Helen Lee
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View article: Discordance between antibiotic therapy and recurrenturinary tract infections in young children with thirdgenerationcephalosporin-resistant infections
Discordance between antibiotic therapy and recurrenturinary tract infections in young children with thirdgenerationcephalosporin-resistant infections Open
Completing a third-generation cephalosporin course when isolates are not susceptible to thirdgeneration cephalosporins can increase early UTI recurrence rates in Korean children. Reviewing susceptibility on day 5 and switching to an active…
View article: P-652. Evaluation of Empiric Antibiotic Use for Community Acquired Pneumonia
P-652. Evaluation of Empiric Antibiotic Use for Community Acquired Pneumonia Open
Background Pneumonia is one of the most common infections resulting in hospitalization. Timely and appropriate empiric antibiotic treatment is crucial to improve prognosis in patients with community-acquired pneumonia (CAP). However, the u…
View article: 2594. Rate of Methicillin-Resistant <i>Staphylococcus aureus</i> Infection Among Patients Hospitalized for Community-Acquired Pneumonia
2594. Rate of Methicillin-Resistant <i>Staphylococcus aureus</i> Infection Among Patients Hospitalized for Community-Acquired Pneumonia Open
Background National clinical practice guidelines for community-acquired pneumonia (CAP) suggest empiric treatment for methicillin-resistant Staphylococcus aureus (MRSA) among hospitalized patients with risk factors including prior respirat…
View article: Rapid Fabrication of Glass Micro and Nanostructures via Laser-assisted Hot Embossing
Rapid Fabrication of Glass Micro and Nanostructures via Laser-assisted Hot Embossing Open
The escalating demand for glass that exhibits various surface functions has encouraged efforts to develop more efficient and economical micro-/nano-patterning of glass substrates.We propose rapid hot embossing of glass micro-/nanostructure…
View article: Supplementary Materials and Methods from Cyclophosphamide-Mediated Tumor Priming for Enhanced Delivery and Antitumor Activity of HER2-Targeted Liposomal Doxorubicin (MM-302)
Supplementary Materials and Methods from Cyclophosphamide-Mediated Tumor Priming for Enhanced Delivery and Antitumor Activity of HER2-Targeted Liposomal Doxorubicin (MM-302) Open
Supplementary Materials and Methods. This file contains information on the reagents, methods for the evaluation of cell viability, preparation of liposomes and details on the image analysis.
View article: Supplementary Materials and Methods from Cyclophosphamide-Mediated Tumor Priming for Enhanced Delivery and Antitumor Activity of HER2-Targeted Liposomal Doxorubicin (MM-302)
Supplementary Materials and Methods from Cyclophosphamide-Mediated Tumor Priming for Enhanced Delivery and Antitumor Activity of HER2-Targeted Liposomal Doxorubicin (MM-302) Open
Supplementary Materials and Methods. This file contains information on the reagents, methods for the evaluation of cell viability, preparation of liposomes and details on the image analysis.
View article: Data from Cyclophosphamide-Mediated Tumor Priming for Enhanced Delivery and Antitumor Activity of HER2-Targeted Liposomal Doxorubicin (MM-302)
Data from Cyclophosphamide-Mediated Tumor Priming for Enhanced Delivery and Antitumor Activity of HER2-Targeted Liposomal Doxorubicin (MM-302) Open
Given the bulky nature of nanotherapeutics relative to small molecules, it is hypothesized that effective tumor delivery and penetration are critical barriers to their clinical activity. HER2-targeted PEGylated liposomal doxorubicin (MM-30…
View article: Figure S1 from Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery
Figure S1 from Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery Open
The effect of combination PDP and nal-IRI on tumour growth inhibition is synergistic in orthotopic MIA PaCa-2 mouse model.
View article: Data from <sup>64</sup>Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer
Data from <sup>64</sup>Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer Open
Purpose: Therapeutic nanoparticles are designed to deliver their drug payloads through enhanced permeability and retention (EPR) in solid tumors. The extent of EPR and its variability in human tumors is highly debated and has been p…
View article: Data from Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery
Data from Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery Open
Physiologic barriers to drug delivery and selection for drug resistance limit survival outcomes in cancer patients. In this study, we present preclinical evidence that a subtumoricidal photodynamic priming (PDP) strategy can relieve drug d…
View article: Figure S3 from Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery
Figure S3 from Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery Open
Relationship between primary tumour weight and distant metastatic burden during disease progression.
View article: Data from <sup>64</sup>Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer
Data from <sup>64</sup>Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer Open
Purpose: Therapeutic nanoparticles are designed to deliver their drug payloads through enhanced permeability and retention (EPR) in solid tumors. The extent of EPR and its variability in human tumors is highly debated and has been p…
View article: Figure S5 from Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery
Figure S5 from Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery Open
Endpoint primary metastatic burdens were comparable mice treated with 'nal-IR' and 'PDT + nal-IRI'.
View article: Figure S2 from Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery
Figure S2 from Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery Open
Sub-tumouricidal PDP does not increase systemic toxicity of chemotherapy. Changes in mouse body weight were monitored longitudinally before and after treatment.
View article: Figure S4 from Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery
Figure S4 from Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery Open
Combination of PDP and a single cycle of na-IRI did not achieve long-term survivial benefit. Kaplan-Meier plot of animal overall survival.
View article: Figure S3 from Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery
Figure S3 from Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery Open
Relationship between primary tumour weight and distant metastatic burden during disease progression.
View article: Supplementary Data from <sup>64</sup>Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer
Supplementary Data from <sup>64</sup>Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer Open
Fig. S1. MM-302 tumor deposition in preclinical xenografts as a function of HER2 expression. Fig. S2. Preclinical assessment of minimum 64Cu-MM-302 tumor delivery for anti-tumor activity. Fig. S3. Maximum intensity projection images of sel…
View article: Figure S4 from Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery
Figure S4 from Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery Open
Combination of PDP and a single cycle of na-IRI did not achieve long-term survivial benefit. Kaplan-Meier plot of animal overall survival.
View article: Data from Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery
Data from Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery Open
Physiologic barriers to drug delivery and selection for drug resistance limit survival outcomes in cancer patients. In this study, we present preclinical evidence that a subtumoricidal photodynamic priming (PDP) strategy can relieve drug d…
View article: Figure S2 from Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery
Figure S2 from Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery Open
Sub-tumouricidal PDP does not increase systemic toxicity of chemotherapy. Changes in mouse body weight were monitored longitudinally before and after treatment.
View article: Figure S5 from Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery
Figure S5 from Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery Open
Endpoint primary metastatic burdens were comparable mice treated with 'nal-IR' and 'PDT + nal-IRI'.
View article: Supplementary Data from <sup>64</sup>Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer
Supplementary Data from <sup>64</sup>Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer Open
Fig. S1. MM-302 tumor deposition in preclinical xenografts as a function of HER2 expression. Fig. S2. Preclinical assessment of minimum 64Cu-MM-302 tumor delivery for anti-tumor activity. Fig. S3. Maximum intensity projection images of sel…
View article: Figure S1 from Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery
Figure S1 from Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery Open
The effect of combination PDP and nal-IRI on tumour growth inhibition is synergistic in orthotopic MIA PaCa-2 mouse model.
View article: Identification of Lower Water Use and Higher Nutritional Value Agricultural Food Commodities in California
Identification of Lower Water Use and Higher Nutritional Value Agricultural Food Commodities in California Open
OBJECTIVES: As the world's population increases, a focus on nutrition security and water sustainability is needed to ensure the availability of resources for the survival and wellbeing of future generations. The agricultural (Ag) sector ac…
View article: Correction: Increasing harms for bingo players: digitisation, commercialisation and regulatory inadequacy: a multi-site case study
Correction: Increasing harms for bingo players: digitisation, commercialisation and regulatory inadequacy: a multi-site case study Open
View article: Increasing harms for bingo players: digitisation, commercialisation and regulatory inadequacy: a multi-site case study
Increasing harms for bingo players: digitisation, commercialisation and regulatory inadequacy: a multi-site case study Open
Background Bingo is often understood as a low-harm form of gambling. This view has been challenged by a growing body of literature identifying gambling harm to bingo players in a range of countries. In this study, we aimed to identify whic…
View article: Evaluation of SAMBA II: A Qualitative and Semiquantitative HIV Point-of-Care Nucleic Acid Test.
Evaluation of SAMBA II: A Qualitative and Semiquantitative HIV Point-of-Care Nucleic Acid Test. Open
The SAMBA II POC NATs showed high sensitivity, specificity, and concordance with the gold standard assay, indicating its potential use in diagnostics and monitoring. Future work will evaluate POC NAT implementation in the US.
View article: Evolving Understandings of Bingo in Four Decades of Literature: From Eyes Down to New Vistas
Evolving Understandings of Bingo in Four Decades of Literature: From Eyes Down to New Vistas Open
Bingo is a distinct, enduring but understudied form of gambling. It provides comfort and pleasure to many of its players while also causing harm to some. While traditionally seen as low harm, it is being reshaped by technological and regul…
View article: Repurposing of Medicines in the EU: Launch of a Pilot Framework
Repurposing of Medicines in the EU: Launch of a Pilot Framework Open
Repurposing of authorised medicines has been under discussion for a long time. Drug repurposing is the process of identifying a new use for an existing medicine in an indication outside the scope of the original approved indication. Indeed…
View article: Multi-Family Therapy for First Episode Psychosis: Experiences of Families in Singapore
Multi-Family Therapy for First Episode Psychosis: Experiences of Families in Singapore Open
Aim: This qualitative study examined the experiences of families with Multi-Family Therapy (MFT) provided by the Early Psychosis Intervention Programme (EPIP) in Singapore. The MFT was piloted over a period of 2 years and findings from thi…