Helen L. Wright
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View article: Cytokine-Induced Transcriptional Changes in Human Neutrophils Reveal Immune Regulatory Plasticity
Cytokine-Induced Transcriptional Changes in Human Neutrophils Reveal Immune Regulatory Plasticity Open
Introduction Neutrophils are innate immune cells that play a central role in the inflammatory response. They produce an array of destructive molecules and antimicrobial proteases that characterise the cells as front-line defenders, crucial…
View article: An NMR Metabolomics Analysis Pipeline for Human Neutrophil Samples with Limited Source Material
An NMR Metabolomics Analysis Pipeline for Human Neutrophil Samples with Limited Source Material Open
Background/Objectives: Untargeted 1H NMR metabolomics is a robust and reproducible approach used to study the metabolism in biological samples, providing unprecedented insight into altered cellular processes associated with human diseases.…
View article: Serum metabolomics identifies unique inflammatory signatures to distinguish rheumatoid arthritis responders and non-responders to TNF inhibitor therapy
Serum metabolomics identifies unique inflammatory signatures to distinguish rheumatoid arthritis responders and non-responders to TNF inhibitor therapy Open
Introduction Rheumatoid arthritis (RA) is an auto-immune disease which causes irreversible damage to tissue and cartilage within synovial joints. Rapid diagnosis and treatment with disease-modifying therapies is essential to reduce inflamm…
View article: Autophagy inhibitors block pathogenic NET release in immune-mediated inflammatory disease without impairing host defence
Autophagy inhibitors block pathogenic NET release in immune-mediated inflammatory disease without impairing host defence Open
Objectives Activation of neutrophils and release of neutrophil extracellular traps (NETs), proteases and reactive oxygen species (ROS) is pathogenic in immune-mediated inflammatory diseases like rheumatoid arthritis (RA) and systemic lupus…
View article: The complex role of neutrophils in healthy aging, inflammaging, and frailty
The complex role of neutrophils in healthy aging, inflammaging, and frailty Open
Immune function alters as we age, and is often accompanied by chronic, low-grade inflammation termed “inflammaging.” This leads cells to develop a senescence-associated secretory phenotype and release a range of proinflammatory cytokines a…
View article: Autophagy inhibitors block pathogenic NET release in immune-mediated inflammatory disease without impairing host defence
Autophagy inhibitors block pathogenic NET release in immune-mediated inflammatory disease without impairing host defence Open
Objectives Activation of neutrophils and release of neutrophil extracellular traps (NETs), proteases and reactive oxygen species (ROS) is pathogenic in immune-mediated inflammatory diseases like rheumatoid arthritis (RA) and systemic lupus…
View article: Complexity of the neutrophil transcriptome in early and severe rheumatoid arthritis: a role for microRNAs?
Complexity of the neutrophil transcriptome in early and severe rheumatoid arthritis: a role for microRNAs? Open
Neutrophils are innate immune cells that drive the progression of rheumatoid arthritis through the release of reactive oxygen species, neutrophil extracellular traps, and proteases that damage host tissues. Neutrophil activation is regulat…
View article: Systematic Review and Meta-analysis of Admission Inflammatory Biomarkers for Evaluating Prognosis in Acute Type A Aortic Dissection
Systematic Review and Meta-analysis of Admission Inflammatory Biomarkers for Evaluating Prognosis in Acute Type A Aortic Dissection Open
Acute type A aortic dissection (ATAAD) is traumatic and life-threatening involving a split of the intima media along a variable length of the aorta from aortic root to aortic bifurcation. The pathology results in a local and systemic infla…
View article: Cytokine-Induced Transcriptional Changes in Human Neutrophils Reveal Immune Regulatory Plasticity
Cytokine-Induced Transcriptional Changes in Human Neutrophils Reveal Immune Regulatory Plasticity Open
Neutrophils are the major cellular constituent of blood leukocytes and play a central role in the inflammatory response, producing an array of destructive molecules and antimicrobial proteases that characterise the cells as front-line defe…
View article: Multiomics analysis of neutrophils in SLE: insights from adult and paediatric disease
Multiomics analysis of neutrophils in SLE: insights from adult and paediatric disease Open
Neutrophils contribute to systemic lupus erythematosus (SLE) pathogenesis through reactive oxygen species and neutrophil extracellular trap (NET) production, and increased apoptotic debris which causes autoantibody production and immune co…
View article: The small molecule inhibitor 3PO is a modulator of neutrophil metabolism, ROS production, and NET release
The small molecule inhibitor 3PO is a modulator of neutrophil metabolism, ROS production, and NET release Open
Neutrophils are key effector leukocytes of the innate immune system and play a pivotal role in defending the host against microbial infections. Recent studies have identified a crucial link between glycolysis and neutrophil cellular functi…
View article: Complexity of the neutrophil transcriptome in early and severe rheumatoid arthritis. A role for microRNAs?
Complexity of the neutrophil transcriptome in early and severe rheumatoid arthritis. A role for microRNAs? Open
Neutrophils are innate immune cells that drive the progression of rheumatoid arthritis (RA) through the release of reactive oxygen species (ROS), neutrophil extracellular traps (NETs) and proteases that damage host tissues. Neutrophil acti…
View article: Serum metabolomics identifies unique inflammatory signatures to distinguish rheumatoid arthritis responders and non-responders to TNF inhibitor therapy
Serum metabolomics identifies unique inflammatory signatures to distinguish rheumatoid arthritis responders and non-responders to TNF inhibitor therapy Open
Introduction Rheumatoid arthritis (RA) is an auto-immune disease which causes irreversible damage to tissue and cartilage within synovial joints. Rapid diagnosis and treatment with disease-modifying therapies is essential to reduce inflamm…
View article: Circulating neutrophil extracellular trap-forming neutrophils in rheumatoid arthritis exacerbation are majority dual endothelin-1/signal peptide receptor+ subtype
Circulating neutrophil extracellular trap-forming neutrophils in rheumatoid arthritis exacerbation are majority dual endothelin-1/signal peptide receptor+ subtype Open
Neutrophil extracellular traps (NETs) are associated with rheumatoid arthritis pathogenesis and severity. Since homeostatic NET-forming neutrophils [NET+Ns] have beneficial roles in defense against pathogens, their distinction from pro-inj…
View article: New insights into healthy ageing, inflammageing and frailty using metabolomics
New insights into healthy ageing, inflammageing and frailty using metabolomics Open
Human ageing is a normal process and does not necessarily result in the development of frailty. A mix of genetic, environmental, dietary, and lifestyle factors can have an impact on ageing, and whether an individual develops frailty. Frail…
View article: miRNA-132-5p mediates a negative feedback regulation of IL-8 secretion through S100A8/A9 downregulation in neutrophil-like HL-60 cells
miRNA-132-5p mediates a negative feedback regulation of IL-8 secretion through S100A8/A9 downregulation in neutrophil-like HL-60 cells Open
Background Neutrophils are an important source of pro-inflammatory and immunomodulatory cytokines. This makes neutrophils efficient drivers of interactions with immune and non-immune cells to maintain homeostasis and modulate the inflammat…
View article: PFKFB3 is a critical regulator of neutrophil metabolism and function in rheumatoid arthritis
PFKFB3 is a critical regulator of neutrophil metabolism and function in rheumatoid arthritis Open
1. ABSTRACT Neutrophils are key effector leukocytes of the innate immune system and play a pivotal role in defending the host against microbial infections. Recent studies have identified a crucial link between glycolysis and neutrophil cel…
View article: Regulation of dermal fibroblasts by human neutrophil peptides
Regulation of dermal fibroblasts by human neutrophil peptides Open
Human neutrophil peptides (HNPs) can induce cell proliferation and activation so their growth promoting activities may have potential clinical benefit. This study investigated the effects of HNPs on human dermal fibroblasts. Differential g…
View article: Platelet TLR7 is essential for the formation of platelet–neutrophil complexes and low-density neutrophils in lupus nephritis
Platelet TLR7 is essential for the formation of platelet–neutrophil complexes and low-density neutrophils in lupus nephritis Open
Objectives Platelets and low-density neutrophils (LDNs) are major players in the immunopathogenesis of SLE. Despite evidence showing the importance of platelet–neutrophil complexes (PNCs) in inflammation, little is known about the relation…
View article: Markers of immune dysregulation in response to the ageing gut: insights from aged murine gut microbiota transplants
Markers of immune dysregulation in response to the ageing gut: insights from aged murine gut microbiota transplants Open
Background Perturbations in the composition and diversity of the gut microbiota are accompanied by a decline in immune homeostasis during ageing, characterized by chronic low-grade inflammation and enhanced innate immunity. Genetic insight…
View article: LAT1 enables T cell activation under inflammatory conditions: a new therapeutic target for rheumatoid arthritis
LAT1 enables T cell activation under inflammatory conditions: a new therapeutic target for rheumatoid arthritis Open
Objective To assess the L-type amino acid transporter-1 (LAT1) as a possible therapeutic target for rheumatoid arthritis (RA). Methods Synovial LAT1 expression was monitored by immunohistochemistry and transcriptomic datasets. The contribu…
View article: Bi-allelic <i>FRA10AC1</i> variants in a multisystem human syndrome
Bi-allelic <i>FRA10AC1</i> variants in a multisystem human syndrome Open
Journal Article Bi-allelic FRA10AC1 variants in a multisystem human syndrome Get access Siddharth Banka, Siddharth Banka Division of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health,…
View article: Metabolic Profiling of Rheumatoid Arthritis Neutrophils Reveals Altered Energy Metabolism That Is Not Affected by JAK Inhibition
Metabolic Profiling of Rheumatoid Arthritis Neutrophils Reveals Altered Energy Metabolism That Is Not Affected by JAK Inhibition Open
Neutrophils play a key role in the pathophysiology of rheumatoid arthritis (RA) where release of ROS and proteases directly causes damage to joints and tissues. Neutrophil function can be modulated by Janus Kinase (JAK) inhibitor drugs, in…
View article: Metabolic profiling of rheumatoid arthritis neutrophils reveals altered energy metabolism that is not affected by JAK inhibition
Metabolic profiling of rheumatoid arthritis neutrophils reveals altered energy metabolism that is not affected by JAK inhibition Open
Neutrophils play a key role in the pathophysiology of rheumatoid arthritis (RA) where release of ROS and proteases directly causes damage to joints and tissues. Neutrophil function can be modulated by Janus Kinase (JAK) inhibitor drugs, in…
View article: Anti-Inflammatory Effects and Decreased Formation of Neutrophil Extracellular Traps by Enoxaparin in COVID-19 Patients
Anti-Inflammatory Effects and Decreased Formation of Neutrophil Extracellular Traps by Enoxaparin in COVID-19 Patients Open
Neutrophil Extracellular Traps (NETs) are a contributing factor of vascular thrombosis and alveolar damage in COVID-19 patients. As enoxaparin is currently used to inhibit vascular thrombosis, this study aimed to investigate whether enoxap…
View article: An improved culture protocol for the differentiation and survival of human promyelocytic leukaemia PLB-985 cell-line into mature neutrophil-like granulocytes
An improved culture protocol for the differentiation and survival of human promyelocytic leukaemia PLB-985 cell-line into mature neutrophil-like granulocytes Open
Circulating blood neutrophils are short-lived, lack proliferation capacity and cannot be transfected in vitro to express exogenous genes or proteins. These properties have made the ex vivo genetic manipulation of neutrophils challenging an…
View article: Matrix metalloproteinase‐13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha‐1 antitrypsin: Implications for osteoarthritis
Matrix metalloproteinase‐13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha‐1 antitrypsin: Implications for osteoarthritis Open
Matrix metalloproteinase‐13 (MMP‐13) is a uniquely important collagenase that promotes the irreversible destruction of cartilage collagen in osteoarthritis (OA). Collagenase activation is a key control point for cartilage breakdown to occu…
View article: Internalization of Neutrophil-Derived Microvesicles Modulates TNFα-Stimulated Proinflammatory Cytokine Production in Human Fibroblast-Like Synoviocytes
Internalization of Neutrophil-Derived Microvesicles Modulates TNFα-Stimulated Proinflammatory Cytokine Production in Human Fibroblast-Like Synoviocytes Open
Neutrophil-derived microvesicles (NDMVs) have the potential to exert anti-inflammatory effects. Our study aimed to explore the effects of NDMVs on proinflammatory cytokines expressed by tumor necrosis factor α (TNFα)-stimulated fibroblast-…
View article: Neutrophils in the Pathogenesis of Rheumatoid Arthritis and Systemic Lupus Erythematosus: Same Foe Different M.O.
Neutrophils in the Pathogenesis of Rheumatoid Arthritis and Systemic Lupus Erythematosus: Same Foe Different M.O. Open
Dysregulated neutrophil activation contributes to the pathogenesis of autoimmune diseases including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Neutrophil-derived reactive oxygen species (ROS) and granule proteases ar…