Helena Bergsten
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View article: Author response: Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm
Author response: Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm Open
View article: Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm
Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm Open
The M protein is an essential virulence factor of Streptococcus pyogenes, or group A streptococci (GAS), one of the most common and dangerous human pathogens. Molecular and functional characterization of M protein variants and their intera…
View article: Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm
Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm Open
The M protein is an essential virulence factor of Streptococcus pyogenes, or group A streptococcus (GAS), one of the most common and dangerous human pathogens. Molecular and functional characterization of M protein variants and their inter…
View article: Author response: Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm
Author response: Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm Open
View article: Distinct MAIT cell phenotypes associated with sepsis clinical outcome in emergency department patients
Distinct MAIT cell phenotypes associated with sepsis clinical outcome in emergency department patients Open
Objectives Rapid diagnosis and intervention are critical for sepsis patient outcomes. However, diagnosis is challenging because of a heterogenic patient group as well as sometimes vague symptoms when the patient presents at the emergency d…
View article: Structural basis for collagen recognition by the <i>Streptococcus pyogenes</i> M3 protein and its involvement in biofilm
Structural basis for collagen recognition by the <i>Streptococcus pyogenes</i> M3 protein and its involvement in biofilm Open
The M protein is an essential virulence factor of Streptococcus pyogenes , or group A streptococcus (GAS), one of the most common and dangerous human pathogens. Molecular and functional characterization of M protein variants and their inte…
View article: The HLA-B –21 M/T dimorphism associates with disease severity in COVID-19
The HLA-B –21 M/T dimorphism associates with disease severity in COVID-19 Open
View article: The intricate pathogenicity of Group A <i>Streptococcus</i> : A comprehensive update
The intricate pathogenicity of Group A <i>Streptococcus</i> : A comprehensive update Open
Group A Streptococcus (GAS) is a versatile pathogen that targets human lymphoid, decidual, skin, and soft tissues. Recent advancements have shed light on its airborne transmission, lymphatic spread, and interactions with neuronal sy…
View article: Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19
Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19 Open
Background Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to severe disease with increased morbidity and mortality among certain risk groups. The presence of autoantibodies against type I interferons (…
View article: Elucidation of independently modulated genes in <i>Streptococcus pyogenes</i> reveals carbon sources that control its expression of hemolytic toxins
Elucidation of independently modulated genes in <i>Streptococcus pyogenes</i> reveals carbon sources that control its expression of hemolytic toxins Open
Streptococcus pyogenes can cause a wide variety of acute infections throughout the body of its human host. An underlying transcriptional regulatory network (TRN) is responsible for altering the physiological state of the bacterium to adapt…
View article: Elucidation of independently modulated genes in Streptococcus pyogenes reveals carbon sources that control its expression of hemolytic toxins
Elucidation of independently modulated genes in Streptococcus pyogenes reveals carbon sources that control its expression of hemolytic toxins Open
Streptococcus pyogenes can cause a wide variety of acute infections throughout the body of its human host. The underlying transcriptional regulatory network (TRN) is responsible for altering the physiological state of the bacterium to adap…
View article: Elucidation of independently modulated genes in <i>Streptococcus pyogenes</i> reveals carbon sources that control its expression of hemolytic toxins
Elucidation of independently modulated genes in <i>Streptococcus pyogenes</i> reveals carbon sources that control its expression of hemolytic toxins Open
Streptococcus pyogenes can cause a wide variety of acute infections throughout the body of its human host. The underlying transcriptional regulatory network (TRN) is responsible for altering the physiological state of the bacterium to adap…
View article: Elucidation of Independently Modulated Genes in Streptococcus Pyogenes Reveals Carbon Sources that Control its Expression of Hemolytic Toxins
Elucidation of Independently Modulated Genes in Streptococcus Pyogenes Reveals Carbon Sources that Control its Expression of Hemolytic Toxins Open
View article: High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19
High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19 Open
Significance Accumulating evidence shows that granulocytes are key modulators of the immune response to SARS-CoV-2 infection, and their dysregulation could significantly impact COVID-19 severity and patient recovery after virus clearance. …
View article: Adjunctive Rifampicin Increases Antibiotic Efficacy in Group A Streptococcal Tissue Infection Models
Adjunctive Rifampicin Increases Antibiotic Efficacy in Group A Streptococcal Tissue Infection Models Open
Biofilm has recently been highlighted as a complicating feature of necrotizing soft tissue infections (NSTI) caused by Streptococcus pyogenes (i.e., group A Streptococcus [GAS]) contributing to a persistence of bacteria in tissue despite p…
View article: High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19
High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19 Open
Since the outset of the COVID-19 pandemic, increasing evidence suggests that the innate immune responses play an important role in the disease development. A dysregulated inflammatory state has been proposed as key driver of clinical compl…
View article: Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity
Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity Open
Significance While broad efforts toward getting an overview of immune cell and soluble factor alterations in COVID-19 are under way, a deep and comprehensive understanding of the mononuclear phagocyte system, including circulating progenit…
View article: MAIT cell activation and dynamics associated with COVID-19 disease severity
MAIT cell activation and dynamics associated with COVID-19 disease severity Open
MAIT cell activation and decline in blood are associated with COVID-19 severity, features that dynamically recover in convalescence.
View article: Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19 Open
View article: Risk Factors and Predictors of Mortality in Streptococcal Necrotizing Soft-tissue Infections: A Multicenter Prospective Study
Risk Factors and Predictors of Mortality in Streptococcal Necrotizing Soft-tissue Infections: A Multicenter Prospective Study Open
Background Necrotizing soft-tissue infections (NSTI) are life-threatening conditions often caused by β-hemolytic streptococci, group A Streptococcus (GAS) in particular. Optimal treatment is contentious. The INFECT cohort includes the larg…
View article: Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue Infections
Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue Infections Open
Analyses of plasma collected pre- and postadministration of intravenous immunoglobulin (IVIG) from patients with group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-trigg…
View article: MAIT Cells Are Major Contributors to the Cytokine Response in Group A Streptococcal Toxic Shock Syndrome
MAIT Cells Are Major Contributors to the Cytokine Response in Group A Streptococcal Toxic Shock Syndrome Open
Streptococcal toxic shock syndrome (STSS) is a rapidly progressing, life-threatening, systemic reaction to invasive infection caused by group A streptococci (GAS). GAS superantigens are key mediators of STSS through their potent activation…
View article: Biofilm in group A streptococcal necrotizing soft tissue infections
Biofilm in group A streptococcal necrotizing soft tissue infections Open
Necrotizing fasciitis caused by group A streptococcus (GAS) is a life-threatening, rapidly progressing infection. At present, biofilm is not recognized as a potential problem in GAS necrotizing soft tissue infections (NSTI), as it is typic…
View article: Modeling staphylococcal pneumonia in a human 3D lung tissue model system delineates toxin-mediated pathology
Modeling staphylococcal pneumonia in a human 3D lung tissue model system delineates toxin-mediated pathology Open
Staphylococcus aureus necrotizing pneumonia is recognized as a toxin-mediated disease, but yet the tissue destructive events remain elusive partly due to lack of mechanistic studies in human lung tissue. In this study, a 3D tissue model co…