Helu Liu
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View article: Flourishing chemosynthetic life at the greatest depths of hadal trenches
Flourishing chemosynthetic life at the greatest depths of hadal trenches Open
Hadal trenches, some of the Earth's least explored and understood environments, have long been proposed to harbour chemosynthesis-based communities1,2. Despite increasing attention, actual documentation of such communities has been excepti…
View article: Evolution and genetic adaptation of fishes to the deep sea
Evolution and genetic adaptation of fishes to the deep sea Open
The deep sea, especially hadal zones, characterized by high-hydrostatic pressure, low temperatures, and near-total darkness, present some of the most challenging environments for life on Earth. However, teleost fish have successfully colon…
View article: Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy
Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy Open
While cell fate determination and maintenance are important in establishing and preserving tissue identity and function during development, aberrant cell fate transition leads to cancer cell heterogeneity and resistance to treatment. Here,…
View article: Analytical performance evaluation of the Mindray enzymatic assay for hemoglobin A1c measurement
Analytical performance evaluation of the Mindray enzymatic assay for hemoglobin A1c measurement Open
Hemoglobin A 1c (HbA 1c ) plays a crucial role in diabetes management. We aimed to evaluate the analytical performance of a new enzymatic method kit for HbA 1c measurement. The performance of the enzymatic method, including precision, accu…
View article: Genetic adaptations of sea anemone to hydrothermal environment
Genetic adaptations of sea anemone to hydrothermal environment Open
Hydrothermal vent habitats are characterized by high hydrostatic pressure, darkness, and the continuous release of toxic metal ions into the surrounding environment where sea anemones and other invertebrates thrive. Nevertheless, the under…
View article: Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy
Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy Open
While cell fate determination and maintenance are important in establishing and preserving tissue identity and function during development, aberrant cell fate transition leads to cancer cell heterogeneity and resistance to treatment. Here,…
View article: A local translation program regulates centriole amplification in the airway epithelium
A local translation program regulates centriole amplification in the airway epithelium Open
Biogenesis of organelles requires targeting of a subset of proteins to specific subcellular domains by signal peptides or mechanisms controlling mRNA localization and local translation. How local distribution and translation of specific mR…
View article: IL16 Regulates Osteoarthritis Progression as a Target Gene of Novel-miR-81
IL16 Regulates Osteoarthritis Progression as a Target Gene of Novel-miR-81 Open
Objective Functional polymorphisms of interleukin 16 (IL16) have been reported to be closely related to the risk of osteoarthritis (OA). However, how IL16 affects OA remains unclear. In this study, the role of IL16 in OA and the possible m…
View article: SARS-CoV-2 Nsp14 protein associates with IMPDH2 and activates NF-κB signaling
SARS-CoV-2 Nsp14 protein associates with IMPDH2 and activates NF-κB signaling Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to NF-κB activation and induction of pro-inflammatory cytokines, though the underlying mechanism for this activation is not fully understood. Our results reveal t…
View article: Nsun4 and Mettl3 mediated translational reprogramming of Sox9 promotes BMSC chondrogenic differentiation
Nsun4 and Mettl3 mediated translational reprogramming of Sox9 promotes BMSC chondrogenic differentiation Open
The chondrogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) has been used in the treatment and repair of cartilage defects; however, the in-depth regulatory mechanisms by which RNA modifications are involved in t…
View article: A local translation program regulates centriole amplification in the airway epithelium
A local translation program regulates centriole amplification in the airway epithelium Open
Biogenesis of organelles requires targeting of a subset of proteins to specific subcellular domains by signal peptides or mechanisms controlling mRNA localization and local translation. How local distribution and translation of specific mR…
View article: Prom1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epithelium
Prom1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epithelium Open
Differences in ciliary morphology and dynamics among multiciliated cells of the respiratory tract have been well reported and known to contribute to efficient mucociliary clearance. Nevertheless, little is known about how phenotypic differ…
View article: SARS-CoV-2 Nsp14 activates NF-κB signaling and induces IL-8 upregulation
SARS-CoV-2 Nsp14 activates NF-κB signaling and induces IL-8 upregulation Open
Summary Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to NF-κB activation and induction of pro-inflammatory cytokines, though the underlying mechanism for this activation is not fully understood. Our results …
View article: Full-length Transcriptome Sequences and Identification of Putative Genes for Carotenoids Accumulation in Polymorphic Noble Scallop Chlamys Nobilis
Full-length Transcriptome Sequences and Identification of Putative Genes for Carotenoids Accumulation in Polymorphic Noble Scallop Chlamys Nobilis Open
Background: Carotenoids are ubiquitous in marine bivalves and the accumulation mechanism has attracted widespread interest, but still remains unclear. The enrichment carotenoids noble scallop Chlamys nobilis provide a model animal to expla…
View article: Sequence and phylogenetic analysis of the mitochondrial genome for a giant clam commensal shrimp <i>Anchistus australis</i> (Decapoda: Caridea: Palaemonidae)
Sequence and phylogenetic analysis of the mitochondrial genome for a giant clam commensal shrimp <i>Anchistus australis</i> (Decapoda: Caridea: Palaemonidae) Open
The shrimp Anchistus australis was a giant clam commensal species. Here, we explored in detail its mitochondrial (mt) genome, which was 15,396 bp in length, containing 13 protein-coding genes, 2 ribosomal RNA genes, 21 transfer RNA genes, …
View article: Two Novel Short Peptidoglycan Recognition Proteins (PGRPs) From the Deep Sea Vesicomyidae Clam Archivesica packardana: Identification, Recombinant Expression and Bioactivity
Two Novel Short Peptidoglycan Recognition Proteins (PGRPs) From the Deep Sea Vesicomyidae Clam Archivesica packardana: Identification, Recombinant Expression and Bioactivity Open
Vesicomyidae clams are common species living in cold seeps, which incorporates symbiotic bacteria into their body maintaining endosymbiosis relationship. As members of pattern recognition receptor (PRR) family, peptidoglycan recognition pr…
View article: Comparative mitochondrial genomic analyses of three chemosynthetic vesicomyid clams from deep‐sea habitats
Comparative mitochondrial genomic analyses of three chemosynthetic vesicomyid clams from deep‐sea habitats Open
Vesicomyid clams of the subfamily Pliocardinae are among the dominant chemosymbiotic bivalves found in sulfide‐rich deep‐sea habitats. Plastic morphologies and present molecular data could not resolve taxonomic uncertainties. The complete …
View article: Characteristics of the Copper,Zinc Superoxide Dismutase of a Hadal Sea Cucumber (Paelopatides sp.) from the Mariana Trench
Characteristics of the Copper,Zinc Superoxide Dismutase of a Hadal Sea Cucumber (Paelopatides sp.) from the Mariana Trench Open
Superoxide dismutases (SODs) are among the most important antioxidant enzymes and show great potential in preventing adverse effects during therapeutic trials. In the present study, cloning, expression, and characterization of a novel Cu,Z…
View article: Molecular Cloning and Functional Characterisation of a Polyunsaturated Fatty Acid Elongase in a Marine Bivalve <i>Crassostrea</i><i> </i><i>angulata</i>
Molecular Cloning and Functional Characterisation of a Polyunsaturated Fatty Acid Elongase in a Marine Bivalve <i>Crassostrea</i><i> </i><i>angulata</i> Open
The elongases of fatty acids (ELO) are essential for long chain polyunsaturated fatty acid (LC-PUFA) biosynthesis, and their activities depend on the substrates. The full length cDNA of Crassostrea angulata ELO (CaELO) was cloned by RACE P…
View article: Evaluation of Plasma miR-21 and miR-152 as Diagnostic Biomarkers for Common Types of Human Cancers
Evaluation of Plasma miR-21 and miR-152 as Diagnostic Biomarkers for Common Types of Human Cancers Open
Stable blood based miRNA species have allowed for the differentiation of patients with various types of cancer. Therefore, specific blood-based miRNA might be considered as a methodology which could be informative of the presence of cancer…
View article: A de novo transcriptome of the noble scallop, Chlamys nobilis, focusing on mining transcripts for carotenoid-based coloration
A de novo transcriptome of the noble scallop, Chlamys nobilis, focusing on mining transcripts for carotenoid-based coloration Open
Transcriptome analysis of noble scallop reveals a novel scavenger receptor significantly associated with orange scallop rich in carotenoid content. Our findings pave the way for further functional elucidation of this gene and molecular bas…