Helen Turley
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View article: Data from TRAP1 Regulates Proliferation, Mitochondrial Function, and Has Prognostic Significance in NSCLC
Data from TRAP1 Regulates Proliferation, Mitochondrial Function, and Has Prognostic Significance in NSCLC Open
The TNF receptor-associated protein 1 (TRAP1) is a mitochondrial HSP that has been related to drug resistance and protection from apoptosis in colorectal and prostate cancer. Here, the effect of TRAP1 ablation on cell proliferation, surviv…
View article: Data from TRAP1 Regulates Proliferation, Mitochondrial Function, and Has Prognostic Significance in NSCLC
Data from TRAP1 Regulates Proliferation, Mitochondrial Function, and Has Prognostic Significance in NSCLC Open
The TNF receptor-associated protein 1 (TRAP1) is a mitochondrial HSP that has been related to drug resistance and protection from apoptosis in colorectal and prostate cancer. Here, the effect of TRAP1 ablation on cell proliferation, surviv…
View article: Supplementary Movie 2 from TRAP1 Regulates Proliferation, Mitochondrial Function, and Has Prognostic Significance in NSCLC
Supplementary Movie 2 from TRAP1 Regulates Proliferation, Mitochondrial Function, and Has Prognostic Significance in NSCLC Open
WMV - 9842K, Video of TRAP1-siRNA1 treated A549 cell growth.
View article: Supplementary Movie 2 from TRAP1 Regulates Proliferation, Mitochondrial Function, and Has Prognostic Significance in NSCLC
Supplementary Movie 2 from TRAP1 Regulates Proliferation, Mitochondrial Function, and Has Prognostic Significance in NSCLC Open
WMV - 9842K, Video of TRAP1-siRNA1 treated A549 cell growth.
View article: Supplementary Movie 1 from TRAP1 Regulates Proliferation, Mitochondrial Function, and Has Prognostic Significance in NSCLC
Supplementary Movie 1 from TRAP1 Regulates Proliferation, Mitochondrial Function, and Has Prognostic Significance in NSCLC Open
WMV - 9857K, Video of scr-siRNA treated A549 cell growth.
View article: Supplementary Movie 1 from TRAP1 Regulates Proliferation, Mitochondrial Function, and Has Prognostic Significance in NSCLC
Supplementary Movie 1 from TRAP1 Regulates Proliferation, Mitochondrial Function, and Has Prognostic Significance in NSCLC Open
WMV - 9857K, Video of scr-siRNA treated A549 cell growth.
View article: Supplementary Figure 3 from Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis <i>In Vivo</i> and Inhibition Enhances Anti-VEGF Therapy
Supplementary Figure 3 from Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis <i>In Vivo</i> and Inhibition Enhances Anti-VEGF Therapy Open
(244 KB) - Bar chart of scoring of immunohistochemistry and representative immunohistochemistry images of HT29 shCA9 and EV xenografts with and without Bevacizumab treatment. CAIX expression (**p<0.01 ***p<0.001, n=5), proportion of necros…
View article: Data from The G-Protein–Coupled Receptor CLR Is Upregulated in an Autocrine Loop with Adrenomedullin in Clear Cell Renal Cell Carcinoma and Associated with Poor Prognosis
Data from The G-Protein–Coupled Receptor CLR Is Upregulated in an Autocrine Loop with Adrenomedullin in Clear Cell Renal Cell Carcinoma and Associated with Poor Prognosis Open
Purpose: The G-protein–coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) and its ligand peptide adrenomedullin (encoded by ADM gene) are implicated in tumor angiogenesis in mouse models but poorly defined in human cancers. We…
View article: Data from The G-Protein–Coupled Receptor CLR Is Upregulated in an Autocrine Loop with Adrenomedullin in Clear Cell Renal Cell Carcinoma and Associated with Poor Prognosis
Data from The G-Protein–Coupled Receptor CLR Is Upregulated in an Autocrine Loop with Adrenomedullin in Clear Cell Renal Cell Carcinoma and Associated with Poor Prognosis Open
Purpose: The G-protein–coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) and its ligand peptide adrenomedullin (encoded by ADM gene) are implicated in tumor angiogenesis in mouse models but poorly defined in human cancers. We…
View article: Supplementary Figure 4 from Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis <i>In Vivo</i> and Inhibition Enhances Anti-VEGF Therapy
Supplementary Figure 4 from Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis <i>In Vivo</i> and Inhibition Enhances Anti-VEGF Therapy Open
(8129 KB) - Bar chart of scoring of immunohistochemistry and representative immunohistochemistry images of HT29 xenografts with and without acetazolomide and/or Bevacizumab treatment. CAIX expression (vehicle (DMSO) *p<0.05, n=5; ATZ **p<0…
View article: Supplementary Figure Legends 1-4 from Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis <i>In Vivo</i> and Inhibition Enhances Anti-VEGF Therapy
Supplementary Figure Legends 1-4 from Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis <i>In Vivo</i> and Inhibition Enhances Anti-VEGF Therapy Open
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View article: Data from Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis <i>In Vivo</i> and Inhibition Enhances Anti-VEGF Therapy
Data from Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis <i>In Vivo</i> and Inhibition Enhances Anti-VEGF Therapy Open
Purpose: Bevacizumab, an anti-VEGFA antibody, inhibits the developing vasculature of tumors, but resistance is common. Antiangiogenic therapy induces hypoxia and we observed increased expression of hypoxia-regulated genes, including carbon…
View article: Supplementary Methods and Figure Legends and Figures from The G-Protein–Coupled Receptor CLR Is Upregulated in an Autocrine Loop with Adrenomedullin in Clear Cell Renal Cell Carcinoma and Associated with Poor Prognosis
Supplementary Methods and Figure Legends and Figures from The G-Protein–Coupled Receptor CLR Is Upregulated in an Autocrine Loop with Adrenomedullin in Clear Cell Renal Cell Carcinoma and Associated with Poor Prognosis Open
PDF file, 840K, Supplementary Materials and Methods, Supplementary Figure Legends and Supplementary Figures Supplementary Figure S1. Transcriptional profile of ADM expression in paired patient-matched normal and carcinoma tissues. Suppleme…
View article: Supplementary Figure 2 from Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis <i>In Vivo</i> and Inhibition Enhances Anti-VEGF Therapy
Supplementary Figure 2 from Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis <i>In Vivo</i> and Inhibition Enhances Anti-VEGF Therapy Open
(1056 KB) - Analysis of CA9 RNA expression in U87 xenografts untreated and with chronic Bevacizumab treatment. Bevacizumab treatement increased CA9 expression (***p<0.001, n=5).
View article: Supplementary Figure 4 from Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis <i>In Vivo</i> and Inhibition Enhances Anti-VEGF Therapy
Supplementary Figure 4 from Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis <i>In Vivo</i> and Inhibition Enhances Anti-VEGF Therapy Open
(8129 KB) - Bar chart of scoring of immunohistochemistry and representative immunohistochemistry images of HT29 xenografts with and without acetazolomide and/or Bevacizumab treatment. CAIX expression (vehicle (DMSO) *p<0.05, n=5; ATZ **p<0…
View article: Supplementary Figure 1 from Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis <i>In Vivo</i> and Inhibition Enhances Anti-VEGF Therapy
Supplementary Figure 1 from Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis <i>In Vivo</i> and Inhibition Enhances Anti-VEGF Therapy Open
(1543 KB) - Analysis of the viable tumour volume at the first endpoint of the HCT116 and HT29 xenograft and spheroid experiments revealed that the CAIX expressors had increased viable tissue in HCT116 (A) xenografts (40% more viable tissue…
View article: Data from Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis <i>In Vivo</i> and Inhibition Enhances Anti-VEGF Therapy
Data from Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis <i>In Vivo</i> and Inhibition Enhances Anti-VEGF Therapy Open
Purpose: Bevacizumab, an anti-VEGFA antibody, inhibits the developing vasculature of tumors, but resistance is common. Antiangiogenic therapy induces hypoxia and we observed increased expression of hypoxia-regulated genes, including carbon…
View article: Supplementary Methods and Figure Legends and Figures from The G-Protein–Coupled Receptor CLR Is Upregulated in an Autocrine Loop with Adrenomedullin in Clear Cell Renal Cell Carcinoma and Associated with Poor Prognosis
Supplementary Methods and Figure Legends and Figures from The G-Protein–Coupled Receptor CLR Is Upregulated in an Autocrine Loop with Adrenomedullin in Clear Cell Renal Cell Carcinoma and Associated with Poor Prognosis Open
PDF file, 840K, Supplementary Materials and Methods, Supplementary Figure Legends and Supplementary Figures Supplementary Figure S1. Transcriptional profile of ADM expression in paired patient-matched normal and carcinoma tissues. Suppleme…
View article: Supplementary Figure 1 from Expression of Terminally Glycosylated Calcitonin Receptor–Like Receptor in Uterine Leiomyoma: Endothelial Phenotype and Association with Microvascular Density
Supplementary Figure 1 from Expression of Terminally Glycosylated Calcitonin Receptor–Like Receptor in Uterine Leiomyoma: Endothelial Phenotype and Association with Microvascular Density Open
Supplementary Figure 1 from Expression of Terminally Glycosylated Calcitonin Receptor–Like Receptor in Uterine Leiomyoma: Endothelial Phenotype and Association with Microvascular Density
View article: Data from Expression of Terminally Glycosylated Calcitonin Receptor–Like Receptor in Uterine Leiomyoma: Endothelial Phenotype and Association with Microvascular Density
Data from Expression of Terminally Glycosylated Calcitonin Receptor–Like Receptor in Uterine Leiomyoma: Endothelial Phenotype and Association with Microvascular Density Open
Purpose: The role for the hypoxia-inducible angiogenic factor adrenomedullin (AM) in tumor growth and progression has been suggested. Calcitonin receptor–like receptor (CL) is a G protein–coupled receptor (GPCR) that mediates effects of AM…
View article: Supplementary Figure 3 from Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis <i>In Vivo</i> and Inhibition Enhances Anti-VEGF Therapy
Supplementary Figure 3 from Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis <i>In Vivo</i> and Inhibition Enhances Anti-VEGF Therapy Open
(244 KB) - Bar chart of scoring of immunohistochemistry and representative immunohistochemistry images of HT29 shCA9 and EV xenografts with and without Bevacizumab treatment. CAIX expression (**p<0.01 ***p<0.001, n=5), proportion of necros…
View article: Supplementary Figure 1 from Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis <i>In Vivo</i> and Inhibition Enhances Anti-VEGF Therapy
Supplementary Figure 1 from Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis <i>In Vivo</i> and Inhibition Enhances Anti-VEGF Therapy Open
(1543 KB) - Analysis of the viable tumour volume at the first endpoint of the HCT116 and HT29 xenograft and spheroid experiments revealed that the CAIX expressors had increased viable tissue in HCT116 (A) xenografts (40% more viable tissue…
View article: Supplementary Figure 1 from Expression of Terminally Glycosylated Calcitonin Receptor–Like Receptor in Uterine Leiomyoma: Endothelial Phenotype and Association with Microvascular Density
Supplementary Figure 1 from Expression of Terminally Glycosylated Calcitonin Receptor–Like Receptor in Uterine Leiomyoma: Endothelial Phenotype and Association with Microvascular Density Open
Supplementary Figure 1 from Expression of Terminally Glycosylated Calcitonin Receptor–Like Receptor in Uterine Leiomyoma: Endothelial Phenotype and Association with Microvascular Density
View article: Supplementary Figure 2 from Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis <i>In Vivo</i> and Inhibition Enhances Anti-VEGF Therapy
Supplementary Figure 2 from Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis <i>In Vivo</i> and Inhibition Enhances Anti-VEGF Therapy Open
(1056 KB) - Analysis of CA9 RNA expression in U87 xenografts untreated and with chronic Bevacizumab treatment. Bevacizumab treatement increased CA9 expression (***p<0.001, n=5).
View article: Supplementary Figure Legends 1-4 from Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis <i>In Vivo</i> and Inhibition Enhances Anti-VEGF Therapy
Supplementary Figure Legends 1-4 from Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis <i>In Vivo</i> and Inhibition Enhances Anti-VEGF Therapy Open
(72 KB)
View article: Data from Expression of Terminally Glycosylated Calcitonin Receptor–Like Receptor in Uterine Leiomyoma: Endothelial Phenotype and Association with Microvascular Density
Data from Expression of Terminally Glycosylated Calcitonin Receptor–Like Receptor in Uterine Leiomyoma: Endothelial Phenotype and Association with Microvascular Density Open
Purpose: The role for the hypoxia-inducible angiogenic factor adrenomedullin (AM) in tumor growth and progression has been suggested. Calcitonin receptor–like receptor (CL) is a G protein–coupled receptor (GPCR) that mediates effects of AM…
View article: Supplementary Methods, Figure Legends 1-6, Tables 1-6 from The Histone Demethylase JMJD2B Is Regulated by Estrogen Receptor α and Hypoxia, and Is a Key Mediator of Estrogen Induced Growth
Supplementary Methods, Figure Legends 1-6, Tables 1-6 from The Histone Demethylase JMJD2B Is Regulated by Estrogen Receptor α and Hypoxia, and Is a Key Mediator of Estrogen Induced Growth Open
Supplementary Methods, Figure Legends 1-6, Tables 1-6 from The Histone Demethylase JMJD2B Is Regulated by Estrogen Receptor α and Hypoxia, and Is a Key Mediator of Estrogen Induced Growth