Helena Carla Castro
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View article: Synthesis and evaluation of antibacterial and antibiofilm agents based on phenylamino-substituted 1,4-benzoquinones
Synthesis and evaluation of antibacterial and antibiofilm agents based on phenylamino-substituted 1,4-benzoquinones Open
Aim: This work describes the synthesis and antimicrobial evaluation of 6-aminated 1,4-benzoquinones (6-AQs) against seven resistant pathogens.Materials & methods: The 6-AQs, synthesized via a Michael addition reaction between bromoquinone …
View article: Immune Reactions of Vector Insects to Parasites and Pathogens
Immune Reactions of Vector Insects to Parasites and Pathogens Open
This overview initially describes insect immune reactions and then brings together present knowledge of the interactions of vector insects with their invading parasites and pathogens. It is a way of introducing this Special Issue with subs…
View article: Immune Reactions of Vector Insects to Parasites and Pathogens
Immune Reactions of Vector Insects to Parasites and Pathogens Open
This overview initially describes insect immune reactions and then brings together present knowledge of the interactions of vector insects with their invading parasites and pathogens. It is a way of introducing this special issue with subs…
View article: <i>In </i><i>Silico</i> and <i>in </i><i>Vitro</i> Analysis of Pyrazolone Derivatives against Zika Virus and Identification of Potential NS5 Methyltransferase Inhibitors by Molecular Docking
<i>In </i><i>Silico</i> and <i>in </i><i>Vitro</i> Analysis of Pyrazolone Derivatives against Zika Virus and Identification of Potential NS5 Methyltransferase Inhibitors by Molecular Docking Open
Zika virus (ZIKV), a mosquito-borne flavivirus, has been associated with benign infections for decades. However, it has become a public health concern due to its association with severe fetal and neurological complications. Although many e…
View article: ANIMALS USED IN RESEARCH AND ITS PROTECTION: FROM THE BEGINNINGS TO THE XXI CENTURY
ANIMALS USED IN RESEARCH AND ITS PROTECTION: FROM THE BEGINNINGS TO THE XXI CENTURY Open
Activities involving the use of animals in research date back to more than 2,000 years BCE.At the time, animals were used in surgeries and comparative studies aimed at elucidating the mysteries surrounding the functioning of living organis…
View article: Antiviral activity of terpenes isolated from marine brown seaweeds against herpes simplex virus type 2
Antiviral activity of terpenes isolated from marine brown seaweeds against herpes simplex virus type 2 Open
Herpes simplex virus type 2 (HSV-2) is the most common agent of sexually transmitted infections around the world. Currently, no vaccine is available, and acyclovir is the reference compound in treatment HSV-2 infections. However, the emerg…
View article: Streptomyces: a natural source of anti-Candida agents
Streptomyces: a natural source of anti-Candida agents Open
Introduction. There is an urgent need to source new compounds that can combat the current threat of serious infection caused by Candida spp. and contend with the problem of antimicrobial resistance. Gap. A synthesis of the evidence availab…
View article: Brazilian laboratory rats and mice: decades pass, but parasite infections remain
Brazilian laboratory rats and mice: decades pass, but parasite infections remain Open
Rats and mice are the most used experimental models in research. Globally, animal houses are subjected to parasite outbreaks. In Brazil, the parasitological profile is used to reflect the sanitary condition of laboratory animals and must b…
View article: Frontiers in the search for new antimicrobials: new perspectives
Frontiers in the search for new antimicrobials: new perspectives Open
Infections caused by bacteria and fungi resistant to antimicrobials are one of the main public health problems in the world. These microorganisms are associated with high rates of morbidity and mortality and also with high hospital costs. …
View article: Animal pollinated crops and cultivars – a quantitative assessment of Pollinator Dependence values and evaluation of methodological approaches
Animal pollinated crops and cultivars – a quantitative assessment of Pollinator Dependence values and evaluation of methodological approaches Open
Pollinator dependence (PD) of a crop is a key estimate for assessing pollinator's contribution to agriculture, guiding management plans and policies for sustainable crop production.However, currently available global compilations of crops …
View article: Gene set enrichment analysis indicates convergence in the mTOR signalling pathway between syndromic and non-syndromic autism
Gene set enrichment analysis indicates convergence in the mTOR signalling pathway between syndromic and non-syndromic autism Open
Autism is a developmental disorder that affects around 62.1 million people globally. Estimates of its prevalence have been on the rise. Recent research suggests that in the United States alone, the cost of caring for individuals with autis…
View article: Development of Mobile &lt;i&gt;Apps&lt;/i&gt; for Deaf Patients by Nursing Students: Let’s Consider the Difficulties through Deaf’s Perspective
Development of Mobile <i>Apps</i> for Deaf Patients by Nursing Students: Let’s Consider the Difficulties through Deaf’s Perspective Open
Communication between healthcare professionals and patients is essential for getting the right treatment and full recovery. However, the deaf community find difficulties worldwide as they need to communicate basically through sign language…
View article: Brazilian laboratory rats and mice: decades pass, but parasite infections remain
Brazilian laboratory rats and mice: decades pass, but parasite infections remain Open
Rats and mice are the most used experimental models in research. Globally, animal houses are subjected to parasite outbreaks. In Brazil, the parasitological profile is used to reflect the sanitary condition of laboratory animals and must b…
View article: Reaching the Final Endgame for Constant Waves of COVID-19
Reaching the Final Endgame for Constant Waves of COVID-19 Open
Despite intramuscular vaccines saving millions of lives, constant devastating waves of SARS-CoV-2 infections continue. The elimination of COVID-19 is challenging, but necessary in order to avoid millions more people who would suffer from l…
View article: Development of novel montmorillonite-based sustained release system for oral bromopride delivery.
Development of novel montmorillonite-based sustained release system for oral bromopride delivery. Open
The drug delivery systems are an important strategy of pharmaceutical technology to modulate undesirable properties, increasing efficacy, and reducing the side effects of active pharmaceutical ingredients (API). The sustained release is a …
View article: Students Conceptions from a Countryside Area of a Continental Nation about Sciences Practical Classes: A Brazilian Case Study
Students Conceptions from a Countryside Area of a Continental Nation about Sciences Practical Classes: A Brazilian Case Study Open
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil
View article: Preparation and scale up of extended-release tablets of bromopride
Preparation and scale up of extended-release tablets of bromopride Open
Reproducibility of the tablet manufacturing process and control of its pharmaceutics properties depends on the optimization of formulation aspects and process parameters. Computer simulation such as Design of Experiments (DOE) can be used …
View article: Preparation and evaluation of red propolis and nystatin cyclodextrin inclusion complexes against oral microbiome opportunistic microorganisms
Preparation and evaluation of red propolis and nystatin cyclodextrin inclusion complexes against oral microbiome opportunistic microorganisms Open
The human oral cavity is colonized by a diversity of microorganisms living harmoniously. When an imbalance occurs in this population, also called dysbiosis, opportunistic microorganisms lead to oral infections. Nystatin, a traditional anti…
View article: Ancient Egypt: Gifted People Learn by Playing with Home Enrichment during Pandemic
Ancient Egypt: Gifted People Learn by Playing with Home Enrichment during Pandemic Open
With the social distancing imposed by the pandemic caused by SARS COV-2, many students around the world found themselves estranged from their schools and friends, with limited access, in many cases, to an educational environment. The liter…
View article: Synthetic Derivatives against Wild-Type and Non-Wild-Type Sporothrix brasiliensis: In Vitro and In Silico Analyses
Synthetic Derivatives against Wild-Type and Non-Wild-Type Sporothrix brasiliensis: In Vitro and In Silico Analyses Open
Recently, the well-known geographically wide distribution of sporotrichosis in Brazil, combined with the difficulties of effective domestic feline treatment, has emphasized the pressing need for new therapeutic alternatives. This work cons…
View article: Chemistry and Giftedness: A Delight Full and Catalytic Mixture in a Home Enrichment Model
Chemistry and Giftedness: A Delight Full and Catalytic Mixture in a Home Enrichment Model Open
Considering the importance of an enriched environment to promote meaningful, autonomous and motivating learning for High Abilities or Gifted students (HA/Gs) and the gaps left by most schools worldwide in attending this public, this work d…
View article: Nasal therapy—The missing link in optimising strategies to improve prevention and treatment of COVID-19
Nasal therapy—The missing link in optimising strategies to improve prevention and treatment of COVID-19 Open
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View article: Using <i>in vivo</i> animal models for studying SARS-CoV-2
Using <i>in vivo</i> animal models for studying SARS-CoV-2 Open
Studies have reported the use of nonhuman primates, ferrets, mice, Syrian hamsters, lagomorphs, mink, and zebrafish in experiments that aimed to understand the course of COVID-19 or test vaccines and other drugs. In contrast, the assays wi…
View article: Perceptions and Feelings of Brazilian Health Care Professionals Regarding the Effects of COVID-19: Cross-sectional Web-Based Survey
Perceptions and Feelings of Brazilian Health Care Professionals Regarding the Effects of COVID-19: Cross-sectional Web-Based Survey Open
Background The importance of health professionals has been recognized in COVID-19 pandemic–affected countries, especially in those such as Brazil, which is one of the top 3 countries that have been affected in the world. However, the worke…
View article: Facing Racism and Sexism in Science by Fighting Against Social Implicit Bias: A Latina and Black Woman’s Perspective
Facing Racism and Sexism in Science by Fighting Against Social Implicit Bias: A Latina and Black Woman’s Perspective Open
The editors of several major journals have recently asserted the importance of combating racism and sexism in science. This is especially relevant now, as the COVID-19 pandemic may have led to a widening of the gender and racial/ethnicity …