Hélène Salvator
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View article: Somatostatin receptors 3 and 5 potentiate cholinergic-nerve-mediated contraction in human bronchus
Somatostatin receptors 3 and 5 potentiate cholinergic-nerve-mediated contraction in human bronchus Open
Aim The role of somatostatin (SST) in the modulation of cholinergic neurotransmission has not been explored previously in human bronchi. We investigated the effects of SST, selective agonists of the five SST receptors SSTR, and octreotide …
View article: Consecutive non-Aspergillus Fungal Invasive Infections in Chronic Granulomatous Disease: Data from the French National Reference Center for Primary ImmunoDeficiencies and literature review
Consecutive non-Aspergillus Fungal Invasive Infections in Chronic Granulomatous Disease: Data from the French National Reference Center for Primary ImmunoDeficiencies and literature review Open
View article: Differences in the Inflammatory Response and Corticoid Responsiveness of Human Lung Macrophages and Parenchymal Explants Exposed to Cigarette Smoke Extracts
Differences in the Inflammatory Response and Corticoid Responsiveness of Human Lung Macrophages and Parenchymal Explants Exposed to Cigarette Smoke Extracts Open
Smoking is the main cause of chronic obstructive pulmonary disease (COPD) and is associated with corticosteroid resistance. Given the paucity of data on human lung preparations, macrophages (LMs), and parenchymal explants (LPEs) were expos…
View article: Clinical relevance of microvascular endothelial dysfunction in idiopathic pulmonary fibrosis
Clinical relevance of microvascular endothelial dysfunction in idiopathic pulmonary fibrosis Open
Background Endothelial dysfunction (ED) is involved in the pathophysiology of idiopathic pulmonary fibrosis (IPF). Reactive hyperaemia peripheral arterial tonometry (RH-PAT) is a rapid, reproducible, noninvasive technique for assessing per…
View article: Differences in the inflammatory response and corticoid responsiveness of human lung macrophages and parenchymal explants exposed to cigarette smoke extracts
Differences in the inflammatory response and corticoid responsiveness of human lung macrophages and parenchymal explants exposed to cigarette smoke extracts Open
International audience
View article: Tuberculosis in otherwise healthy adults with inherited TNF deficiency
Tuberculosis in otherwise healthy adults with inherited TNF deficiency Open
Severe defects in human IFNγ immunity predispose individuals to both Bacillus Calmette–Guérin disease and tuberculosis, whereas milder defects predispose only to tuberculosis 1 . Here we report two adults with recurrent pulmonary tuberculo…
View article: Combination of real-time and hyphenated mass spectrometry for improved characterisation of exhaled breath biomarkers in clinical research
Combination of real-time and hyphenated mass spectrometry for improved characterisation of exhaled breath biomarkers in clinical research Open
View article: Real-time breath metabolomics to assess early response to CFTR modulators in adults with cystic fibrosis: an open-label proof-of-concept study
Real-time breath metabolomics to assess early response to CFTR modulators in adults with cystic fibrosis: an open-label proof-of-concept study Open
Background The combination of CFTR modulators ivacaftor/tezacaftor/elexacaftor (ETI) achieves unprecedented improvements in clinical symptoms and respiratory function of people with cystic fibrosis. Yet, evaluation is difficult in people w…
View article: Anti–Interleukin-23 Autoantibodies in Adult-Onset Immunodeficiency
Anti–Interleukin-23 Autoantibodies in Adult-Onset Immunodeficiency Open
Among patients with a variety of mycobacterial, bacterial, or fungal infections, the presence of neutralizing anti-interleukin-23 was associated with severe, persistent opportunistic infections. (Funded by the National Institute of Allergy…
View article: The IL-4/13-induced production of M2 chemokines by human lung macrophages is enhanced by adenosine and PGE2
The IL-4/13-induced production of M2 chemokines by human lung macrophages is enhanced by adenosine and PGE2 Open
NECA and PGE2 enhanced the IL-4/IL-13-induced production of M2a chemokines. The inhibition of PDE4 by roflumilast did not alter the production of these chemokines. These results contrast totally with the previously reported inhi…
View article: Therapeutic drug monitoring of corticosteroids/β2-agonists in the hair of patients with asthma: an open-label feasibility study
Therapeutic drug monitoring of corticosteroids/β2-agonists in the hair of patients with asthma: an open-label feasibility study Open
Background: Although adherence to inhaled medication is critically important for treatment efficiency, around half of patients taking these drugs are non-adherent or make critical errors when using their delivery device. Segmental hair ana…
View article: Quand penser à un déficit immunitaire en pathologie respiratoire?
Quand penser à un déficit immunitaire en pathologie respiratoire? Open
International audience
View article: Enhanced real-time mass spectrometry breath analysis for the diagnosis of COVID-19
Enhanced real-time mass spectrometry breath analysis for the diagnosis of COVID-19 Open
Background Although rapid screening for and diagnosis of coronavirus disease 2019 (COVID-19) are still urgently needed, most current testing methods are long, costly or poorly specific. The objective of the present study was to determine w…
View article: Enhanced real-time mass spectrometry breath analysis for the diagnosis of COVID-19
Enhanced real-time mass spectrometry breath analysis for the diagnosis of COVID-19 Open
Background Although rapid screening for and diagnosis of COVID-19 are still urgently needed, most current testing methods are either long, costly, and/or poorly specific. The objective of the present study was to determine whether or not a…
View article: STAT3 mutation-associated airway epithelial defects in Job syndrome
STAT3 mutation-associated airway epithelial defects in Job syndrome Open
View article: Neutralizing GM-CSF autoantibodies in pulmonary alveolar proteinosis, cryptococcal meningitis and severe nocardiosis
Neutralizing GM-CSF autoantibodies in pulmonary alveolar proteinosis, cryptococcal meningitis and severe nocardiosis Open
Background Anti GM-CSF autoantibodies (aAb) have been related to acquired pulmonary alveolar proteinosis (PAP) and described in cases of severe infections such as cryptococcosis and nocardiosis in previously healthy subjects. Whether there…
View article: Ruxolitinib inhibits cytokine production by human lung macrophages without impairing phagocytic ability
Ruxolitinib inhibits cytokine production by human lung macrophages without impairing phagocytic ability Open
Background: The Janus kinase (JAK) 1/2 inhibitor ruxolitinib has been approved in an indication of myelofibrosis and is a candidate for the treatment of a number of inflammatory or autoimmune diseases. We assessed the effects of ruxolitini…
View article: Curative allogeneic hematopoietic stem cell transplantation following reduced toxicity conditioning in adults with primary immunodeficiency
Curative allogeneic hematopoietic stem cell transplantation following reduced toxicity conditioning in adults with primary immunodeficiency Open
View article: Biomedical detection dogs for the identification of SARS-CoV-2 infections from axillary sweat and breath samples <sup>**</sup>
Biomedical detection dogs for the identification of SARS-CoV-2 infections from axillary sweat and breath samples <sup>**</sup> Open
A Polymerase Chain Reaction (PCR) test of a nasal swab is still the ‘gold standard’ for detecting a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, PCR testing could be usefully complemented by non-invasive…
View article: Neutralizing GM-CSF autoantibodies in pulmonary alveolar proteinosis, cryptococcal meningitis and severe nocardiosis
Neutralizing GM-CSF autoantibodies in pulmonary alveolar proteinosis, cryptococcal meningitis and severe nocardiosis Open
Background Anti GM-CSF autoantibodies (aAb) have been related to acquired pulmonary alveolar proteinosis (PAP) and described in cases of severe infections such as cryptococcosis and nocardiosis in previously healthy subjects. Whether there…
View article: Cryptococcus gattii Species Complex as an Opportunistic Pathogen: Underlying Medical Conditions Associated with the Infection
Cryptococcus gattii Species Complex as an Opportunistic Pathogen: Underlying Medical Conditions Associated with the Infection Open
The C. neoformans and C. gattii species complex causes cryptococcosis. The C. neoformans species complex is known as an opportunistic pathogen since it primarily infects immunocompromised patients. C. gattii species complex has been referr…
View article: Adiponectin Inhibits the Production of TNF-α, IL-6 and Chemokines by Human Lung Macrophages
Adiponectin Inhibits the Production of TNF-α, IL-6 and Chemokines by Human Lung Macrophages Open
Background: Obesity is associated with an elevated risk of severe respiratory infections and inflammatory lung diseases. The objectives were to investigate 1) the production of adiponectin by human lung explants, 2) the expression of the a…
View article: Pulmonary Alveolar Proteinosis After Allogeneic Hematopoietic Stem-Cell Transplantation in Adults
Pulmonary Alveolar Proteinosis After Allogeneic Hematopoietic Stem-Cell Transplantation in Adults Open
View article: High incidence of hyperventilation syndrome after COVID-19
High incidence of hyperventilation syndrome after COVID-19 Open
International audience
View article: Automated AI-Driven CT Quantification of Lung Disease Predicts Adverse Outcomes in Patients Hospitalized for COVID-19 Pneumonia
Automated AI-Driven CT Quantification of Lung Disease Predicts Adverse Outcomes in Patients Hospitalized for COVID-19 Pneumonia Open
The purpose of our work was to assess the independent and incremental value of AI-derived quantitative determination of lung lesions extent on initial CT scan for the prediction of clinical deterioration or death in patients hospitalized w…
View article: COVID-19 and Pneumocystis jirovecii pneumonia: Back to the basics
COVID-19 and Pneumocystis jirovecii pneumonia: Back to the basics Open
View article: Adiponectin inhibits the production of TNF-alpha, IL-6 and chemokines by human lung macrophages
Adiponectin inhibits the production of TNF-alpha, IL-6 and chemokines by human lung macrophages Open
Background and purpose: Obesity is associated with an elevated risk of severe respiratory infections and inflammatory lung diseases. The objectives were to investigate (i) the production of adiponectin by human lung explants, (ii) the expr…
View article: Risk factors for a severe form of COVID‐19 after allogeneic haematopoietic stem cell transplantation: a Société Francophone de Greffe de Moelle et de Thérapie cellulaire (SFGM‐TC) multicentre cohort study
Risk factors for a severe form of COVID‐19 after allogeneic haematopoietic stem cell transplantation: a Société Francophone de Greffe de Moelle et de Thérapie cellulaire (SFGM‐TC) multicentre cohort study Open
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), emerged in China in December 2019 and rapidly spread worldwide. Epidemiological studies in the general population identified older…
View article: Clinical Relevance of the Anti-inflammatory Effects of Roflumilast on Human Bronchus: Potentiation by a Long-Acting Beta-2-Agonist
Clinical Relevance of the Anti-inflammatory Effects of Roflumilast on Human Bronchus: Potentiation by a Long-Acting Beta-2-Agonist Open
Background: Roflumilast is an option for treating patients with severe COPD and frequent exacerbations despite optimal therapy with inhaled drugs. The present study focused on whether the phosphodiesterase (PDE) 4 inhibitor roflumilast and…
View article: Metabolomics of exhaled breath in critically ill COVID-19 patients: A pilot study
Metabolomics of exhaled breath in critically ill COVID-19 patients: A pilot study Open