Helena Harder
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View article: Correction: Palliative long-term abdominal drains vs. large volume paracentesis for refractory ascites secondary to cirrhosis: protocol for a definitive randomised controlled trial (REDUCe2 study)
Correction: Palliative long-term abdominal drains vs. large volume paracentesis for refractory ascites secondary to cirrhosis: protocol for a definitive randomised controlled trial (REDUCe2 study) Open
View article: Palliative long-term abdominal drains vs. large volume paracentesis for refractory ascites secondary to cirrhosis: protocol for a definitive randomised controlled trial (REDUCe2 study)
Palliative long-term abdominal drains vs. large volume paracentesis for refractory ascites secondary to cirrhosis: protocol for a definitive randomised controlled trial (REDUCe2 study) Open
View article: Palliative Long-term Abdominal Drains vs. Large Volume Paracentesis for refractory ascites secondary to cirrhosis: study protocol for a randomised controlled trial
Palliative Long-term Abdominal Drains vs. Large Volume Paracentesis for refractory ascites secondary to cirrhosis: study protocol for a randomised controlled trial Open
Background Ascites remains the most common complication of cirrhosis and a frequent reason for hospitalisation in advanced chronic liver disease (ACLD). Ascites is associated with significant symptom burden, caregiver workload and poor hea…
View article: Incidence and management of diarrhoea associated with abemaciclib and endocrine therapy for hormone-receptor positive, HER2-negative metastatic breast cancer: the UK patients’ experiences
Incidence and management of diarrhoea associated with abemaciclib and endocrine therapy for hormone-receptor positive, HER2-negative metastatic breast cancer: the UK patients’ experiences Open
View article: Exploring the real-world experience of abemaciclib treatment for HR +, HER2 − metastatic breast cancer—a qualitative analysis of the IMPACTOR study
Exploring the real-world experience of abemaciclib treatment for HR +, HER2 − metastatic breast cancer—a qualitative analysis of the IMPACTOR study Open
Purpose The IMPACTOR study (IMPact of AbemaCiclib on patienTs’ rOles and Responsibilities–ISRCTN17281696) was developed to capture experiences of women with MBC being treated with abemaciclib in a real-world setting. The primary aim was to…
View article: Uptake, utility and resource requirements of a genetic counselling telephone helpline within the BRCA-DIRECT digital pathway for mainstreamed BRCA testing in patients with breast cancer
Uptake, utility and resource requirements of a genetic counselling telephone helpline within the BRCA-DIRECT digital pathway for mainstreamed BRCA testing in patients with breast cancer Open
Background We trialled the first digital pathway (BRCA-DIRECT) aiming to improve capacity for mainstreamed BRCA testing within UK breast oncology services. Patients received standardised digital pretest information, with saliva sampling an…
View article: BRCA-DIRECT digital pathway for diagnostic germline genetic testing within a UK breast oncology setting: a randomised, non-inferiority trial
BRCA-DIRECT digital pathway for diagnostic germline genetic testing within a UK breast oncology setting: a randomised, non-inferiority trial Open
View article: BRCA-DIRECT digital pathway for diagnostic germline genetic testing within a UK breast oncology setting: a randomised, non-inferiority trial
BRCA-DIRECT digital pathway for diagnostic germline genetic testing within a UK breast oncology setting: a randomised, non-inferiority trial Open
BACKGROUND Genetic testing to identify germline high-risk pathogenic variants in breast cancer susceptibility genes is an important step in the breast cancer diagnostic pathway. To expand capacity and reduce turnaround time, testing is inc…
View article: Symptomatic presentation of cancer in primary care: a scoping review of patients’ experiences and needs during the cancer diagnostic pathway
Symptomatic presentation of cancer in primary care: a scoping review of patients’ experiences and needs during the cancer diagnostic pathway Open
Objectives The objective was to map the experiences and needs of patients presenting with symptoms of suspected cancer in the primary care interval (from when they first present to primary care to their first appointment or referral to a s…
View article: Improving outcomes for women aged 70 years or above with early breast cancer: research programme including a cluster RCT
Improving outcomes for women aged 70 years or above with early breast cancer: research programme including a cluster RCT Open
Background In breast cancer management, age-related practice variation is widespread, with older women having lower rates of surgery and chemotherapy than younger women, based on the premise of reduced treatment tolerance and benefit. This…
View article: Knowledge, awareness, attitudes and screening practices towards breast and cervical cancer among women in Nepal: a scoping review
Knowledge, awareness, attitudes and screening practices towards breast and cervical cancer among women in Nepal: a scoping review Open
Aim Breast and cervical cancers have emerged as major global health challenges and disproportionately affect women in low- and middle-income countries, including Nepal. This scoping review aimed to map the knowledge, attitudes and screenin…
View article: Process evaluation of the Bridging the Age Gap in Breast Cancer decision support intervention cluster randomised trial
Process evaluation of the Bridging the Age Gap in Breast Cancer decision support intervention cluster randomised trial Open
View article: Bridging The Age Gap: observational cohort study of effects of chemotherapy and trastuzumab on recurrence, survival and quality of life in older women with early breast cancer
Bridging The Age Gap: observational cohort study of effects of chemotherapy and trastuzumab on recurrence, survival and quality of life in older women with early breast cancer Open
View article: Bridging the age gap in breast cancer: cluster randomized trial of two decision support interventions for older women with operable breast cancer on quality of life, survival, decision quality, and treatment choices
Bridging the age gap in breast cancer: cluster randomized trial of two decision support interventions for older women with operable breast cancer on quality of life, survival, decision quality, and treatment choices Open
Background Rates of surgery and adjuvant therapy for breast cancer vary widely between breast units. This may contribute to differences in survival. This cluster RCT evaluated the impact of decision support interventions (DESIs) for older …
View article: Cluster randomised trial to evaluate the clinical benefits of decision support interventions for older women with operable breast cancer
Cluster randomised trial to evaluate the clinical benefits of decision support interventions for older women with operable breast cancer Open
View article: Observational cohort study to determine the degree and causes of variation in the rate of surgery or primary endocrine therapy in older women with operable breast cancer
Observational cohort study to determine the degree and causes of variation in the rate of surgery or primary endocrine therapy in older women with operable breast cancer Open
View article: The development and initial evaluation of the Diarrhoea Management Diary (DMD) in patients with metastatic breast cancer
The development and initial evaluation of the Diarrhoea Management Diary (DMD) in patients with metastatic breast cancer Open
View article: Sexual functioning in 4,418 postmenopausal women participating in UKCTOCS: a qualitative free-text analysis
Sexual functioning in 4,418 postmenopausal women participating in UKCTOCS: a qualitative free-text analysis Open
Objective: Sexual well-being can contribute significantly to the overall quality of women's lives. This qualitative study aimed to examine sexual activity, functioning, and satisfaction in a large sample of postmenopausal women from the UK…
View article: Efficient development and usability testing of decision support interventions for older women with breast cancer
Efficient development and usability testing of decision support interventions for older women with breast cancer Open
It was possible to use a template DESI to efficiently create a second prototype for a different treatment option (chemotherapy). Both DESIs were acceptable and considered helpful to support/augment consultations. Development of acceptable …
View article: Cancer survivors’ experiences of a community-based cancer-specific exercise programme: results of an exploratory survey
Cancer survivors’ experiences of a community-based cancer-specific exercise programme: results of an exploratory survey Open
View article: A user-centred approach to developing bWell, a mobile app for arm and shoulder exercises after breast cancer treatment
A user-centred approach to developing bWell, a mobile app for arm and shoulder exercises after breast cancer treatment Open
View article: Bridging the age gap in breast cancer: evaluation of decision support interventions for older women with operable breast cancer: protocol for a cluster randomised controlled trial
Bridging the age gap in breast cancer: evaluation of decision support interventions for older women with operable breast cancer: protocol for a cluster randomised controlled trial Open
Introduction While breast cancer outcomes are improving steadily in younger women due to advances in screening and improved therapies, there has been little change in outcomes among the older age group. It is inevitable that comorbidities/…
View article: A feasibility study exploring the role of pre-operative assessment when examining the mechanism of ‘chemo-brain’ in breast cancer patients
A feasibility study exploring the role of pre-operative assessment when examining the mechanism of ‘chemo-brain’ in breast cancer patients Open
View article: A study of the validity and the reliability of the Geriatric Anxiety Inventory in screening for anxiety after stroke in older inpatients
A study of the validity and the reliability of the Geriatric Anxiety Inventory in screening for anxiety after stroke in older inpatients Open
Objectives: To investigate the validity and reliability of the Geriatric Anxiety Inventory in screening for anxiety in older inpatients post-stroke. Design: Longitudinal. Subjects: A total of 81 inpatients with stroke aged 65 years or olde…
View article: P084 Feasibility study to examine underlying mechanisms for “Chemo Fog”
P084 Feasibility study to examine underlying mechanisms for “Chemo Fog” Open
P084 Feasibility study to examine underlying mechanisms for “Chemo Fog” V. Jenkins *, H. Harder, M. Cercingani, H. Whiteley-Jones, R. Thwaites, L. Mullen, N. Harrison, K. Davies, C. Zammit, S. Sacre. SHORE-C Brighton & Sussex Medical Schoo…