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View article: Biomarkers of Underlying Alzheimer Disease Pathology & Neuro-inflammation, But Not Peripheral Inflammation, Predict Disease Clinically-Significant Progression in Mild-Moderate Alzheimer's Disease
Biomarkers of Underlying Alzheimer Disease Pathology & Neuro-inflammation, But Not Peripheral Inflammation, Predict Disease Clinically-Significant Progression in Mild-Moderate Alzheimer's Disease Open
Background Novel prognostic biomarkers are urgently needed in older adults with Alzheimer Disease (AD). Peripheral inflammation, systemic inflammatory events (SIEs) and delirium are increasingly recognised as AD risk factors, but their imp…
View article: Clinical performance of the fully automated Lumipulse plasma p‐tau217 assay in mild cognitive impairment and mild dementia
Clinical performance of the fully automated Lumipulse plasma p‐tau217 assay in mild cognitive impairment and mild dementia Open
Introduction Plasma phosphorylated tau (p‐tau)217 is a leading blood‐biomarker for the detection of amyloid beta (Aβ) pathology. We assessed the performance of a fully automated plasma p‐tau217 immunoassay to detect Aβ pathology in mild co…
View article: Brain Health Interventions in Clinical Practice: A Framework for Implementation and Provisional Results from Ireland’s first Brain Health Clinic
Brain Health Interventions in Clinical Practice: A Framework for Implementation and Provisional Results from Ireland’s first Brain Health Clinic Open
Background At a population level, it is acknowledged that around 40% of all causes of dementia are attributable to twelve potentially modifiable risk factors (MRFs) identified by The Lancet Commission on Dementia Prevention. Preventative m…
View article: Projected Annual Lecanemab Treatment Eligibility in an Irish Regional Specialist Memory Clinic
Projected Annual Lecanemab Treatment Eligibility in an Irish Regional Specialist Memory Clinic Open
Objectives The advent of Disease Modifying Therapies (DMTs) for the treatment of Alzheimer's Disease (AD) has the potential to transform the lives of those with early AD. Timely identification of eligible patients is needed to ensure treat…
View article: Circulating Interleukin-17A is associated with executive function in middle aged adults with and without type 2 diabetes
Circulating Interleukin-17A is associated with executive function in middle aged adults with and without type 2 diabetes Open
Midlife cardiovascular risk factors such as Type 2 Diabetes (T2DM) and obesity are associated with the later development of cognitive impairment and dementia. Systemic inflammation is postulated as a crucial mechanism, yet there are few st…
View article: Investigating Transcutaneous Vagus Nerve Stimulation in Amnestic Mild Cognitive Impairment
Investigating Transcutaneous Vagus Nerve Stimulation in Amnestic Mild Cognitive Impairment Open
Background New treatments are urgently needed for individuals with Mild Cognitive Impairment (MCI) - in particular for those with amnestic MCI, of whom a high proportion have underlying Alzheimer's Disease (AD). Transcutaneous Vagus Nerve …
View article: Plasma P-tau217 Demonstrates Excellent Diagnostic and Prognostic Performance as a Blood-Based Biomarker for Alzheimer Disease in Older Adults
Plasma P-tau217 Demonstrates Excellent Diagnostic and Prognostic Performance as a Blood-Based Biomarker for Alzheimer Disease in Older Adults Open
Background There has been unprecedented progress in the development of blood-based biomarkers (BBMs such as p-tau217 to detect Alzheimer Disease (AD) pathology – characterised by the accumulation of Amyloid-Beta (Aβ) and hyper-phosphorylat…
View article: Spatiotemporal Gait Characteristics and Neuropsychological Performance in Midlife
Spatiotemporal Gait Characteristics and Neuropsychological Performance in Midlife Open
Background Midlife risk factors such as Type 2 Diabetes Mellitus (T2DM) confer a significantly increased risk of cognitive impairment in later life, with executive function, memory and attention domains often affected first. Spatiotemporal…
View article: Discrete Relationships between Spatiotemporal Gait Characteristics and Domain-Specific Neuropsychological Performance in Midlife
Discrete Relationships between Spatiotemporal Gait Characteristics and Domain-Specific Neuropsychological Performance in Midlife Open
Midlife risk factors such as type 2 diabetes mellitus (T2DM) confer a significantly increased risk of cognitive impairment in later life with executive function, memory, and attention domains often affected first. Spatiotemporal gait chara…
View article: Navigating the future of Alzheimer’s care in Ireland - a service model for disease-modifying therapies in small and medium-sized healthcare systems
Navigating the future of Alzheimer’s care in Ireland - a service model for disease-modifying therapies in small and medium-sized healthcare systems Open
Background A new class of antibody-based drug therapy with the potential for disease modification is now available for Alzheimer’s disease (AD). However, the complexity of drug eligibility, administration, cost, and safety of such disease …
View article: New horizons in the diagnosis and management of Alzheimer’s Disease in older adults
New horizons in the diagnosis and management of Alzheimer’s Disease in older adults Open
Alzheimer’s Disease (ad) is the most common cause of dementia, and in addition to cognitive decline, it directly contributes to physical frailty, falls, incontinence, institutionalisation and polypharmacy in older adults. Increasing availa…
View article: Protocol for the Tallaght University Hospital Institute for Memory and Cognition-Biobank for Research in Ageing and Neurodegeneration
Protocol for the Tallaght University Hospital Institute for Memory and Cognition-Biobank for Research in Ageing and Neurodegeneration Open
Introduction Alzheimer’s disease and other dementias affect >50 million individuals globally and are characterised by broad clinical and biological heterogeneity. Cohort and biobank studies have played a critical role in advancing the unde…
View article: Neuromodulation for Mild Cognitive Impairment: Improvements in Spatial Navigation and Associative Memory with Acute Transcutaneous Vagus Nerve Stimulation: VINCI‐AD
Neuromodulation for Mild Cognitive Impairment: Improvements in Spatial Navigation and Associative Memory with Acute Transcutaneous Vagus Nerve Stimulation: VINCI‐AD Open
Background New therapeutic strategies to treat Mild Cognitive Impairment (MCI) are urgently needed. Transcutaneous Vagus Nerve Stimulation (tVNS) is a neuromodulation technique which uses a handheld device to peripherally stimulate the aff…
View article: Navigating the future of Alzheimer's care in Ireland - A service model for disease-modifying therapies in small and medium-sized healthcare systems
Navigating the future of Alzheimer's care in Ireland - A service model for disease-modifying therapies in small and medium-sized healthcare systems Open
Background A new class of antibody-based drug therapy with the potential for disease modification is becoming available for Alzheimer’s disease (AD). However, the complexity of drug eligibility, administration, cost, and safety of disease …
View article: 110 Identification of Urinary Incontinence through Comprehensive Geriatric Assessment among an integrated care programme of older persons population
110 Identification of Urinary Incontinence through Comprehensive Geriatric Assessment among an integrated care programme of older persons population Open
Background Urinary incontinence (UI) is an under-reported and treatable condition, associated with reduced quality of life. The Integrated Care programme of Older Persons (ICPOP) supports people with complex care needs in their home. There…
View article: An Update on Apathy in Alzheimer’s Disease
An Update on Apathy in Alzheimer’s Disease Open
Apathy is a complex multi-dimensional syndrome that affects up to 70% of individuals with Alzheimer’s disease (AD). Whilst many frameworks to define apathy in AD exist, most include loss of motivation or goal-directed behaviour as the cent…
View article: 356 OLDER PERSONS LIVING ALONE IN INTEGRATED CARE: DEPRESSION, LOW EDUCATION AND FUEL POVERTY
356 OLDER PERSONS LIVING ALONE IN INTEGRATED CARE: DEPRESSION, LOW EDUCATION AND FUEL POVERTY Open
Background An important consequence of population ageing has been the increasing number of older adults who live alone. According to TILDA data, older adults with the lowest levels of education tend to experience most social isolation and …
View article: 341 ROLE AND TOLERANCE OF LUMBAR PUNCTURE TESTS FOR CSF BIOMARKERS OF ALZHEIMER'S DEMENTIA IN A SPECIALIZED MEMORY CLINIC
341 ROLE AND TOLERANCE OF LUMBAR PUNCTURE TESTS FOR CSF BIOMARKERS OF ALZHEIMER'S DEMENTIA IN A SPECIALIZED MEMORY CLINIC Open
Background People living with mild cognitive symptoms often require clarity on the underlying aetiology of their symptoms, and with the advent of disease modifying therapies for Alzheimer’s Disease (AD), establishing diagnostic accuracy fo…
View article: 219 A SOLITARY AWARENESS - PROFILING TIME TO RECOGNITION OF MEMORY LOSS IN A TERTIARY MEMORY SERVICE
219 A SOLITARY AWARENESS - PROFILING TIME TO RECOGNITION OF MEMORY LOSS IN A TERTIARY MEMORY SERVICE Open
Background Approximately 64,000 people live with dementia in Ireland with expected increases to 150,000 by 2045. Best practice recommends that patients benefit from timely diagnosis. Whilst the presence of cognitive impairment should promp…
View article: 17 CROSS-SECTIONAL AND LONGITUDINAL RELATIONSHIPS BETWEEN MOBILITY, NEUROPSYCHOLOGICAL PERFORMANCE AND FALLS IN COMMUNITY-DWELLING OLDER ADULTS: DATA FROM TUDA
17 CROSS-SECTIONAL AND LONGITUDINAL RELATIONSHIPS BETWEEN MOBILITY, NEUROPSYCHOLOGICAL PERFORMANCE AND FALLS IN COMMUNITY-DWELLING OLDER ADULTS: DATA FROM TUDA Open
Background Impaired mobility is associated with incident cognitive impairment and dementia. However, the complex bi-directional temporal relationships between subtle impairments in neuropsychological performance, mobility trajectories and …
View article: Potential eligibility for Aducanumab therapy in an Irish specialist cognitive service—Utilising cerebrospinal fluid biomarkers and appropriate use criteria
Potential eligibility for Aducanumab therapy in an Irish specialist cognitive service—Utilising cerebrospinal fluid biomarkers and appropriate use criteria Open
Objectives Aducanumab is a monoclonal antibody which has recently been licenced for use by the food and drug administration for treatment of patients with mild cognitive impairment due to Alzheimer's disease (AD) or mild AD dementia. Appro…
View article: “The Wandering Nerve Linking Heart and Mind” – The Complementary Role of Transcutaneous Vagus Nerve Stimulation in Modulating Neuro-Cardiovascular and Cognitive Performance
“The Wandering Nerve Linking Heart and Mind” – The Complementary Role of Transcutaneous Vagus Nerve Stimulation in Modulating Neuro-Cardiovascular and Cognitive Performance Open
The vagus nerve is the longest nerve in the human body, providing afferent information about visceral sensation, integrity and somatic sensations to the CNS via brainstem nuclei to subcortical and cortical structures. Its efferent arm infl…
View article: 1062 GAIT SPEED AND EXECUTIVE PERFORMANCE IN PEOPLE WITH MILD COGNITIVE IMPAIRMENT
1062 GAIT SPEED AND EXECUTIVE PERFORMANCE IN PEOPLE WITH MILD COGNITIVE IMPAIRMENT Open
Introduction The Motoric Cognitive Risk Syndrome has highlighted the link between cognitive and motor performance, and the associated incremental higher risk of developing dementia. There is considerable debate regarding what aspects of co…
View article: 1003 UTILITY AND TOLERABILITY OF CSF <scp>AD</scp> BIOMARKERS IN A GERIATRICIAN-LED MEMORY SERVICE
1003 UTILITY AND TOLERABILITY OF CSF <span>AD</span> BIOMARKERS IN A GERIATRICIAN-LED MEMORY SERVICE Open
Introduction People with mild cognitive symptoms often require diagnostic clarity and with the advent of disease modifying therapies for Alzheimer’s disease (ad), establishing diagnostic accuracy for amyloid and tau pathology in ad will be…
View article: 965 INTEGRATED CARE HOME OWNERSHIP AND FINANCIAL VULNERABILITY
965 INTEGRATED CARE HOME OWNERSHIP AND FINANCIAL VULNERABILITY Open
Introduction Lack of home ownership is associated higher rates of mental and physical ill-health and death1. According to longitudinal data in Ireland, 92% of persons aged 75 and over own their homes outright with approximately 8% living i…