Explanipedia

A preliminary study of thoracic CT screening combined with quantitative CT for the determination of bone density in the thoracic spine Open

Dan Zhang, Shu‐xian Cui, Q Wang, Helin Feng, Min Ma , et al. · 2025

Objective To explore the diagnostic value of thoracic spine bone density in QCT bone density measurement. Methods The CT imaging data of 149patients whose thoracic CT examinations included the whole thoracic spine and lumbar spine(L1-L3) w…

Single-Cell and Spatial Profiling of Tumor Microenvironment Heterogeneity in Human Osteosarcomas Open

Xuejing Zheng, Jinbo Yuan, Jin Peng, Xuejun Wang, Rui-Ming Xu , et al. · 2025

Osteosarcoma, a highly heterogeneous malignant bone tumor, exhibits substantial interpatient and intratumoral heterogeneity. Utilizing integrated single-cell RNA sequencing and spatial transcriptomics, we uncovered distinct tumor microenvi…

Sexual Dimorphism in Gene Expression: A Genome-Wide Study of Tissue and Chromosome Dependencies Open

Jiamin Ma, Lishi Wang, Gang Yuan, Chrishan M. Fernando, Lan Yao , et al. · 2025

Males and females possess nearly identical genomes, yet they exhibit significant differences in disease morbidity, prevalence, severity, therapeutic response, and mortality. To explore these differences, we conducted a comprehensive analys…

Augmenting Protein Degradation Capacity of PROTAC through Energy Metabolism Regulation and Targeted Drug Delivery Open

Mixiao Tan, Xiaoyang Li, Long Cheng, Xianli Long, Guoliang Cao , et al. · 2024

The ubiquitin‐proteasome system (UPS) is responsible for degrading over 70–80% of cellular proteins. Consequently, proteolysis‐targeting chimeras (PROTACs) are developed to induce the ubiquitination and subsequent degradation of proteins o…

The dual role of ferroptosis in anthracycline-based chemotherapy includes reducing resistance and increasing toxicity Open

Jiazheng Zhao, Ning Zhang, Xiaowei Ma, Ming Li, Helin Feng · 2023

Targeting iron metabolism in osteosarcoma Open

Xiaowei Ma, Jiazheng Zhao, Helin Feng · 2023

Osteosarcoma (OS) is the most common primary solid malignant tumour of bone, with rapid progression and a very poor prognosis. Iron is an essential nutrient that makes it an important player in cellular activities due to its inherent abili…

Innovation in proximal femoral replacement for oncology patients—A novel eggshell procedure Open

Jiazheng Zhao, Xiaowei Ma, Helin Feng · 2023

Our eggshell procedure is convenient and accessible. On the one hand, it can reduce surgical side injuries without adding additional complications, and on the other it allows to improve joint mobility and life quality while diminishing the…

Percutaneous pedicle screw fixation combined with percutaneous vertebroplasty for the treatment of thoracic and lumbar metastatic tumors Open

Xiaowei Ma, Yi Zhao, Jiazheng Zhao, Hongzeng Wu, Helin Feng · 2023

Patients with spinal metastases have a great risk of spinal instability and even spinal cord compression while enduring pain. Therefore, timely and appropriate surgical treatment is an effective means to stabilize the spine and avoid spina…

Analysis of sex differential genes at whole genome level reveals their organ-and chromosome-dependent expressions, regulations, and interactions Open

Jiamin Ma, Lishi Wang, Gang Yuan, Chrishan M. Fernando, Lan Yao , et al. · 2022

Males and females possess genomes that are almost identical but differ in morbidity, prevalence, severity, response to therapies and mortality of many diseases. We comprehensively analyzed gene expression data in seven tissues from BXD rec…

Targeting KDM4 for treating PAX3-FOXO1–driven alveolar rhabdomyosarcoma Open

Shivendra V. Singh, Ahmed Abu‐Zaid, Hongjian Jin, Jie Fang, Qiong Wu , et al. · 2022

Chimeric transcription factors drive lineage-specific oncogenesis but are notoriously difficult to target. Alveolar rhabdomyosarcoma (RMS) is an aggressive childhood soft tissue sarcoma transformed by the pathognomonic Paired Box 3–Forkhea…

Outstanding prognostic value of novel ferroptosis-related genes in chemoresistance osteosarcoma patients Open

Jiazheng Zhao, Yi Zhao, Xiaowei Ma, Helin Feng, Litao Jia · 2022

Osteosarcoma (OS) is the most common bone-derived tumor, and chemoresistance is a pivotal factor in the poor prognosis of patients with OS. Ferroptosis, as an emerging modality of regulated cell death, has demonstrated potential value in t…

Immunological and prognostic significance of novel ferroptosis-related genes in soft tissue sarcoma Open

Jiazheng Zhao, Yi Zhao, Xiaowei Ma, Helin Feng, Rongmin Cui · 2022

Background Ferroptosis has exhibited great potential in the treatment of cancer and has gained widespread attention in soft tissue sarcoma (STS). The aim was to explore the immunological and prognostic significance of novel ferroptosis-rel…

Comprehensive imaging and pathology of solitary patellar metastasis from breast cancer with literature review on its diagnosis and prognosis. Open

Jiazheng Zhao, Yi Zhao, Xiaowei Ma, Helin Feng, Xiaoyan Gao · 2022

Cases of patellar metastases from malignant tumors are extremely rare but do exist. Due to the insidious onset and non-specific symptoms, it is worthwhile to alert clinicians. The diagnostic value of positron emission tomography/computed t…

From Anti-PD-1/PD-L1 to CTLA-4 and to MUC1—Is the Better Response to Treatment in Smokers of Cancer Patients Drug Specific? Open

Lishi Wang, Fengxia Liu, Jing Li, Li Ma, Helin Feng , et al. · 2021

Whether smokers respond to anti-cancer drugs differently than non-smokers remains controversial. The objective of this study is to explore whether the better response of the smokers is specific to therapy of anti-PD-1/PD-L1, anti-checkpoin…

Targeting ferroptosis in osteosarcoma Open

Jiazheng Zhao, Yi Zhao, Xiaowei Ma, Benzheng Zhang, Helin Feng · 2021

Osteosarcoma (OS) is the most common primary bone tumour in children and adolescents, with high degree of malignancy and an extremely poor prognosis. Ferroptosis, a non-traditional mode of regulated cell death (RCD) characterised by iron-d…

Expression of JMJD2B and HIF-1α in Rhabdomyosarcoma Tissues and Their Prognostic Significance Open

WU Hongzeng, Jiazheng Zhao, Zhao Yi, Xiaowei Ma, Helin Feng · 2021

Objective To explore the expression and prognostic significance of histone demethylase JMJD2B and HIF-1α in rhabdomyosarcoma(RMS) tissues. Methods A total of 78 RMS patients were followed up to obtain survival time, and immunohistochemical…

Percutaneous pedicle screw fixation combined with percutaneous vertebroplasty for the treatment of thoracic and lumbar metastatic tumor Open

Xiaowei Ma, Yi Zhao, Jiazheng Zhao, Hongzeng Wu, Helin Feng · 2021

Background Evaluation of the clinical efficacy of percutaneous pedicle screw fixation (PPSF) combined with percutaneous vertebroplasty (PVP) in the treatment of thoracic and lumbar metastatic tumor. Methods 20 patients with thoracic and lu…

Oesophageal carcinoma with solitary patellar metastasis: a rare case report Open

Yi Zhao, Qianqian Zhang, Helin Feng, Xiyan Zhu · 2021

The incidence of tumours found in the patella, including primary and metastatic tumours, is low. Solitary metastasis of oesophageal carcinoma (OC) in the patella is even rarer. A 50-year-old man presented to our clinic because of pain and …

Gastrointestinal stromal tumor with multisegmental spinal metastases as first presentation: A case report and review of the literature Open

Yan Kong, Xiaowei Ma, Qianqian Zhang, Yi Zhao, Helin Feng · 2021

By reviewing 26 previously reported cases of spinal metastasis in GIST, it was found that spinal metastasis of GIST has become more common in recent years, so the possibility of early spinal metastasis should be recognized. CT and MRI are …

Smoking as a Predictor of Cell Surface Receptor Anti PD-1/PD-L1, MUC1, and CTLA-4 as the First Line or Monotherapy and Multiple Therapy Among Them in NSCLC Patients Open

Lishi Wang, FengXia Liu, Jing Li, Li Ma, Helin Feng , et al. · 2021

Responses of smoking and nonsmoking cancer patients to drug treatment Open

Lishi Wang, Helin Feng, Jing Li, FengXia Liu, Qingyi Liu , et al. · 2020

PROSPERO registration number: CRD42019146402.

Association of JMJD2B and Hypoxia-Inducible Factor 1 Expressions with Poor Prognosis in Osteosarcoma Open

Xujian Liu, Qianqian Zhang, Yi Zhao, Jianjun Xun, Hongzeng Wu , et al. · 2020

Background . JMJD2B has been reported to be implicated in malignant tumors. This study is aimed at exploring the expression and prognostic significance of JMJD2B in osteosarcoma and its association with hypoxia-inducible factor 1 (HIF1). M…

Association of sirtuin-1 and vascular endothelial growth factor expression with tumor progression and poor prognosis in liposarcoma Open

Hongzeng Wu, Qianqian Zhang, Yi Zhao, Fengzhou Xu, Jinming Zhang , et al. · 2020

Objectives A relationship exists between sirtuin-1 expression and growth and survival of malignant tumors. This study aimed to investigate the prognostic value of sirtuin-1 and vascular endothelial growth factor (VEGF) expression in patien…

Leptin acts on mesenchymal stem cells to promote chemoresistance in osteosarcoma cells Open

Helin Feng, Qianqian Zhang, Yi Zhao, Lili Zhao, Baoen Shan · 2020

Leptin signaling influences osteoblastogenesis and modulates the fate of mesenchymal stem cells (MSCs) during bone and cartilage regeneration. Although MSCs abound in the osteosarcoma (OS) microenvironment, and leptin exhibits pro-tumorige…

Leptin promotes proliferation and invasion of osteosarcoma cells byupregulating the expression of SIRT1 Open

Helin Feng, Xiaochong Zhang, Qianqian Zhang, Ze Li, Lili Zhao · 2020

Osteosarcoma (OS) is a primary high-grade malignant bone neoplasm, and the prognosis of OS remains poor due to early metastasis. Leptin plays an essential role in tumorigenesis, but the role of leptin in the development of O... | Find, rea…

Smokers with PD-L1 Positive Status Benefit More than Non-Smokers in All Types of Cancer When Treated by Anti- PD-1 and PD-L1 Drugs Open

Lishi Wang, FengXia Liu, Jing Li, Helin Feng, Li Ma , et al. · 2020

Outcome Based on Metastatic Humerus and Surgical Fixation: Finding of a Systematic Review Open

Helin Feng, Hongzeng Wu, Helin Feng, Jianfa Xu, Jianjun Xun , et al. · 2019

Background: As for treating metastatic humerus, open reduction with internal fixation (ORIF), intramedullary nail fixation as well as reconstruction of endoprosthesis act as the approaches with highest frequency in surgeries. In the curren…

Bioinformatics analysis of Ewing's sarcoma: Seeking key candidate genes and pathways Open

Jinming Zhang, Yao Zhang, Ze Li, Hongzeng Wu, Jianjun Xun , et al. · 2019

Ewing's sarcoma (ES) is the second most common bone tumor among children and adolescents worldwide. However, the genes and signaling pathways involved in ES tumorigenesis and progression remain unclear. The present study used two gene-expr…

Transferrin receptor-1 and VEGF are prognostic factors for osteosarcoma Open

Hongzeng Wu, Jinming Zhang, Ruoheng Dai, Jianfa Xu, Helin Feng · 2019

TfR1 and VEGF are potential prognostic factors for osteosarcoma.

Mechanism of miR-143-3p inhibiting proliferation, migration and invasion of osteosarcoma cells by targeting MAPK7 Open

Yu Hou, Helin Feng, Jianbao Jiao, Ligang Qian, Bo Sun , et al. · 2019

Objective: To investigate the effects of miR-143-3p and MAPK7 on the proliferation, migration, and invasion of U2OS human osteosarcoma (OS) cells. Methods: The expression of miR-143-3p and MAPK7 in U2OS cells were detected by…

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