Hélène Coppin
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View article: A human anti-matriptase-2 antibody limits iron overload, α-globin aggregates, and splenomegaly in β-thalassemic mice
A human anti-matriptase-2 antibody limits iron overload, α-globin aggregates, and splenomegaly in β-thalassemic mice Open
Iron plays a major role in the deterioration of β-thalassemia. Indeed, the high levels of transferrin saturation and iron delivered to erythroid progenitors are associated with production of α-globin precipitates that negatively affect ery…
View article: NEW INSIGHTS INTO THE HEPATIC IRON PHENOTYPE OF BMP6 KNOCKOUT MICE
NEW INSIGHTS INTO THE HEPATIC IRON PHENOTYPE OF BMP6 KNOCKOUT MICE Open
Objective Bmp6 knockout (KO) mice progressively accumulate a significant amount of iron in their liver as they age due to a defect in hepcidin (Hamp) expression and an upregulation of the iron exporter ferroportin (Fpn). In this study, we …
View article: Uropathogenic E. coli induces DNA damage in the bladder
Uropathogenic E. coli induces DNA damage in the bladder Open
Urinary tract infections (UTIs) are among the most common outpatient infections, with a lifetime incidence of around 60% in women. We analysed urine samples from 223 patients with community-acquired UTIs and report the presence of the clea…
View article: Endoplasmic reticulum stress controls iron metabolism through TMPRSS6 repression and hepcidin mRNA stabilization by RNA-binding protein HuR
Endoplasmic reticulum stress controls iron metabolism through TMPRSS6 repression and hepcidin mRNA stabilization by RNA-binding protein HuR Open
International audience
View article: Uropathogenic<i>E. coli</i>induces DNA damage in the bladder
Uropathogenic<i>E. coli</i>induces DNA damage in the bladder Open
Urinary tract infections (UTIs) are among the most common outpatient infections, with a lifetime incidence of around 60% in women. We analysed urine samples from 223 patients with community-acquired UTIs and report the presence of a metabo…
View article: LJ000328, a novel ALK2/3 kinase inhibitor, represses hepcidin and significantly improves the phenotype of IRIDA
LJ000328, a novel ALK2/3 kinase inhibitor, represses hepcidin and significantly improves the phenotype of IRIDA Open
International audience
View article: Spleen iron, molybdenum, and manganese concentrations are coregulated in hepcidin‐deficient and secondary iron overload models in mice
Spleen iron, molybdenum, and manganese concentrations are coregulated in hepcidin‐deficient and secondary iron overload models in mice Open
Iron excess increases the hepatic expression of hepcidin, the systemic iron metabolism regulator that favors iron sequestration in the spleen. Genetic iron overload related to hepcidin insufficiency decreases the spleen iron concentration …
View article: 1007 Analysis of cutaneous microbiota between two age-group of Caucasian women
1007 Analysis of cutaneous microbiota between two age-group of Caucasian women Open
View article: Deletion of BMP6 worsens the phenotype of HJV-deficient mice and attenuates hepcidin levels reached after LPS challenge
Deletion of BMP6 worsens the phenotype of HJV-deficient mice and attenuates hepcidin levels reached after LPS challenge Open
Key Points Loss of Bmp6 further represses hepcidin expression in the liver of Hjv knockout mice and markedly worsens the iron phenotype of females. Induction of hepcidin by LPS is not prevented by lack of Bmp6 and/or Hjv but its level post…
View article: An essential role for the bmp-smad pathway in hepcidin induction during ER stress and NAFLD/NASH
An essential role for the bmp-smad pathway in hepcidin induction during ER stress and NAFLD/NASH Open
An essential role for the bmp-smad pathway in hepcidin induction during ER stress and NAFLD/NASH. 7. Congress of the International Biolron Society (IBIS)
View article: Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B
Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B Open
International audience
View article: Erythroferrone contributes to hepcidin repression in a mouse model of malarial anemia
Erythroferrone contributes to hepcidin repression in a mouse model of malarial anemia Open
Malaria, a major global health challenge worldwide, is accompanied by a severe anemia secondary to hemolysis and increased erythrophagocytosis. Iron is an essential functional component of erythrocyte hemoglobin and its availability is con…
View article: Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice
Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice Open
Key Points Hyperactivation of the BMP-SMAD pathway blunts EPO-mediated hepcidin inhibition. Lack of BMP-SMAD pathway inhibition by matriptase-2 abrogates the ERFE-mediated hepcidin suppression in response to EPO.
View article: Targeting iron-mediated retinal degeneration by local delivery of transferrin
Targeting iron-mediated retinal degeneration by local delivery of transferrin Open
View article: Differing impact of the deletion of hemochromatosis‐associated molecules HFE and transferrin receptor‐2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin
Differing impact of the deletion of hemochromatosis‐associated molecules HFE and transferrin receptor‐2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin Open
Hereditary hemochromatosis, which is characterized by inappropriately low levels of hepcidin, increased dietary iron uptake, and systemic iron accumulation, has been associated with mutations in the HFE, transferrin receptor‐2 (TfR2), and …