Helen H. Boone
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View article: Idiopathic subglottic stenosis arises at the epithelial interface of host and pathogen
Idiopathic subglottic stenosis arises at the epithelial interface of host and pathogen Open
Background Idiopathic subglottic stenosis (iSGS) is a rare fibrotic disease of the proximal airway affecting adult Caucasian women nearly exclusively. Life-threatening ventilatory obstruction occurs secondary to pernicious subglottic mucos…
View article: Upper respiratory tract microbiota dynamics following COVID-19 in adults
Upper respiratory tract microbiota dynamics following COVID-19 in adults Open
To date, little is known about the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for the coronavirus disease 2019 (COVID-19) pandemic, on the upper respiratory tract (URT) microbiota over tim…
View article: Idiopathic subglottic stenosis arises at the interface of host and pathogen
Idiopathic subglottic stenosis arises at the interface of host and pathogen Open
Idiopathic subglottic stenosis (iSGS) is a rare fibrotic disease of the proximal airway affecting adult Caucasian women nearly exclusively. Life-threatening ventilatory obstruction occurs secondary to pernicious subglottic mucosal scar. Di…
View article: Severe COVID-19 Is Associated With an Altered Upper Respiratory Tract Microbiome
Severe COVID-19 Is Associated With an Altered Upper Respiratory Tract Microbiome Open
Background The upper respiratory tract (URT) is the portal of entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and SARS-CoV-2 likely interacts with the URT microbiome. However, understanding of the associations betwee…
View article: Metatranscriptomics to characterize respiratory virome, microbiome, and host response directly from clinical samples
Metatranscriptomics to characterize respiratory virome, microbiome, and host response directly from clinical samples Open
We developed a metatranscriptomics method that can simultaneously capture the respiratory virome, microbiome, and host response directly from low biomass samples. Using nasal swab samples, we capture RNA virome with sufficient sequencing d…
View article: Additional file 13 of Microbial community structure and composition is associated with host species and sex in Sigmodon cotton rats
Additional file 13 of Microbial community structure and composition is associated with host species and sex in Sigmodon cotton rats Open
Additional file 13: Supplemental File 3. LEfSe analysis of 16S rRNA gene sequencing data between S. fulviventer and S. hispidus across all body sites at the genus level.
View article: Additional file 12 of Microbial community structure and composition is associated with host species and sex in Sigmodon cotton rats
Additional file 12 of Microbial community structure and composition is associated with host species and sex in Sigmodon cotton rats Open
Additional file 12: Supplemental File 2. GeneSelector analysis of 16S rRNA gene sequencing data between S. fulviventer and S. hispidus across all body sites at the genus and family level.
View article: Additional file 11 of Microbial community structure and composition is associated with host species and sex in Sigmodon cotton rats
Additional file 11 of Microbial community structure and composition is associated with host species and sex in Sigmodon cotton rats Open
Additional file 11: Supplemental File 1. DESeq2 analysis of 16S rRNA gene sequencing data between S. fulviventer and S. hispidus across all body sites at the genus and family level.
View article: Additional file 15 of Microbial community structure and composition is associated with host species and sex in Sigmodon cotton rats
Additional file 15 of Microbial community structure and composition is associated with host species and sex in Sigmodon cotton rats Open
Additional file 15: Supplemental File 5. DESeq2 analysis of whole metagenomic sequencing data between S. fulviventer and S. hispidus across all body sites at the species level.
View article: Additional file 18 of Microbial community structure and composition is associated with host species and sex in Sigmodon cotton rats
Additional file 18 of Microbial community structure and composition is associated with host species and sex in Sigmodon cotton rats Open
Additional file 18: Supplemental File 8. All annotated MetaCyc pathways identified by HUMANn2 from whole metagenomic sequencing data.
View article: Additional file 17 of Microbial community structure and composition is associated with host species and sex in Sigmodon cotton rats
Additional file 17 of Microbial community structure and composition is associated with host species and sex in Sigmodon cotton rats Open
Additional file 17: Supplemental File 7. Raw counts from 16S rRNA sequencing data at all levels for both cotton rat cohorts.
View article: Additional file 19 of Microbial community structure and composition is associated with host species and sex in Sigmodon cotton rats
Additional file 19 of Microbial community structure and composition is associated with host species and sex in Sigmodon cotton rats Open
Additional file 19: Supplemental File 9. Statistical comparison of MetaCyc pathway comparison between S. fulviventer and S. hispidus.
View article: Additional file 14 of Microbial community structure and composition is associated with host species and sex in Sigmodon cotton rats
Additional file 14 of Microbial community structure and composition is associated with host species and sex in Sigmodon cotton rats Open
Additional file 14: Supplemental File 4. DESeq2 analysis of 16S rRNA gene sequencing data between male and female cotton rats (both S. fulviventer and S. hispidus) across all body sites at the genus and family level.
View article: Additional file 16 of Microbial community structure and composition is associated with host species and sex in Sigmodon cotton rats
Additional file 16 of Microbial community structure and composition is associated with host species and sex in Sigmodon cotton rats Open
Additional file 16: Supplemental File 6. Proportional counts from 16S rRNA sequencing data at all levels for both cotton rat cohorts.
View article: Microbial Community Structure and Composition is Associated with Host Species and Sex in Sigmodon Cotton Rats
Microbial Community Structure and Composition is Associated with Host Species and Sex in Sigmodon Cotton Rats Open
Background: The cotton rat (genus Sigmodon) is an essential small animal model for the study of human infectious disease and viral therapeutic development. However, the impact of the host microbiome on infection outcomes has not been explo…
View article: Microbial Community Structure and Composition is Associated With Host Species and Sex in Sigmodon Cotton Rats
Microbial Community Structure and Composition is Associated With Host Species and Sex in Sigmodon Cotton Rats Open
Background: The cotton rat (genus Sigmodon ) is an essential small animal model for the study of human infectious disease and viral therapeutic development. However, the impact of the host microbiome on infection outcomes has not been expl…
View article: Metatranscriptomics to characterize respiratory virome, microbiome, and host response directly from clinical samples
Metatranscriptomics to characterize respiratory virome, microbiome, and host response directly from clinical samples Open
We developed a metatranscriptomics method that can simultaneously capture the respiratory virome, microbiome, and host response directly from low-biomass clinical samples. Using nasal swab samples, we have demonstrated that this method cap…
View article: The Salivary Microbiome Is Altered in Children With Eosinophilic Esophagitis and Correlates With Disease Activity
The Salivary Microbiome Is Altered in Children With Eosinophilic Esophagitis and Correlates With Disease Activity Open
OBJECTIVES: Eosinophilic esophagitis (EoE) is an allergen-mediated inflammatory disease affecting the esophagus. Although microbial communities may affect the host immune responses, little is known about the role of the microbiome in EoE. …
View article: Dietary Arginine Regulates Severity of Experimental Colitis and Affects the Colonic Microbiome
Dietary Arginine Regulates Severity of Experimental Colitis and Affects the Colonic Microbiome Open
There is great interest in safe and effective alternative therapies that could benefit patients with inflammatory bowel diseases (IBD). L-arginine (Arg) is a semi-essential amino acid with a variety of physiological effects. In this contex…