Explanipedia

Burden of Modifiable Risk Factors in Young-Onset Cryptogenic Ischemic Stroke by High-Risk Patent Foramen Ovale Open

Jukka Putaala, Nicolas Martinez‐Majander, Michelle Leppert, Lauri Tulkki, Jani Pirinen , et al. · 2025

BACKGROUND: The incidence of young-onset ischemic stroke is rising, driven by cryptogenic ischemic stroke (CIS) and patients without vascular risk factors. This study examines the burden and associations of modifiable traditional, nontradi…

Correction: OBSCN undergoes extensive alternative splicing during human cardiac and skeletal muscle development Open

Ali Oghabian, Per Harald Jonson, S. Natraj Gayathri, Mridul Johari, Ella Nippala , et al. · 2025

Validation of a biomarker‐based mortality score for cardiogenic shock patients: Comparison with a clinical risk score Open

Elina Hynninen, Heli Tolppanen, Mercedes Rivas‐Lasarte, Tuukka Tarvasmäki, Veli‐Pekka Harjola , et al. · 2025

Aims Cardiogenic shock (CS) is the deadliest manifestation of acute heart failure, with persistently high mortality rates and a lack of recent therapeutic breakthroughs. Accurate risk prediction is crucial in clinical decision‐making and t…

Complications with Left Bundle Branch Area Pacing: The Flip Side of the Coin Open

Samuel Stempfel, Heli Tolppanen, Valérian Valiton, Haran Burri · 2025

Left bundle branch area pacing has been a breakthrough in pacing therapy and is being increasingly adopted. It delivers a more physiological form of pacing compared with right ventricular and biventricular pacing and also avoids the risk o…

Association of Hypertension With Early‐Onset Cryptogenic Ischemic Stroke by the Presence of Patent Foramen Ovale: A Case–Control Study Open

Jukka Putaala, Bettina von Sarnowski, Ulf Schminke, Raila Busch, Nicolas Martinez‐Majander , et al. · 2024

Single catheter ablation of atrioventricular node in a patient with dextrocardia and permanent atrial fibrillation via peripheral vascular access using remote magnetic navigation: a case report Open

Pekka Raatikainen, Annukka Marjamaa, Heli Tolppanen, Jarkko Karvonen, Aapo L. Aro · 2024

Background Cardiac interventions may be challenging in patients with congenital cardiac abnormalities. This case reports cardiac resynchronisation therapy pacemaker (CRT-P) implantation, and single catheter ablation of atrioventricular (AV…

OBSCN undergoes extensive alternative splicing during human cardiac and skeletal muscle development Open

Ali Oghabian, Per Harald Jonson, Mridul Johari, David Gómez‐Andrés, Francina Munell , et al. · 2024

Background Highly expressed in skeletal muscles, the gene Obscurin (i.e. OBSCN) has 121 non-overlapping exons and codes for some of the largest known mRNAs in human genome. Furthermore, it is known to play an essential role in muscle devel…

The effect of hydroxychloroquine on cholesterol metabolism in statin treated patients after myocardial infarction Open

Lotta Ulander, Piia Simonen, Heli Tolppanen, Otto Hartman, Tuomas T. Rissanen , et al. · 2023

Combined with a high-dose statin, hydroxychloroquine had no additional effect on serum cholesterol concentration or cholesterol absorption. However, the findings suggest that hydroxychloroquine interferes with lanosterol synthesis, and the…

Soluble urokinase-type plasminogen activator receptor improves early risk stratification in cardiogenic shock Open

Mari Hongisto, Johan Lassus, Tuukka Tarvasmäki, Jordi Sans‐Roselló, Heli Tolppanen , et al. · 2022

Aims Soluble urokinase–type plasminogen activator receptor (suPAR) is a biomarker reflecting the level of immune activation. It has been shown to have prognostic value in acute coronary syndrome and heart failure as well as in critical ill…

Hydroxychloroquine reduces interleukin-6 levels after myocardial infarction: The randomized, double-blind, placebo-controlled OXI pilot trial Open

Lotta Ulander, Heli Tolppanen, Otto Hartman, Tuomas T. Rissanen, Riitta Paakkanen , et al. · 2021

In patients with myocardial infarction, hydroxychloroquine reduced IL-6 levels significantly more than did placebo without causing any clinically significant adverse events. A larger randomized clinical trial is warranted to prove the pote…

Soluble triggering receptor expressed on myeloid cells-1 is a marker of organ injuries in cardiogenic shock: results from the CardShock Study Open

Antoine Kimmoun, Kévin Duarte, Veli‐Pekka Harjola, Tuukka Tarvasmäki, Bruno Lévy , et al. · 2021

Mortality risk prediction in elderly patients with cardiogenic shock: results from the CardShock study Open

Mari Hongisto, Johan Lassus, Tuukka Tarvasmäki, Alessandro Sionís, Jordi Sans‐Roselló , et al. · 2021

Aims This study aimed to assess the utility of contemporary clinical risk scores and explore the ability of two biomarkers [growth differentiation factor‐15 (GDF‐15) and soluble ST2 (sST2)] to improve risk prediction in elderly patients wi…

Sydämen kroonisen vajaatoiminnan diagnostiikka Open

Heli Tolppanen · 2021

Association of miR-21-5p, miR-122-5p, and miR-320a-3p with 90-Day Mortality in Cardiogenic Shock Open

Mikko Hänninen, Toni Jäntti, Heli Tolppanen, Heli Segersvärd, Tuukka Tarvasmäki , et al. · 2020

Cardiogenic shock (CS) is a life-threatening emergency. New biomarkers are needed in order to detect patients at greater risk of adverse outcome. Our aim was to assess the characteristics of miR-21-5p, miR-122-5p, and miR-320a-3p in CS and…

The heart failure specialists of tomorrow: a network for young cardiovascular scientists and clinicians Open

Markus S. Anker, Claire Bouleti, Theodoros Christodoulides, Ángela Durante, Edit Gara , et al. · 2020

The “Heart failure specialists of Tomorrow” (HoT) group gathers young researchers, physicians, basic scientists, nurses and many other professions under the auspices of the Heart Failure Association of the European Society of Cardiology. A…

Prognostic impact of angiographic findings, procedural success, and timing of percutaneous coronary intervention in cardiogenic shock Open

Tuija Sabell, Marek Banaszewski, Johan Lassus, Markku S. Nieminen, Heli Tolppanen , et al. · 2020

Aims Urgent revascularization is the mainstay of treatment in acute coronary syndrome (ACS) related cardiogenic shock (CS). The aim was to investigate the association of angiographic results with 90‐day mortality. Procedural complications …

sGC Stimulators and Activators Open

Heli Tolppanen, Piotr Ponikowski · 2019

Nitric oxide (NO)-soluble guanylate cyclase(sGC)-cGMP signalling is impaired in HF syndromes, which could predispose to vascular oxidative stress. Nitrates directly stimulate cGMP, but are limited by tolerance. Therapeutic targets that aim…

Levels of Growth Differentiation Factor 15 and Early Mortality Risk Stratification in Cardiogenic Shock Open

Mari Hongisto, Anu Kataja, Tuukka Tarvasmäki, Anu Holopainen, Tuija Javanainen , et al. · 2019

PROGNOSTICATION IN ACUTE HEART FAILURE AND CARDIOGENIC SHOCK - FOCUS ON ELECTROCARDIOGRAPHY AND BIOMARKERS Open

Heli Tolppanen · 2019

Acute heart failure (AHF) is a leading cause of hospitalizations in patients over the age of 65 worldwide, and is associated with high mortality. Cardiogenic shock (CS), the most severe form of AHF, is characterized by hypotension and end-…

Circulating levels of <span>microRNA</span> 423‐5p are associated with 90 day mortality in cardiogenic shock Open

Toni Jäntti, Heli Segersvärd, Heli Tolppanen, Tuukka Tarvasmäki, Johan Lassus , et al. · 2018

Aims The role of microRNAs has not been studied in cardiogenic shock. We examined the potential role of miR‐423‐5p level to predict mortality and associations of miR‐423‐5p with prognostic markers in cardiogenic shock. Methods and results …

Predictive value of the baseline electrocardiogram ST‐segment pattern in cardiogenic shock: Results from the CardShock Study Open

Tuija Javanainen, Heli Tolppanen, Johan Lassus, Markku S. Nieminen, Alessandro Sionís , et al. · 2018

Background The most common aetiology of cardiogenic shock (CS) is acute coronary syndrome (ACS), but even up to 20%–50% of CS is caused by other disorders. ST‐segment deviations in the electrocardiogram (ECG) have been investigated in pati…

Prevalence, Temporal Evolution, and Impact on Survival of Ventricular Conduction Blocks in Patients With Acute Coronary Syndrome and Cardiogenic Shock Open

Heli Tolppanen, Tuija Javanainen, Jordi Sans‐Roselló, Jiří Pařenica, Tuomo Nieminen , et al. · 2018

4998Current use and impact on 30-day mortality of pulmonary artery catheter in cardiogenic shock patients: results from the CardShock Study Open

Mercedes Rivas Lasarte, Jordi Sans‐Roselló, Montserrat Vilà, Heli Tolppanen, Johan Lassus , et al. · 2017

hemodynamic measure that may be useful to predict RVF in patients with EXCOR ® , especially when classic parameters are not definitive.

P663Marked elevation of GDF-15 in cardiogenic shock: early discrimination between survivors and non-survivors Open

Mari Hongisto, Johan Lassus, Tuukka Tarvasmäki, Heli Tolppanen, Kari Pulkki , et al. · 2017

and D) showed significantly higher incidence of MACEs (HR 1.36, p=0.002 and HR 1.40, p=0.008), but not lower hs-CRP and lower eGFR subset; group B (HR 1.24, 95% CI 0.94-1.64,p=0.131). Conclusion:In the present study, higher hs-CRP subset s…

Adrenomedullin: a marker of impaired hemodynamics, organ dysfunction, and poor prognosis in cardiogenic shock Open

Heli Tolppanen, Mercedes Rivas‐Lasarte, Johan Lassus, Jordi Sans‐Roselló, Oliver Hartmann , et al. · 2017

Bio-ADM is a valuable prognosticator and marker of impaired hemodynamics in CS patients. High levels of bio-ADM may show shock refractoriness and developing end-organ dysfunction and thus help to guide therapeutic approach in patients with…

Use of noninvasive and invasive mechanical ventilation in cardiogenic shock: A prospective multicenter study Open

Mari Hongisto, Johan Lassus, Tuukka Tarvasmäki, Alessandro Sionís, Heli Tolppanen , et al. · 2016

Physiological changes in pregnancy Open

Priya Soma‐Pillay, Catherine Nelson‐Piercy, Heli Tolppanen, Alexandre Mebazaa · 2016

Physiological changes occur in pregnancy to nurture the developing foetus and prepare the mother for labour and delivery. Some of these changes influence normal biochemical values while others may mimic symptoms of medical disease. It is i…

Effect of precipitating factors of acute heart failure on readmission and long‐term mortality Open

Mattia Arrigo, Heli Tolppanen, Malha Sadoune, Elodie Féliot, Antônio Lúcio Teixeira , et al. · 2016

Aims Acute heart failure (AHF) is one of the leading causes of unscheduled hospitalization and is associated with frequent readmissions and substantial mortality. Precipitating factors of AHF influence short‐term mortality, but their effec…

Ventricular conduction abnormalities as predictors of long‐term survival in acute <i>de novo</i> and decompensated chronic heart failure Open

Heli Tolppanen, Krista Siirilä‐Waris, Veli‐Pekka Harjola, David Marono, Jiří Pařenica , et al. · 2015

Aims Data on the prognostic role of left and right bundle branch blocks (LBBB and RBBB), and nonspecific intraventricular conduction delay (IVCD; QRS ≥ 110 ms, no BBB) in acute heart failure (AHF) are controversial. Our aim was to investig…

Acute heart failure and cardiogenic shock: a multidisciplinary practical guidance Open

Alexandre Mebazaa, Heli Tolppanen, Christian Mueller, Johan Lassus, Salvatore DiSomma , et al. · 2015

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