Helmut Thissen
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View article: Gold Nanoclusters as Smart Nanoplatforms for Targeted Cancer Therapy
Gold Nanoclusters as Smart Nanoplatforms for Targeted Cancer Therapy Open
Gold nanoclusters (AuNCs), known for their biocompatibility, intrinsic fluorescence, and magnetic properties represent an interesting nanomaterial for targeted drug delivery. Herein, a multifunctional platform is designed based on AuNCs mo…
View article: Machine Learning‐Assisted Prediction and Generation of Antimicrobial Peptides
Machine Learning‐Assisted Prediction and Generation of Antimicrobial Peptides Open
Antimicrobial peptides (AMPs) offer a highly potent alternative solution due to their broad‐spectrum activity and minimum resistance development against the rapidly evolving antibiotic‐resistant pathogens. Herein, to accelerate the discove…
View article: Clinical challenges and opportunities related to the biological responses experienced by indwelling and implantable bioelectronic medical devices
Clinical challenges and opportunities related to the biological responses experienced by indwelling and implantable bioelectronic medical devices Open
Implantable electrodes have been utilized for decades to stimulate, sense, or monitor a broad range of biological processes, with examples ranging from glucose monitoring devices to cochlear implants. While the underlying science related t…
View article: Advances in additive manufacturing of auxetic structures for biomedical applications
Advances in additive manufacturing of auxetic structures for biomedical applications Open
Auxetic structures, a class of metamaterials, exhibit a unique negative Poisson's ratio behavior. Their mechanical properties demonstrate considerable potential for applications in biomedical engineering. Recent advances in additive manufa…
View article: Bioactive polymer composite scaffolds fabricated from 3D printed negative molds enable bone formation and vascularization
Bioactive polymer composite scaffolds fabricated from 3D printed negative molds enable bone formation and vascularization Open
Scaffolds for bone defect treatment should ideally support vascularization and promote bone formation, to facilitate the translation into biomedical device applications. This study presents a novel approach utilizing 3D-printed water-disso…
View article: Synergistic Polymer Coatings with Antibacterial and Antiviral Properties for Healthcare Applications
Synergistic Polymer Coatings with Antibacterial and Antiviral Properties for Healthcare Applications Open
[Image: see text] The role of frequently touched surfaces in the transmission of infectious diseases is well-documented, and the urgent need for effective surface technologies with antipathogen activity has been highlighted by the recent g…
View article: Selecting the best surface analysis method for your materials/samples
Selecting the best surface analysis method for your materials/samples Open
There are a large number of surface analytical methods, each with their own strengths and limitations. This review provides tools and an amalgamated source of information to those new to surface characterization or to those who would like …
View article: A surface-independent bioglue using photo-crosslinkable benzophenone moiety
A surface-independent bioglue using photo-crosslinkable benzophenone moiety Open
The UV-crosslinkable benzophenone (BP) “bio-glue” efficiently crosslinks with various surfaces and biomolecules. The beauty of this bio-glue lies in its simplicity and broad applicability, requiring no sophisticated equipment or reaction c…
View article: Fluoropolymer Functionalization of Organ-on-Chip Platform Increases Detection Sensitivity for Cannabinoids
Fluoropolymer Functionalization of Organ-on-Chip Platform Increases Detection Sensitivity for Cannabinoids Open
Microfluidic technology is applied across various research areas including organ-on-chip (OOC) systems. The main material used for microfluidics is polydimethylsiloxane (PDMS), a silicone elastomer material that is biocompatible, transpare…
View article: Advances in Design and Development of Lumi-Solve: A Novel Drug-Eluting Photo-Angioplasty Device
Advances in Design and Development of Lumi-Solve: A Novel Drug-Eluting Photo-Angioplasty Device Open
View article: Anti-infective characteristics of a new Carbothane ventricular assist device driveline
Anti-infective characteristics of a new Carbothane ventricular assist device driveline Open
This study provides experimental evidence to support the anti-biofilm activity of the Carbothane driveline and uncovered specific physicochemical features that may explain its ability to inhibit biofilm formation.
View article: One Step Antimicrobial Coatings for Medical Device Applications Based on Low Fouling Polymers Containing Selenium Nanoparticles
One Step Antimicrobial Coatings for Medical Device Applications Based on Low Fouling Polymers Containing Selenium Nanoparticles Open
View article: SARS‐CoV‐2 Virus Detection Via a Polymeric Nanochannel‐Based Electrochemical Biosensor
SARS‐CoV‐2 Virus Detection Via a Polymeric Nanochannel‐Based Electrochemical Biosensor Open
The development of simple, cost‐effective, rapid, and quantitative diagnostic tools remains critical to monitor infectious COVID‐19 disease. Although numerous diagnostic platforms, including rapid antigen tests, are developed and used, the…
View article: Porous Silicon Nanocarriers with Stimulus‐Cleavable Linkers for Effective Cancer Therapy
Porous Silicon Nanocarriers with Stimulus‐Cleavable Linkers for Effective Cancer Therapy Open
Porous silicon nanoparticles (pSiNPs) are widely utilized as drug carriers due to their excellent biocompatibility, large surface area, and versatile surface chemistry. However, the dispersion in pore size and biodegradability of pSiNPs ar…
View article: Industry Viable Electrochemical DNA Detection Sensor Architecture via a Stem-Loop Methylene Blue Redox Reporter and Rapid In Situ Probe Immobilization Method for Pharmacogenetic Biomarker Testing Application
Industry Viable Electrochemical DNA Detection Sensor Architecture via a Stem-Loop Methylene Blue Redox Reporter and Rapid In Situ Probe Immobilization Method for Pharmacogenetic Biomarker Testing Application Open
Identification of biomarkers in clinical applications for diagnostics at the point-of-care (POC) setting requires the development of industry viable biosensing platform. Herein, we report such development of biosensor architecture for the …
View article: Addressing a future pandemic: how can non-biological complex drugs prepare us for antimicrobial resistance threats?
Addressing a future pandemic: how can non-biological complex drugs prepare us for antimicrobial resistance threats? Open
Non-biological complex drugs (NBCDs) are an emerging class of therapeutics that show multi-mechanistic antimicrobial activity and hold great promise as next generation antimicrobial agents.
View article: Polymeric Nanoneedle Arrays Mediate Stiffness‐Independent Intracellular Delivery (Adv. Funct. Mater. 3/2022)
Polymeric Nanoneedle Arrays Mediate Stiffness‐Independent Intracellular Delivery (Adv. Funct. Mater. 3/2022) Open
Polymeric Nanoneedle Arrays In article number 2104828, Yaping Chen, Nicolas H. Voelcker, Roey Elnathan, and co-workers demonstrate the fabrication of relatively low-cost and high throughput polymeric nanoneedles from cell culture polystyre…
View article: The Requirement of Genetic Diagnostic Technologies for Environmental Surveillance of Antimicrobial Resistance
The Requirement of Genetic Diagnostic Technologies for Environmental Surveillance of Antimicrobial Resistance Open
Antimicrobial resistance (AMR) is threatening modern medicine. While the primary cost of AMR is paid in the healthcare domain, the agricultural and environmental domains are also reservoirs of resistant microorganisms and hence perpetual s…
View article: Next Generation Cell Culture Tools Featuring Micro‐ and Nanotopographies for Biological Screening
Next Generation Cell Culture Tools Featuring Micro‐ and Nanotopographies for Biological Screening Open
Cells can perceive complex mechanical cues across both the micro‐ and nanoscale which can influence their development. While causative effects between surface topography and cellular function can be demonstrated, the variability in materia…
View article: Precision Surface Microtopography Regulates Cell Fate via Changes to Actomyosin Contractility and Nuclear Architecture
Precision Surface Microtopography Regulates Cell Fate via Changes to Actomyosin Contractility and Nuclear Architecture Open
Cells are able to perceive complex mechanical cues from their microenvironment, which in turn influences their development. Although the understanding of these intricate mechanotransductive signals is evolving, the precise roles of substra…
View article: Conjugation of Polysulfobetaine via Poly(pyrogallol) Coatings for Improving the Antifouling Efficacy of Biomaterials
Conjugation of Polysulfobetaine via Poly(pyrogallol) Coatings for Improving the Antifouling Efficacy of Biomaterials Open
Antifouling treatment is critical to certain biomedical devices for their functions and patients' life. Facial, versatile, and universal coating methods to conjugate antifouling materials on a wide variety of biomaterials are beneficial fo…
View article: Films and Materials Derived from Aminomalononitrile
Films and Materials Derived from Aminomalononitrile Open
In recent years major advances in surface chemistry and surface functionalization have been performed through the development, most often inspired by living organisms, of versatile methodologies. Among those, the contact of substrates with…
View article: Nanobody-displaying porous silicon nanoparticles for the co-delivery of siRNA and doxorubicin
Nanobody-displaying porous silicon nanoparticles for the co-delivery of siRNA and doxorubicin Open
Targeted delivery of chemotherapeutics to cancer cells has the potential to yield high drug concentrations in cancer cells while minimizing any unwanted side effects.
View article: Dual Action Antimicrobial Surfaces: Alternating Photopatterns Maintain Contact‐Killing Properties with Reduced Biofilm Formation
Dual Action Antimicrobial Surfaces: Alternating Photopatterns Maintain Contact‐Killing Properties with Reduced Biofilm Formation Open
View article: Gelatin Hydrogels Reinforced by Absorbable Nanoparticles and Fibrils Cured In Situ by Visible Light for Tissue Adhesive Applications
Gelatin Hydrogels Reinforced by Absorbable Nanoparticles and Fibrils Cured In Situ by Visible Light for Tissue Adhesive Applications Open
Most gelatin hydrogels used in regenerative medicine applications today are fabricated by photocrosslinking due to the convenience and speed of this method. However, in most cases photoinitiators are used, which require UV light, which, in…
View article: Hyperosmotic Infusion and Oxidized Surfaces Are Essential for Biofilm Formation of Staphylococcus capitis From the Neonatal Intensive Care Unit
Hyperosmotic Infusion and Oxidized Surfaces Are Essential for Biofilm Formation of Staphylococcus capitis From the Neonatal Intensive Care Unit Open
Staphylococcus capitis is an opportunistic pathogen often implicated in bloodstream infections in the neonatal intensive care unit (NICU). This is assisted by its ability to form biofilms on indwelling central venous catheters (CVC)…
View article: Evaluation of the Novel Antimicrobial BCP3 in a Coating for Endotracheal Tubes
Evaluation of the Novel Antimicrobial BCP3 in a Coating for Endotracheal Tubes Open
Ventilator-associated pneumonia (VAP) is a highly common hospital-acquired infection affecting people that require mechanical ventilation. The endotracheal tube (ETT) used during the ventilation process provides a surface that can allow ba…
View article: Microencapsulation improves chondrogenesis<i>in vitro</i>and cartilaginous matrix stability<i>in vivo</i>compared to bulk encapsulation
Microencapsulation improves chondrogenesis<i>in vitro</i>and cartilaginous matrix stability<i>in vivo</i>compared to bulk encapsulation Open
The encapsulation of cells into microgels is attractive for applications in tissue regeneration.
View article: Astrochemistry and Astrobiology: Materials Science in Wonderland?
Astrochemistry and Astrobiology: Materials Science in Wonderland? Open
Astrochemistry and astrobiology, the fascinating disciplines that strive to unravel the origin of life, have opened unprecedented and unpredicted vistas into exotic compounds as well as extreme or complex reaction conditions of potential r…
View article: Tunable Chemical and Topographic Patterns Based on Binary Colloidal Crystals (BCCs) to Modulate MG63 Cell Growth
Tunable Chemical and Topographic Patterns Based on Binary Colloidal Crystals (BCCs) to Modulate MG63 Cell Growth Open
More effective and diversified surface modification strategies are required for materials used in biomedical engineering. Combining surface modification involving bioactive signals or nonfouling polymers with tunable topography has the pot…