Hélène Duplan
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View article: 0739 Prevention of hev-blue light-induced skin lipofuscin accumulation with a triasorb-containing formulation
0739 Prevention of hev-blue light-induced skin lipofuscin accumulation with a triasorb-containing formulation Open
View article: Scalp Microbiome Dynamics Can Contribute to the Clinical Effect of a Novel Antiseborrheic Dermatitis Shampoo Containing Patented Antifungal Actives: A Randomized Controlled Study
Scalp Microbiome Dynamics Can Contribute to the Clinical Effect of a Novel Antiseborrheic Dermatitis Shampoo Containing Patented Antifungal Actives: A Randomized Controlled Study Open
NCT06578962 (retrospectively registered on 28 August 2024).
View article: Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging
Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging Open
View article: Effects of solar radiations on stratum corneum hydration: Part <scp>II</scp>, protective action of solar filters
Effects of solar radiations on stratum corneum hydration: Part <span>II</span>, protective action of solar filters Open
The skin surface lipids (SSLs) film, composed of sebum and keratinocyte membrane lipids, is crucial to the barrier function of the stratum corneum (SC). The first part of this study investigated the impact of solar radiation on the SC base…
View article: The facial microbiome and metabolome across different geographic regions
The facial microbiome and metabolome across different geographic regions Open
Facial skin is more exposed to the outside environment, and it is usually affected by environmental factors. Characterization of the skin microbiome and metabolome of individuals from different geographic regions will help to understand th…
View article: A Comprehensive Comparison of Tissue Processing Methods for High-Quality MALDI Imaging of Lipids in Reconstructed Human Epidermis
A Comprehensive Comparison of Tissue Processing Methods for High-Quality MALDI Imaging of Lipids in Reconstructed Human Epidermis Open
Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) has become an important tool for skin analysis, as it allows the simultaneous detection and localization of diverse molecular species within a sample. The …
View article: Metabolomics analysis of plasma with an extended coverage using two-dimensional liquid chromatography mass spectrometry
Metabolomics analysis of plasma with an extended coverage using two-dimensional liquid chromatography mass spectrometry Open
International audience
View article: A multi-omic approach to understand solar exposure impact on skin ecosystem and evaluate a new SPF50+ sunscreen efficacy
A multi-omic approach to understand solar exposure impact on skin ecosystem and evaluate a new SPF50+ sunscreen efficacy Open
International audience
View article: Effects of solar radiations on stratum corneum hydration: Part I, protective role of skin surface lipids
Effects of solar radiations on stratum corneum hydration: Part I, protective role of skin surface lipids Open
This study used Raman spectroscopy to develop a new approach to evaluate the effects of solar radiation on the stratum corneum (SC). The method measures the SC's hydration and dehydration kinetics by calculating the vOH/vCH ratio to monito…
View article: Characterization of triglycerides photooxidation under solar radiations: A stepwise Raman study
Characterization of triglycerides photooxidation under solar radiations: A stepwise Raman study Open
Triglycerides (TGs) are one of the main components of the glycerolipid family. Their main task in cells is to store excess fatty acids. TG energy storage is mainly concentrated in adipocytes. TGs and free fatty acids constitute the majorit…
View article: Recent advances in understanding inflammatory acne: Deciphering the relationship between<i>Cutibacterium acnes</i>and Th17 inflammatory pathway
Recent advances in understanding inflammatory acne: Deciphering the relationship between<i>Cutibacterium acnes</i>and Th17 inflammatory pathway Open
Acne vulgaris is a common chronic inflammatory skin disease of the pilosebaceous units. Four factors contribute to acne: hyperseborrhea and dysseborrhea, follicular hyperkeratinisation, skin microbiome dysbiosis and local immuno‐inflammati…
View article: <i>Myrtus communis</i> and Celastrol enriched plant cell culture extracts control together the pivotal role of <i>Cutibacterium acnes</i> and inflammatory pathways in acne
<i>Myrtus communis</i> and Celastrol enriched plant cell culture extracts control together the pivotal role of <i>Cutibacterium acnes</i> and inflammatory pathways in acne Open
Introduction Acne is a multifactorial inflammatory disease of the pilosebaceous unit in which Cutibacterium acnes is one of the main triggers. A strong predominance of C. acnes phylotype IA1 is present in acne skin with higher biofilm orga…
View article: Skin surface lipids photo‐oxidation: A vibrational spectroscopy study
Skin surface lipids photo‐oxidation: A vibrational spectroscopy study Open
Skin surface lipid (SSL) film is a mixture of sebum and epidermal lipids protecting the skin from the effects of the environment such as solar radiation. SSLs are a suitable target and scavenger for all reactive oxygen species (ROS) genera…
View article: Specific protection of sensitive skin against environmental stress by maintenance and improvement of barrier function
Specific protection of sensitive skin against environmental stress by maintenance and improvement of barrier function Open
Background Sensitive skin is a common condition that can severely impact quality of life. Several mechanisms are thought to be involved, including those affecting the skin barrier function, hydration and skin innervation. Objectives To inv…
View article: Que peut apporter la chromatographie liquide bidimensionnelle en heart-cutting à la métabolomique non ciblée ?
Que peut apporter la chromatographie liquide bidimensionnelle en heart-cutting à la métabolomique non ciblée ? Open
International audience
View article: 356 Investigating for Extracellular Vesicles miRNA involved in the dialog between dermis and epidermis, as potential targets for antiaging interventions in skin
356 Investigating for Extracellular Vesicles miRNA involved in the dialog between dermis and epidermis, as potential targets for antiaging interventions in skin Open
View article: 242 High potency activities of a Tangerine extract to target Rosaceae imprints
242 High potency activities of a Tangerine extract to target Rosaceae imprints Open
View article: 373 Effect of Haritaki fruit extract on Senescence Associated Secretory Phenotype and miR 30a-3p over-expression in senescent dermal fibroblasts’ extracellular vesicles
373 Effect of Haritaki fruit extract on Senescence Associated Secretory Phenotype and miR 30a-3p over-expression in senescent dermal fibroblasts’ extracellular vesicles Open
View article: 153 Effect of AVENE thermal spring water on skin barrier mechanical properties by atomic force microscopy
153 Effect of AVENE thermal spring water on skin barrier mechanical properties by atomic force microscopy Open
View article: Cosmetics Europe evaluation of 6 in silico skin penetration models
Cosmetics Europe evaluation of 6 in silico skin penetration models Open
The ADME TF aims to develop in silico skin penetration models using in vitro human skin penetration data for 25 chemicals solubilized in wataer. Since there are widely differing opinions on different in silico models, we evaluated 3 open s…
View article: 600 Evaluation of anti-hairloss shampoo through in vitro activity in human hair follicule dermal papilla cells and sensorial study
600 Evaluation of anti-hairloss shampoo through in vitro activity in human hair follicule dermal papilla cells and sensorial study Open
View article: Comprehensive characterization of the structure and properties of human stratum corneum relating to barrier function and skin hydration: modulation by a moisturizer formulation
Comprehensive characterization of the structure and properties of human stratum corneum relating to barrier function and skin hydration: modulation by a moisturizer formulation Open
The stratum corneum (SC) is key in the maintenance of the biomechanical barrier and hydration of skin. Our previous investigations showed beneficial effects of a combination of emollients on water capture and retention and protein and lipi…
View article: Partition coefficient and diffusion coefficient determinations of 50 compounds in human intact skin, isolated skin layers and isolated stratum corneum lipids
Partition coefficient and diffusion coefficient determinations of 50 compounds in human intact skin, isolated skin layers and isolated stratum corneum lipids Open
A standard protocol was used to determine partition (K) and diffusion (D) coefficients in dermatomed human skin and isolated human skin layers for 50 compounds relevant to cosmetics ingredients. K values were measured in dermatomed skin, i…
View article: Protective properties of Avène Thermal Spring Water on biomechanical, ultrastructural and clinical parameters of human skin
Protective properties of Avène Thermal Spring Water on biomechanical, ultrastructural and clinical parameters of human skin Open
Background Thermal Spring Water (TSW) has been recognized to have beneficial effects on skin; however, the mechanisms underlying these are not completely elucidated. Aims We compared the effects of Avène TSW with mineral‐rich (MR) TSW on t…
View article: Protective effect of <i>Aquaphilus dolomiae</i> extract‐G1, ADE‐G1, on tight junction barrier function in a <i>Staphylococcus aureus</i>‐infected atopic dermatitis model
Protective effect of <i>Aquaphilus dolomiae</i> extract‐G1, ADE‐G1, on tight junction barrier function in a <i>Staphylococcus aureus</i>‐infected atopic dermatitis model Open
Background Atopic dermatitis (AD) is a common skin disease characterized by recurrent pruritic inflammatory skin lesions and defects of the skin barrier. Bacterial infection with Staphylococcus aureus contributes to increased severity of A…
View article: Broad spectrum repairing properties of an extract of <i>Aquaphilus dolomiae</i> on <i>in vitro</i> and <i>ex vivo</i> models of injured skin
Broad spectrum repairing properties of an extract of <i>Aquaphilus dolomiae</i> on <i>in vitro</i> and <i>ex vivo</i> models of injured skin Open
Background A biological concentrate was produced from cultures of an Avène aquatic microflora isolate, namely Aquaphilus dolomiae . Some of the beneficial effects on diseased and damaged skin are thought to be due to the presence of this m…
View article: 596 Complementary sun protection of two antioxidants (OTZ and DTG) in a sunscreen emulsion based on skin release
596 Complementary sun protection of two antioxidants (OTZ and DTG) in a sunscreen emulsion based on skin release Open
View article: <p>Efficacy of a Dermocosmetic Serum Combining Bakuchiol and Vanilla Tahitensis Extract to Prevent Skin Photoaging in vitro and to Improve Clinical Outcomes for Naturally Aged Skin</p>
Efficacy of a Dermocosmetic Serum Combining Bakuchiol and Vanilla Tahitensis Extract to Prevent Skin Photoaging in vitro and to Improve Clinical Outcomes for Naturally Aged Skin Open
BK+VTE combination demonstrated anti-aging efficacy and might provide a substantial benefit in the daily care of naturally aged skin in women, through their synergistic effect on inflammaging and senescence.
View article: Claudin-1 decrease impacts epidermal barrier function in atopic dermatitis lesions dose-dependently
Claudin-1 decrease impacts epidermal barrier function in atopic dermatitis lesions dose-dependently Open
View article: Measurement of the penetration of 56 cosmetic relevant chemicals into and through human skin using a standardized protocol
Measurement of the penetration of 56 cosmetic relevant chemicals into and through human skin using a standardized protocol Open
OECD test guideline 428 compliant protocol using human skin was used to test the penetration of 56 cosmetic‐relevant chemicals. The penetration of finite doses (10 μL/cm 2 ) of chemicals was measured over 24 hours. The dermal delivery (DD)…