Helena C. Chui
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View article: Automatic detection of arterial input function for brain <scp>DCE</scp>‐<scp>MRI</scp> in multi‐site cohorts
Automatic detection of arterial input function for brain <span>DCE</span>‐<span>MRI</span> in multi‐site cohorts Open
Purpose Arterial input function (AIF) extraction is a crucial step in quantitative pharmacokinetic modeling of DCE‐MRI. This work proposes a robust deep learning model that can precisely extract an AIF from DCE‐MRI images. Methods A divers…
View article: Dysregulation of cerebral perfusion dynamics is associated with Alzheimer's disease
Dysregulation of cerebral perfusion dynamics is associated with Alzheimer's disease Open
INTRODUCTION A novel physio‐marker, termed “cerebrovascular dynamics index” (CDI), was developed and evaluated in a multi‐center National Institutes of Health (NIH)–funded study for improved diagnosis of mild cognitive impairment (MCI) and…
View article: Racial/Ethnic Disparities in Alzheimer’s Disease Risk: Role of Exposure to Ambient Fine Particles
Racial/Ethnic Disparities in Alzheimer’s Disease Risk: Role of Exposure to Ambient Fine Particles Open
BACKGROUND: Whether racial/ethnic disparities in Alzheimer's disease (AD) risk may be explained by ambient fine particles (PM2.5) has not been studied. METHOD: We conducted a prospective, population-based study on a cohort of Black (n = 48…
View article: Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD
Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD Open
Background Cellular senescence, a hallmark of aging, has been implicated in Alzheimer’s disease (AD) pathogenesis. Cholesterol accumulation is known to drive cellular senescence; however, its underlying mechanisms are not fully understood.…
View article: Carotid stiffening with impaired damping is associated with cognitive impairment and reduced cerebral perfusion in elderly adults
Carotid stiffening with impaired damping is associated with cognitive impairment and reduced cerebral perfusion in elderly adults Open
Background Emerging evidence indicates that arterial stiffening is associated with aging and cognitive impairment. Arterial stiffness is typically assessed by measuring pulse wave velocity (PWV) between carotid and femoral arteries. A rece…
View article: Physio‐markers based on predictive models of cerebral hemodynamics yield accurate diagnosis of cognitive impairment and differentiate MCI from AD
Physio‐markers based on predictive models of cerebral hemodynamics yield accurate diagnosis of cognitive impairment and differentiate MCI from AD Open
Background A multi‐center study in Los Angeles (USC), Kansas City (KUMC) and Dallas (UT‐SWMC) quantified via predictive modeling the dynamics of cerebral perfusion regulation (CO2 vasoreactivity and cerebral autoregulation) in MCI/AD patie…
View article: Higher amyloid burden is associated with faster reduction in cerebral blood flow: a longitudinal study
Higher amyloid burden is associated with faster reduction in cerebral blood flow: a longitudinal study Open
Background Amyloid accumulation is one of the main pathophysiological hallmarks of Alzheimer’s disease (AD) and is closely associated with neuronal dysfunction and cognitive decline. Except for amyloid pathology, accumulating evidence has …
View article: Association of pulsatility of lenticulostriate arteries with cognitive decline in elderly adults: a 7T dual‐VENC PC‐MRI study
Association of pulsatility of lenticulostriate arteries with cognitive decline in elderly adults: a 7T dual‐VENC PC‐MRI study Open
Background Cerebral small vessel disease (cSVD) is a major cause of vascular dementia. Mounting evidence suggests that cSVD pathology is closely linked to vascular dysfunction of lenticulostriate arteries (LSAs). Arterial pulsatility, quan…
View article: A simple measure of voluntary control of breathing is an effective physio‐marker for differentiating MCI from mild AD patients and MCI/AD patients from cognitively normal controls
A simple measure of voluntary control of breathing is an effective physio‐marker for differentiating MCI from mild AD patients and MCI/AD patients from cognitively normal controls Open
Background Control of breathing is known to be adversely affected by cognitive impairment, often associated with sleep apnea or disordered breathing during sleep in MCI/AD. The origin of this disorder is thought to be in the dysfunction of…
View article: Decreased functional connectivity is associated with increased levels of Cerebral Spinal Fluid soluble-PDGFRβ, a marker of blood brain barrier breakdown, in older adults
Decreased functional connectivity is associated with increased levels of Cerebral Spinal Fluid soluble-PDGFRβ, a marker of blood brain barrier breakdown, in older adults Open
Resting-state functional connectivity (FC) is suggested to be cross-sectionally associated with both vascular burden and Alzheimer's disease (AD) pathology. For instance, studies in pre-clinical AD subjects have shown increases of cerebral…
View article: Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD
Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD Open
View article: Adherence to a MIND-Like Dietary Pattern, Long-Term Exposure to Fine Particulate Matter Air Pollution, and MRI-Based Measures of Brain Volume: The Women’s Health Initiative Memory Study-MRI
Adherence to a MIND-Like Dietary Pattern, Long-Term Exposure to Fine Particulate Matter Air Pollution, and MRI-Based Measures of Brain Volume: The Women’s Health Initiative Memory Study-MRI Open
BACKGROUND: Previous studies suggest that certain dietary patterns and constituents may be beneficial to brain health. Airborne exposures to fine particulate matter [particulate matter with aerodynamic diameter ≤2.5 μm (PM2.5)] are neuroto…
View article: 20‐year depressive symptoms, dementia, and structural neuropathology in older women
20‐year depressive symptoms, dementia, and structural neuropathology in older women Open
INTRODUCTION The course of depressive symptoms and dementia risk is unclear, as are potential structural neuropathological common causes. METHODS Utilizing joint latent class mixture models, we identified longitudinal trajectories of annua…
View article: Assessment of arterial pulsatility of cerebral perforating arteries using <scp>7T</scp> high‐resolution <scp>dual‐VENC</scp> phase‐contrast <scp>MRI</scp>
Assessment of arterial pulsatility of cerebral perforating arteries using <span>7T</span> high‐resolution <span>dual‐VENC</span> phase‐contrast <span>MRI</span> Open
Purpose Directly imaging the function of cerebral perforating arteries could provide valuable insight into the pathology of cerebral small vessel diseases (cSVD). Arterial pulsatility has been identified as a useful biomarker for assessing…
View article: Slow‐breathing induced hypocapnia mitigates deficit of vasoreactivity measured in patients with cognitive impairment
Slow‐breathing induced hypocapnia mitigates deficit of vasoreactivity measured in patients with cognitive impairment Open
Background A multi‐center study in Los Angeles (USC), Kansas City (KUMC) and Dallas (UT‐SWMC) has been quantifying the dynamics of CO2 vasoreactivity in MCI/AD patients and cognitively normal controls under spontaneous resting conditions. …
View article: Lower Physical Activity Is Associated With Objective But Not Subjective Cognitive Impairment In Older Adults Without Dementia
Lower Physical Activity Is Associated With Objective But Not Subjective Cognitive Impairment In Older Adults Without Dementia Open
Background Physical activity has been associated with better performance on cognitive assessments for older adults in both observational and interventional studies. Older adults who exercise the 150 minutes a week recommended by the Physic…
View article: Larger hippocampal and temporal lobe volume may associate with early rapid forgetting in cognitively healthy individuals with a predisposition to Alzheimer’s disease
Larger hippocampal and temporal lobe volume may associate with early rapid forgetting in cognitively healthy individuals with a predisposition to Alzheimer’s disease Open
Background Growing need exists to link volumetric brain analysis to functional cognitive performance in early prediction of Alzheimer’s disease. Method In cognitively healthy older adults ( N = 40; M age = 71.7±7.7 years), we established a…
View article: Elevated Carotid Pulse Wave Velocity is associated with Cognitive Impairment and Cerebral Amyloid Deposition: A Phase‐Contrast MRI Study
Elevated Carotid Pulse Wave Velocity is associated with Cognitive Impairment and Cerebral Amyloid Deposition: A Phase‐Contrast MRI Study Open
Background Previous studies have indicated that arterial stiffness could play an important role in the AD pathology. Arterial stiffness is typically measured by pulse wave velocity (PWV) from central and peripheral arteries. Recent work ha…
View article: Association of urine dicarboxylic acid levels with intracranial volume–normalized brain regions and with white matter hypo‐intensities
Association of urine dicarboxylic acid levels with intracranial volume–normalized brain regions and with white matter hypo‐intensities Open
Background Non‐invasive molecules related to AD imaging biomarkers can reveal disease mechanisms and may help in the mass screening of an aging population. Our study aims to determine if urine dicarboxylic acids (DCA) that changed in AD ar…
View article: Alzheimer’s Related Neurodegeneration Mediates Air Pollution Effects on Medial Temporal Lobe Atrophy
Alzheimer’s Related Neurodegeneration Mediates Air Pollution Effects on Medial Temporal Lobe Atrophy Open
Exposure to ambient air pollution, especially particulate matter with aerodynamic diameter <2.5 μm (PM 2.5 ) and nitrogen dioxide (NO 2 ), are environmental risk factors for Alzheimer’s disease and related dementia. The medial temporal lob…
View article: Association between late-life air pollution exposure and medial temporal lobe atrophy in older women
Association between late-life air pollution exposure and medial temporal lobe atrophy in older women Open
Background Ambient air pollution exposures increase risk for Alzheimer’s disease (AD) and related dementias, possibly due to structural changes in the medial temporal lobe (MTL). However, existing MRI studies examining exposure effects on …
View article: Use of the Spanish English Neuropsychological Assessment Scale in older adult Latines and those at risk for autosomal dominant Alzheimer’s disease
Use of the Spanish English Neuropsychological Assessment Scale in older adult Latines and those at risk for autosomal dominant Alzheimer’s disease Open
Verbal delayed recall and object naming measures appear to be most sensitive to age-related changes in older adult samples and mutation-related changes in distinguishing ADAD carriers from non-carriers. Future research should examine the s…
View article: Association Between Self- and Proxy-Reported Depression and Quality of Life in Mild-Moderate Alzheimer's Disease
Association Between Self- and Proxy-Reported Depression and Quality of Life in Mild-Moderate Alzheimer's Disease Open
View article: White matter hyperintensity volume modifies the association between CSF vascular inflammatory biomarkers and regional FDG-PET along the Alzheimer’s disease continuum
White matter hyperintensity volume modifies the association between CSF vascular inflammatory biomarkers and regional FDG-PET along the Alzheimer’s disease continuum Open
View article: Carotid pulse wave velocity measured using a fast single‐slice oblique‐sagittal phase‐contrast MRI is associated with cognitive impairment
Carotid pulse wave velocity measured using a fast single‐slice oblique‐sagittal phase‐contrast MRI is associated with cognitive impairment Open
Background Arterial stiffness is one of the earliest markers of vascular dysfunction 1 . Elevated arterial stiffness leads to the transmission of excessive pulsations into the downstream microvasculature, which may be linked to cognitive i…
View article: The relationship of history of psychiatric and substance use disorders on risk of dementia among racial and ethnic groups in the United States
The relationship of history of psychiatric and substance use disorders on risk of dementia among racial and ethnic groups in the United States Open
Introduction Dementia is characterized by significant declines in cognitive, physical, social, and behavioral functioning, and includes multiple subtypes that differ in etiology. There is limited evidence of the influence of psychiatric an…
View article: Decreased functional connectivity is associated with increased levels of Cerebral Spinal Fluid soluble-PDGFRβ, a marker of blood brain barrier breakdown, in older adults
Decreased functional connectivity is associated with increased levels of Cerebral Spinal Fluid soluble-PDGFRβ, a marker of blood brain barrier breakdown, in older adults Open
Resting-state functional connectivity (FC) is suggested to be cross-sectionally associated with both vascular burden and Alzheimer's disease (AD) pathology. For instance, studies in pre-clinical AD subjects have shown increases of cerebral…
View article: Microstructural mapping of dentate gyrus pathology in Alzheimer’s disease: A 16.4 Tesla MRI study
Microstructural mapping of dentate gyrus pathology in Alzheimer’s disease: A 16.4 Tesla MRI study Open
The dentate gyrus (DG) is an integral portion of the hippocampal formation, and it is composed of three layers. Quantitative magnetic resonance (MR) imaging has the capability to map brain tissue microstructural properties which can be exp…
View article: The association between white matter hyperintensities and amyloid and tau deposition
The association between white matter hyperintensities and amyloid and tau deposition Open
View article: White Matter Hyperintensity Volume Modifies the Association between CSF Vascular Inflammatory Biomarkers and Regional FDG-PET Along the Alzheimer's Disease Continuum
White Matter Hyperintensity Volume Modifies the Association between CSF Vascular Inflammatory Biomarkers and Regional FDG-PET Along the Alzheimer's Disease Continuum Open