Helmut Denk
YOU?
Author Swipe
View article: Cytochrome P450 as possible link between Mallory-Denk body formation in DDC-intoxicated mouse liver and human steatohepatitis
Cytochrome P450 as possible link between Mallory-Denk body formation in DDC-intoxicated mouse liver and human steatohepatitis Open
Mallory-Denk bodies (MDBs) are hepatocytic inclusions in alcohol-related (ASH) and metabolic dysfunction-associated (MASH) steatohepatitis as well as in some other apparently etiologically different chronic human liver disorders. They are …
View article: Mallory-Denk bodies and hepatocellular senescence: a causal relationship?
Mallory-Denk bodies and hepatocellular senescence: a causal relationship? Open
Mallory-Denk bodies (MDBs) are hepatocellular cytoplasmic inclusions, which occur in certain chronic liver diseases, such as alcohol-related (ASH) and metabolic dysfunction-associated (MASH) steatohepatitis, copper toxicosis, some drug-ind…
View article: Priming, Triggering, Adaptation and Senescence (PTAS): A Hypothesis for a Common Damage Mechanism of Steatohepatitis
Priming, Triggering, Adaptation and Senescence (PTAS): A Hypothesis for a Common Damage Mechanism of Steatohepatitis Open
Understanding the pathomechanism of steatohepatitis (SH) is hampered by the difficulty of distinguishing between causes and consequences, by the broad spectrum of aetiologies that can produce the phenotype, and by the long time-span during…
View article: Improved pathology reporting in NAFLD/NASH for clinical trials
Improved pathology reporting in NAFLD/NASH for clinical trials Open
Non-alcoholic fatty liver disease (NAFLD), a disorder characterised by pathological accumulation of non-visible free fatty acids and visible triglyceride in hepatocytes, is on the rise globally in both adult and paediatric populations.1 Ev…
View article: Development and prognostic relevance of a histologic grading and staging system for alcohol-related liver disease
Development and prognostic relevance of a histologic grading and staging system for alcohol-related liver disease Open
Patients with alcohol-related liver disease (ALD) may undergo liver biopsy to assess disease severity. We developed a system to classify ALD under the microscope by grading ALD activity and staging the extent of liver scarring. We validate…
View article: Different Roles of p62 (SQSTM1) Isoforms in Keratin-Related Protein Aggregation
Different Roles of p62 (SQSTM1) Isoforms in Keratin-Related Protein Aggregation Open
p62/Sequestosome-1 (p62) is a multifunctional adaptor protein and is also a constant component of disease-associated protein aggregates, including Mallory–Denk bodies (MDBs), in steatohepatitis and hepatocellular carcinoma. We investigated…
View article: From the origin of NASH to the future of metabolic fatty liver disease
From the origin of NASH to the future of metabolic fatty liver disease Open
Non-alcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease worldwide. Understanding the pathological and molecular hallmarks from its first description to definitions of disease entities, classifica…
View article: Fifty years of impact on liver pathology: a history of the Gnomes
Fifty years of impact on liver pathology: a history of the Gnomes Open
Professional societies play a major role in medicine and science. The societies tend to be large with well-developed administrative structures. An additional model, however, is based on small groups of experts who meet regularly in an egal…
View article: Causability and explainability of artificial intelligence in medicine
Causability and explainability of artificial intelligence in medicine Open
Explainable artificial intelligence (AI) is attracting much interest in medicine. Technically, the problem of explainability is as old as AI itself and classic AI represented comprehensible retraceable approaches. However, their weakness w…
View article: Keratin 18-deficiency results in steatohepatitis and liver tumors in old mice: A model of steatohepatitis-associated liver carcinogenesis
Keratin 18-deficiency results in steatohepatitis and liver tumors in old mice: A model of steatohepatitis-associated liver carcinogenesis Open
Our findings show that K18 deficiency of hepatocytes leads to steatosis, increasing with age, and finally to SH. K18 deficiency and age promote liver tumor development in mice, frequently on the basis of chromosomal instability, resembling…
View article: p62/Sequestosome-1 Is Indispensable for Maturation and Stabilization of Mallory-Denk Bodies
p62/Sequestosome-1 Is Indispensable for Maturation and Stabilization of Mallory-Denk Bodies Open
Mallory-Denk bodies (MDBs) are hepatocytic protein aggregates found in steatohepatitis and several other chronic liver diseases as well as hepatocellular carcinoma. MDBs are mainly composed of phosphorylated keratins and stress protein p62…