Explanipedia

How low can we go? Comparison of liberal and restrictive red cell transfusion thresholds in paediatric allogeneic haematopoietic stem cell transplantation: A randomized multicentre feasibility trial Open

Helen V. New, Elaine Sanderson, Valerie Hopkins, Helen Thomas, Adam Gassas , et al. · 2025

Summary Optimal red blood cell transfusion thresholds for children with bone marrow failure are uncertain; a previous study was stopped following concerns about veno‐occlusive disease. The aims of this study in allogeneic haematopoietic st…

Plasma transfusions in neonatal intensive care units: a prospective observational study Open

Nina A. M. Houben, Suzanne Fustolo‐Gunnink, Karin Fijnvandraat, Camila Caram‐Deelder, Marta Aguar , et al. · 2025

Objective Despite lack of evidence supporting efficacy, prophylactic fresh frozen plasma and Octaplas transfusions may be administered to very preterm infants to reduce bleeding risk. International variation in plasma transfusion practices…

Potential sitosterolemia in necrobiotic xanthogranuloma: Comment on “Extensive yellowish masses in bilateral orbit and neck” Open

Peng‐Yu Chen, Yuan‐Yu Hong, Helen V. New, Zhuangli Tang, Sui‐Qing Cai · 2024

Platelet transfusion in neonatal intensive care units of 22 European countries: a prospective observational study Open

Nina A. M. Houben, Enrico Lopriore, Karin Fijnvandraat, Camila Caram‐Deelder, Marta Aguar , et al. · 2024

Red Blood Cell Transfusion in European Neonatal Intensive Care Units, 2022 to 2023 Open

Nina A. M. Houben, Suzanne Fustolo‐Gunnink, Karin Fijnvandraat, Camila Caram‐Deelder, Marta Aguar , et al. · 2024

Importance Red blood cell (RBC) transfusions are frequently administered to preterm infants born before 32 weeks of gestation in the neonatal intensive care unit (NICU). Two randomized clinical trials (Effects of Transfusion Thresholds on …

Supplemental Iron and Recombinant Erythropoietin for Anemia in Infants Born Very Preterm: A Survey of Clinical Practice in Europe Open

Nora Johanna Reibel-Georgi, Alexandra Scrivens, Lisanne E. Heeger, Enrico Lopriore, Helen V. New , et al. · 2024

This survey highlights wide heterogeneity in evaluating erythropoietic activity and iron deficiency in infants born preterm. Variation in iron supplementation during infancy likely reflects an inadequate evidence base. Current evidence on …

Why might cord blood be a better source of platelets for transfusion to neonates? Open

Valeria Cortesi, Giacomo Cavallaro, Genny Raffaeli, Stefano Ghirardello, Fabio Mosca , et al. · 2024

Thrombocytopenia (defined as a platelet count <150×10⁹/L) is a common condition in preterm neonates and may occur in 18-35% of all infants admitted to the Neonatal Intensive Care Unit (NICU). Neonatal platelet functionality in t…

Clinical Practice Guideline for Red Blood Cell Transfusion Thresholds in Very Preterm Neonates Open

Emöke Deschmann, Christof Dame, Martha Sola‐Visner, Susanna F. Fustolo‐Gunnink, Gordon Guyatt , et al. · 2024

Importance Red blood cell (RBC) transfusion is a common medical intervention to treat anemia in very preterm neonates; however, best transfusion practices, such as thresholds, remain uncertain. Objective To develop recommendations for clin…

Two-year outcomes following a randomised platelet transfusion trial in preterm infants Open

Carmel Maria Moore, Angela D’Amore, Suzanne Fustolo‐Gunnink, Cara Hudson, Alice Newton , et al. · 2023

Objective Assess mortality and neurodevelopmental outcomes at 2 years of corrected age in children who participated in the PlaNeT-2/MATISSE (Platelets for Neonatal Transfusion - 2/Management of Thrombocytopenia in Special Subgroup) study, …

Survey of transfusion practices in preterm infants in Europe Open

Alexandra Scrivens, Nora Johanna Reibel, Lisanne E. Heeger, Simon Stanworth, Enrico Lopriore , et al. · 2023

Background Preterm infants commonly receive red blood cell (RBC), platelet and fresh frozen plasma (FFP) transfusions. The aim of this Neonatal Transfusion Network survey was to describe current transfusion practices in Europe and to compa…

International guidelines regarding the role of IVIG in the management of Rh‐ and ABO‐mediated haemolytic disease of the newborn Open

Lani Lieberman, Enrico Lopriore, Jillian M. Baker, Rachel S. Bercovitz, Robert D. Christensen , et al. · 2022

Haemolytic disease of the newborn (HDN) can be associated with significant morbidity. Prompt treatment with intensive phototherapy (PT) and exchange transfusions (ETs) can dramatically improve outcomes. ET is invasive and associated with r…

International Forum on Policies and Practice for Transfusion of ABO and RhD Non‐Identical Platelets: Summary Open

Rebecca Cardigan, Helen V. New, Lise J Estcourt, Е Б Жибурт, Rounak Dubey , et al. · 2021

International Forum on Policies and Practice for Transfusion of ABO and RhD Non‐Identical Platelets: Responses Open

Rebecca Cardigan, Helen V. New, Lise J Estcourt, Е Б Жибурт, Rounak Dubey , et al. · 2021

Question 1We have apheresis (70%) and whole blood derived (buffy coat) (30%).Each pool is derived from four to five donors.Whole blood processing is mostly manual.Platelets are suspended in plasma or in SSP+ [1].Рlatelets for neonates/infa…

Changes in the Use of Fresh-Frozen Plasma Transfusions in Preterm Neonates: A Single Center Experience Open

Nina A. M. Houben, Lisanne E. Heeger, Simon Stanworth, Helen V. New, Johanna G. van der Bom , et al. · 2020

The aim of this study was to evaluate changes in the use of fresh-frozen plasma (FFP) transfusions and the use of clotting tests in preterm neonates in our center over the past two decades. In this retrospective cohort analysis, we include…

British Society for Haematology Guidelines on transfusion for fetuses, neonates and older children (Br J Haematol. 2016;175:784–828). Addendum August 2020 Open

Helen V. New, Simon Stanworth, Ruth Gottstein, Carol Cantwell, Jennifer Berryman , et al. · 2020

Following publication of the British Society for Haematology (BSH) transfusion guidelines for fetuses, neonates and older children,1 there have been a number of changes requiring this addendum, prior to full revision of the guideline. For …

Guidelines on the use of irradiated blood components Open

Theodora Foukaneli, Paul Kerr, Paula Bolton‐Maggs, Rebecca Cardigan, Alasdair Coles , et al. · 2020

This article is available to RD&E staff via NHS OpenAthens. Click on the Publisher URL, and log in with NHS OpenAthens if prompted.

Washed red cells: theory and practice Open

Rebecca Cardigan, Helen V. New, Hazel Tinegate, Stephen Thomas · 2020

Washing of red cells is sometimes performed to reduce allergic reactions due to contaminating plasma proteins or to reduce the concentration of potassium accumulating in the supernatant of red cells during storage as an alternative to tran…

Effects of the COVID-19 pandemic on supply and use of blood for transfusion Open

Simon Stanworth, Helen V. New, Torunn Oveland Apelseth, Susan J Brunskill, Rebecca Cardigan , et al. · 2020

A survey of extracorporeal photopheresis treatment in pediatric patients in the United Kingdom Open

Aisling M. Flinn, Sheba Macheka, Mary Slatter, Anna‐Maria Ewins, Brenda Gibson , et al. · 2020

Extracorporeal photopheresis (ECP) is a second‐line therapy in acute and chronic GVHD and solid organ transplant rejection. We report ECP use in 98 pediatric patients in seven UK centers from 2010 to 2017, the majority treated for aGVHD (7…

Fatigue, executive function and psychological effects in children with immune thrombocytopenia: a cross‐sectional study Open

Sarah Towner, Zoë Berger, Penny Titman, Helen V. New, Kate Theodore , et al. · 2020

Summary Childhood ITP is often considered to be a relatively mild haematological disorder, with only a minority of patients requiring treatment for troublesome bleeding. Over recent years, wider effects of the condition have been identifie…

Vox Sanguinis International Forum on paediatric indications for blood component transfusion Open

Mie Topholm Bruun, Mark H. Yazer, Philip C. Spinella, Kjell Titlestad, Miquel Lozano , et al. · 2019

neonatal patients -10-15 ml/kg.

Vox Sanguinis International Forum on paediatric indications for blood component transfusion: Summary Open

Mie Topholm Bruun, Mark H. Yazer, Philip C. Spinella, Kjell Titlestad, Miquel Lozano , et al. · 2019

Characteristics and incidence of transfusion-associated necrotizing enterocolitis in the UK Open

Christopher Faraday, Sheima Hamad, Kelsey Jones, Kathleen Sim, Shobha Cherian , et al. · 2018

Background and aims: The etiology of necrotizing enterocolitis (NEC) is unclear and postulated as being multifactorial. It has been suggested that one causative factor is the transfusion of packed red blood cells (PRBCs) leading to …

Characteristics and incidence of transfusion-associated necrotizing enterocolitis in the UK Open

Christopher Faraday, Sheima Hamad, Kelsey Jones, Kathleen Sim, Shobha Cherian , et al. · 2018

Background and aims: The etiology of necrotizing enterocolitis (NEC) is unclear and postulated as being multifactorial. It has been suggested that one causative factor is the transfusion of packed red blood cells (PRBCs) leading to …

Characteristics and incidence of transfusion-associated necrotizing enterocolitis in the UK Open

Christopher Faraday, Sheima Hamad, Kelsey Jones, Kathleen Sim, Shobha Cherian , et al. · 2018

Background and aims: The etiology of necrotizing enterocolitis (NEC) is unclear and postulated as being multifactorial. It has been suggested that one causative factor is the transfusion of packed red blood cells (PRBCs) leading to …

The administration of blood components: a British Society for Haematology Guideline Open

Susan Robinson, Alex L. Harris, Sarah Atkinson, Claire Atterbury, Paula Bolton‐Maggs , et al. · 2017

This guideline was compiled according to the BSH process at http://www.b-s-h.org.uk/guidelines/. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) nomenclature was used to evaluate the levels of evidence and to …

Guidelines on transfusion for fetuses, neonates and older children Open

Helen V. New, Jennifer Berryman, Paula Bolton‐Maggs, Carol Cantwell, Elizabeth Chalmers , et al. · 2016

The guideline is a revision of the 2004 British Committee for Standards in Haematology (BCSH) guideline on transfusion in neonates and older children (BCSH, 2004). Although there has been little evidence on which to base paediatric clinica…

G125(P) Uk transfusion-associated necrotising enterocolitis cases identified through a multicentre audit Open

S N Hamad, Kelsey Jones, Korching Sim, Shobha Cherian, James Fitzsimons , et al. · 2015

Aim Transfusion-associated necrotising enterocolitis (TANEC) has been reported from The Americas and various European countries at rates comprising 27−38% of necrotising enterocolitis (NEC) cases. While the role of packed red blood cell (P…

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