Helmuth Reuter
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View article: Surgeon variation: a south african spinal pathology treatment survey
Surgeon variation: a south african spinal pathology treatment survey Open
Purpose To investigate variation in treatment decisions among spine surgeons in South Africa and the association between surgeon characteristics and the treatment they select. Methods We surveyed 79 South African spine surgeons. We present…
View article: Abdominal erythema ab igne—beyond the rash
Abdominal erythema ab igne—beyond the rash Open
View article: Regeneration of Pancreatic Beta Cells by Modulation of Molecular Targets Using Plant-Derived Compounds: Pharmacological Mechanisms and Clinical Potential
Regeneration of Pancreatic Beta Cells by Modulation of Molecular Targets Using Plant-Derived Compounds: Pharmacological Mechanisms and Clinical Potential Open
Type 2 diabetes (T2D) is characterized by pancreatic beta-cell dysfunction, increased cell death and loss of beta-cell mass despite chronic treatment. Consequently, there has been growing interest in developing beta cell-centered therapies…
View article: AB0963 SAFETY OF DISEASE-MODIFYING ANTI-RHEUMATIC DRUGS IN SPONDYLOARTHRITIS: A RETROSPECTIVE REVIEW FROM A SOUTH AFRICAN RHEUMATOLOGY CENTRE
AB0963 SAFETY OF DISEASE-MODIFYING ANTI-RHEUMATIC DRUGS IN SPONDYLOARTHRITIS: A RETROSPECTIVE REVIEW FROM A SOUTH AFRICAN RHEUMATOLOGY CENTRE Open
View article: Characterisation of a Standard Fan Test Facility to Accommodate Reflection of Sound During Noise Measurements
Characterisation of a Standard Fan Test Facility to Accommodate Reflection of Sound During Noise Measurements Open
Axial flow fans are fundamental to air-cooled condensers. While they provide the air flow for heat transfer, they also generate noise, which is a growing environmental concern. Sound reflections are characterised in an existing fan perform…
View article: Ivermectin exposures reported to the Poisons Information Helpline in South Africa during the COVID-19 pandemic
Ivermectin exposures reported to the Poisons Information Helpline in South Africa during the COVID-19 pandemic Open
Background. Ivermectin is an antiparasitic drug that has shown in vitro activity against COVID‑19. Clinical studies supporting ivermectin for COVID‑19 prevention and treatment are conflicting, with important limitations. Public support for…
View article: Bleeding and thrombosis outcomes in hospitalised COVID-19 patients on low-molecular-weight heparin and antiplatelet therapy
Bleeding and thrombosis outcomes in hospitalised COVID-19 patients on low-molecular-weight heparin and antiplatelet therapy Open
Background. An increased incidence of thromboembolic events in hospitalised COVID‐19 patients has been demonstrated despite the use of low‐molecular‐weight heparin (LMWH). Antiplatelet therapy prior to admission and early in the di…
View article: Therapeutic Benefit in Rheumatoid Cachexia Illustrated Using a Novel Primary Human Triple Cell Coculture Model
Therapeutic Benefit in Rheumatoid Cachexia Illustrated Using a Novel Primary Human Triple Cell Coculture Model Open
Background. The loss of muscle mass in rheumatoid arthritis (RA), termed rheumatoid cachexia, is predicted to result from the complex interactions between different cell types involved in the maintenance of skeletal muscle mass, namely, my…
View article: A retrospective review of calls to the Poisons Information Helpline of the Western Cape during the first 6 months of the COVID-19 pandemic in South Africa
A retrospective review of calls to the Poisons Information Helpline of the Western Cape during the first 6 months of the COVID-19 pandemic in South Africa Open
A change in the profile of poison exposures was observed during the COVID-19 pandemic. Lockdown regulations and greater availability of antiseptics and disinfectants probably led to the increase in exposures. Although symptoms were mostly …
View article: Drug concentration at the site of disease in children with pulmonary tuberculosis
Drug concentration at the site of disease in children with pulmonary tuberculosis Open
Background Current TB treatment for children is not optimized to provide adequate drug levels in TB lesions. Dose optimization of first-line antituberculosis drugs to increase exposure at the site of disease could facilitate more optimal t…
View article: Development of active tuberculosis in patients treated with biological disease-modifying antirheumatic drugs
Development of active tuberculosis in patients treated with biological disease-modifying antirheumatic drugs Open
Background. Biological disease-modifying antirheumatic drugs (bDMARDs) have been shown to be highly effective in the treatment of rheumatic conditions, but may increase the risk of infections. Development of tuberculosis (TB) while on bDMA…
View article: The Population Pharmacokinetics of Meropenem in Adult Patients With Rifampicin-Sensitive Pulmonary Tuberculosis
The Population Pharmacokinetics of Meropenem in Adult Patients With Rifampicin-Sensitive Pulmonary Tuberculosis Open
Background: Meropenem is being investigated for repurposing as an anti-tuberculosis drug. This study aimed to develop a meropenem population pharmacokinetics model in patients with pulmonary tuberculosis and identify covariates explaining …
View article: Higher SARS-CoV-2 seroprevalence in workers with lower socioeconomic status in Cape Town, South Africa
Higher SARS-CoV-2 seroprevalence in workers with lower socioeconomic status in Cape Town, South Africa Open
Background Inequality is rife throughout South Africa. The first wave of COVID-19 may have affected people in lower socioeconomic groups worse than the affluent. The SARS-CoV-2 seroprevalence and the specificity of anti-SARS-CoV-2 antibody…
View article: Ivermectin for COVID-19: Promising but not yet conclusive
Ivermectin for COVID-19: Promising but not yet conclusive Open
CITATION: Van Rensburg, R. et al. 2021. Ivermectin for COVID-19 : promising but not yet conclusive. South African Medical Journal, 111(3):188, doi:10.7196/SAMJ.2021.v111i3.15522.
View article: Higher SARS-CoV-2 Seroprevalence in Workers with Lower Socioeconomic Status in Cape Town, South Africa.
Higher SARS-CoV-2 Seroprevalence in Workers with Lower Socioeconomic Status in Cape Town, South Africa. Open
Background: South Africa has a high degree of inequality between population groups. The first wave of COVID-19 may have affected people in lower socioeconomic groups worse than the affluent. The SARS-CoV-2 seroprevalence and the specificit…
View article: Incident tuberculosis disease in patients receiving biologic therapies in the Western Cape, South Africa from 2007 to 2018
Incident tuberculosis disease in patients receiving biologic therapies in the Western Cape, South Africa from 2007 to 2018 Open
View article: The pharmacokinetics of para‐aminosalicylic acid and its relationship to efficacy and intolerance
The pharmacokinetics of para‐aminosalicylic acid and its relationship to efficacy and intolerance Open
Following its introduction as an antituberculosis agent close to 75 years ago, the use of para‐aminosalicylic acid (PAS) has been limited by gastrointestinal intolerance and multiple formulations were produced in attempts to reduce its occ…
View article: Benefit v. risk when using chloroquine in patients with severe COVID-19 disease
Benefit v. risk when using chloroquine in patients with severe COVID-19 disease Open
CITATION: Decloedt, E. H. et al. 2020. Benefit v. risk when using chloroquine in patients with severe COVID-19 disease. South African Medical Journal, doi.org/10.7196/SAMJ.2020.v110i5.14761.
View article: Issue Information
Issue Information Open
Aims and Scope: For more than 50 years, clinical pharmacologists, clinical and pharmaceutical researchers, drug development specialists, physicians, nurses, and other medical professionals have relied on The Journal of Clinical Pharmacolog…
View article: An overview of analgesics - anticonvulsants, antidepressants, and other medications (Part 3)
An overview of analgesics - anticonvulsants, antidepressants, and other medications (Part 3) Open
Pain is classified by various descriptions. Chronic pain has been described as being neuropathic (due to nervous system lesions), nociceptive (due to tissue damage), or mixed (a combination of neuropathic and nociceptive). The addition of …
View article: FRI0230 CLINICAL AND ECHOCARDIOGRAPHIC CHARACTERISTICS OF MYOCARDIAL INJURY IN SYSTEMIC LUPUS ERYTHEMATOSUS, CLASSIFIED ACCORDING TO CARDIAC MAGNETIC RESONANCECRITERIA
FRI0230 CLINICAL AND ECHOCARDIOGRAPHIC CHARACTERISTICS OF MYOCARDIAL INJURY IN SYSTEMIC LUPUS ERYTHEMATOSUS, CLASSIFIED ACCORDING TO CARDIAC MAGNETIC RESONANCECRITERIA Open
View article: An overview of analgesics: NSAIDs, paracetamol, and topical analgesics Part 1
An overview of analgesics: NSAIDs, paracetamol, and topical analgesics Part 1 Open
CITATION: Van Rensburg, R. & Reuter, H. 2019. An overview of analgesics : NSAIDs, paracetamol, and topical analgesics Part 1. South African Family Practice, 61(1):S4-S10, doi:10.1080/20786190.2019.1610228.
View article: An overview of analgesics: opioids, tramadol, and tapentadol (Part 2)
An overview of analgesics: opioids, tramadol, and tapentadol (Part 2) Open
Pain can be caused by several mechanisms, and the development of chronic pain (also known as pain chronification) is a complex and often unpredictable process. Opioids, tramadol, and tapentadol provide pharmacological solutions to chronic …
View article: An overview of analgesics: NSAIDs, paracetamol, and topical analgesics
An overview of analgesics: NSAIDs, paracetamol, and topical analgesics Open
Pain is a complex and unique experience. It encompasses several pathways, involving nociceptive signal generation (transduction) and propagation (transmission), as well as perception and modulation of the nociceptive stimuli. Nonsteroidal …
View article: The epidemiology and severity of scorpion envenoming in South Africa as managed by the Tygerberg Poisons Information Centre over a 10 year period
The epidemiology and severity of scorpion envenoming in South Africa as managed by the Tygerberg Poisons Information Centre over a 10 year period Open
The incidence of severe scorpionism to the TPIC was low. Care should be taken when children are involved and when calls are received more than six hours after the sting. TPIC consultants as well as healthcare professionals working in semi-…
View article: P2492Baroreflex activation therapy in heart failure with reduced ejection fraction improves cardiopulmonary function during exercise
P2492Baroreflex activation therapy in heart failure with reduced ejection fraction improves cardiopulmonary function during exercise Open
View article: Critical evaluation of causality assessment of herb–drug interactions in patients
Critical evaluation of causality assessment of herb–drug interactions in patients Open
The aim of this review was to assess the severity of adverse drug reactions (ADRs) due to herb–drug interactions (HDI) in patients taking herbs and prescribed medications based on published evidence. Electronic databases of PubMed, the Coc…
View article: Teaching Medicines Development in Africa
Teaching Medicines Development in Africa Open
Back ground
View article: Speckle tracking echocardiography in acute lupus myocarditis: comparison to conventional echocardiography
Speckle tracking echocardiography in acute lupus myocarditis: comparison to conventional echocardiography Open
Aims Lupus myocarditis occurs in 5–10% of patients with systemic lupus erythematosus (SLE). No single feature is diagnostic of lupus myocarditis. Speckle tracking echocardiography (STE) can detect subclinical left ventricular dysfunction i…
View article: An overview of the biological disease modifying drugs available for arthritic conditions in South Africa
An overview of the biological disease modifying drugs available for arthritic conditions in South Africa Open
The past decade has seen a major change in the treatment options and strategies for rheumatoid arthritis (RA) and the other immune-mediated arthritic diseases. The disease modifying antirheumatic drugs (DMARDs) are now used in early stages…