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View article: Comparative Effects of Glenzocimab and Eptifibatide on Bleeding Severity in 2 Mouse Models of Intracranial Hemorrhage
Comparative Effects of Glenzocimab and Eptifibatide on Bleeding Severity in 2 Mouse Models of Intracranial Hemorrhage Open
Background Antiplatelet drugs represent potential candidates for protecting the penumbral microcirculation during cerebral ischemia and improving the benefits of arterial recanalization in ischemic stroke. Yet while the efficacy of such ad…
View article: OC 10.3 Platelets Mediate Intracranial Aneurysm Formation and Rupture in Mice
OC 10.3 Platelets Mediate Intracranial Aneurysm Formation and Rupture in Mice Open
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View article: Imaging Cerebral Arteries Tortuosity and Velocities by Transcranial Doppler Ultrasound Is a Reliable Assessment of Brain Aneurysm in Mouse Models
Imaging Cerebral Arteries Tortuosity and Velocities by Transcranial Doppler Ultrasound Is a Reliable Assessment of Brain Aneurysm in Mouse Models Open
Background During the past few decades, several pathophysiological processes contributing to intracranial aneurysm (IA) rupture have been identified, including irregular IA shape, altered hemodynamic stress within the IA, and vessel wall i…
View article: PAI-1 production by reactive astrocytes drives tissue dysfibrinolysis in multiple sclerosis models
PAI-1 production by reactive astrocytes drives tissue dysfibrinolysis in multiple sclerosis models Open
View article: Imaging Modalities for Intracranial Aneurysm: More Than Meets the Eye
Imaging Modalities for Intracranial Aneurysm: More Than Meets the Eye Open
Intracranial aneurysms (IA) are often asymptomatic and have a prevalence of 3 to 5% in the adult population. The risk of IA rupture is low, however when it occurs half of the patients dies from subarachnoid hemorrhage (SAH). To avoid this …
View article: Imaging cerebral arteries tortuosity and velocities by transcranial Doppler ultrasound is a reliable assessment of brain aneurysm in mouse models
Imaging cerebral arteries tortuosity and velocities by transcranial Doppler ultrasound is a reliable assessment of brain aneurysm in mouse models Open
Background and Purpose Intracranial aneurysms (IAs) are common vascular abnormalities of the brain with a prevalence of 3.2% in the general population. In the past few decades, several pathophysiological processes leading to IA rupture wer…
View article: Tissue plasminogen activator worsens experimental autoimmune encephalomyelitis by complementary actions on lymphoid and myeloid cell responses
Tissue plasminogen activator worsens experimental autoimmune encephalomyelitis by complementary actions on lymphoid and myeloid cell responses Open
Background Tissue plasminogen activator (tPA) is a serine protease involved in fibrinolysis. It is released by endothelial cells, but also expressed by neurons and glial cells in the central nervous system (CNS). Interestingly, this enzyme…
View article: Nonionotropic Action of Endothelial NMDA Receptors on Blood–Brain Barrier Permeability via Rho/ROCK-Mediated Phosphorylation of Myosin
Nonionotropic Action of Endothelial NMDA Receptors on Blood–Brain Barrier Permeability via Rho/ROCK-Mediated Phosphorylation of Myosin Open
Increase in blood–brain barrier (BBB) permeability is a crucial step in neuroinflammatory processes. We previously showed that N Methyl D Aspartate Receptor (NMDARs), expressed on cerebral endothelial cells forming the BBB, regulate immune…
View article: Platelets Are at the Nexus of Vascular Diseases
Platelets Are at the Nexus of Vascular Diseases Open
Platelets are important actors of cardiovascular diseases (CVD). Current antiplatelet drugs that inhibit platelet aggregation have been shown to be effective in CVD treatment. However, the management of bleeding complications is still an i…
View article: Astrocytes regulate the balance between plasminogen activation and plasmin clearance via cell-surface actin
Astrocytes regulate the balance between plasminogen activation and plasmin clearance via cell-surface actin Open
Plasminogen activation is involved in many processes within the central nervous system, including synaptic plasticity, neuroinflammation and neurodegeneration. However, the mechanisms that regulate plasminogen activation in the brain still…