Helisa H. Wippel
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View article: Borrelia PeptideAtlas: A proteome resource of common Borrelia burgdorferi isolates for Lyme research
Borrelia PeptideAtlas: A proteome resource of common Borrelia burgdorferi isolates for Lyme research Open
Lyme disease is caused by an infection with the spirochete Borrelia burgdorferi, and is the most common vector-borne disease in North America. B. burgdorferi isolates harbor extensive genomic and proteomic variability and further compariso…
View article: Combining quantitative proteomics and interactomics for a deeper insight into molecular differences between human cell lines
Combining quantitative proteomics and interactomics for a deeper insight into molecular differences between human cell lines Open
Cellular functional pathways have evolved through selection based on fitness benefits conferred through protein intra- and inter-molecular interactions that comprise all protein conformational features and protein-protein interactions, col…
View article: Borrelia PeptideAtlas: A proteome resource of common<i>Borrelia burgdorferi</i>isolates for Lyme research
Borrelia PeptideAtlas: A proteome resource of common<i>Borrelia burgdorferi</i>isolates for Lyme research Open
Lyme disease, caused by an infection with the spirochete Borrelia burgdorferi , is the most common vector-borne disease in North America. B. burgdorferi strains harbor extensive genomic and proteomic variability and further comparison is k…
View article: Multiplexed Isobaric Quantitative Cross-Linking Reveals Drug-Induced Interactome Changes in Breast Cancer Cells
Multiplexed Isobaric Quantitative Cross-Linking Reveals Drug-Induced Interactome Changes in Breast Cancer Cells Open
The study of protein structures and interactions is critical to understand their function. Chemical cross-linking of proteins with mass spectrometry (XL-MS) is a rapidly developing structural biology technique able to provide valuable insi…
View article: Highly diluted compounds effects on B16-F10 melanogenesis, reactive oxygen species (ROS) production and tumorigenesis.
Highly diluted compounds effects on B16-F10 melanogenesis, reactive oxygen species (ROS) production and tumorigenesis. Open
Background: Cutaneous melanoma is a highly malignant tumor derived from pigment-producing (melanin) melanocytes of skin epidermis. Cutaneous pigmentation is described as the major physiologic defense against UV radiation. During melanin bi…
View article: Multiplexed Cross-Linking with Isobaric Quantitative Protein Interaction Reporter Technology
Multiplexed Cross-Linking with Isobaric Quantitative Protein Interaction Reporter Technology Open
Chemical cross-linking with mass spectrometry (XL-MS) has emerged as a useful technique for interrogating protein structures and interactions. When combined with quantitative proteomics strategies, protein conformational and interaction dy…
View article: Quantitative interactome analysis with chemical cross-linking and mass spectrometry
Quantitative interactome analysis with chemical cross-linking and mass spectrometry Open
View article: In-Cell Labeling and Mass Spectrometry for Systems-Level Structural Biology
In-Cell Labeling and Mass Spectrometry for Systems-Level Structural Biology Open
Biological systems have evolved to utilize proteins to accomplish nearly all functional roles needed to sustain life. A majority of biological functions occur within the crowded environment inside cells and subcellular compartments where p…
View article: Crosslinking mass spectrometry: A link between structural biology and systems biology
Crosslinking mass spectrometry: A link between structural biology and systems biology Open
Protein structure underpins functional roles in all biological processes; therefore, improved understanding of protein structures is of fundamental importance in nearly all biological and biomedical research areas. Traditional techniques s…
View article: Deciphering the architecture and interactome of hnRNP proteins and enigmRBPs
Deciphering the architecture and interactome of hnRNP proteins and enigmRBPs Open
RNA-binding proteins (RBPs) have conserved domains and consensus sequences that interact with RNAs and other regulatory proteins forming ribonucleoprotein (RNP) complexes. Chemical crosslinking of proteins provides insights into RNP comple…
View article: Proteomics pinpoints alterations in grade I meningiomas of male versus female patients
Proteomics pinpoints alterations in grade I meningiomas of male versus female patients Open
View article: Unveiling the partners of the DRBD2-mRNP complex, an RBP in Trypanosoma cruzi and ortholog to the yeast SR-protein Gbp2
Unveiling the partners of the DRBD2-mRNP complex, an RBP in Trypanosoma cruzi and ortholog to the yeast SR-protein Gbp2 Open
The identification of regulatory proteins in the DRBD2-mRNP complex corroborates the important role of DRBD2 in gene expression regulation in T. cruzi. We consider these results an important contribution to future studies regarding gene ex…
View article: Additional file 5: of Unveiling the partners of the DRBD2-mRNP complex, an RBP in Trypanosoma cruzi and ortholog to the yeast SR-protein Gbp2
Additional file 5: of Unveiling the partners of the DRBD2-mRNP complex, an RBP in Trypanosoma cruzi and ortholog to the yeast SR-protein Gbp2 Open
Table S2. Transcripts identified by the ribonomic analysis of the DRBD2-mRNP complex. Transcripts identified by RNA-seq from the DRBD2-mRNP complex from epimastigotes in exponential growth. The table also shows the transcripts regulated by…
View article: Additional file 4: of Unveiling the partners of the DRBD2-mRNP complex, an RBP in Trypanosoma cruzi and ortholog to the yeast SR-protein Gbp2
Additional file 4: of Unveiling the partners of the DRBD2-mRNP complex, an RBP in Trypanosoma cruzi and ortholog to the yeast SR-protein Gbp2 Open
Table S1. Complete information of the shotgun proteomic analysis of the DRBD2-mRNP complex. Unique proteins: proteins identified only in DRBD2 IP assays. Signal: sum of PatternLab’s normalized label-free quantitation derived from the extra…
View article: Additional file 7: of Unveiling the partners of the DRBD2-mRNP complex, an RBP in Trypanosoma cruzi and ortholog to the yeast SR-protein Gbp2
Additional file 7: of Unveiling the partners of the DRBD2-mRNP complex, an RBP in Trypanosoma cruzi and ortholog to the yeast SR-protein Gbp2 Open
Table S4. Complete information of the ribonomic analysis of the DRBD2-mRNP complex. (XLSX 4213 kb)
View article: Additional file 6: of Unveiling the partners of the DRBD2-mRNP complex, an RBP in Trypanosoma cruzi and ortholog to the yeast SR-protein Gbp2
Additional file 6: of Unveiling the partners of the DRBD2-mRNP complex, an RBP in Trypanosoma cruzi and ortholog to the yeast SR-protein Gbp2 Open
Table S3. DRBD2-mRNP complex RNA-seq mapping statistics information. (XLSX 5 kb)
View article: Assessing the partners of the RBP9-mRNP complex in <i>Trypanosoma cruzi</i> using shotgun proteomics and RNA-seq
Assessing the partners of the RBP9-mRNP complex in <i>Trypanosoma cruzi</i> using shotgun proteomics and RNA-seq Open
Gene expression regulation in trypanosomes differs from other eukaryotes due to absence of transcriptional regulation for most of their genes. RNA-binding proteins (RBPs) associate with mRNAs and other regulatory proteins to form ribonucle…
View article: Assessing the partners of RBP9-mRNP complex in <i>Trypanosoma cruzi</i> using shotgun proteomics and RNA-seq
Assessing the partners of RBP9-mRNP complex in <i>Trypanosoma cruzi</i> using shotgun proteomics and RNA-seq Open
Gene expression regulation in trypanosomes differs from other eukaryotes due to absence of transcriptional regulation for most of their genes. RNA-binding proteins (RBPs) associate with mRNAs and other regulatory proteins to form ribonucle…
View article: Assessing the partners of the RBP9-mRNP complex in <i>Trypanosoma cruzi</i> using shotgun proteomics and RNA-seq
Assessing the partners of the RBP9-mRNP complex in <i>Trypanosoma cruzi</i> using shotgun proteomics and RNA-seq Open
Gene expression regulation in trypanosomes differs from other eukaryotes due to absence of transcriptional regulation for most of their genes. RNA-binding proteins (RBPs) associate with mRNAs and other regulatory proteins to form ribonucle…