenient method for drug testing by using only 10 μL o…
View article: Predicting the Need for Surfactant Replacement Therapy in Very Preterm Infants by Combining Gastric Fluid Metabolomics with Neonatal Data
Predicting the Need for Surfactant Replacement Therapy in Very Preterm Infants by Combining Gastric Fluid Metabolomics with Neonatal Data Open
Respiratory distress syndrome (RDS) is a major respiratory morbidity associated with prematurity. In this case-control study, we prospectively evaluated whether targeted metabolomic analysis (gas chromatography–mass spectrometry) of the ga…
View article: Current Practices in LC-MS Untargeted Metabolomics: A Scoping Review on the Use of Pooled Quality Control Samples
Current Practices in LC-MS Untargeted Metabolomics: A Scoping Review on the Use of Pooled Quality Control Samples Open
Untargeted metabolomics is an analytical approach with numerous applications serving as an effective metabolic phenotyping platform to characterize small molecules within a biological system. Data quality can be challenging to evaluate and…
View article: The Effects of Pilates Exercise Training Combined with Walking on Cardiorespiratory Fitness, Functional Capacity, and Disease Activity in Patients with Non-Radiologically Confirmed Axial Spondylitis
The Effects of Pilates Exercise Training Combined with Walking on Cardiorespiratory Fitness, Functional Capacity, and Disease Activity in Patients with Non-Radiologically Confirmed Axial Spondylitis Open
The objective of the study was to examine the effects of Pilates exercise training combined with walking on cardiorespiratory fitness, functional capacity, and disease activity in patients with non-radiologically confirmed axial spondyliti…
View article: Volumetric Absorptive Microsampling in the Analysis of Endogenous Metabolites
Volumetric Absorptive Microsampling in the Analysis of Endogenous Metabolites Open
Volumetric absorptive microsampling (VAMS) has arisen as a relevant tool in biological analysis, offering simplified sampling procedures and enhanced stability. Most of the attention VAMS has received in the past decade has been from pharm…