Helmut Laumen
YOU?
Author Swipe
View article: Hereditary chronic pancreatitis induced plasticity cooperates with mutant Kras in early pancreatic carcinogenesis
Hereditary chronic pancreatitis induced plasticity cooperates with mutant Kras in early pancreatic carcinogenesis Open
Background Chronic pancreatitis (CP) is a risk factor for pancreatic cancer, with inherited cases conferring a markedly increased risk. The underlying mechanisms driving malignant transformation by CP remain poorly understood. Objective Co…
View article: From Genes to Environment: Elucidating Pancreatic Carcinogenesis Through Genetically Engineered and Risk Factor-Integrated Mouse Models
From Genes to Environment: Elucidating Pancreatic Carcinogenesis Through Genetically Engineered and Risk Factor-Integrated Mouse Models Open
Pancreatic cancer is characterized by late diagnosis, therapy resistance, and poor prognosis, necessitating the exploration of early carcinogenesis and prevention methods. Preclinical mouse models have evolved from cell line-based to human…
View article: Gender-specific changes of the gut microbiome correlate with tumor development in murine models of pancreatic cancer
Gender-specific changes of the gut microbiome correlate with tumor development in murine models of pancreatic cancer Open
Background Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with dismal outcome. Recently, microbiome signatures were demonstrated to influence disease progression or to correlate with PDAC development. To improve understan…
View article: Targeting HDACs in Pancreatic Neuroendocrine Tumor Models
Targeting HDACs in Pancreatic Neuroendocrine Tumor Models Open
Compared to pancreatic adenocarcinoma (PDAC), pancreatic neuroendocrine tumors (PanNET) represent a rare and heterogeneous tumor entity. In addition to surgical resection, several therapeutic approaches, including biotherapy, targeted ther…
View article: Genetic analysis of the <i>STIM1</i> gene in chronic pancreatitis
Genetic analysis of the <i>STIM1</i> gene in chronic pancreatitis Open
Chronic pancreatitis is a complex disease that involves many factors, both genetic and environmental. Over the past two decades, molecular genetic analysis of five genes that are highly expressed in human pancreatic acinar cells, namely PR…
View article: Dynamic modelling of an ACADS genotype in fatty acid oxidation – Application of cellular models for the analysis of common genetic variants
Dynamic modelling of an ACADS genotype in fatty acid oxidation – Application of cellular models for the analysis of common genetic variants Open
Both, genotyped LCL and regulated shRNA-knockdown are valuable tools to model moderate, gradual gene-regulatory effects of common variants on cellular phenotypes. Decreasing ACADS expression levels modulate short and surprisingly also long…
View article: Genome-wide association study identifies inversion in the <i>CTRB1-CTRB2</i> locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis
Genome-wide association study identifies inversion in the <i>CTRB1-CTRB2</i> locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis Open
Objective Alcohol-related pancreatitis is associated with a disproportionately large number of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility to alcoholic chronic pancreatitis (CP) is poorly ch…
View article: Allele-specific quantitative proteomics unravels molecular mechanisms modulated by cis-regulatory PPARG locus variation
Allele-specific quantitative proteomics unravels molecular mechanisms modulated by cis-regulatory PPARG locus variation Open
Genome-wide association studies identified numerous disease risk loci. Delineating molecular mechanisms influenced by cis-regulatory variants is essential to understand gene regulation and ultimately disease pathophysiology. Combining bioi…
View article: Effects of Genetic Loci Associated with Central Obesity on Adipocyte Lipolysis
Effects of Genetic Loci Associated with Central Obesity on Adipocyte Lipolysis Open
This report provides evidence for specific WHRadjBMI-associated loci as candidates to modulate adipocyte lipolysis. Additionally, our data suggests that genetically increased central fat accumulation is unlikely to be a major cause of alte…